Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of RCC2 mRNA] | CTD | PMID:31150632 | 1,2-dimethylhydrazine | multiple interactions | ISO | Rcc2 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RCC2 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of RCC2 mRNA | CTD | PMID:26496021 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of RCC2 mRNA | CTD | PMID:35192832 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Rcc2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of RCC2 mRNA | CTD | PMID:21570461 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of RCC2 mRNA | CTD | PMID:21346803 | 2-hydroxypropanoic acid | decreases expression | ISO | RCC2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of RCC2 mRNA | CTD | PMID:30851411 | 2-methylcholine | affects expression | ISO | RCC2 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of RCC2 mRNA | CTD | PMID:21179406 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | RCC2 (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of RCC2 protein | CTD | PMID:31675489 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Rcc2 (Mus musculus) | 6480464 | bisphenol S affects the methylation of RCC2 gene | CTD | PMID:31683443 | 4-amino-2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 4-amino-2 and 6-dinitrotoluene affects the expression of RCC2 mRNA | CTD | PMID:21346803 | 4-hydroxyphenyl retinamide | increases expression | ISO | Rcc2 (Mus musculus) | 6480464 | Fenretinide results in increased expression of RCC2 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of RCC2 mRNA | CTD | PMID:24780913 and PMID:30047161 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of RCC2 mRNA | CTD | PMID:28959563 | acrylamide | increases expression | ISO | RCC2 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of RCC2 mRNA | CTD | PMID:32763439 | aflatoxin B1 | affects expression | ISO | RCC2 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of RCC2 protein | CTD | PMID:20106945 | aflatoxin B1 | increases expression | ISO | RCC2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of RCC2 mRNA | CTD | PMID:22100608 | aflatoxin B1 | decreases expression | ISO | Rcc2 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of RCC2 mRNA | CTD | PMID:19770486 | all-trans-retinoic acid | decreases expression | ISO | RCC2 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of RCC2 mRNA | CTD | PMID:33167477 | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of RCC2 mRNA | CTD | PMID:30047161 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of RCC2 mRNA | CTD | PMID:30779732 | antirheumatic drug | decreases expression | ISO | RCC2 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of RCC2 mRNA | CTD | PMID:24449571 | aristolochic acid A | increases expression | ISO | RCC2 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of RCC2 protein | CTD | PMID:33212167 | arsane | affects methylation | ISO | RCC2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of RCC2 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | RCC2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of RCC2 gene | CTD | PMID:25304211 | atrazine | decreases expression | ISO | RCC2 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of RCC2 mRNA | CTD | PMID:22378314 | belinostat | decreases expression | ISO | RCC2 (Homo sapiens) | 6480464 | belinostat results in decreased expression of RCC2 mRNA | CTD | PMID:19606018 | benzo[a]pyrene | decreases expression | ISO | Rcc2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of RCC2 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | increases expression | ISO | RCC2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of RCC2 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | affects methylation | ISO | RCC2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of RCC2 polyA tail and Benzo(a)pyrene affects the methylation of RCC2 promoter | CTD | PMID:27901495 and PMID:30157460 | benzo[a]pyrene | decreases methylation | ISO | RCC2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of RCC2 3' UTR | CTD | PMID:27901495 | bis(2-ethylhexyl) phthalate | increases expression | ISO | RCC2 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of RCC2 protein | CTD | PMID:31163220 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of RCC2 mRNA | CTD | PMID:26496021 | bisphenol A | decreases expression | ISO | RCC2 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of RCC2 protein | CTD | PMID:37567409 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of RCC2 mRNA | CTD | PMID:30816183 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of RCC2 mRNA | CTD | PMID:19167457 | cadmium atom | multiple interactions | ISO | RCC2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of RCC2 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | RCC2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of RCC2 mRNA | CTD | PMID:35301059 | carbon nanotube | increases expression | ISO | Rcc2 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chlorpyrifos | decreases expression | ISO | Rcc2 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of RCC2 mRNA | CTD | PMID:37019170 | chromium(6+) | affects expression | ISO | Rcc2 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of RCC2 mRNA | CTD | PMID:28472532 | cisplatin | decreases expression | ISO | RCC2 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of RCC2 mRNA | CTD | PMID:27594783 | clobetasol | increases expression | ISO | Rcc2 (Mus musculus) | 6480464 | Clobetasol results in increased expression of RCC2 mRNA | CTD | PMID:27462272 | cobalt dichloride | increases expression | ISO | Rcc2 (Mus musculus) | 6480464 | cobaltous chloride results in increased expression of RCC2 mRNA | CTD | PMID:21139344 | cobalt dichloride | decreases expression | ISO | RCC2 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of RCC2 mRNA | CTD | PMID:19320972 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of RCC2 mRNA | CTD | PMID:26577399 | cyclosporin A | increases expression | ISO | RCC2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of RCC2 mRNA | CTD | PMID:20106945 | decabromodiphenyl ether | decreases expression | ISO | RCC2 (Homo sapiens) | 6480464 | decabromobiphenyl ether results in decreased expression of RCC2 protein | CTD | PMID:31675489 | dibutyl phthalate | decreases expression | ISO | Rcc2 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of RCC2 mRNA | CTD | PMID:17361019 and PMID:21266533 | dicrotophos | increases expression | ISO | RCC2 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of RCC2 mRNA | CTD | PMID:28302478 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of RCC2 mRNA | CTD | PMID:21551480 | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of RCC2 mRNA | CTD | PMID:29391264 | enzyme inhibitor | multiple interactions | ISO | RCC2 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RCC2 protein | CTD | PMID:23301498 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of RCC2 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | Rcc2 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RCC2 mRNA | CTD | PMID:22206623 | FR900359 | increases phosphorylation | ISO | RCC2 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of RCC2 protein | CTD | PMID:37730182 | inulin | multiple interactions | ISO | Rcc2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of RCC2 mRNA | CTD | PMID:36331819 | ivermectin | decreases expression | ISO | RCC2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of RCC2 protein | CTD | PMID:32959892 | lead(0) | affects expression | ISO | RCC2 (Homo sapiens) | 6480464 | Lead affects the expression of RCC2 mRNA | CTD | PMID:28903495 | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of RCC2 mRNA | CTD | PMID:30047161 | methylphenidate | decreases expression | ISO | Rcc2 (Mus musculus) | 6480464 | Methylphenidate results in decreased expression of RCC2 mRNA | CTD | PMID:22470460 | miconazole | increases expression | ISO | Rcc2 (Mus musculus) | 6480464 | Miconazole results in increased expression of RCC2 mRNA | CTD | PMID:27462272 | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of RCC2 mRNA | CTD | PMID:24136188 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of RCC2 mRNA | CTD | PMID:25729387 | paracetamol | affects expression | ISO | Rcc2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of RCC2 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of RCC2 mRNA | CTD | PMID:33387578 | perfluorononanoic acid | increases expression | ISO | RCC2 (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in increased expression of RCC2 mRNA | CTD | PMID:32588087 | perfluorooctane-1-sulfonic acid | increases expression | ISO | Rcc2 (Mus musculus) | 6480464 | perfluorooctane sulfonic acid results in increased expression of RCC2 protein | CTD | PMID:26178269 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Rcc2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of RCC2 mRNA | CTD | PMID:36331819 | pirinixic acid | multiple interactions | ISO | Rcc2 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RCC2 mRNA | CTD | PMID:19710929 | rac-lactic acid | decreases expression | ISO | RCC2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of RCC2 mRNA | CTD | PMID:30851411 | resveratrol | multiple interactions | ISO | RCC2 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of RCC2 mRNA | CTD | PMID:23557933 | SB 431542 | multiple interactions | ISO | RCC2 (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in decreased expression of RCC2 protein | CTD | PMID:37664457 | sodium fluoride | increases expression | ISO | Rcc2 (Mus musculus) | 6480464 | Sodium Fluoride results in increased expression of RCC2 mRNA | CTD | PMID:27862939 | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of RCC2 mRNA | CTD | PMID:19281266 | sulfadimethoxine | increases expression | EXP | | 6480464 | Sulfadimethoxine results in increased expression of RCC2 mRNA | CTD | PMID:30047161 | temozolomide | increases expression | ISO | RCC2 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of RCC2 mRNA | CTD | PMID:31758290 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of RCC2 mRNA | CTD | PMID:16239168 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of RCC2 mRNA] | CTD | PMID:31150632 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of RCC2 mRNA | CTD | PMID:31150632 | tetrachloromethane | increases expression | ISO | Rcc2 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of RCC2 mRNA | CTD | PMID:27339419 and PMID:31919559 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of RCC2 mRNA | CTD | PMID:23411599 and PMID:34492290 | titanium dioxide | increases expression | ISO | Rcc2 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of RCC2 mRNA | CTD | PMID:23557971 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of RCC2 mRNA | CTD | PMID:25729387 | Tributyltin oxide | decreases phosphorylation | ISO | Rcc2 (Mus musculus) | 6480464 | bis(tri-n-butyltin)oxide results in decreased phosphorylation of RCC2 protein | CTD | PMID:22174045 | trichostatin A | decreases expression | ISO | RCC2 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of RCC2 mRNA | CTD | PMID:19606018 | trichostatin A | affects expression | ISO | RCC2 (Homo sapiens) | 6480464 | trichostatin A affects the expression of RCC2 mRNA | CTD | PMID:28542535 | trimellitic anhydride | increases expression | ISO | Rcc2 (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of RCC2 mRNA | CTD | PMID:19042947 | triptonide | decreases expression | ISO | Rcc2 (Mus musculus) | 6480464 | triptonide results in decreased expression of RCC2 mRNA | CTD | PMID:33045310 | troglitazone | decreases expression | ISO | Rcc2 (Mus musculus) | 6480464 | troglitazone results in decreased expression of RCC2 mRNA | CTD | PMID:28973697 | valproic acid | affects expression | ISO | Rcc2 (Mus musculus) | 6480464 | Valproic Acid affects the expression of RCC2 mRNA | CTD | PMID:17963808 | valproic acid | affects expression | ISO | RCC2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of RCC2 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | RCC2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of RCC2 mRNA | CTD | PMID:19101580 more ... | vancomycin | decreases expression | ISO | Rcc2 (Mus musculus) | 6480464 | Vancomycin results in decreased expression of RCC2 mRNA | CTD | PMID:18930951 | zinc atom | increases expression | ISO | RCC2 (Homo sapiens) | 6480464 | Zinc deficiency results in increased expression of RCC2 mRNA | CTD | PMID:22171008 | zinc(0) | increases expression | ISO | RCC2 (Homo sapiens) | 6480464 | Zinc deficiency results in increased expression of RCC2 mRNA | CTD | PMID:22171008 | |