Arrdc1 (arrestin domain containing 1) - Rat Genome Database

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Gene: Arrdc1 (arrestin domain containing 1) Rattus norvegicus
Analyze
Symbol: Arrdc1
Name: arrestin domain containing 1
RGD ID: 1309961
Description: Predicted to enable several functions, including arrestin family protein binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including extracellular vesicle biogenesis; negative regulation of Notch signaling pathway; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasmic vesicle; extracellular vesicle; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human ARRDC1 (arrestin domain containing 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-arrestin 1; arrestin domain-containing protein 1; LOC366001
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,133,190 - 28,140,378 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl328,133,191 - 28,140,687 (-)EnsemblGRCr8
mRatBN7.237,735,002 - 7,742,195 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,735,011 - 7,742,197 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx310,839,750 - 10,846,806 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,425,978 - 19,433,034 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,615,814 - 17,622,874 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,129,876 - 2,137,161 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,129,879 - 2,136,936 (-)Ensemblrn6Rnor6.0
Rnor_5.032,112,656 - 2,119,844 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,232,018 - 3,239,076 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera32,564,240 - 2,571,297 (-)NCBICelera
RGSC_v3.133,232,017 - 3,239,188 (-)NCBI
Cytogenetic Map3p13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:19056867   PMID:22315426   PMID:23236378   PMID:23376485   PMID:23533145   PMID:23886940   PMID:27462458  


Genomics

Comparative Map Data
Arrdc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,133,190 - 28,140,378 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl328,133,191 - 28,140,687 (-)EnsemblGRCr8
mRatBN7.237,735,002 - 7,742,195 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,735,011 - 7,742,197 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx310,839,750 - 10,846,806 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,425,978 - 19,433,034 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,615,814 - 17,622,874 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,129,876 - 2,137,161 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,129,879 - 2,136,936 (-)Ensemblrn6Rnor6.0
Rnor_5.032,112,656 - 2,119,844 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,232,018 - 3,239,076 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera32,564,240 - 2,571,297 (-)NCBICelera
RGSC_v3.133,232,017 - 3,239,188 (-)NCBI
Cytogenetic Map3p13NCBI
ARRDC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,605,686 - 137,615,360 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9137,605,619 - 137,616,227 (+)Ensemblhg38GRCh38
GRCh379140,500,138 - 140,509,812 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,619,917 - 139,629,633 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349137,775,942 - 137,785,646NCBI
Celera9111,023,757 - 111,033,473 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,962,058 - 109,971,771 (+)NCBIHuRef
CHM1_19140,648,827 - 140,658,543 (+)NCBICHM1_1
T2T-CHM13v2.09149,857,368 - 149,867,042 (+)NCBIT2T-CHM13v2.0
Arrdc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,815,364 - 24,825,347 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl224,815,364 - 24,825,264 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38224,925,352 - 24,935,335 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,925,352 - 24,935,252 (-)Ensemblmm10GRCm38
MGSCv37224,780,872 - 24,790,801 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36224,747,361 - 24,757,172 (-)NCBIMGSCv36mm8
Celera224,647,499 - 24,657,496 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.84NCBI
Arrdc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,479,468 - 5,490,990 (+)Ensembl
ChiLan1.0NW_0049555135,479,468 - 5,486,489 (+)NCBIChiLan1.0ChiLan1.0
ARRDC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2111,739,046 - 1,748,723 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan191,741,381 - 1,751,044 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,711,276 - 108,720,942 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,664,787 - 137,668,688 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,664,787 - 137,668,688 (+)EnsemblpanPan2panpan1.1
ARRDC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,178,423 - 48,187,051 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,179,098 - 48,187,022 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha947,365,102 - 47,373,727 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0949,040,038 - 49,048,665 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,040,713 - 49,048,640 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1947,816,339 - 47,824,973 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,115,486 - 48,124,099 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,162,003 - 48,170,627 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arrdc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,883,206 - 202,893,288 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669483,134 - 491,856 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936669484,446 - 491,843 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARRDC1
(Sus scrofa - pig)		 No map positions available.
ARRDC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112598,686 - 608,282 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12595,342 - 608,198 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660584,745,671 - 4,755,253 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arrdc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760468,069 - 475,070 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624760464,914 - 475,070 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Arrdc1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1512,255,399 - 12,262,542 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Arrdc1
69 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:126
Interacting mature miRNAs:141
Transcripts:ENSRNOT00000010169
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH140267  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.237,735,094 - 7,735,314 (+)MAPPERmRatBN7.2
Rnor_6.032,129,964 - 2,130,183NCBIRnor6.0
Rnor_5.032,112,744 - 2,112,963UniSTSRnor5.0
RGSC_v3.433,232,104 - 3,232,323UniSTSRGSC3.4
Celera32,564,326 - 2,564,545UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010169   ⟹   ENSRNOP00000010169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,133,191 - 28,140,247 (-)Ensembl
mRatBN7.2 Ensembl37,735,011 - 7,742,197 (-)Ensembl
Rnor_6.0 Ensembl32,129,879 - 2,136,936 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000130027   ⟹   ENSRNOP00000100709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,133,191 - 28,140,687 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000160561   ⟹   ENSRNOP00000105854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,133,191 - 28,140,432 (-)Ensembl
RefSeq Acc Id: NM_001100770   ⟹   NP_001094240
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,133,190 - 28,140,247 (-)NCBI
mRatBN7.237,735,009 - 7,742,066 (-)NCBI
Rnor_6.032,129,878 - 2,136,936 (-)NCBI
Rnor_5.032,112,656 - 2,119,844 (-)NCBI
RGSC_v3.433,232,018 - 3,239,076 (-)RGD
Celera32,564,240 - 2,571,297 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233630   ⟹   XP_006233692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,133,190 - 28,140,375 (-)NCBI
mRatBN7.237,735,002 - 7,742,193 (-)NCBI
Rnor_6.032,129,876 - 2,137,063 (-)NCBI
Rnor_5.032,112,656 - 2,119,844 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233631   ⟹   XP_006233693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,133,190 - 28,140,375 (-)NCBI
mRatBN7.237,735,002 - 7,742,193 (-)NCBI
Rnor_6.032,129,876 - 2,137,062 (-)NCBI
Rnor_5.032,112,656 - 2,119,844 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105575   ⟹   XP_038961503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,133,190 - 28,140,376 (-)NCBI
mRatBN7.237,735,002 - 7,742,193 (-)NCBI
RefSeq Acc Id: XM_039105576   ⟹   XP_038961504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,133,190 - 28,140,378 (-)NCBI
mRatBN7.237,735,002 - 7,742,195 (-)NCBI
RefSeq Acc Id: XM_039105577   ⟹   XP_038961505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,133,190 - 28,140,378 (-)NCBI
mRatBN7.237,735,002 - 7,742,195 (-)NCBI
RefSeq Acc Id: NP_001094240   ⟸   NM_001100770
- UniProtKB: Q68FT0 (UniProtKB/Swiss-Prot),   B0BNL6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233692   ⟸   XM_006233630
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006233693   ⟸   XM_006233631
- Peptide Label: isoform X5
- UniProtKB: A6JSZ3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010169   ⟸   ENSRNOT00000010169
RefSeq Acc Id: XP_038961505   ⟸   XM_039105577
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038961504   ⟸   XM_039105576
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038961503   ⟸   XM_039105575
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000105854   ⟸   ENSRNOT00000160561
Ensembl Acc Id: ENSRNOP00000100709   ⟸   ENSRNOT00000130027
Protein Domains
Arrestin C-terminal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BNL6-F1-model_v2 AlphaFold B0BNL6 1-434 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691852
Promoter ID:EPDNEW_R2377
Type:initiation region
Name:Arrdc1_1
Description:arrestin domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,136,965 - 2,137,025EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309961 AgrOrtholog
BioCyc Gene G2FUF-50496 BioCyc
Ensembl Genes ENSRNOG00000007622 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010169 ENTREZGENE
  ENSRNOT00000010169.6 UniProtKB/Swiss-Prot
  ENSRNOT00000160561 ENTREZGENE
Gene3D-CATH 2.60.40.640 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110015 IMAGE-MGC_LOAD
  IMAGE:7931820 IMAGE-MGC_LOAD
InterPro Arrestin-like_N UniProtKB/Swiss-Prot
  Arrestin_C UniProtKB/Swiss-Prot
  Arrestin_C-like UniProtKB/Swiss-Prot
  Arrestin_domain-protein UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
KEGG Report rno:366001 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188522 IMAGE-MGC_LOAD
  MGC:94863 IMAGE-MGC_LOAD
NCBI Gene 366001 ENTREZGENE
PANTHER ARRESTIN DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot
  ARRESTIN DOMAIN-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot
Pfam Arrestin_C UniProtKB/Swiss-Prot
  Arrestin_N UniProtKB/Swiss-Prot
PhenoGen Arrdc1 PhenoGen
RatGTEx ENSRNOG00000007622 RatGTEx
SMART Arrestin_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot
UniProt A0ABK0L8U9_RAT UniProtKB/TrEMBL
  A0ABK0LVY7_RAT UniProtKB/TrEMBL
  A6JSZ3 ENTREZGENE, UniProtKB/TrEMBL
  ARRD1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q68FT0 ENTREZGENE
UniProt Secondary Q68FT0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Arrdc1  arrestin domain containing 1  Arrdc1_predicted  arrestin domain containing 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Arrdc1_predicted  arrestin domain containing 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED