Adh6a (alcohol dehydrogenase 6A (class V)) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Adh6a (alcohol dehydrogenase 6A (class V)) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Adh6a
Name: alcohol dehydrogenase 6A (class V)
RGD ID: 1310029
Description: Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity and zinc ion binding activity. Predicted to be involved in retinoic acid metabolic process and retinol metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol; INTERACTS WITH 1,2-dimethylhydrazine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC295498
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82229,497,121 - 229,519,403 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2229,497,173 - 229,519,401 (+)EnsemblGRCr8
mRatBN7.22226,823,775 - 226,846,005 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2226,823,730 - 226,846,003 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2234,584,024 - 234,591,993 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02232,483,760 - 232,491,729 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02227,348,436 - 227,356,405 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02243,577,086 - 243,599,357 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,577,082 - 243,599,400 (+)Ensemblrn6Rnor6.0
Rnor_5.02262,121,117 - 262,138,062 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42235,842,525 - 235,850,491 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2218,994,731 - 219,002,709 (+)NCBICelera
RGSC_v3.12235,798,836 - 235,837,233 (+)NCBI
Cytogenetic Map2q44NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation

Genomics

Variants

.
Variants in Adh6a
212 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:78
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000016556
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2212145502231732847Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2202029709236904960Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2219814164239320906Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2218051934251712708Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2221088977243501206Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2223810546243965570Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 2 40 37 77 81 52 30 52 6 220 89 5 19 62 82 29 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000016556   ⟹   ENSRNOP00000016556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2229,497,173 - 229,519,401 (+)Ensembl
mRatBN7.2 Ensembl2226,823,730 - 226,846,003 (+)Ensembl
Rnor_6.0 Ensembl2243,577,082 - 243,599,400 (+)Ensembl
RefSeq Acc Id: NM_001106475   ⟹   NP_001099945
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82229,511,435 - 229,519,401 (+)NCBI
mRatBN7.22226,838,037 - 226,846,003 (+)NCBI
Rnor_6.02243,591,385 - 243,599,351 (+)NCBI
Rnor_5.02262,121,117 - 262,138,062 (+)NCBI
RGSC_v3.42235,842,525 - 235,850,491 (+)RGD
Celera2218,994,731 - 219,002,709 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233371   ⟹   XP_006233433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82229,497,121 - 229,519,403 (+)NCBI
mRatBN7.22226,823,775 - 226,846,005 (+)NCBI
Rnor_6.02243,577,086 - 243,599,357 (+)NCBI
Rnor_5.02262,121,117 - 262,138,062 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099945 (Get FASTA)   NCBI Sequence Viewer  
  XP_006233433 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL82316 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016556
  ENSRNOP00000016556.7
RefSeq Acc Id: NP_001099945   ⟸   NM_001106475
- UniProtKB: D3ZT84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233433   ⟸   XM_006233371
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000016556   ⟸   ENSRNOT00000016556
Protein Domains
Alcohol dehydrogenase-like C-terminal   Alcohol dehydrogenase-like N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZT84-F1-model_v2 AlphaFold D3ZT84 1-388 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691786
Promoter ID:EPDNEW_R2311
Type:single initiation site
Name:Adh6a_1
Description:alcohol dehydrogenase 6A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02243,577,067 - 243,577,127EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310029 AgrOrtholog
BioCyc Gene G2FUF-51075 BioCyc
Ensembl Genes ENSRNOG00000012281 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016556 ENTREZGENE
  ENSRNOT00000016556.8 UniProtKB/TrEMBL
Gene3D-CATH Medium-chain alcohol dehydrogenases, catalytic domain UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro ADH_C UniProtKB/TrEMBL
  ADH_GroES-like UniProtKB/TrEMBL
  ADH_Zn_CS UniProtKB/TrEMBL
  GroES-like UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  PKS_ER UniProtKB/TrEMBL
KEGG Report rno:295498 UniProtKB/TrEMBL
NCBI Gene 295498 ENTREZGENE
PANTHER ALCOHOL DEHYDROGENASE UniProtKB/TrEMBL
  ALCOHOL DEHYDROGENASE 6A (CLASS V) UniProtKB/TrEMBL
Pfam ADH_N UniProtKB/TrEMBL
  ADH_zinc_N UniProtKB/TrEMBL
PharmGKB ADH6 RGD
PhenoGen Adh6a PhenoGen
PROSITE ADH_ZINC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012281 RatGTEx
SMART PKS_ER UniProtKB/TrEMBL
Superfamily-SCOP GroES_like UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
UniProt A6HW30_RAT UniProtKB/TrEMBL
  D3ZT84 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Adh6a  alcohol dehydrogenase 6A (class V)   Adh6a_predicted  alcohol dehydrogenase 6A (class V) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Adh6a_predicted  alcohol dehydrogenase 6A (class V) (predicted)      Symbol and Name status set to approved 70820 APPROVED