Adh6a (alcohol dehydrogenase 6A (class V)) - Rat Genome Database

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Gene: Adh6a (alcohol dehydrogenase 6A (class V)) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Adh6a
Name: alcohol dehydrogenase 6A (class V)
RGD ID: 1310029
Description: Predicted to enable NAD-retinol dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent; and zinc ion binding activity. Predicted to be involved in ethanol oxidation; retinoic acid metabolic process; and retinol metabolic process. Predicted to be active in cytosol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC295498
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82229,497,121 - 229,519,403 (+)NCBIGRCr8
mRatBN7.22226,823,775 - 226,846,005 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2226,823,730 - 226,846,003 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2234,584,024 - 234,591,993 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02232,483,760 - 232,491,729 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02227,348,436 - 227,356,405 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02243,577,086 - 243,599,357 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,577,082 - 243,599,400 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02262,121,117 - 262,138,062 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42235,842,525 - 235,850,491 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12235,798,836 - 235,837,233 (+)NCBI
Celera2218,994,731 - 219,002,709 (+)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation

Genomics

Variants

.
Variants in Adh6a
136 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:78
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000016556
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system renal system reproductive system respiratory system appendage
High
Medium
Low 1 10 10 10 18 9 11
Below cutoff 2 23 35 26 16 26 1 1 14 25 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016556   ⟹   ENSRNOP00000016556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2226,823,730 - 226,846,003 (+)Ensembl
Rnor_6.0 Ensembl2243,577,082 - 243,599,400 (+)Ensembl
RefSeq Acc Id: NM_001106475   ⟹   NP_001099945
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82229,511,435 - 229,519,401 (+)NCBI
mRatBN7.22226,838,037 - 226,846,003 (+)NCBI
Rnor_6.02243,591,385 - 243,599,351 (+)NCBI
Rnor_5.02262,121,117 - 262,138,062 (+)NCBI
RGSC_v3.42235,842,525 - 235,850,491 (+)RGD
Celera2218,994,731 - 219,002,709 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233371   ⟹   XP_006233433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82229,497,121 - 229,519,403 (+)NCBI
mRatBN7.22226,823,775 - 226,846,005 (+)NCBI
Rnor_6.02243,577,086 - 243,599,357 (+)NCBI
Rnor_5.02262,121,117 - 262,138,062 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099945 (Get FASTA)   NCBI Sequence Viewer  
  XP_006233433 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL82316 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016556.6
Reference Protein Sequences
RefSeq Acc Id: NP_001099945   ⟸   NM_001106475
- UniProtKB: A6HW30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233433   ⟸   XM_006233371
- Peptide Label: isoform X1
- UniProtKB: D3ZT84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016556   ⟸   ENSRNOT00000016556
Protein Domains
Alcohol dehydrogenase-like C-terminal   Alcohol dehydrogenase-like N-terminal   Enoyl reductase (ER)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZT84-F1-model_v2 AlphaFold D3ZT84 1-388 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691786
Promoter ID:EPDNEW_R2311
Type:single initiation site
Name:Adh6a_1
Description:alcohol dehydrogenase 6A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02243,577,067 - 243,577,127EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310029 AgrOrtholog
BioCyc Gene G2FUF-51075 BioCyc
Ensembl Genes ENSRNOG00000012281 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016556.7 UniProtKB/TrEMBL
Gene3D-CATH Medium-chain alcohol dehydrogenases, catalytic domain UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro ADH_C UniProtKB/TrEMBL
  ADH_GroES-like UniProtKB/TrEMBL
  ADH_Zn_CS UniProtKB/TrEMBL
  GroES-like UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  PKS_ER UniProtKB/TrEMBL
KEGG Report rno:295498 UniProtKB/TrEMBL
NCBI Gene 295498 ENTREZGENE
PANTHER ALCOHOL DEHYDROGENASE UniProtKB/TrEMBL
  ALCOHOL DEHYDROGENASE 6A (CLASS V) UniProtKB/TrEMBL
Pfam ADH_N UniProtKB/TrEMBL
  ADH_zinc_N UniProtKB/TrEMBL
PharmGKB ADH6 RGD
PhenoGen Adh6a PhenoGen
PROSITE ADH_ZINC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012281 RatGTEx
SMART PKS_ER UniProtKB/TrEMBL
Superfamily-SCOP GroES_like UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
UniProt A6HW30 ENTREZGENE, UniProtKB/TrEMBL
  D3ZT84 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Adh6a  alcohol dehydrogenase 6A (class V)   Adh6a_predicted  alcohol dehydrogenase 6A (class V) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Adh6a_predicted  alcohol dehydrogenase 6A (class V) (predicted)      Symbol and Name status set to approved 70820 APPROVED