Fbln7 (fibulin 7) - Rat Genome Database

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Gene: Fbln7 (fibulin 7) Rattus norvegicus
Analyze
Symbol: Fbln7
Name: fibulin 7
RGD ID: 1310131
Description: Predicted to enable heparan sulfate proteoglycan binding activity and heparin binding activity. Predicted to be involved in cell adhesion. Predicted to be located in extracellular matrix and extracellular space. Orthologous to human FBLN7 (fibulin 7); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: fibulin-7; LOC296145; RGD1310131; similar to hypothetical protein FLJ37440
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83136,564,825 - 136,601,205 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3136,564,917 - 136,601,198 (+)EnsemblGRCr8
mRatBN7.23116,111,581 - 116,145,839 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3116,111,677 - 116,147,983 (+)EnsemblmRatBN7.2
Rnor_6.03121,407,981 - 121,441,660 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3121,408,146 - 121,440,787 (+)Ensemblrn6Rnor6.0
Rnor_5.03128,570,997 - 128,604,273 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43116,482,978 - 116,516,878 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3114,938,655 - 114,972,526 (+)NCBICelera
RGSC_v3.13116,372,821 - 116,421,824 (+)NCBI
Cytogenetic Map3q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21423176   PMID:23376485  


Genomics

Comparative Map Data
Fbln7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83136,564,825 - 136,601,205 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3136,564,917 - 136,601,198 (+)EnsemblGRCr8
mRatBN7.23116,111,581 - 116,145,839 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3116,111,677 - 116,147,983 (+)EnsemblmRatBN7.2
Rnor_6.03121,407,981 - 121,441,660 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3121,408,146 - 121,440,787 (+)Ensemblrn6Rnor6.0
Rnor_5.03128,570,997 - 128,604,273 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43116,482,978 - 116,516,878 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3114,938,655 - 114,972,526 (+)NCBICelera
RGSC_v3.13116,372,821 - 116,421,824 (+)NCBI
Cytogenetic Map3q36NCBI
FBLN7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382112,138,385 - 112,244,708 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2112,138,385 - 112,188,218 (+)Ensemblhg38GRCh38
GRCh372112,895,962 - 112,945,795 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362112,612,433 - 112,662,262 (+)NCBIBuild 36Build 36hg18NCBI36
Celera2106,100,477 - 106,149,878 (-)NCBICelera
Cytogenetic Map2q13-q14.1NCBI
HuRef2105,408,706 - 105,458,095 (+)NCBIHuRef
CHM1_12112,900,391 - 112,949,097 (+)NCBICHM1_1
T2T-CHM13v2.02112,565,320 - 112,671,583 (+)NCBIT2T-CHM13v2.0
Fbln7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392128,705,791 - 128,738,954 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2128,704,901 - 128,738,954 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382128,863,865 - 128,897,034 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2128,862,981 - 128,897,034 (+)Ensemblmm10GRCm38
MGSCv372128,689,668 - 128,722,770 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362128,555,419 - 128,587,244 (+)NCBIMGSCv36mm8
Celera2130,091,846 - 130,124,813 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.63NCBI
Fbln7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,948,750 - 1,981,308 (-)Ensembl
ChiLan1.0NW_0049554701,950,806 - 1,981,308 (-)NCBIChiLan1.0ChiLan1.0
FBLN7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21215,891,535 - 15,939,822 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A15,890,281 - 15,942,570 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A89,823,598 - 89,871,788 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A113,267,035 - 113,315,015 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A113,267,035 - 113,315,015 (+)EnsemblpanPan2panpan1.1
FBLN7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11736,525,866 - 36,574,671 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1736,525,756 - 36,571,523 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1736,296,716 - 36,345,242 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01737,303,451 - 37,349,531 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1737,303,308 - 37,349,524 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11736,422,061 - 36,470,732 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01736,494,034 - 36,542,529 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01736,707,318 - 36,755,881 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fbln7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629281,894,272 - 81,922,800 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936783788,750 - 819,486 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936783788,759 - 817,699 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBLN7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl344,214,000 - 44,266,921 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1344,215,037 - 44,266,984 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2345,808,765 - 45,861,247 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FBLN7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11415,207,739 - 15,256,917 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1415,208,829 - 15,256,199 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660804,428,330 - 4,477,164 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbln7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624749201,888 - 235,491 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624749201,888 - 235,038 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fbln7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15107,656,389 - 107,691,458 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fbln7
210 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:98
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000023708
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3136091420155634702Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
RH138304  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23116,145,587 - 116,145,728 (+)MAPPERmRatBN7.2
Rnor_6.03121,441,120 - 121,441,260NCBIRnor6.0
Rnor_5.03128,571,108 - 128,571,248UniSTSRnor5.0
RGSC_v3.43116,516,584 - 116,516,724UniSTSRGSC3.4
Celera3114,971,986 - 114,972,126UniSTS
RH 3.4 Map3996.4UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 12 66 160 81 80 50 78 50 6 320 177 11 138 72 92 30 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023708   ⟹   ENSRNOP00000023708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3136,564,924 - 136,601,197 (+)Ensembl
mRatBN7.2 Ensembl3116,111,677 - 116,147,983 (+)Ensembl
Rnor_6.0 Ensembl3121,408,146 - 121,440,787 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000159457   ⟹   ENSRNOP00000105621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3136,564,917 - 136,601,197 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000172139   ⟹   ENSRNOP00000100255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3136,564,942 - 136,601,198 (+)Ensembl
RefSeq Acc Id: XM_063284986   ⟹   XP_063141056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83136,564,825 - 136,601,205 (+)NCBI
RefSeq Acc Id: XM_063284987   ⟹   XP_063141057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83136,579,844 - 136,601,205 (+)NCBI
RefSeq Acc Id: XM_215832   ⟹   XP_215832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83136,564,855 - 136,601,205 (+)NCBI
mRatBN7.23116,111,581 - 116,145,839 (+)NCBI
Rnor_6.03121,407,981 - 121,441,660 (+)NCBI
Rnor_5.03128,570,997 - 128,604,273 (-)NCBI
RGSC_v3.43116,482,978 - 116,516,878 (+)RGD
Sequence:
RefSeq Acc Id: XP_215832   ⟸   XM_215832
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000023708   ⟸   ENSRNOT00000023708
RefSeq Acc Id: XP_063141056   ⟸   XM_063284986
- Peptide Label: isoform X1
- UniProtKB: D3ZSY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141057   ⟸   XM_063284987
- Peptide Label: isoform X3
- UniProtKB: D3ZSY7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105621   ⟸   ENSRNOT00000159457
Ensembl Acc Id: ENSRNOP00000100255   ⟸   ENSRNOT00000172139
Protein Domains
EGF-like   Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZSY7-F1-model_v2 AlphaFold D3ZSY7 1-440 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310131 AgrOrtholog
BioCyc Gene G2FUF-47932 BioCyc
Ensembl Genes ENSRNOG00000017550 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023708 ENTREZGENE
  ENSRNOT00000023708.8 UniProtKB/TrEMBL
  ENSRNOT00000159457.1 UniProtKB/TrEMBL
  ENSRNOT00000172139 ENTREZGENE
  ENSRNOT00000172139.1 UniProtKB/TrEMBL
Gene3D-CATH Complement Module, domain 1 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro ECM_structural_protein UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_Ca-bd UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Fibulin_C UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP UniProtKB/TrEMBL
KEGG Report rno:296145 UniProtKB/TrEMBL
NCBI Gene 296145 ENTREZGENE
PANTHER EGF-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  FIBULIN-7 UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  Fibulin_C UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/TrEMBL
  Sushi UniProtKB/TrEMBL
PhenoGen Fbln7 PhenoGen
PRINTS EGFBLOOD UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  SUSHI UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017550 RatGTEx
SMART CCP UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
Superfamily-SCOP Complement_control_module UniProtKB/TrEMBL
  EGF/Laminin UniProtKB/TrEMBL
UniProt A0ABK0L7X5_RAT UniProtKB/TrEMBL
  A0ABK0LUX5_RAT UniProtKB/TrEMBL
  A6HQ40 ENTREZGENE, UniProtKB/TrEMBL
  D3ZSY7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-27 Fbln7  fibulin 7  RGD1310131_predicted  similar to hypothetical protein FLJ37440 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1310131_predicted  similar to hypothetical protein FLJ37440 (predicted)  LOC296145_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC296145_predicted  similar to hypothetical protein FLJ37440 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL