Cwf19l2 (CWF19 like cell cycle control factor 2) - Rat Genome Database

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Gene: Cwf19l2 (CWF19 like cell cycle control factor 2) Rattus norvegicus
Analyze
Symbol: Cwf19l2
Name: CWF19 like cell cycle control factor 2
RGD ID: 1310083
Description: Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of post-mRNA release spliceosomal complex. Orthologous to human CWF19L2 (CWF19 like cell cycle control factor 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; chloroprene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CWF19-like 2, cell cycle control; CWF19-like 2, cell cycle control (S. pombe); CWF19-like protein 2; LOC362804
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr866,036,158 - 6,102,686 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl66,026,861 - 6,102,635 (-)EnsemblGRCr8
mRatBN7.26290,148 - 356,636 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6281,685 - 356,604 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6506,515 - 572,953 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06815,805 - 882,242 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06340,227 - 406,631 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0618,970,616 - 19,037,176 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl618,970,564 - 19,055,924 (+)Ensemblrn6Rnor6.0
Rnor_5.0628,868,716 - 28,935,276 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47418,368 - 485,802 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6115,555 - 181,554 (-)NCBICelera
RGSC_v3.17418,367 - 482,123 (+)NCBI
Cytogenetic Map6q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090  


Genomics

Comparative Map Data
Cwf19l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr866,036,158 - 6,102,686 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl66,026,861 - 6,102,635 (-)EnsemblGRCr8
mRatBN7.26290,148 - 356,636 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6281,685 - 356,604 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6506,515 - 572,953 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06815,805 - 882,242 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06340,227 - 406,631 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0618,970,616 - 19,037,176 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl618,970,564 - 19,055,924 (+)Ensemblrn6Rnor6.0
Rnor_5.0628,868,716 - 28,935,276 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47418,368 - 485,802 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6115,555 - 181,554 (-)NCBICelera
RGSC_v3.17418,367 - 482,123 (+)NCBI
Cytogenetic Map6q11NCBI
CWF19L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811107,326,360 - 107,457,825 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11107,321,601 - 107,457,842 (-)Ensemblhg38GRCh38
GRCh3711107,197,086 - 107,328,551 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611106,702,293 - 106,830,406 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3411106,702,292 - 106,830,406NCBI
Celera11104,362,890 - 104,483,437 (-)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11103,133,370 - 103,254,160 (-)NCBIHuRef
CHM1_111107,080,175 - 107,211,650 (-)NCBICHM1_1
T2T-CHM13v2.011107,333,512 - 107,464,989 (-)NCBIT2T-CHM13v2.0
Cwf19l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3993,403,592 - 3,479,236 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl93,403,592 - 3,479,236 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3893,403,592 - 3,479,236 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl93,403,592 - 3,479,236 (+)Ensemblmm10GRCm38
MGSCv3793,404,085 - 3,479,236 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3693,404,085 - 3,479,236 (+)NCBIMGSCv36mm8
Celera3119,215,796 - 119,285,730 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.06NCBI
Cwf19l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554129,766,910 - 9,861,027 (-)Ensembl
ChiLan1.0NW_0049554129,758,751 - 9,861,019 (-)NCBIChiLan1.0ChiLan1.0
CWF19L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29108,025,853 - 108,203,804 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111109,157,101 - 109,297,820 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011102,219,339 - 102,345,865 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111105,702,934 - 105,828,168 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11105,702,934 - 105,828,149 (-)EnsemblpanPan2panpan1.1
CWF19L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1524,936,700 - 25,080,927 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl524,833,373 - 25,080,451 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha524,852,125 - 25,005,758 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0524,963,467 - 25,107,620 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl524,963,519 - 25,107,618 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1525,015,519 - 25,159,677 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0524,902,624 - 25,047,003 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0524,964,115 - 25,111,783 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cwf19l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494790,229,976 - 90,343,408 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365511,193,109 - 1,306,533 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CWF19L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl935,967,204 - 36,059,749 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1935,967,198 - 36,059,780 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2940,006,188 - 40,106,971 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CWF19L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1198,749,892 - 98,885,698 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl198,766,109 - 98,885,671 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604327,061,434 - 27,186,945 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cwf19l2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247842,113,153 - 2,253,466 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cwf19l2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17166,722 - 224,916 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cwf19l2
401 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:322
Count of miRNA genes:196
Interacting mature miRNAs:232
Transcripts:ENSRNOT00000030803
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6125740059Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6120510098Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000030803   ⟹   ENSRNOP00000030298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl66,036,158 - 6,102,629 (-)Ensembl
mRatBN7.2 Ensembl6293,816 - 356,587 (-)Ensembl
Rnor_6.0 Ensembl618,970,616 - 19,037,176 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090121   ⟹   ENSRNOP00000072455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl66,026,861 - 6,102,629 (-)Ensembl
mRatBN7.2 Ensembl6281,685 - 356,604 (-)Ensembl
Rnor_6.0 Ensembl618,970,564 - 19,055,924 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000146877   ⟹   ENSRNOP00000110062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl66,036,158 - 6,102,635 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000153588   ⟹   ENSRNOP00000099647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl66,036,158 - 6,102,629 (-)Ensembl
RefSeq Acc Id: NM_001135003   ⟹   NP_001128475
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr866,036,158 - 6,102,578 (-)NCBI
mRatBN7.26290,148 - 356,572 (-)NCBI
Rnor_6.0618,970,616 - 19,037,176 (+)NCBI
Rnor_5.0628,868,716 - 28,935,276 (+)NCBI
RGSC_v3.47418,368 - 485,802 (+)RGD
Celera6115,555 - 181,554 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063262176   ⟹   XP_063118246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr866,048,910 - 6,102,686 (-)NCBI
RefSeq Acc Id: XR_005505551
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr866,051,811 - 6,102,686 (-)NCBI
mRatBN7.26305,753 - 356,636 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001128475 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118246 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM02599 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030298.5
  ENSRNOP00000072455.1
  ENSRNOP00000099647
  ENSRNOP00000099647.1
  ENSRNOP00000110062.1
RefSeq Acc Id: NP_001128475   ⟸   NM_001135003
- UniProtKB: A0A0G2K305 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072455   ⟸   ENSRNOT00000090121
Ensembl Acc Id: ENSRNOP00000030298   ⟸   ENSRNOT00000030803
RefSeq Acc Id: XP_063118246   ⟸   XM_063262176
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000110062   ⟸   ENSRNOT00000146877
Ensembl Acc Id: ENSRNOP00000099647   ⟸   ENSRNOT00000153588
Protein Domains
Cwf19-like C-terminal   Cwf19-like protein C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K305-F1-model_v2 AlphaFold A0A0G2K305 1-898 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694413
Promoter ID:EPDNEW_R4929
Type:initiation region
Name:Cwf19l2_1
Description:CWF19-like 2, cell cycle control
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0618,970,601 - 18,970,661EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310083 AgrOrtholog
BioCyc Gene G2FUF-38826 BioCyc
Ensembl Genes ENSRNOG00000024372 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030803.6 UniProtKB/TrEMBL
  ENSRNOT00000090121.3 UniProtKB/TrEMBL
  ENSRNOT00000146877.1 UniProtKB/TrEMBL
  ENSRNOT00000153588 ENTREZGENE
  ENSRNOT00000153588.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.428.10 UniProtKB/TrEMBL
InterPro Cwf19-like UniProtKB/TrEMBL
  Cwf19-like_C_dom-1 UniProtKB/TrEMBL
  Cwf19-like_C_dom-2 UniProtKB/TrEMBL
  HIT-like_sf UniProtKB/TrEMBL
NCBI Gene 362804 ENTREZGENE
PANTHER CWF19-LIKE PROTEIN 2 UniProtKB/TrEMBL
  PTHR12072 UniProtKB/TrEMBL
Pfam CwfJ_C_1 UniProtKB/TrEMBL
  CwfJ_C_2 UniProtKB/TrEMBL
PhenoGen Cwf19l2 PhenoGen
RatGTEx ENSRNOG00000024372 RatGTEx
Superfamily-SCOP His_triad-like_motif UniProtKB/TrEMBL
UniProt A0A0G2K305 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LDX8_RAT UniProtKB/TrEMBL
  A0ABK0M071_RAT UniProtKB/TrEMBL
  D4A877_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-07-20 Cwf19l2  CWF19 like cell cycle control factor 2  Cwf19l2  CWF19-like 2, cell cycle control (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Cwf19l2  CWF19-like 2, cell cycle control (S. pombe)   Cwf19l2_predicted  CWF19-like 2, cell cycle control (S. pombe) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cwf19l2_predicted  CWF19-like 2, cell cycle control (S. pombe) (predicted)      Symbol and Name status set to approved 70820 APPROVED