Advanced Search (OLGA)

Gene: Kdm2b (lysine demethylase 2B) Rattus norvegicus

Analyze

Symbol:

Kdm2b

Name:

lysine demethylase 2B

RGD ID:

1310217

Description:

Predicted to enable several functions, including histone H3K36 demethylase activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including brain development; embryonic morphogenesis; and negative regulation of neuron apoptotic process. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II; positive regulation of cell growth; and positive regulation of stem cell population maintenance. Predicted to be located in nucleus. Predicted to be part of PcG protein complex. Used to study T-cell non-Hodgkin lymphoma. Orthologous to human KDM2B (lysine demethylase 2B); PARTICIPATES IN DNA modification pathway; histone modification pathway; INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; bis(2-ethylhexyl) phthalate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

F-box and leucine-rich repeat protein 10; Fbxl10; LOC304495; lysine (K)-specific demethylase 2B; lysine-specific demethylase 2B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KDM2B (lysine demethylase 2B)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Kdm2b (lysine (K)-specific demethylase 2B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Kdm2b (lysine demethylase 2B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KDM2B (lysine demethylase 2B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KDM2B (lysine demethylase 2B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Kdm2b (lysine demethylase 2B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KDM2B (lysine demethylase 2B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KDM2B (lysine demethylase 2B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Kdm2b (lysine demethylase 2B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Kdm2b (lysine demethylase 2B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	KDM2B (lysine demethylase 2B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	KDM2B (lysine demethylase 2B)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Kdm2b (lysine (K)-specific demethylase 2B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Kdm2b (lysine (K)-specific demethylase 2B)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	LOC100536129 (lysine-specific demethylase 2B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	LOC100536129 (lysine-specific demethylase 2B)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	JHD1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	JHD1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Kdm2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Kdm2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	jhdm-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	jhdm-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	kdm2b	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder)
Xenopus tropicalis (tropical clawed frog):	kdm2b	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	39,224,422 - 39,362,126 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	39,235,301 - 39,362,127 (+)	Ensembl				GRCr8
mRatBN7.2	12	33,566,530 - 33,701,366 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	33,574,657 - 33,701,355 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	34,753,500 - 34,880,474 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	35,364,864 - 35,491,838 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	34,416,500 - 34,543,259 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	39,021,924 - 39,161,954 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	39,078,119 - 39,161,956 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	40,918,049 - 41,054,953 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	34,672,334 - 34,802,802 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	35,254,131 - 35,380,144 (+)	NCBI		Celera
RGSC_v3.1	12	34,528,594 - 34,666,191 (+)	NCBI
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute lymphoblastic leukemia (ISO)

Developmental Disabilities (ISO)

genetic disease (ISO)

neural tube defect (ISO)

Neurodevelopmental Disorders (ISO)

pancreatic ductal carcinoma (ISO)

schizophrenia (ISO)

severe combined immunodeficiency (ISO)

T-cell non-Hodgkin lymphoma (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

calcitriol (ISO)

choline (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

diethylstilbestrol (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

glycidol (EXP)

ketoconazole (ISO)

L-methionine (ISO)

menadione (ISO)

methoxychlor (EXP)

N-methylformamide (ISO)

okadaic acid (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pinostrobin (ISO)

pirinixic acid (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tebuconazole (ISO)

temozolomide (ISO)

testosterone (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

tungsten (ISO)

uranium atom (ISO)

valproic acid (ISO)

vincristine (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

chromatin organization (IEA)

chromatin remodeling (IBA,IEA,ISO)

DNA-templated transcription (IEA)

embryonic camera-type eye morphogenesis (ISO)

embryonic organ morphogenesis (IEA)

forebrain development (ISO)

fourth ventricle development (ISO)

hindbrain development (ISO)

initiation of neural tube closure (ISO)

lateral ventricle development (ISO)

midbrain development (ISO)

midbrain-hindbrain boundary morphogenesis (ISO)

negative regulation of neural precursor cell proliferation (ISO)

negative regulation of neuron apoptotic process (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

neural tube closure (IEA)

positive regulation of cell growth (ISO)

positive regulation of stem cell population maintenance (ISO)

regulation of transcription by RNA polymerase II (IBA)

spermatogenesis (ISO)

third ventricle development (ISO)

Cellular Component

chromosome (IEA)

nucleolus (IEA)

nucleoplasm (ISO)

nucleus (IEA,ISO)

PcG protein complex (ISO)

Molecular Function

dioxygenase activity (IEA)

DNA binding (IEA)

histone demethylase activity (IBA)

histone H3K36 demethylase activity (IEA,ISO)

histone H3K36me/H3K36me2 demethylase activity (IEA)

metal ion binding (IEA)

oxidoreductase activity (IEA)

protein binding (ISO)

RNA binding (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (ISO)

rRNA binding (IEA)

sequence-specific DNA binding (IEA)

transcription coregulator activity (IBA)

unmethylated CpG binding (ISO)

zinc ion binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

DNA modification pathway (ISO)

histone modification pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Histone lysine methylation dynamics: establishment, regulation, and biological impact.	Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
2.	Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly.	Fukuda T, etal., Mol Cell Neurosci. 2011 Mar;46(3):614-24. doi: 10.1016/j.mcn.2011.01.001. Epub 2011 Jan 8.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia.	He J, etal., Blood. 2011 Apr 7;117(14):3869-80. doi: 10.1182/blood-2010-10-312736. Epub 2011 Feb 10.
6.	ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection.	Long HK, etal., Biochem Soc Trans. 2013 Jun;41(3):727-40. doi: 10.1042/BST20130028.
7.	Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process.	Pfau R, etal., Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1907-12. doi: 10.1073/pnas.0711865105. Epub 2008 Feb 4.
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Comprehensive gene review and curation	RGD comprehensive gene curation
12.	KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs.	Tzatsos A, etal., J Clin Invest. 2013 Feb 1;123(2):727-39. doi: 10.1172/JCI64535. Epub 2013 Jan 16.

Additional References at PubMed

PMID:12477932	PMID:16943429	PMID:21245044	PMID:21540074	PMID:26237645	PMID:29276034	PMID:30701683	PMID:36610229

Genomics

Comparative Map Data

Kdm2b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	39,224,422 - 39,362,126 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	39,235,301 - 39,362,127 (+)	Ensembl				GRCr8
mRatBN7.2	12	33,566,530 - 33,701,366 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	33,574,657 - 33,701,355 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	34,753,500 - 34,880,474 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	35,364,864 - 35,491,838 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	34,416,500 - 34,543,259 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	39,021,924 - 39,161,954 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	39,078,119 - 39,161,956 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	40,918,049 - 41,054,953 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	34,672,334 - 34,802,802 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	35,254,131 - 35,380,144 (+)	NCBI		Celera
RGSC_v3.1	12	34,528,594 - 34,666,191 (+)	NCBI
Cytogenetic Map	12	q16	NCBI

KDM2B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	121,408,461 - 121,582,279 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	121,429,096 - 121,582,279 (-)	Ensembl			hg38	GRCh38
GRCh37	12	121,866,899 - 122,018,928 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	120,351,282 - 120,503,272 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	120,329,621 - 120,481,609	NCBI
Celera	12	121,504,570 - 121,659,235 (-)	NCBI		Celera
Cytogenetic Map	12	q24.31	NCBI
HuRef	12	118,876,689 - 119,030,563 (-)	NCBI		HuRef
CHM1_1	12	121,835,483 - 121,987,302 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	121,399,894 - 121,575,445 (-)	NCBI		T2T-CHM13v2.0

Kdm2b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	123,008,727 - 123,127,333 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	123,008,728 - 123,127,886 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	122,870,664 - 122,989,270 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	122,870,665 - 122,989,823 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	123,320,677 - 123,439,101 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	123,131,285 - 123,249,709 (-)	NCBI		MGSCv36	mm8
Celera	5	119,957,271 - 120,084,228 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	62.63	NCBI

Kdm2b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	6,774,059 - 6,887,171 (+)	Ensembl
ChiLan1.0	NW_004955482	6,774,021 - 6,885,113 (+)	NCBI	ChiLan1.0	ChiLan1.0

KDM2B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	129,514,895 - 129,684,962 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	129,511,238 - 129,666,874 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	119,027,633 - 119,183,779 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	122,401,296 - 122,556,980 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	122,401,296 - 122,555,246 (-)	Ensembl			panPan2	panpan1.1

KDM2B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	7,625,857 - 7,746,049 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	7,598,931 - 7,745,113 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	7,778,701 - 7,911,744 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	7,871,067 - 8,003,890 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	7,850,561 - 8,002,965 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	7,802,586 - 7,935,340 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	7,892,991 - 8,022,611 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	7,848,879 - 7,978,638 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Kdm2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	156,582,047 - 156,708,113 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936558	2,771,420 - 2,897,292 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936558	2,771,420 - 2,897,694 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KDM2B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	31,165,950 - 31,203,091 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	31,057,121 - 31,203,093 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	32,925,246 - 32,951,346 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KDM2B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	116,805,541 - 116,957,236 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	116,796,370 - 116,956,334 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	128,077,630 - 128,228,683 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kdm2b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624747	21,922,249 - 22,047,246 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Kdm2b
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	30,834,088 - 30,960,270 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Kdm2b
1059 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	179
Count of miRNA genes:	119
Interacting mature miRNAs:	150
Transcripts:	ENSRNOT00000044071
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	50386405	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	37764145	51558799	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
70169	Eae13	Experimental allergic encephalomyelitis QTL 13		0.032	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	12	29775522	42298555	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	33700432	51558799	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
631829	Alc6	Alcohol consumption QTL 6	4.7		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	34243475	43352593	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	49212240	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat

Markers in Region

D5Mit34

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	17	74,764,533 - 74,764,648	NCBI	Rnor5.0
Rnor_5.0	12	8,671,276 - 8,671,441	NCBI	Rnor5.0
RGSC_v3.4	17	80,708,403 - 80,708,517	UniSTS	RGSC3.4
RGSC_v3.4	12	5,876,949 - 5,877,113	UniSTS	RGSC3.4
Celera	12	7,246,795 - 7,246,959	UniSTS
Celera	17	68,761,754 - 68,761,868	UniSTS
Celera	12	35,283,557 - 35,283,676	UniSTS
Cytogenetic Map	12	q16	UniSTS

AA925036

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	33,700,961 - 33,701,078 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	39,161,581 - 39,161,697	NCBI	Rnor6.0
Rnor_5.0	12	41,054,580 - 41,054,696	UniSTS	Rnor5.0
RGSC_v3.4	12	34,802,427 - 34,802,543	UniSTS	RGSC3.4
Celera	12	35,379,769 - 35,379,885	UniSTS
RH 3.4 Map	12	605.5	UniSTS
Cytogenetic Map	12	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100679	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598337	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089472	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089475	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089483	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089485	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271326	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271327	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271328	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271329	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271331	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271332	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271333	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271334	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271335	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271336	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271337	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC082040	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224397	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000044071 ⟹ ENSRNOP00000050408

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	39,290,173 - 39,362,127 (+)	Ensembl
mRatBN7.2 Ensembl	12	33,629,189 - 33,701,337 (+)	Ensembl
Rnor_6.0 Ensembl	12	39,078,119 - 39,161,956 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094475 ⟹ ENSRNOP00000078467

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	39,235,478 - 39,361,227 (+)	Ensembl
mRatBN7.2 Ensembl	12	33,574,657 - 33,700,438 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106205 ⟹ ENSRNOP00000089414

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	39,236,064 - 39,362,127 (+)	Ensembl
mRatBN7.2 Ensembl	12	33,575,256 - 33,701,337 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107393 ⟹ ENSRNOP00000091279

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	39,235,478 - 39,362,126 (+)	Ensembl
mRatBN7.2 Ensembl	12	33,574,660 - 33,701,337 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119628 ⟹ ENSRNOP00000082558

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	39,331,637 - 39,362,127 (+)	Ensembl
mRatBN7.2 Ensembl	12	33,670,914 - 33,701,355 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000146321 ⟹ ENSRNOP00000105523

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	39,235,301 - 39,362,127 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000163872 ⟹ ENSRNOP00000101594

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	39,276,689 - 39,362,127 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000165085 ⟹ ENSRNOP00000107970

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	39,235,478 - 39,362,126 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000166421 ⟹ ENSRNOP00000111972

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	39,277,798 - 39,362,127 (+)	Ensembl

RefSeq Acc Id:

NM_001100679 ⟹ NP_001094149

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,235,478 - 39,362,126 (+)	NCBI
mRatBN7.2	12	33,574,660 - 33,701,337 (+)	NCBI
Rnor_6.0	12	39,022,000 - 39,161,954 (+)	NCBI
Rnor_5.0	12	40,918,049 - 41,054,953 (+)	NCBI
RGSC_v3.4	12	34,672,334 - 34,802,802 (+)	RGD
Celera	12	35,254,131 - 35,380,144 (+)	RGD

Sequence:

show sequence

TGAAAATGGTTTCCTAGGACTTTGCAAACGGATCTGCTTAAGTGTTGGTGCAAAACTTTGTAGA
TATCGGCTCTGGCTTGCTCTATTTATTTATTTTTTTTTTGGTTTCTTTTCTTTGGTCTTCCCTC
CTTTCCCCCTCCGCCAAAATGCAGGGGGCAGGAGTGTTGACAATTAATTGGTGAACTCCCCTAA
AAAAATGGAGGCAGAGAAAGACTCTGGAAGAAGATTGCGTGCGATTGACCGCCAGAGATACGAC
GAGAACGAAGACTTGTCGGACGTGGAGGAAATTGTCAGCGTCCGTGGCTTCAGCCTGGAGGAGA
AGCTACGTAGCCAGCTATACCAGGGGGACTTCGTGCATGCCATGGAAGGCAAAGATTTTAACTA
TGAGTACGTACAGAGAGAAGCTCTCAGGGTTCCCCTGGTTTTTCGAGACAAGGATGGACTAGGA
ATCAAGATGCCAGACCCTGACTTCACAGTCCGAGACGTCAAACTCCTGGTGGGGAGTCGCCGGC
TGGTGGACGTGATGGACGTGAACACCCAGAAGGGCACGGAGATGAGCATGTCCCAGTTCGTGCG
TTACTACGAGACACCAGAGGCACAGAGGGACAAACTGTACAATGTCATCAGCCTCGAGTTCAGC
CATACGAAGCTGGAGCATCTAGTCAAGCGTCCCACTGTGGTGGACCTGGTCGACTGGGTGGACA
ACATGTGGCCCCAACATCTAAAGGAAAAGCAGACAGAAGCCACAAACGCCCTTGCCGAGATGAA
ATACCCCAAAGTGAAGAAGTACTGTCTGATGAGCGTGAAGGGCTGTTTCACCGACTTCCACATT
GACTTTGGAGGCACCTCCGTGTGGTACCATGTTTTCCGTGGCGGGAAGATCTTTTGGCTGATCC
CCCCAACCCTGCACAACTTGGCTCTGTATGAGGAGTGGGTGCTGTCTGGCAAACAGAGTGACAT
CTTTCTGGGAGACCGAGTGGAACGCTGCCAAAGAATTGAGCTGAAGCAAGGCTACACATTTTTC
ATCCCTTCTGGTTGGATCCATGCAGTGTACACGCCCGTGGACTCTCTGGTGTTCGGCGGGAACA
TCCTGCACAGCTTCAACGTGCCCATGCAGCTGCGCATCTACGAGATCGAGGACAGGACCCGGGT
TCAGCCCAAGTTCCGTTACCCCTTCTACTATGAGATGTGCTGGTATGTCTTGGAGAGATACGTG
TACTGTGTGACCCAGCGCTCCTACCTCACTCAGGAATACCAGCGAGAATTAATGCTCATTGATG
CCCCAAGAAAAAACAGTGTAGACGGTTTCTCATCTGATTCCTGGCTGGAGATGGAGGAGGAGTC
CCGTGAGCAGCAGCTCCAGGAGGAGGAGGACAAGGAAGAGGAAGGGGATGGTGCAGACAAAACA
CCCAAGCCACCCACCGAGGGCCCCACCTCACCCACCAGCACCCAGTCGGAAGACCAGGACAGCA
CAGGGAAGAAGCCTAAAGCCCCTGCTATGCGATTCCTCAAGAGGACTTTGTCCAATGAGTCCGA
GGAAAGTGTCAAGTCCACAGCGATGCCCGTAGACTACCCCAAGACGCCCACAGGCTCCCCGGCC
ACTGAGGTTTCTACCAAGTGGACTCACCTTACCGAATTTGAACTGAAGGGCTTGAAAGCCCTGG
TTGAAAAACTAGAGTCTCTTCCGGAGAATAAGAAGTGTGTCCCTGAGGGAATTGAGGACCCCCA
GGCCCTCCTGGAAGGTGTTAAGAATGTACTGAAGGAACACGTGGATGATGACCCCAACCTGGCC
ATCACCGGGGTCCCCGTGGTCAGTTGGCCAAAGAAAACTCCAAAGAACCGGGTGGTGGGTCGGC
CTAAGGGCAAGTTGGGCCCGGCCTCAGCGGTGAAGTTGGCTGCCAACCGAACAACAGCAGGAGC
TCGCAGGCGCCGGACGCGATGCCGCAAGTGCGAGGCCTGCCTGCGGACGGAGTGTGGAGAGTGC
CACTTTTGCAAGGACATGAAGAAGTTCGGAGGTCCTGGGCGCATGAAGCAGAGCTGCATCATGC
GGCAGTGCATCGCGCCAGTGCTGCCCCACACCGCCGTGTGCCTTGTGTGTGGCGAGGCAGGGAA
GGAGGACACAGTGGAAGAGGAAGAAGGCAAGTTTAACCTCATGCTCATGGAGTGCTCCATCTGC
AACGAGATCATCCACCCTGGATGCCTTAAGATTAAGGAATCAGAGGGTGTGGTCAACGATGAGC
TTCCCAACTGCTGGGAGTGTCCGAAGTGTAACCATGCCGGCAAGACCGGGAAACAAAAGCGTGG
CCCTGGCTTTAAGTATGCCTCCAACTTGCCTGGCTCCTTGCTCAAGGAGCAGAAGATGAACCGG
GACAACAAGGAAGGGCAGGAGCCTGCCAAGCGGAGGAGTGAGTGTGAAGAGGCCCCCCGTCGCA
GGTCAGACGAGCACCCCAAGAAGGTGCCTACAGATGGCATCCTCCGCCGAAAGTCTGACGATGT
GCACCTGAGGAGGAAGCGGAAATACGAGAAGCCCCAAGAGCTGAGTGCACGCAAGCGAGCCTCG
ACGCTTCAAACGTCCCCCGGTTCCTCCTCTCACCTCTCGCCGAGGCCCCCTCTAGGCAGCAGTC
TCAGCCCTTGGTGGAGATCCAGTCTCACTTACTTCCAGCAGCAGCTAAAACCTGGCAAAGAAGA
TAAGCTTCTCAGGAAAAAGCGGCGGTCCTGGAAGAACGCTGAGGATCGGCTGTCACTGGCCAAC
AAGCCCCTTCGGCGCTTCAAGCAGGAGCCAGAGGACGACCTGCCTGAGGCACCTCCTAAGACCC
GGGAGAGTGATCAGTCACGGTCCAGCTCGCCCACAGCTGGGCCCAGCACTGAGGGGGCCGAGGG
CCCAGAAGAGAAGAGGAAGGTGAAGATGCGCCGGAAACGGCGGCTTCCCAACAAGGAGTTGAGC
AAAGAGCTAAGCAAGGAGCTCAACCACGAGATCCAAAAGACAGAGAGCACCTTAGCCCACGAGA
ACCACCAGCCTATCAAGTCAGAGCCCGAGAGTGAAAACGAGGAGCCAAAGAGGCCCTTAAGCCA
CTGCGAGCGCCCGCACCGCTTCAGCAAAGGGCTCAACGGCACTCCTCGGGAGCTGCGGCACTCA
CTGGGACCTGGGCTTCGCAGCCCACCTCGTGTCATCTCCCGGCCCCCGCCCTCTACATCCCCAC
CCAAGTGCATCCAGATGGAGCGTCACGTGATCCGGCCACCACCCATCAGCCCCCCACCTGACTC
GCTGCCCCTGGATGATGGAGCAGCCCATGTCATGCATAGGGAGGTGTGGATGGCAGTCTTCAGC
TACCTCAGCCACCAAGACCTGTGTGTCTGCATGCGGGTCTGCAGGACCTGGAACCGCTGGTGCT
GCGATAAGCGGTTGTGGACCCGCATCGACCTGAACCACTGCAAGTCCATCACTCCCCTGATGCT
GAGCGGCATCATCCGGCGGCAGCCGGTCTCCCTGGATCTCAGCTGGACCAACATCTCCAAGAAG
CAGCTGAGCTGGCTCATCAACCGGTTGCCTGGGCTCCGAGACTTGGTGCTGTCAGGCTGCTCAT
GGATCGCTGTCTCAGCCCTCTGTAGCTCCAGTTGTCCACTGCTCCGGACCCTGGATGTCCAGTG
GGTAGAAGGACTAAAGGATGCCCAGATGCGGGATCTCCTGTCTCCACCCACAGACAACAGGCCA
GGTCAAATGGACAATCGGAGCAAGCTCCGGAACATTGTGGAACTGCGCCTAGCTGGCCTGGACA
TCACAGATGTCTCCCTGCGGCTCATTATTCGCCATATGCCCCTGCTCTCCAAGCTCCACCTCAG
TTACTGTAACCACGTCACTGATCAGTCCATCAACCTGCTCACTGCGGTCGGCACCACCACCCGG
GACTCTCTGACAGAGATCAACCTATCGGACTGCAATAAGGTCACTGACCAGTGCCTGTCCTTCT
TCAAACGCTGTGGAAATATCTGTCATATTGACCTGAGGTACTGCAAGCAAGTCACCAAGGAAGG
CTGTGAGCAGTTCATAGCTGAAATGTCTGTGAGTGTCCAGTTTGGGCAAGTGGAAGAGAAACTC
CTGCAAAAACTAAGTTAGCTCCAGGACAAGGATGTAAATATGGGGGTTTGGGGGAATACAGCCA
GGGAGAGGGAAGACTGCAGAGACAAGTGGGCCTGTATTTCCCTTTGGAATCTGAAACGAGACTA
CAGGACACAGTTCTGTTTTGCAAGTCTTGCCAAGGGAGAAGCCGTTCAACCACCCATTTGGGGA
TGAGTGAGCCAGATGTTTTCCTTTGCTCTTTCTACATCGTAACTGCACTGCTTCTGGACCATTT
CTAAGGCGGCCTTTAGAAGACATTCCAATTGCAAAGGAAGATGAGCTTCAGAGAAATCCTCTTA
GAAGCCTGAGTTTAGTGTTTTTATCAGCAGCTTCTGTTTGGGACACCTTGTTCCTTGCAATGCT
GAGGCTTCTGGTGTCAACATGGAGTGGACCACAAACACCACCTGCAGCCATCTTGACACATTTT
GTTTAGTTGGTTTTGTTACACCTTACATTATGCAGAACTATTTTTGTATAAATTGTTTAAAAAT
TATTTATGCAAGATTTGAATGCATACCAGTGTTTTTATTATTTAGATTGCCAACTGTCCTTCAG
GTAGGAGAGAACTTAACCTGTATTTTGTCAACATAAAAAGCCCATCTCCAGATGTGCCCAGGTG
TGACGGGGGCTATGACCTTCCACTTAAAAAAGCATGTTTAACTGGATGCTGAGAGCCTACTCTG
TATGTCAAGAAGTTACAAGCATGTTGTGGATGTGTGTAAAGTATAGTCCAGGTAAAGACACTTT
GCCAAGTTTCAATAGAATTCACCTTTTCCTCAAAGTTTTACAATGCAGACTTCGGCCTTTACAC
TCAGGAGGGTTTTGCTCCAAGCATGAGCTCTTGTATTCTATTTACATAGATCTAATTTATACCA
TGAGTCAGGTAGAGTAAATGTGCCCATAGCCTTTCCTCTGTCCCCTCCTTTCAAGTGTTCAGTT
CTCACTTAAGTTGGTAAGCTGGCTATTTTCTAGTTGTCAAGTTCTGCAACCCTGTGTGCCATTG
TTGTTTGGTGGTATCCTAACCTTTCCCTGATGAGGTTTTACCTTTGTTGGATTTGTATAAACAG
TTGTAC

hide sequence

RefSeq Acc Id:

XM_039089472 ⟹ XP_038945400

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,230,758 - 39,361,559 (+)	NCBI
mRatBN7.2	12	33,575,187 - 33,701,366 (+)	NCBI

RefSeq Acc Id:

XM_039089475 ⟹ XP_038945403

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,230,752 - 39,361,559 (+)	NCBI
mRatBN7.2	12	33,574,667 - 33,701,365 (+)	NCBI

RefSeq Acc Id:

XM_039089483 ⟹ XP_038945411

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,331,615 - 39,361,559 (+)	NCBI
mRatBN7.2	12	33,670,827 - 33,701,366 (+)	NCBI

RefSeq Acc Id:

XM_039089484 ⟹ XP_038945412

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,331,617 - 39,361,559 (+)	NCBI
mRatBN7.2	12	33,670,828 - 33,701,366 (+)	NCBI

RefSeq Acc Id:

XM_039089485 ⟹ XP_038945413

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,331,616 - 39,361,559 (+)	NCBI
mRatBN7.2	12	33,670,827 - 33,701,366 (+)	NCBI

RefSeq Acc Id:

XM_063271326 ⟹ XP_063127396

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,230,752 - 39,361,559 (+)	NCBI

RefSeq Acc Id:

XM_063271327 ⟹ XP_063127397

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,230,752 - 39,361,559 (+)	NCBI

RefSeq Acc Id:

XM_063271328 ⟹ XP_063127398

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,230,745 - 39,361,559 (+)	NCBI

RefSeq Acc Id:

XM_063271329 ⟹ XP_063127399

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,224,422 - 39,361,559 (+)	NCBI

RefSeq Acc Id:

XM_063271330 ⟹ XP_063127400

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,230,747 - 39,361,559 (+)	NCBI

RefSeq Acc Id:

XM_063271331 ⟹ XP_063127401

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,277,892 - 39,361,559 (+)	NCBI

RefSeq Acc Id:

XM_063271332 ⟹ XP_063127402

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,277,899 - 39,361,559 (+)	NCBI

RefSeq Acc Id:

XM_063271333 ⟹ XP_063127403

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,276,670 - 39,361,559 (+)	NCBI

RefSeq Acc Id:

XM_063271334 ⟹ XP_063127404

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,276,681 - 39,361,559 (+)	NCBI

RefSeq Acc Id:

XM_063271335 ⟹ XP_063127405

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,276,072 - 39,361,559 (+)	NCBI

RefSeq Acc Id:

XM_063271336 ⟹ XP_063127406

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,286,999 - 39,361,559 (+)	NCBI

RefSeq Acc Id:

XM_063271337 ⟹ XP_063127407

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,288,251 - 39,361,559 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001094149	(Get FASTA)	NCBI Sequence Viewer
	XP_038945400	(Get FASTA)	NCBI Sequence Viewer
	XP_038945403	(Get FASTA)	NCBI Sequence Viewer
	XP_038945411	(Get FASTA)	NCBI Sequence Viewer
	XP_038945412	(Get FASTA)	NCBI Sequence Viewer
	XP_038945413	(Get FASTA)	NCBI Sequence Viewer
	XP_063127396	(Get FASTA)	NCBI Sequence Viewer
	XP_063127397	(Get FASTA)	NCBI Sequence Viewer
	XP_063127398	(Get FASTA)	NCBI Sequence Viewer
	XP_063127399	(Get FASTA)	NCBI Sequence Viewer
	XP_063127400	(Get FASTA)	NCBI Sequence Viewer
	XP_063127401	(Get FASTA)	NCBI Sequence Viewer
	XP_063127402	(Get FASTA)	NCBI Sequence Viewer
	XP_063127403	(Get FASTA)	NCBI Sequence Viewer
	XP_063127404	(Get FASTA)	NCBI Sequence Viewer
	XP_063127405	(Get FASTA)	NCBI Sequence Viewer
	XP_063127406	(Get FASTA)	NCBI Sequence Viewer
	XP_063127407	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH82040	(Get FASTA)	NCBI Sequence Viewer
	EDM13662	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000050408
	ENSRNOP00000050408.6
	ENSRNOP00000078467.1
	ENSRNOP00000082558
	ENSRNOP00000082558.1
	ENSRNOP00000089414
	ENSRNOP00000089414.1
	ENSRNOP00000091279
	ENSRNOP00000091279.2
	ENSRNOP00000101594
	ENSRNOP00000101594.1
	ENSRNOP00000105523
	ENSRNOP00000105523.1
	ENSRNOP00000107970
	ENSRNOP00000107970.1
	ENSRNOP00000111972
	ENSRNOP00000111972.1

RefSeq Acc Id:

NP_001094149 ⟸ NM_001100679

- UniProtKB:

A0A8I6ABR9 (UniProtKB/TrEMBL), A6J173 (UniProtKB/TrEMBL), A0A8I5ZKW7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEAEKDSGRRLRAIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYE
YVQREALRVPLVFRDKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRY
YETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNALAEMKY
PKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIF
LGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQ
PKFRYPFYYEMCWYVLERYVYCVTQRSYLTQEYQRELMLIDAPRKNSVDGFSSDSWLEMEEESR
EQQLQEEEDKEEEGDGADKTPKPPTEGPTSPTSTQSEDQDSTGKKPKAPAMRFLKRTLSNESEE
SVKSTAMPVDYPKTPTGSPATEVSTKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQA
LLEGVKNVLKEHVDDDPNLAITGVPVVSWPKKTPKNRVVGRPKGKLGPASAVKLAANRTTAGAR
RRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKE
DTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGP
GFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHPKKVPTDGILRRKSDDVH
LRRKRKYEKPQELSARKRASTLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDK
LLRKKRRSWKNAEDRLSLANKPLRRFKQEPEDDLPEAPPKTRESDQSRSSSPTAGPSTEGAEGP
EEKRKVKMRRKRRLPNKELSKELSKELNHEIQKTESTLAHENHQPIKSEPESENEEPKRPLSHC
ERPHRFSKGLNGTPRELRHSLGPGLRSPPRVISRPPPSTSPPKCIQMERHVIRPPPISPPPDSL
PLDDGAAHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLS
GIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWV
EGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDVSLRLIIRHMPLLSKLHLSY
CNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGC
EQFIAEMSVSVQFGQVEEKLLQKLS

hide sequence

Ensembl Acc Id:

ENSRNOP00000050408 ⟸ ENSRNOT00000044071

RefSeq Acc Id:	XP_038945403 ⟸ XM_039089475
- Peptide Label:	isoform X5
- UniProtKB:	A0A8I5ZKW7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038945400 ⟸ XM_039089472
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I6A9S6 (UniProtKB/TrEMBL), A0A8I5ZKW7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038945411 ⟸ XM_039089483
- Peptide Label:	isoform X12

RefSeq Acc Id:	XP_038945413 ⟸ XM_039089485
- Peptide Label:	isoform X14

RefSeq Acc Id:	XP_038945412 ⟸ XM_039089484
- Peptide Label:	isoform X13
- UniProtKB:	A0A8I5ZXA0 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000089414 ⟸ ENSRNOT00000106205

Ensembl Acc Id:

ENSRNOP00000078467 ⟸ ENSRNOT00000094475

Ensembl Acc Id:

ENSRNOP00000091279 ⟸ ENSRNOT00000107393

Ensembl Acc Id:

ENSRNOP00000082558 ⟸ ENSRNOT00000119628

RefSeq Acc Id:	XP_063127399 ⟸ XM_063271329
- Peptide Label:	isoform X6
- UniProtKB:	A0A8I5ZKW7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127398 ⟸ XM_063271328
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I5ZKW7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127400 ⟸ XM_063271330
- Peptide Label:	isoform X7
- UniProtKB:	A0A8I5ZKW7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127397 ⟸ XM_063271327
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5ZKW7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127396 ⟸ XM_063271326
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZKW7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127405 ⟸ XM_063271335
- Peptide Label:	isoform X10
- UniProtKB:	F1LLW9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127403 ⟸ XM_063271333
- Peptide Label:	isoform X10
- UniProtKB:	F1LLW9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127404 ⟸ XM_063271334
- Peptide Label:	isoform X10
- UniProtKB:	F1LLW9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127401 ⟸ XM_063271331
- Peptide Label:	isoform X8
- UniProtKB:	F1LLW9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127402 ⟸ XM_063271332
- Peptide Label:	isoform X9
- UniProtKB:	F1LLW9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127406 ⟸ XM_063271336
- Peptide Label:	isoform X11
- UniProtKB:	F1LLW9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127407 ⟸ XM_063271337
- Peptide Label:	isoform X11
- UniProtKB:	F1LLW9 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000105523 ⟸ ENSRNOT00000146321

Ensembl Acc Id:

ENSRNOP00000101594 ⟸ ENSRNOT00000163872

Ensembl Acc Id:

ENSRNOP00000107970 ⟸ ENSRNOT00000165085

Ensembl Acc Id:

ENSRNOP00000111972 ⟸ ENSRNOT00000166421

Protein Domains

CXXC-type JmjC PHD-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LLW9-F1-model_v2	AlphaFold	F1LLW9	1-1078	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310217	AgrOrtholog
BioCyc Gene	G2FUF-19278	BioCyc
Ensembl Genes	ENSRNOG00000025702	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000044071	ENTREZGENE
	ENSRNOT00000044071.7	UniProtKB/TrEMBL
	ENSRNOT00000094475.2	UniProtKB/TrEMBL
	ENSRNOT00000106205	ENTREZGENE
	ENSRNOT00000106205.2	UniProtKB/TrEMBL
	ENSRNOT00000107393	ENTREZGENE
	ENSRNOT00000107393.2	UniProtKB/TrEMBL
	ENSRNOT00000119628	ENTREZGENE
	ENSRNOT00000119628.2	UniProtKB/TrEMBL
	ENSRNOT00000146321	ENTREZGENE
	ENSRNOT00000146321.1	UniProtKB/TrEMBL
	ENSRNOT00000163872	ENTREZGENE
	ENSRNOT00000163872.1	UniProtKB/TrEMBL
	ENSRNOT00000165085	ENTREZGENE
	ENSRNOT00000165085.1	UniProtKB/TrEMBL
	ENSRNOT00000166421	ENTREZGENE
	ENSRNOT00000166421.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.58.1360	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
	3.80.10.10	UniProtKB/TrEMBL
	Cupin	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7131492	IMAGE-MGC_LOAD
InterPro	Cupin_8	UniProtKB/TrEMBL
	F-box_dom_cyclin-like	UniProtKB/TrEMBL
	JHD	UniProtKB/TrEMBL
	JHDM1_Histone_Demethylase	UniProtKB/TrEMBL
	JmjC_dom	UniProtKB/TrEMBL
	L_dom-like	UniProtKB/TrEMBL
	Leu-rich_rpt_Cys-con_subtyp	UniProtKB/TrEMBL
	Znf_CXXC	UniProtKB/TrEMBL
	Znf_FYVE_PHD	UniProtKB/TrEMBL
	Znf_PHD	UniProtKB/TrEMBL
	Znf_PHD-finger	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
KEGG Report	rno:304495	UniProtKB/TrEMBL
MGC_CLONE	MGC:95184	IMAGE-MGC_LOAD
NCBI Gene	304495	ENTREZGENE
PANTHER	PHD/F-BOX CONTAINING PROTEIN	UniProtKB/TrEMBL
Pfam	Cupin_8	UniProtKB/TrEMBL
	F-box-like	UniProtKB/TrEMBL
	JHD	UniProtKB/TrEMBL
	PHD_4	UniProtKB/TrEMBL
	zf-CXXC	UniProtKB/TrEMBL
PhenoGen	Kdm2b	PhenoGen
PROSITE	JMJC	UniProtKB/TrEMBL
	ZF_CXXC	UniProtKB/TrEMBL
	ZF_PHD_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000025702	RatGTEx
SMART	JmjC	UniProtKB/TrEMBL
	LRR_CC	UniProtKB/TrEMBL
	PHD	UniProtKB/TrEMBL
Superfamily-SCOP	Clavaminate synthase-like	UniProtKB/TrEMBL
	FYVE_PHD_ZnF	UniProtKB/TrEMBL
	RNI-like	UniProtKB/TrEMBL
UniProt	A0A8I5ZKW7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZXA0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A9S6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ABR9	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0L0I5_RAT	UniProtKB/TrEMBL
	A0ABK0LIT9_RAT	UniProtKB/TrEMBL
	A0ABK0M2X4_RAT	UniProtKB/TrEMBL
	A0ABK0M4B9_RAT	UniProtKB/TrEMBL
	A6J173	ENTREZGENE, UniProtKB/TrEMBL
	F1LLW9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-17	Kdm2b	lysine demethylase 2B	Kdm2b	lysine (K)-specific demethylase 2B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-05-06	Kdm2b	lysine (K)-specific demethylase 2B	Fbxl10	F-box and leucine-rich repeat protein 10	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Fbxl10	F-box and leucine-rich repeat protein 10	Fbxl10_predicted	F-box and leucine-rich repeat protein 10 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Fbxl10_predicted	F-box and leucine-rich repeat protein 10 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations