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Gene: Tmprss3 (transmembrane serine protease 3) Rattus norvegicus

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Symbol:

Tmprss3

Name:

transmembrane serine protease 3

RGD ID:

1310135

Description:

Predicted to enable serine-type peptidase activity and sodium channel regulator activity. Predicted to be involved in sensory perception of sound. Predicted to act upstream of or within intracellular sodium ion homeostasis. Predicted to be located in endoplasmic reticulum membrane and neuronal cell body. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 8 and sensorineural hearing loss. Orthologous to human TMPRSS3 (transmembrane serine protease 3); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; bis(2-ethylhexyl) phthalate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC309665; transmembrane protease serine 3; transmembrane protease, serine 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMPRSS3 (transmembrane serine protease 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Tmprss3 (transmembrane protease, serine 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tmprss3 (transmembrane serine protease 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMPRSS3 (transmembrane serine protease 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMPRSS3 (transmembrane serine protease 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tmprss3 (transmembrane serine protease 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TMPRSS3 (transmembrane serine protease 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMPRSS3 (transmembrane serine protease 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmprss3 (transmembrane serine protease 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tmprss3 (transmembrane serine protease 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	MTR (5-methyltetrahydrofolate-homocysteine methyltransferase)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	TMPRSS3 (transmembrane serine protease 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tmprss3 (transmembrane protease, serine 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmprss3a (transmembrane serine protease 3a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	LOC101885235 (transmembrane protease serine 3-like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	LOC101885235 (transmembrane protease serine 3-like)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG11836	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG11836	Alliance	DIOPT (InParanoid\|OrthoInspector)
Caenorhabditis elegans (roundworm):	try-1	Alliance	DIOPT (Hieranoid\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG18735	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG18735	Alliance	DIOPT (InParanoid\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG3355	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG3355	Alliance	DIOPT (InParanoid\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG4386	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG4386	Alliance	DIOPT (InParanoid\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG4613	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG4613	Alliance	DIOPT (InParanoid\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG4914	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG4914	Alliance	DIOPT (InParanoid\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG9294	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG9294	Alliance	DIOPT (InParanoid\|OrthoInspector)
Xenopus tropicalis (tropical clawed frog):	tmprss3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	9,253,497 - 9,275,167 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	9,255,467 - 9,275,720 (-)	Ensembl				GRCr8
mRatBN7.2	20	9,254,102 - 9,273,808 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	9,254,109 - 9,274,363 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	9,948,938 - 9,968,144 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	9,310,108 - 9,329,314 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	9,785,246 - 9,804,454 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	9,910,522 - 9,929,705 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	9,910,522 - 9,929,705 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	12,090,226 - 12,109,848 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	9,545,077 - 9,564,261 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	10,778,412 - 10,797,597 (-)	NCBI		Celera
RGSC_v3.1	20	9,546,507 - 9,565,698 (-)	NCBI
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive nonsyndromic deafness (ISO)

autosomal recessive nonsyndromic deafness 8 (ISO)

genetic disease (ISO)

Hearing Loss (ISO)

nonsyndromic deafness (ISO)

pancreatic ductal carcinoma (ISO)

pneumoconiosis (ISO)

sensorineural hearing loss (ISO)

Waardenburg syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP)

butanal (ISO)

Butylbenzyl phthalate (ISO)

C60 fullerene (EXP)

cadmium dichloride (EXP)

CGP 52608 (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

Enterolactone (ISO)

ethylparaben (ISO)

N-nitrosodiethylamine (ISO)

okadaic acid (ISO)

paracetamol (ISO)

pentanal (ISO)

perfluorooctanoic acid (ISO)

phytoestrogen (ISO)

pinosylvin (ISO)

progesterone (ISO)

raloxifene (ISO)

resveratrol (ISO)

serpentine asbestos (ISO)

sulforaphane (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP)

thiram (ISO)

trans-pinosylvin (ISO)

trichloroethene (EXP)

tris(2-butoxyethyl) phosphate (ISO)

tungsten (ISO)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular sodium ion homeostasis (ISO)

protein processing (IBA)

proteolysis (IEA)

sensory perception of sound (IBA,IEA,ISO)

Cellular Component

endoplasmic reticulum (IEA,ISO)

endoplasmic reticulum membrane (IEA,ISO)

membrane (IEA)

neuronal cell body (IEA,ISO)

Molecular Function

hydrolase activity (IEA)

peptidase activity (IEA)

serine-type endopeptidase activity (IEA)

serine-type peptidase activity (IBA,IEA)

sodium channel regulator activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	The transmembrane serine protease (TMPRSS3) mutated in deafness DFNB8/10 activates the epithelial sodium channel (ENaC) in vitro.	Guipponi M, etal., Hum Mol Genet. 2002 Nov 1;11(23):2829-36.
4.	Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies.	Iacobuzio-Donahue CA, etal., Cancer Res. 2003 Dec 15;63(24):8614-22.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	Insertion of beta-satellite repeats identifies a transmembrane protease causing both congenital and childhood onset autosomal recessive deafness.	Scott HS, etal., Nat Genet. 2001 Jan;27(1):59-63.

Additional References at PubMed

PMID:16780588	PMID:17918732	PMID:21454591	PMID:22086001

Genomics

Comparative Map Data

Tmprss3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	9,253,497 - 9,275,167 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	9,255,467 - 9,275,720 (-)	Ensembl				GRCr8
mRatBN7.2	20	9,254,102 - 9,273,808 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	9,254,109 - 9,274,363 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	9,948,938 - 9,968,144 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	9,310,108 - 9,329,314 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	9,785,246 - 9,804,454 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	9,910,522 - 9,929,705 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	9,910,522 - 9,929,705 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	12,090,226 - 12,109,848 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	9,545,077 - 9,564,261 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	10,778,412 - 10,797,597 (-)	NCBI		Celera
RGSC_v3.1	20	9,546,507 - 9,565,698 (-)	NCBI
Cytogenetic Map	20	p12	NCBI

TMPRSS3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	42,371,890 - 42,396,052 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	42,371,840 - 42,396,119 (-)	Ensembl			hg38	GRCh38
GRCh37	21	43,791,999 - 43,816,161 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	42,665,068 - 42,689,269 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	21	42,675,054 - 42,689,269	NCBI
Celera	21	28,940,972 - 28,965,175 (-)	NCBI		Celera
Cytogenetic Map	21	q22.3	NCBI
HuRef	21	29,209,266 - 29,234,349 (-)	NCBI		HuRef
CHM1_1	21	43,352,168 - 43,377,125 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	21	40,761,358 - 40,785,622 (-)	NCBI		T2T-CHM13v2.0

Tmprss3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	31,398,237 - 31,419,478 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	31,398,239 - 31,417,951 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	31,179,263 - 31,200,504 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	31,179,265 - 31,198,977 (-)	Ensembl			mm10	GRCm38
MGSCv37	17	31,316,210 - 31,335,919 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	30,906,277 - 30,924,761 (-)	NCBI		MGSCv36	mm8
Celera	17	32,096,501 - 32,116,151 (-)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	15.8	NCBI

Tmprss3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	39,332,052 - 39,354,488 (+)	Ensembl
ChiLan1.0	NW_004955407	39,332,517 - 39,351,699 (+)	NCBI	ChiLan1.0	ChiLan1.0

TMPRSS3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	38,424,833 - 38,451,937 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	33,280,075 - 33,304,405 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	28,679,488 - 28,703,313 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	41,997,642 - 42,022,740 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	41,997,642 - 42,022,740 (-)	Ensembl			panPan2	panpan1.1

TMPRSS3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	36,706,229 - 36,730,444 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	36,707,723 - 36,730,520 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	35,857,157 - 35,881,007 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	36,222,870 - 36,246,768 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	36,224,343 - 36,245,196 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	36,115,692 - 36,139,512 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	36,095,952 - 36,119,868 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	36,591,047 - 36,614,888 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tmprss3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	35,965,571 - 35,987,749 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936500	1,480,688 - 1,501,735 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936500	1,480,688 - 1,501,735 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMPRSS3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	205,709,663 - 205,732,824 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	205,707,501 - 205,733,037 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	216,114,614 - 216,137,024 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMPRSS3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	86,248,792 - 86,273,715 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	86,245,507 - 86,272,196 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666054	14,209,710 - 14,233,132 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmprss3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	28,064,539 - 28,083,566 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624745	28,064,414 - 28,087,319 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tmprss3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	18	2,680,961 - 2,700,434 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tmprss3
163 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	150
Count of miRNA genes:	114
Interacting mature miRNAs:	130
Transcripts:	ENSRNOT00000001540
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	4189476	49189476	Rat
4889870	Pur30	Proteinuria QTL 30	19	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	8043920	29865039	Rat
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24164241	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	1	27341128	Rat
1598870	Bp289	Blood pressure QTL 289	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	8216359	53216359	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29193376	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29193376	Rat
1581577	Pur15	Proteinuria QTL 15	4.38	0.0002	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	20	8043920	15089182	Rat
1598858	Cm61	Cardiac mass QTL 61	3.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	20	8216359	53216359	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578510	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	1	26925056	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1	33724594	Rat
7387283	Uae44	Urinary albumin excretion QTL 44		0.1712	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	20	1	26128279	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600300	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1533083	46533083	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	1	34066551	Rat
1331772	Cdexp2	CD45RC expression in CD8 T cells QTL 2	5.7		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	20	3626323	10078622	Rat
631265	Iresp1	Immunoglobin response QTL1	8.3		blood anti-double stranded DNA antibody amount (VT:0004762)	serum anti-DNA antibody level (CMO:0001533)	20	9041099	11115921	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29193376	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29193376	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29193376	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1	14100378	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600300	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	11	49	86	83	82	51	90	51	6	304	171	11	57	58	75	31	3	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107619	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098722	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098723	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098724	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098725	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001540 ⟹ ENSRNOP00000001540

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	9,255,467 - 9,275,720 (-)	Ensembl
mRatBN7.2 Ensembl	20	9,254,109 - 9,274,363 (-)	Ensembl
Rnor_6.0 Ensembl	20	9,910,522 - 9,929,705 (-)	Ensembl

RefSeq Acc Id:

NM_001107619 ⟹ NP_001101089

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	9,255,467 - 9,274,650 (-)	NCBI
mRatBN7.2	20	9,254,109 - 9,273,293 (-)	NCBI
Rnor_6.0	20	9,910,522 - 9,929,705 (-)	NCBI
Rnor_5.0	20	12,090,226 - 12,109,848 (-)	NCBI
RGSC_v3.4	20	9,545,077 - 9,564,261 (-)	RGD
Celera	20	10,778,412 - 10,797,597 (-)	RGD

Sequence:

show sequence

TAAGCAGGTGGAGGTGGAACCGGAACCCAACATCAGAGGCCCTGAGATAGTCACCATGGGGGAA
AACGACCCTCCAGCAGCCGAAGCCCCCTTCTCCTTCCGGTCACTCTTTGGCTTGGACGATTTGA
AAATAAGTTCTGTGGCACCAGATGGAGATGCAGTGGCCGCGCAGATCTTGTCCCTTCTGCCCTT
GAAGTTTTTTCCGATCATCGTCATTGGGATCATAGCCTTGATACTGGCGTTGGCTATCGGCCTG
GGCATCCACTTCGACTGCTCTGGGAAGTACAGGTGCCATTCATCTTTCAAGTGTATTGAACTAA
CAGCCCGATGTGACGGGGTCCCCAATTGCAAGGACGGGGAGGATGAGTACCGTTGCGTGCGGGT
GAGCGGCCAAAGAGCAGCGCTCCAAGTGTTCACGGCTGCTGCATGGAGGACCATGTGTTCAGAT
GACTGGAAAAGCCACTATGCCAAGATTGCCTGTGCCCAGCTGGGGTTTCCCAGCTATGTGAGCT
CAGACCACCTCAGAGTGGATGCACTTGAGGAGCAGTTCCAGGGCGACTTCGTGTCCATCAATCA
CCTCTTGCCAGATGACAAGGTGACCGCATTACACCACTCTGTGTACATGAGGGAAGGCTGCACC
TCAGGCCATGTGGTCACCTTGAAGTGCTCAGCCTGTGGCATGAGAACTGGCTACAGTCCCCGCA
TTGTGGGTGGAAACGTGTCCTCGCTCACTCAGTGGCCCTGGCAGGTCAGCCTCCAGTTCCAGGG
GTACCACCTATGTGGGGGCTCCGTCATCACCCCTCTGTGGATTGTCACCGCTGCGCACTGTGTT
TACGACCTGTACCACCCCAAGTCCTGGACTGTCCAGGTGGGTCTCGTGTCCCTGATGGACAGTC
CTGTGCCCTCCCACCTGGTGGAGAAAATCATCTACCACAGCAAGTACAAACCAAAGCGACTGGG
CAATGACATCGCCCTCATGAAGCTGTCCGAGCCACTCACCTTTGACGAGACCATCCAGCCCATC
TGCCTGCCCAACTCTGAAGAGAACTTTCCAGACGGGAAATTGTGCTGGACCTCAGGATGGGGAG
CCACAGAGGACGGAGGTGACGCCTCCCCTGTCCTGAACCACGCGGCCGTCCCTTTAATTTCAAA
CAAGATCTGCAACCACAGGGATGTGTATGGCGGTATCATTTCACCCTCCATGCTCTGTGCGGGC
TATCTGAAAGGCGGTGTGGACAGCTGCCAGGGAGACAGCGGGGGACCCCTGGTGTGCCAGGAGA
GGAGACTGTGGAAGTTAGTGGGTGCGACAAGCTTTGGAATTGGCTGTGCTGAGGTGAACAAGCC
TGGAGTCTACACACGAATCACCTCCTTCCTGGACTGGATTCACGAACAGTTGGAGAGAGATCTG
AAGACTTGAAGAAGAGGGAACAAGCCAGCACCTGAGCTCCTGAGGGGTGGACACAGCACGGGCC
TTCCCTGGACTCCTGAGTGGACATGTTGGATGGGAGTACCAGCTCTTACCACCCTGCCCATGGC
GTTGAAGCATATCCATCCACTGGGATGAGAACCCTTCCAACCCCGACACCCGGAGTTGCTTGCT
GCTAAAGCCCCTGGCTTTGAGGCTGAAACAACCTTGGACTCATGTACACAAGCGGCACCTTTCC
CGGTCACCCCCCACCCACCCTAGATTTTCTCCTTATAGTTGCTGCCAACACTGGCAAGCTCTCA
TGCACACCAATCGAACACCAGTTGGTGCAGGAACTGCTGGTGTGGATTGTTGAAGACGCAGTCA
CCTATTCGTTCTAGCCCCGGGCTCCAGATCTCAACCCAACTGCCTACTTCCAGGAGCTGGTTTT
GGGAGTGAGGAACTTAGTCTTTGACTGATTCAGTCTGAGGTTTTTTGTTTTTTGTTTTGTTTTG
TTTTGGCTCCGCTGTTTTCTCACAGGATTTGGTGCTTGACGAATTTCTCGCTTCTGAAAGGCGT
CCCTTTGCTTAGCTTGGCCTGTCCTTGGGCTTGAGTGAATGCGTGGCCATGGGCCACGGACACT
GAAATCACGGGCTCACCTCAAAAGCCGACCATGCTACACATGTCGGGAGTTTGCATTTTCCTGT
TAAGGTTTCCCAGCATATCAGAAGTGTACCATATTGTATTGTGGGACTCATAAACAGAGTAAGG
GACACAGGCCAGGTGAAGACAAGACTGGACACTAAAAGCAAGTTGAATAGAGGGGTTCTAAGTT
ACAGGGTCTGCCCCACTTGTCCTCCATGAACTCTGCTAATGGACCACAGCCGATGGTGTCCACA
GCCCCTCTTACATGGCTTACAGTCCTGTGGTCCCTGTATTACCCAGTAACAGAGGAGGGTTTCG
TGAGACACAGGCATTGGTCATTTAAGCTTGTCACAGATGAAGTCTTCAGAGTATGAATCAGTTG
CTTTGTGGCTGCAATAGAAAATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT
GCGCGCGCATACGTGTGTATGTGGTGTGTAGTATGTGTAGTGTGGGTGGGGCCCATCACCAAGA
CAAACTGCCACATAGTCATTGAGCTTTGACCCAACCCTGTCCAAATTAGAGCCCCCCTCTATGG
ATGTAATTTATCTATTAGTCACGGGAAGAAATGATAAACACAACTGGAAATAAAGCACAGAAGT
TAT

hide sequence

RefSeq Acc Id:

XM_039098722 ⟹ XP_038954650

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	9,253,497 - 9,275,153 (-)	NCBI
mRatBN7.2	20	9,254,102 - 9,273,796 (-)	NCBI

RefSeq Acc Id:

XM_039098723 ⟹ XP_038954651

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	9,253,497 - 9,275,160 (-)	NCBI
mRatBN7.2	20	9,254,102 - 9,273,792 (-)	NCBI

RefSeq Acc Id:

XM_039098724 ⟹ XP_038954652

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	9,253,497 - 9,275,167 (-)	NCBI
mRatBN7.2	20	9,254,102 - 9,273,808 (-)	NCBI

RefSeq Acc Id:

XM_039098725 ⟹ XP_038954653

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	9,253,497 - 9,275,151 (-)	NCBI
mRatBN7.2	20	9,254,102 - 9,273,795 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101089	(Get FASTA)	NCBI Sequence Viewer
	XP_038954650	(Get FASTA)	NCBI Sequence Viewer
	XP_038954651	(Get FASTA)	NCBI Sequence Viewer
	XP_038954652	(Get FASTA)	NCBI Sequence Viewer
	XP_038954653	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL97006	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001540
	ENSRNOP00000001540.6

RefSeq Acc Id:

NP_001101089 ⟸ NM_001107619

- UniProtKB:

D3ZY65 (UniProtKB/TrEMBL), A6JJZ0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGENDPPAAEAPFSFRSLFGLDDLKISSVAPDGDAVAAQILSLLPLKFFPIIVIGIIALILALA
IGLGIHFDCSGKYRCHSSFKCIELTARCDGVPNCKDGEDEYRCVRVSGQRAALQVFTAAAWRTM
CSDDWKSHYAKIACAQLGFPSYVSSDHLRVDALEEQFQGDFVSINHLLPDDKVTALHHSVYMRE
GCTSGHVVTLKCSACGMRTGYSPRIVGGNVSSLTQWPWQVSLQFQGYHLCGGSVITPLWIVTAA
HCVYDLYHPKSWTVQVGLVSLMDSPVPSHLVEKIIYHSKYKPKRLGNDIALMKLSEPLTFDETI
QPICLPNSEENFPDGKLCWTSGWGATEDGGDASPVLNHAAVPLISNKICNHRDVYGGIISPSML
CAGYLKGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRITSFLDWIHEQLE
RDLKT

hide sequence

Ensembl Acc Id:

ENSRNOP00000001540 ⟸ ENSRNOT00000001540

RefSeq Acc Id:	XP_038954652 ⟸ XM_039098724
- Peptide Label:	isoform X1
- UniProtKB:	D3ZY65 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038954650 ⟸ XM_039098722
- Peptide Label:	isoform X1
- UniProtKB:	D3ZY65 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038954653 ⟸ XM_039098725
- Peptide Label:	isoform X2
- UniProtKB:	A6JJZ0 (UniProtKB/TrEMBL), D3ZY65 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038954651 ⟸ XM_039098723
- Peptide Label:	isoform X1
- UniProtKB:	D3ZY65 (UniProtKB/TrEMBL)

Protein Domains

Peptidase S1 SRCR

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZY65-F1-model_v2	AlphaFold	D3ZY65	1-453	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310135	AgrOrtholog
BioCyc Gene	G2FUF-4324	BioCyc
Ensembl Genes	ENSRNOG00000001165	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000001540	ENTREZGENE
	ENSRNOT00000001540.7	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
	3.10.250.10	UniProtKB/TrEMBL
	4.10.400.10	UniProtKB/TrEMBL
InterPro	LDL_receptor-like_sf	UniProtKB/TrEMBL
	LDLR_class-A_CS	UniProtKB/TrEMBL
	LDLR_classA_rpt	UniProtKB/TrEMBL
	Peptidase_S1/S6_AS	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1_S6	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	Ser/Cys_Pept_Trypsin-like	UniProtKB/TrEMBL
	SRCR-like_dom_sf	UniProtKB/TrEMBL
	Srcr_rcpt	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
KEGG Report	rno:309665	UniProtKB/TrEMBL
NCBI Gene	309665	ENTREZGENE
PANTHER	ACROSIN-RELATED	UniProtKB/TrEMBL
	TRANSMEMBRANE PROTEASE SERINE 3-LIKE	UniProtKB/TrEMBL
Pfam	Ldl_recept_a	UniProtKB/TrEMBL
	SRCR_2	UniProtKB/TrEMBL
	Trypsin	UniProtKB/TrEMBL
PhenoGen	Tmprss3	PhenoGen
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	LDLRA_1	UniProtKB/TrEMBL
	LDLRA_2	UniProtKB/TrEMBL
	SRCR_2	UniProtKB/TrEMBL
	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001165	RatGTEx
SMART	LDLa	UniProtKB/TrEMBL
	SM00202	UniProtKB/TrEMBL
	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	LDL_rcpt_classA_cys-rich	UniProtKB/TrEMBL
	Pept_Ser_Cys	UniProtKB/TrEMBL
	Srcr_receptor	UniProtKB/TrEMBL
UniProt	A6JJZ0	ENTREZGENE, UniProtKB/TrEMBL
	D3ZY65	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-01-26	Tmprss3	transmembrane serine protease 3	Tmprss3	transmembrane protease, serine 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2007-02-05	Tmprss3	transmembrane protease, serine 3	Tmprss3_predicted	transmembrane protease, serine 3 (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-12	Tmprss3_predicted	transmembrane protease, serine 3 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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