Prepl (prolyl endopeptidase-like) - Rat Genome Database

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Gene: Prepl (prolyl endopeptidase-like) Rattus norvegicus
Analyze
Symbol: Prepl
Name: prolyl endopeptidase-like
RGD ID: 1310143
Description: Predicted to enable peptidase activity. Predicted to be involved in Golgi to plasma membrane protein transport; regulation of synaptic vesicle exocytosis; and retrograde transport, endosome to Golgi. Predicted to be located in cytosol and nucleus. Predicted to be active in Golgi apparatus and cytoskeleton. Predicted to colocalize with trans-Golgi network. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 22. Orthologous to human PREPL (prolyl endopeptidase like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC298771; MGC105586; RGD1310143; similar to RIKEN cDNA D030028O16
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8615,333,107 - 15,362,825 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl615,333,077 - 15,363,231 (+)EnsemblGRCr8
mRatBN7.269,580,367 - 9,609,957 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl69,580,217 - 9,607,772 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx69,869,516 - 9,898,814 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0610,178,893 - 10,208,191 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.069,700,429 - 9,729,763 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.068,316,861 - 8,346,293 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl68,318,979 - 8,346,197 (-)Ensemblrn6Rnor6.0
Rnor_5.068,249,345 - 8,278,750 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.468,419,874 - 8,447,739 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera69,304,799 - 9,331,994 (+)NCBICelera
RGSC_v3.168,419,873 - 8,447,739 (-)NCBI
Cytogenetic Map6q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
asbestos  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
heroin  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
Nutlin-3  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
rac-lactic acid  (ISO)
Salinomycin  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoskeleton  (IBA,IEA,ISO)
cytosol  (IEA)
Golgi apparatus  (IBA,IEA,ISO)
mitochondrion  (ISO)
nucleus  (IEA)
trans-Golgi network  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:21692504   PMID:22871113   PMID:23321636   PMID:23485813   PMID:24610330   PMID:28726805   PMID:34800366  


Genomics

Comparative Map Data
Prepl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8615,333,107 - 15,362,825 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl615,333,077 - 15,363,231 (+)EnsemblGRCr8
mRatBN7.269,580,367 - 9,609,957 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl69,580,217 - 9,607,772 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx69,869,516 - 9,898,814 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0610,178,893 - 10,208,191 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.069,700,429 - 9,729,763 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.068,316,861 - 8,346,293 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl68,318,979 - 8,346,197 (-)Ensemblrn6Rnor6.0
Rnor_5.068,249,345 - 8,278,750 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.468,419,874 - 8,447,739 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera69,304,799 - 9,331,994 (+)NCBICelera
RGSC_v3.168,419,873 - 8,447,739 (-)NCBI
Cytogenetic Map6q12NCBI
PREPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38244,317,607 - 44,361,862 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl244,316,281 - 44,361,862 (-)Ensemblhg38GRCh38
GRCh37244,544,746 - 44,589,001 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36244,399,406 - 44,440,393 (-)NCBIBuild 36Build 36hg18NCBI36
Celera244,383,700 - 44,427,951 (-)NCBICelera
Cytogenetic Map2p21NCBI
HuRef244,281,407 - 44,325,655 (-)NCBIHuRef
CHM1_1244,472,451 - 44,516,684 (-)NCBICHM1_1
T2T-CHM13v2.0244,322,928 - 44,367,164 (-)NCBIT2T-CHM13v2.0
Prepl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391785,370,122 - 85,397,702 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1785,370,898 - 85,397,669 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381785,062,511 - 85,090,504 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1785,063,470 - 85,090,241 (-)Ensemblmm10GRCm38
MGSCv371785,462,817 - 85,489,614 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361784,971,812 - 84,998,534 (-)NCBIMGSCv36mm8
Celera1789,425,166 - 89,451,900 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1755.19NCBI
Prepl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544111,418,299 - 11,453,218 (-)Ensembl
ChiLan1.0NW_00495544111,418,299 - 11,453,889 (-)NCBIChiLan1.0ChiLan1.0
PREPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21282,044,665 - 82,090,876 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A82,048,635 - 82,094,846 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A44,417,735 - 44,463,542 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A45,353,326 - 45,398,203 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A45,353,326 - 45,397,903 (-)EnsemblpanPan2panpan1.1
PREPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11046,733,769 - 46,792,465 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1046,726,676 - 46,792,405 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1046,595,349 - 46,654,047 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01047,613,473 - 47,672,368 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1047,613,473 - 47,672,322 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11047,320,610 - 47,379,420 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01047,611,662 - 47,670,468 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01047,794,300 - 47,853,142 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prepl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629236,209,248 - 36,243,112 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365087,637,882 - 7,674,877 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365087,637,844 - 7,674,232 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PREPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl396,092,334 - 96,159,525 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1396,092,314 - 96,159,533 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23102,248,639 - 102,314,853 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PREPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11462,879,616 - 62,925,265 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1462,875,133 - 62,924,746 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604548,954,858 - 49,006,885 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prepl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473825,802,793 - 25,834,762 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473825,802,156 - 25,835,663 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Prepl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v177,840,658 - 7,869,457 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prepl
259 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:182
Count of miRNA genes:121
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000009660, ENSRNOT00000061826
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
8693699Alc37Alcohol consumption QTL 372.60.224drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6125740059Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6120510098Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
8693690Alc35Alcohol consumption QTL 352.20.606drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
20 13 80 212 91 90 59 132 59 6 446 255 22 190 104 124 31 29 29

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001010951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000009660   ⟹   ENSRNOP00000009660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl615,335,037 - 15,363,231 (+)Ensembl
mRatBN7.2 Ensembl69,582,169 - 9,607,772 (+)Ensembl
Rnor_6.0 Ensembl68,319,175 - 8,344,574 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000061826   ⟹   ENSRNOP00000058540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl615,333,077 - 15,360,627 (+)Ensembl
mRatBN7.2 Ensembl69,580,217 - 9,607,772 (+)Ensembl
Rnor_6.0 Ensembl68,319,058 - 8,346,197 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082353   ⟹   ENSRNOP00000070154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl615,333,395 - 15,362,824 (+)Ensembl
mRatBN7.2 Ensembl69,580,549 - 9,607,772 (+)Ensembl
Rnor_6.0 Ensembl68,318,979 - 8,344,897 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117547   ⟹   ENSRNOP00000076580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl615,333,934 - 15,362,824 (+)Ensembl
mRatBN7.2 Ensembl69,580,245 - 9,607,758 (+)Ensembl
RefSeq Acc Id: NM_001010951   ⟹   NP_001010951
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,395 - 15,362,825 (+)NCBI
mRatBN7.269,580,527 - 9,609,957 (+)NCBI
Rnor_6.068,319,058 - 8,346,197 (-)NCBI
Rnor_5.068,249,345 - 8,278,750 (-)NCBI
RGSC_v3.468,419,874 - 8,447,739 (-)RGD
Celera69,304,799 - 9,331,994 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239697   ⟹   XP_006239759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,371 - 15,362,825 (+)NCBI
mRatBN7.269,580,516 - 9,609,957 (+)NCBI
Rnor_6.068,316,861 - 8,346,220 (-)NCBI
Rnor_5.068,249,345 - 8,278,750 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764456   ⟹   XP_008762678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,367 - 15,362,825 (+)NCBI
mRatBN7.269,580,517 - 9,609,957 (+)NCBI
Rnor_6.068,316,861 - 8,346,220 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764458   ⟹   XP_008762680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,351 - 15,362,825 (+)NCBI
mRatBN7.269,580,489 - 9,609,957 (+)NCBI
Rnor_6.068,316,861 - 8,346,293 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039111895   ⟹   XP_038967823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,117 - 15,362,825 (+)NCBI
mRatBN7.269,580,367 - 9,609,957 (+)NCBI
RefSeq Acc Id: XM_063261601   ⟹   XP_063117671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,367 - 15,362,825 (+)NCBI
RefSeq Acc Id: XM_063261602   ⟹   XP_063117672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,371 - 15,362,825 (+)NCBI
RefSeq Acc Id: XM_063261603   ⟹   XP_063117673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,352 - 15,362,825 (+)NCBI
RefSeq Acc Id: XM_063261604   ⟹   XP_063117674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,396 - 15,362,825 (+)NCBI
RefSeq Acc Id: XM_063261605   ⟹   XP_063117675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,384 - 15,362,825 (+)NCBI
RefSeq Acc Id: XM_063261606   ⟹   XP_063117676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,107 - 15,362,825 (+)NCBI
RefSeq Acc Id: XM_063261607   ⟹   XP_063117677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,385 - 15,362,825 (+)NCBI
RefSeq Acc Id: XM_063261608   ⟹   XP_063117678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,357 - 15,362,825 (+)NCBI
RefSeq Acc Id: XM_063261609   ⟹   XP_063117679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,385 - 15,362,825 (+)NCBI
RefSeq Acc Id: XM_063261610   ⟹   XP_063117680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,333,354 - 15,362,825 (+)NCBI
RefSeq Acc Id: NP_001010951   ⟸   NM_001010951
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot),   A6H9H3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239759   ⟸   XM_006239697
- Peptide Label: isoform X2
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot),   A0A0G2JX67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762680   ⟸   XM_008764458
- Peptide Label: isoform X8
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot),   A6H9H3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762678   ⟸   XM_008764456
- Peptide Label: isoform X5
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070154   ⟸   ENSRNOT00000082353
Ensembl Acc Id: ENSRNOP00000058540   ⟸   ENSRNOT00000061826
Ensembl Acc Id: ENSRNOP00000009660   ⟸   ENSRNOT00000009660
RefSeq Acc Id: XP_038967823   ⟸   XM_039111895
- Peptide Label: isoform X6
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot),   A0A8L2UN13 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000076580   ⟸   ENSRNOT00000117547
RefSeq Acc Id: XP_063117676   ⟸   XM_063261606
- Peptide Label: isoform X4
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063117673   ⟸   XM_063261603
- Peptide Label: isoform X2
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot),   A0A0G2JX67 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117680   ⟸   XM_063261610
- Peptide Label: isoform X8
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot),   A6H9H3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117678   ⟸   XM_063261608
- Peptide Label: isoform X7
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063117671   ⟸   XM_063261601
- Peptide Label: isoform X1
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063117672   ⟸   XM_063261602
- Peptide Label: isoform X1
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063117675   ⟸   XM_063261605
- Peptide Label: isoform X3
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063117679   ⟸   XM_063261609
- Peptide Label: isoform X7
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063117677   ⟸   XM_063261607
- Peptide Label: isoform X7
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063117674   ⟸   XM_063261604
- Peptide Label: isoform X2
- UniProtKB: Q5HZA6 (UniProtKB/Swiss-Prot),   A0A0G2JX67 (UniProtKB/TrEMBL)
Protein Domains
Peptidase S9 prolyl oligopeptidase catalytic   Peptidase S9A N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5HZA6-F1-model_v2 AlphaFold Q5HZA6 1-726 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694380
Promoter ID:EPDNEW_R4905
Type:initiation region
Name:Prepl_1
Description:prolyl endopeptidase-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.068,346,216 - 8,346,276EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310143 AgrOrtholog
BioCyc Gene G2FUF-38656 BioCyc
Ensembl Genes ENSRNOG00000007326 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000061826 ENTREZGENE
  ENSRNOT00000082353 ENTREZGENE
  ENSRNOT00000082353.2 UniProtKB/Swiss-Prot
  ENSRNOT00000117547 ENTREZGENE
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
  Prolyl oligopeptidase, N-terminal domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7312962 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  Pept_S9A_N UniProtKB/Swiss-Prot
  Peptidase_S9 UniProtKB/Swiss-Prot
  Peptidase_S9A UniProtKB/Swiss-Prot
  Serine_Peptidase_S9A UniProtKB/Swiss-Prot
KEGG Report rno:298771 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105586 IMAGE-MGC_LOAD
NCBI Gene 298771 ENTREZGENE
PANTHER PROLYL ENDOPEPTIDASE-LIKE UniProtKB/Swiss-Prot
  PROTEASE FAMILY S9A OLIGOPEPTIDASE UniProtKB/Swiss-Prot
Pfam Peptidase_S9 UniProtKB/Swiss-Prot
  Peptidase_S9_N UniProtKB/Swiss-Prot
PhenoGen Prepl PhenoGen
PRINTS PROLIGOPTASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007326 RatGTEx
Superfamily-SCOP Peptidase/esterase 'gauge' domain UniProtKB/Swiss-Prot
  SSF53474 UniProtKB/Swiss-Prot
UniProt A0A0G2JX67 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5YBR3_RAT UniProtKB/TrEMBL
  A0A8L2UN13 ENTREZGENE, UniProtKB/TrEMBL
  A6H9H3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZ32_RAT UniProtKB/TrEMBL
  PPCEL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-27 Prepl  prolyl endopeptidase-like  RGD1310143  similar to RIKEN cDNA D030028O16  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1310143  similar to RIKEN cDNA D030028O16  RGD1310143_predicted  similar to RIKEN cDNA D030028O16 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1310143_predicted  similar to RIKEN cDNA D030028O16 (predicted)  LOC298771_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC298771_predicted  similar to RIKEN cDNA D030028O16 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL