Tppp (tubulin polymerization promoting protein) - Rat Genome Database

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Pathways
Gene: Tppp (tubulin polymerization promoting protein) Rattus norvegicus
Analyze
Symbol: Tppp
Name: tubulin polymerization promoting protein
RGD ID: 1310121
Description: Predicted to enable several functions, including GTPase activity; magnesium ion binding activity; and protein homodimerization activity. Involved in myelin assembly and positive regulation of myelination. Located in postsynaptic Golgi apparatus. Orthologous to human TPPP (tubulin polymerization promoting protein); INTERACTS WITH (+)-schisandrin B; bisphenol A; Brodifacoum.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC361466; p25-alpha; RGD1310121; similar to 25 kDa brain-specific protein (p25-alpha); TPPP/p25; tubulin polymerization-promoting protein
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,085,680 - 31,109,703 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl131,089,824 - 31,109,654 (-)EnsemblGRCr8
mRatBN7.2129,257,111 - 29,281,134 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,261,255 - 29,281,134 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx129,062,920 - 29,082,772 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0135,062,773 - 35,082,625 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,263,534 - 29,283,386 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0131,866,755 - 31,890,778 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl131,870,899 - 31,890,778 (-)Ensemblrn6Rnor6.0
Rnor_5.0133,291,317 - 33,315,340 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4130,067,686 - 30,087,564 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera127,912,466 - 27,932,345 (-)NCBICelera
RGSC_v3.1130,070,826 - 30,081,026 (-)NCBI
Cytogenetic Map1p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The Golgi Outpost Protein TPPP Nucleates Microtubules and Is Critical for Myelination. Fu MM, etal., Cell. 2019 Sep 19;179(1):132-146.e14. doi: 10.1016/j.cell.2019.08.025. Epub 2019 Sep 12.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation. Lehotzky A, etal., Glia. 2010 Jan 15;58(2):157-68. doi: 10.1002/glia.20909.
4. p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. Lindersson E, etal., J Biol Chem. 2005 Feb 18;280(7):5703-15. Epub 2004 Dec 7.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17105200   PMID:17634366   PMID:18028908   PMID:18563798   PMID:20308065   PMID:21316364   PMID:21832049   PMID:22328514   PMID:23093407   PMID:23629650   PMID:26289831  


Genomics

Comparative Map Data
Tppp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,085,680 - 31,109,703 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl131,089,824 - 31,109,654 (-)EnsemblGRCr8
mRatBN7.2129,257,111 - 29,281,134 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,261,255 - 29,281,134 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx129,062,920 - 29,082,772 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0135,062,773 - 35,082,625 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,263,534 - 29,283,386 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0131,866,755 - 31,890,778 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl131,870,899 - 31,890,778 (-)Ensemblrn6Rnor6.0
Rnor_5.0133,291,317 - 33,315,340 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4130,067,686 - 30,087,564 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera127,912,466 - 27,932,345 (-)NCBICelera
RGSC_v3.1130,070,826 - 30,081,026 (-)NCBI
Cytogenetic Map1p11NCBI
TPPP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385659,862 - 700,727 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5659,862 - 693,997 (-)Ensemblhg38GRCh38
GRCh375659,977 - 693,467 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365712,977 - 746,510 (-)NCBIBuild 36Build 36hg18NCBI36
Celera5756,043 - 773,959 (-)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef5643,544 - 661,474 (-)NCBIHuRef
CHM1_15655,371 - 689,478 (-)NCBICHM1_1
T2T-CHM13v2.05657,955 - 690,778 (-)NCBIT2T-CHM13v2.0
Tppp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391374,157,538 - 74,183,872 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1374,157,526 - 74,183,872 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381374,009,419 - 74,035,753 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1374,009,407 - 74,035,753 (+)Ensemblmm10GRCm38
MGSCv371374,146,867 - 74,173,201 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361374,475,480 - 74,501,755 (+)NCBIMGSCv36mm8
Celera1376,339,205 - 76,365,541 (+)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.15NCBI
TPPP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24884,524 - 920,903 (-)NCBINHGRI_mPanPan1-v2
PanPan1.1 Ensembl5779,090 - 797,979 (-)EnsemblpanPan2panpan1.1
TPPP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13411,633,054 - 11,645,585 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3411,629,378 - 11,642,639 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3416,132,292 - 16,155,356 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03411,523,014 - 11,546,088 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.13411,573,721 - 11,596,758 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03411,553,456 - 11,576,668 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03411,771,142 - 11,787,387 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tppp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213244,680,995 - 244,721,700 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936815842,087 - 883,368 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936815842,279 - 882,985 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPPP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1679,542,928 - 79,556,382 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11679,535,037 - 79,556,383 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TPPP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.14532,328 - 565,826 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl4538,739 - 552,024 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606427,670,650 - 27,835,187 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tppp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624751355,890 - 375,561 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624751355,887 - 375,564 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Tppp
87 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir206rno-miR-206-3pMirtarbaseexternal_infoImmunoblot//Immunocytochemistry//Luciferase reportFunctional MTI19606501

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:110
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000039166
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1529322934184556Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1529322934184556Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1529322934184556Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 86 59 6 346 186 11 143 77 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000039166   ⟹   ENSRNOP00000034617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl131,089,824 - 31,100,581 (-)Ensembl
mRatBN7.2 Ensembl129,261,255 - 29,281,134 (-)Ensembl
Rnor_6.0 Ensembl131,870,899 - 31,890,778 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081225   ⟹   ENSRNOP00000072201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl131,089,824 - 31,108,971 (-)Ensembl
mRatBN7.2 Ensembl129,261,255 - 29,272,513 (-)Ensembl
Rnor_6.0 Ensembl131,870,983 - 31,881,531 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115773   ⟹   ENSRNOP00000085473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl131,089,824 - 31,109,654 (-)Ensembl
mRatBN7.2 Ensembl129,261,255 - 29,281,033 (-)Ensembl
RefSeq Acc Id: NM_001108461   ⟹   NP_001101931
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,089,824 - 31,109,703 (-)NCBI
mRatBN7.2129,261,255 - 29,281,134 (-)NCBI
Rnor_6.0131,870,899 - 31,890,778 (-)NCBI
Rnor_5.0133,291,317 - 33,315,340 (-)NCBI
RGSC_v3.4130,067,686 - 30,087,564 (-)RGD
Celera127,912,466 - 27,932,345 (-)RGD
Sequence:
RefSeq Acc Id: XM_006227793   ⟹   XP_006227855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,085,680 - 31,109,642 (-)NCBI
mRatBN7.2129,257,111 - 29,280,728 (-)NCBI
Rnor_6.0131,866,755 - 31,890,442 (-)NCBI
Rnor_5.0133,291,317 - 33,315,340 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006227794   ⟹   XP_006227856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,085,680 - 31,109,642 (-)NCBI
mRatBN7.2129,257,111 - 29,281,039 (-)NCBI
Rnor_6.0131,866,755 - 31,890,696 (-)NCBI
Rnor_5.0133,291,317 - 33,315,340 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001101931 (Get FASTA)   NCBI Sequence Viewer  
  XP_006227855 (Get FASTA)   NCBI Sequence Viewer  
  XP_006227856 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZQL7 (Get FASTA)   NCBI Sequence Viewer  
  EDL87672 (Get FASTA)   NCBI Sequence Viewer  
  EDL87673 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034617.4
  ENSRNOP00000085473
RefSeq Acc Id: NP_001101931   ⟸   NM_001108461
- UniProtKB: A0A0G2K2D6 (UniProtKB/Swiss-Prot),   D3ZQL7 (UniProtKB/TrEMBL),   A0A5H1ZRV3 (UniProtKB/TrEMBL),   A0A8I6A1G2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227856   ⟸   XM_006227794
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2D6 (UniProtKB/Swiss-Prot),   D3ZQL7 (UniProtKB/TrEMBL),   A0A5H1ZRV3 (UniProtKB/TrEMBL),   A0A8I6A1G2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227855   ⟸   XM_006227793
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2D6 (UniProtKB/Swiss-Prot),   D3ZQL7 (UniProtKB/TrEMBL),   A0A5H1ZRV3 (UniProtKB/TrEMBL),   A0A8I6A1G2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072201   ⟸   ENSRNOT00000081225
Ensembl Acc Id: ENSRNOP00000034617   ⟸   ENSRNOT00000039166
Ensembl Acc Id: ENSRNOP00000085473   ⟸   ENSRNOT00000115773

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQL7-F1-model_v2 AlphaFold D3ZQL7 1-218 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689561
Promoter ID:EPDNEW_R85
Type:single initiation site
Name:Tppp_1
Description:tubulin polymerization promoting protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0131,890,737 - 31,890,797EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310121 AgrOrtholog
BioCyc Gene G2FUF-61937 BioCyc
Ensembl Genes ENSRNOG00000028261 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000039166.7 UniProtKB/Swiss-Prot
  ENSRNOT00000115773 ENTREZGENE
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot
  P25-alpha UniProtKB/Swiss-Prot
KEGG Report rno:361466 UniProtKB/Swiss-Prot
NCBI Gene 361466 ENTREZGENE
PANTHER PTHR12932 UniProtKB/Swiss-Prot
  PTHR12932:SF18 UniProtKB/Swiss-Prot
Pfam p25-alpha UniProtKB/Swiss-Prot
PhenoGen Tppp PhenoGen
RatGTEx ENSRNOG00000028261 RatGTEx
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
UniProt A0A0G2K2D6 ENTREZGENE
  A0A5H1ZRV3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A1G2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZQL7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A0G2K2D6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-27 Tppp  tubulin polymerization promoting protein  RGD1310121_predicted  similar to 25 kDa brain-specific protein (p25-alpha) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1310121_predicted  similar to 25 kDa brain-specific protein (p25-alpha) (predicted)  LOC361466_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361466_predicted  similar to 25 kDa brain-specific protein (p25-alpha) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL