Dok4 (docking protein 4) - Rat Genome Database

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Gene: Dok4 (docking protein 4) Rattus norvegicus
Analyze
Symbol: Dok4
Name: docking protein 4
RGD ID: 1310084
Description: Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within nervous system development and positive regulation of MAPK cascade. Predicted to be active in cytoplasm. Orthologous to human DOK4 (docking protein 4); INTERACTS WITH 6-propyl-2-thiouracil; acetamide; aconitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC361364
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,152,511 - 10,163,182 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1910,152,458 - 10,164,190 (+)EnsemblGRCr8
mRatBN7.21910,146,520 - 10,157,187 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,146,474 - 10,158,203 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1910,110,615 - 10,121,334 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01910,877,459 - 10,888,178 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,164,407 - 10,175,126 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01910,563,423 - 10,574,094 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,563,423 - 10,574,093 (+)Ensemblrn6Rnor6.0
Rnor_5.01910,558,204 - 10,569,911 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41910,585,647 - 10,596,322 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1910,033,165 - 10,043,796 (+)NCBICelera
RGSC_v3.11910,590,459 - 10,602,164 (+)NCBI
Cytogenetic Map19p13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11470823   PMID:12477932   PMID:21264944  


Genomics

Comparative Map Data
Dok4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,152,511 - 10,163,182 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1910,152,458 - 10,164,190 (+)EnsemblGRCr8
mRatBN7.21910,146,520 - 10,157,187 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,146,474 - 10,158,203 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1910,110,615 - 10,121,334 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01910,877,459 - 10,888,178 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,164,407 - 10,175,126 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01910,563,423 - 10,574,094 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,563,423 - 10,574,093 (+)Ensemblrn6Rnor6.0
Rnor_5.01910,558,204 - 10,569,911 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41910,585,647 - 10,596,322 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1910,033,165 - 10,043,796 (+)NCBICelera
RGSC_v3.11910,590,459 - 10,602,164 (+)NCBI
Cytogenetic Map19p13NCBI
DOK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381657,471,922 - 57,487,322 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1657,471,917 - 57,487,382 (-)Ensemblhg38GRCh38
GRCh371657,505,834 - 57,521,234 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361656,063,374 - 56,077,828 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341656,063,374 - 56,077,828NCBI
Celera1642,006,722 - 42,021,228 (-)NCBICelera
Cytogenetic Map16q21NCBI
HuRef1643,373,518 - 43,387,961 (-)NCBIHuRef
CHM1_11658,913,924 - 58,928,449 (-)NCBICHM1_1
T2T-CHM13v2.01663,267,111 - 63,282,532 (-)NCBIT2T-CHM13v2.0
Dok4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,590,456 - 95,602,940 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,590,456 - 95,602,958 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38894,863,828 - 94,876,312 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,863,828 - 94,876,330 (-)Ensemblmm10GRCm38
MGSCv37897,387,728 - 97,400,212 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36897,752,989 - 97,765,403 (-)NCBIMGSCv36mm8
Celera899,188,439 - 99,200,990 (-)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.93NCBI
Dok4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543315,104,394 - 15,116,271 (-)Ensembl
ChiLan1.0NW_00495543315,104,387 - 15,116,118 (-)NCBIChiLan1.0ChiLan1.0
DOK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,942,224 - 66,956,686 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11672,864,263 - 72,877,529 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01637,748,004 - 37,762,435 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,880,899 - 56,888,765 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,880,935 - 56,888,765 (-)EnsemblpanPan2panpan1.1
DOK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1258,945,667 - 58,953,206 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl258,946,397 - 58,953,498 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha255,575,237 - 55,583,108 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0259,484,086 - 59,491,944 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,484,670 - 59,491,939 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,315,471 - 56,323,355 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,323,165 - 57,331,026 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,216,632 - 58,224,522 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dok4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,052,787 - 50,060,739 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364759,528,347 - 9,535,683 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364759,528,342 - 9,535,683 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl619,401,075 - 19,413,654 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1619,400,945 - 19,427,038 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2617,391,781 - 17,417,351 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DOK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1543,403,893 - 43,418,062 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl543,401,576 - 43,412,287 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604732,801,020 - 32,815,160 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dok4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474628,593,901 - 28,604,276 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474628,590,997 - 28,603,872 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dok4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1171,740,261 - 1,747,322 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dok4
78 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:126
Interacting mature miRNAs:136
Transcripts:ENSRNOT00000021037
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131969901Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124694445Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127361636Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
RH130355  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21910,158,274 - 10,158,454 (+)MAPPERmRatBN7.2
Rnor_6.01910,575,182 - 10,575,361NCBIRnor6.0
Rnor_5.01910,569,984 - 10,570,163UniSTSRnor5.0
RGSC_v3.41910,597,410 - 10,597,589UniSTSRGSC3.4
Celera1910,044,884 - 10,045,063UniSTS
RH 3.4 Map1974.84UniSTS
Cytogenetic Map19p12UniSTS
RH141364  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21910,149,009 - 10,149,195 (+)MAPPERmRatBN7.2
Rnor_6.01910,565,917 - 10,566,102NCBIRnor6.0
Rnor_5.01910,560,719 - 10,560,904UniSTSRnor5.0
RGSC_v3.41910,588,141 - 10,588,326UniSTSRGSC3.4
Celera1910,035,659 - 10,035,844UniSTS
RH 3.4 Map1993.8UniSTS
Cytogenetic Map19p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 160 91 90 59 90 59 6 352 189 9 139 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021037   ⟹   ENSRNOP00000021037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1910,152,458 - 10,164,190 (+)Ensembl
mRatBN7.2 Ensembl1910,146,474 - 10,158,203 (+)Ensembl
Rnor_6.0 Ensembl1910,563,423 - 10,574,093 (+)Ensembl
RefSeq Acc Id: NM_001108438   ⟹   NP_001101908
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,152,511 - 10,163,182 (+)NCBI
mRatBN7.21910,146,520 - 10,157,187 (+)NCBI
Rnor_6.01910,563,423 - 10,574,094 (+)NCBI
Rnor_5.01910,558,204 - 10,569,911 (+)NCBI
RGSC_v3.41910,585,647 - 10,596,322 (+)RGD
Celera1910,033,165 - 10,043,796 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101908 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58750 (Get FASTA)   NCBI Sequence Viewer  
  EDL87315 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021037
  ENSRNOP00000021037.6
RefSeq Acc Id: NP_001101908   ⟸   NM_001108438
- UniProtKB: B0BNA8 (UniProtKB/TrEMBL),   F7FET5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021037   ⟸   ENSRNOT00000021037
Protein Domains
IRS-type PTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BNA8-F1-model_v2 AlphaFold B0BNA8 1-325 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700937
Promoter ID:EPDNEW_R11461
Type:multiple initiation site
Name:Dok4_1
Description:docking protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01910,563,411 - 10,563,471EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310084 AgrOrtholog
BioCyc Gene G2FUF-6518 BioCyc
Ensembl Genes ENSRNOG00000015679 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021037 ENTREZGENE
  ENSRNOT00000021037.7 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9101502 IMAGE-MGC_LOAD
InterPro Docking_Protein_DOK UniProtKB/TrEMBL
  DOK4/5/6_PH UniProtKB/TrEMBL
  Insln_rcpt_S1 UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
KEGG Report rno:361364 UniProtKB/TrEMBL
MGC_CLONE MGC:187931 IMAGE-MGC_LOAD
NCBI Gene 361364 ENTREZGENE
PANTHER DOCKING PROTEIN 4 UniProtKB/TrEMBL
  DOCKING PROTEIN RELATED UniProtKB/TrEMBL
Pfam IRS UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
PhenoGen Dok4 PhenoGen
PROSITE IRS_PTB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015679 RatGTEx
SMART IRS UniProtKB/TrEMBL
  PTBI UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt B0BNA8 ENTREZGENE, UniProtKB/TrEMBL
  F7FET5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Dok4  docking protein 4   Dok4_predicted  docking protein 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dok4_predicted  docking protein 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED