Odad3 (outer dynein arm docking complex subunit 3) - Rat Genome Database

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Gene: Odad3 (outer dynein arm docking complex subunit 3) Rattus norvegicus
Analyze
Symbol: Odad3
Name: outer dynein arm docking complex subunit 3
RGD ID: 1310048
Description: Predicted to be involved in cilium movement; outer dynein arm assembly; and regulation of cilium assembly. Predicted to act upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; flagellated sperm motility; and seminiferous tubule development. Predicted to be located in axoneme and centriole. Predicted to be active in ciliary tip; cytoskeleton; and sperm flagellum. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 30. Orthologous to human ODAD3 (outer dynein arm docking complex subunit 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ccdc151; coiled-coil domain containing 151; coiled-coil domain-containing protein 151; LOC315465; outer dynein arm-docking complex subunit 3; RGD1310048; similar to hypothetical protein MGC20983
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,796,909 - 28,810,587 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl828,796,701 - 28,810,511 (-)EnsemblGRCr8
mRatBN7.2820,520,898 - 20,534,499 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,520,898 - 20,534,499 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx824,550,369 - 24,563,404 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,847,512 - 22,860,547 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,750,440 - 20,764,042 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0823,000,912 - 23,014,707 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl823,000,872 - 23,014,499 (-)Ensemblrn6Rnor6.0
Rnor_5.0823,055,696 - 23,069,490 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4821,101,646 - 21,106,600 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera821,911,406 - 21,925,008 (-)NCBICelera
RGSC_v3.1821,093,247 - 21,106,439 (-)NCBI
Cytogenetic Map8q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axoneme  (ISO)
centriole  (ISO)
ciliary basal body  (IBA,ISO)
ciliary rootlet  (IBA)
ciliary tip  (IBA)
cilium  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:24067530   PMID:25192045   PMID:25807483  


Genomics

Comparative Map Data
Odad3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,796,909 - 28,810,587 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl828,796,701 - 28,810,511 (-)EnsemblGRCr8
mRatBN7.2820,520,898 - 20,534,499 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,520,898 - 20,534,499 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx824,550,369 - 24,563,404 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,847,512 - 22,860,547 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,750,440 - 20,764,042 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0823,000,912 - 23,014,707 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl823,000,872 - 23,014,499 (-)Ensemblrn6Rnor6.0
Rnor_5.0823,055,696 - 23,069,490 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4821,101,646 - 21,106,600 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera821,911,406 - 21,925,008 (-)NCBICelera
RGSC_v3.1821,093,247 - 21,106,439 (-)NCBI
Cytogenetic Map8q13NCBI
ODAD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,420,605 - 11,435,782 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1911,420,604 - 11,435,782 (-)Ensemblhg38GRCh38
GRCh371911,531,273 - 11,546,603 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,392,272 - 11,406,980 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1911,426,123 - 11,440,715 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1911,106,715 - 11,121,176 (-)NCBIHuRef
CHM1_11911,532,195 - 11,546,002 (-)NCBICHM1_1
T2T-CHM13v2.01911,547,569 - 11,563,304 (-)NCBIT2T-CHM13v2.0
Odad3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,901,167 - 21,914,268 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,901,167 - 21,913,930 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38921,989,871 - 22,002,972 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,989,871 - 22,002,634 (-)Ensemblmm10GRCm38
MGSCv37921,794,315 - 21,807,078 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36921,740,274 - 21,753,036 (-)NCBIMGSCv36mm8
Celera919,259,559 - 19,272,322 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map98.01NCBI
Odad3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,318,471 - 2,330,508 (-)Ensembl
ChiLan1.0NW_0049554952,318,840 - 2,330,966 (-)NCBIChiLan1.0ChiLan1.0
ODAD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22016,334,433 - 16,348,691 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11915,332,679 - 15,347,684 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,967,913 - 10,982,032 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11911,678,306 - 11,694,190 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1911,678,306 - 11,693,332 (-)EnsemblpanPan2panpan1.1
ODAD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,917,183 - 49,926,417 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,917,350 - 49,926,424 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2049,788,324 - 49,797,557 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02050,435,504 - 50,444,742 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,435,557 - 50,444,749 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,645,796 - 49,655,022 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,071,947 - 50,081,167 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,315,130 - 50,324,355 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Odad3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,853,492 - 208,863,108 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,491,831 - 1,500,843 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,491,598 - 1,501,245 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ODAD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,349,063 - 10,360,292 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl610,349,069 - 10,360,250 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660749,526,608 - 9,540,969 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Odad3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,208,153 - 3,218,637 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248283,207,935 - 3,218,795 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Odad3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1818,239,611 - 18,252,948 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Odad3
125 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:54
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000017820
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
RH132178  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,521,020 - 20,521,202 (+)MAPPERmRatBN7.2
Rnor_6.0823,001,035 - 23,001,216NCBIRnor6.0
Rnor_5.0823,055,819 - 23,056,000UniSTSRnor5.0
RGSC_v3.4821,093,119 - 21,093,300UniSTSRGSC3.4
Celera821,911,529 - 21,911,710UniSTS
RH 3.4 Map8180.8UniSTS
Cytogenetic Map8q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 8 46 153 65 64 34 29 34 6 232 105 9 128 75 84 30 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000017820   ⟹   ENSRNOP00000017820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,796,909 - 28,810,511 (-)Ensembl
mRatBN7.2 Ensembl820,520,898 - 20,534,499 (-)Ensembl
Rnor_6.0 Ensembl823,000,872 - 23,014,499 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000164436   ⟹   ENSRNOP00000098818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,796,701 - 28,810,511 (-)Ensembl
RefSeq Acc Id: NM_001309457   ⟹   NP_001296386
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,796,909 - 28,810,511 (-)NCBI
mRatBN7.2820,520,898 - 20,534,499 (-)NCBI
Rnor_6.0823,000,912 - 23,014,514 (-)NCBI
Celera821,911,406 - 21,925,008 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063265338   ⟹   XP_063121408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,796,909 - 28,810,587 (-)NCBI
RefSeq Acc Id: XM_063265339   ⟹   XP_063121409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,796,909 - 28,810,587 (-)NCBI
RefSeq Acc Id: XM_063265340   ⟹   XP_063121410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,796,909 - 28,810,587 (-)NCBI
RefSeq Acc Id: XM_063265341   ⟹   XP_063121411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,796,909 - 28,806,180 (-)NCBI
RefSeq Acc Id: NP_001296386   ⟸   NM_001309457
- UniProtKB: D4ABL9 (UniProtKB/TrEMBL),   A6JNX0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017820   ⟸   ENSRNOT00000017820
RefSeq Acc Id: XP_063121409   ⟸   XM_063265339
- Peptide Label: isoform X2
- UniProtKB: D4ABL9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121410   ⟸   XM_063265340
- Peptide Label: isoform X3
- UniProtKB: D4ABL9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121408   ⟸   XM_063265338
- Peptide Label: isoform X1
- UniProtKB: D4ABL9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121411   ⟸   XM_063265341
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000098818   ⟸   ENSRNOT00000164436
Protein Domains
ODAD1 central coiled coil region

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ABL9-F1-model_v2 AlphaFold D4ABL9 1-595 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695800
Promoter ID:EPDNEW_R6323
Type:single initiation site
Name:Ccdc151_1
Description:coiled-coil domain containing 151
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0823,014,501 - 23,014,561EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310048 AgrOrtholog
BioCyc Gene G2FUF-31397 BioCyc
Ensembl Genes ENSRNOG00000013263 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017820 ENTREZGENE
  ENSRNOT00000017820.8 UniProtKB/TrEMBL
  ENSRNOT00000164436 ENTREZGENE
  ENSRNOT00000164436.1 UniProtKB/TrEMBL
InterPro CCDC151 UniProtKB/TrEMBL
  ODAD1_CC UniProtKB/TrEMBL
KEGG Report rno:315465 UniProtKB/TrEMBL
NCBI Gene 315465 ENTREZGENE
PANTHER OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 3 UniProtKB/TrEMBL
  PTHR46518 UniProtKB/TrEMBL
Pfam DUF6872 UniProtKB/TrEMBL
PhenoGen Odad3 PhenoGen
RatGTEx ENSRNOG00000013263 RatGTEx
UniProt A0ABK0LFA6_RAT UniProtKB/TrEMBL
  A6JNX0 ENTREZGENE, UniProtKB/TrEMBL
  D4ABL9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-10-12 Odad3  outer dynein arm docking complex subunit 3  Ccdc151  coiled-coil domain containing 151  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-02 Ccdc151  coiled-coil domain containing 151  RGD1310048  similar to hypothetical protein MGC20983   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1310048  similar to hypothetical protein MGC20983   RGD1310048_predicted  similar to hypothetical protein MGC20983 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1310048_predicted  similar to hypothetical protein MGC20983 (predicted)  LOC315465_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC315465_predicted  similar to hypothetical protein MGC20983 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL