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Gene: Trpm6 (transient receptor potential cation channel, subfamily M, member 6) Rattus norvegicus

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Symbol:

Trpm6

Name:

transient receptor potential cation channel, subfamily M, member 6

RGD ID:

1309942

Description:

Predicted to enable calcium channel activity; magnesium ion transmembrane transporter activity; and protein serine/threonine kinase activity. Predicted to be involved in calcium ion transmembrane transport; magnesium ion transmembrane transport; and response to toxic substance. Predicted to act upstream of or within metal ion transport. Predicted to be located in brush border membrane and nucleus. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in intestinal hypomagnesemia 1 and metal metabolism disorder. Orthologous to human TRPM6 (transient receptor potential cation channel subfamily M member 6); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC293874; transient receptor potential cation channel subfamily M member 6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	225,559,528 - 225,747,106 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	225,576,872 - 225,747,108 (+)	Ensembl				GRCr8
mRatBN7.2	1	216,136,407 - 216,320,523 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	216,170,038 - 216,320,520 (+)	Ensembl				mRatBN7.2
Rnor_6.0	1	234,478,908 - 234,631,264 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	234,479,289 - 234,596,971 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	241,578,982 - 241,729,073 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	222,363,324 - 222,502,191 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	213,469,067 - 213,615,762 (+)	NCBI		Celera
RGSC_v3.1	1	222,493,769 - 222,666,592 (+)	NCBI
Cytogenetic Map	1	q51	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cone-rod dystrophy (ISO)

Eye Abnormalities (ISO)

genetic disease (ISO)

intestinal hypomagnesemia 1 (ISO)

metal metabolism disorder (ISO)

primary hypomagnesemia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1-chloro-2,4-dinitrobenzene (ISO)

1-naphthyl isothiocyanate (EXP)

1-Oleoyl-2-acetyl-sn-glycerol (ISO)

1-stearoyl-2-arachidonoyl-sn-glycerol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

alpha-hexylcinnamaldehyde (ISO)

alpha-Zearalanol (EXP)

amitrole (EXP)

amphetamine (EXP)

amphotericin B (ISO)

Azoxymethane (ISO)

barium(0) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

calcium atom (ISO)

calcium(0) (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

dexamethasone (EXP)

dextran sulfate (ISO)

Dibutyl phosphate (ISO)

dichloroacetic acid (ISO)

fulvestrant (ISO)

gadolinium atom (ISO)

genistein (ISO)

glyphosate (EXP)

lanthanum atom (ISO)

methimazole (EXP)

methotrexate (ISO)

N(4)-hydroxycytidine (ISO)

okadaic acid (ISO)

ozone (EXP)

paraquat (EXP)

pentanal (ISO)

phthalaldehyde (ISO)

pirinixic acid (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sirolimus (EXP)

sodium arsenite (ISO)

strontium atom (ISO)

sulfadimethoxine (EXP)

tacrolimus hydrate (EXP)

taurodeoxycholic acid (ISO)

tetrachloromethane (EXP)

tetraphene (ISO)

Theaflavin 3,3'-digallate (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

calcium ion transmembrane transport (IEA,ISO)

calcium ion transport (IBA,IEA)

magnesium ion transmembrane transport (IEA,ISO)

metal ion transport (IEA,ISO)

monoatomic cation transmembrane transport (IBA,IEA)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

protein tetramerization (IEA)

response to toxic substance (IEA,ISO)

transmembrane transport (IEA)

Cellular Component

apical plasma membrane (IBA,IEA,ISO)

brush border membrane (IEA,ISO)

membrane (IEA)

nucleus (IEA,ISO)

plasma membrane (IBA,IEA,ISO)

Molecular Function

ATP binding (IEA)

calcium channel activity (IBA,IEA)

calcium ion transmembrane transporter activity (IEA,ISO)

kinase activity (IEA)

magnesium ion transmembrane transporter activity (IEA,ISO)

metal ion binding (IEA)

monoatomic cation channel activity (IEA,ISO,NAS)

monoatomic ion channel activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IBA,IEA,ISO)

protein serine/threonine kinase activity (IEA,ISO)

transferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation
8.	Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family.	Schlingmann KP, etal., Nat Genet. 2002 Jun;31(2):166-70. Epub 2002 May 28.
9.	Differential regulation of transient receptor potential melastatin 6 and 7 cation channels by ANG II in vascular smooth muscle cells from spontaneously hypertensive rats.	Touyz RM, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R73-8. Epub 2005 Aug 18.

Additional References at PubMed

PMID:14576148	PMID:17575980	PMID:17712480	PMID:18339311	PMID:19656910	PMID:19937979	PMID:21073857	PMID:21951649	PMID:24679001	PMID:25520013	PMID:27925186	PMID:31002158
PMID:34440664

Genomics

Comparative Map Data

Trpm6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	225,559,528 - 225,747,106 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	225,576,872 - 225,747,108 (+)	Ensembl				GRCr8
mRatBN7.2	1	216,136,407 - 216,320,523 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	216,170,038 - 216,320,520 (+)	Ensembl				mRatBN7.2
Rnor_6.0	1	234,478,908 - 234,631,264 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	234,479,289 - 234,596,971 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	241,578,982 - 241,729,073 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	222,363,324 - 222,502,191 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	213,469,067 - 213,615,762 (+)	NCBI		Celera
RGSC_v3.1	1	222,493,769 - 222,666,592 (+)	NCBI
Cytogenetic Map	1	q51	NCBI

TRPM6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	74,722,495 - 74,887,921 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	74,722,495 - 74,888,094 (-)	Ensembl			hg38	GRCh38
GRCh37	9	77,337,411 - 77,502,837 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	76,527,231 - 76,692,830 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	74,566,964 - 74,732,564	NCBI
Celera	9	47,911,447 - 48,077,035 (-)	NCBI		Celera
Cytogenetic Map	9	q21.13	NCBI
HuRef	9	47,159,778 - 47,325,152 (-)	NCBI		HuRef
CHM1_1	9	77,483,852 - 77,649,496 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	86,875,552 - 87,041,025 (-)	NCBI		T2T-CHM13v2.0

Trpm6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	18,707,566 - 18,869,885 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	18,727,347 - 18,869,875 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	19	18,730,177 - 18,892,521 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	18,749,983 - 18,892,511 (+)	Ensembl			mm10	GRCm38
MGSCv37	19	18,824,473 - 18,967,001 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	19	18,817,002 - 18,959,534 (+)	NCBI		MGSCv36	mm8
Celera	19	19,438,745 - 19,578,144 (+)	NCBI		Celera
Cytogenetic Map	19	B	NCBI
cM Map	19	13.21	NCBI

Trpm6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955512	4,179,651 - 4,321,902 (+)	Ensembl
ChiLan1.0	NW_004955512	4,179,194 - 4,323,523 (+)	NCBI	ChiLan1.0	ChiLan1.0

TRPM6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	73,887,787 - 74,054,681 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	73,893,728 - 74,060,622 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	49,949,883 - 50,114,169 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	73,576,594 - 73,742,195 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	73,576,594 - 73,742,195 (-)	Ensembl			panPan2	panpan1.1

TRPM6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	83,250,870 - 83,437,044 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	83,308,788 - 83,436,644 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	83,772,476 - 83,901,214 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	83,758,383 - 83,891,749 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	83,740,158 - 83,887,142 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	83,486,316 - 83,642,749 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	83,204,818 - 83,361,350 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	83,989,135 - 84,122,089 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Trpm6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	130,536,862 - 130,665,571 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936503	10,508,989 - 10,616,972 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936503	10,508,989 - 10,637,424 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRPM6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	227,811,204 - 227,963,309 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	227,809,511 - 228,037,923 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	254,708,592 - 254,863,990 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRPM6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	85,773,663 - 85,954,807 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	85,773,344 - 85,903,293 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	74,218,052 - 74,377,383 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trpm6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624811	2,345,698 - 2,465,385 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624811	2,342,084 - 2,494,601 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Trpm6
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	18,760,619 - 18,901,122 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Trpm6
840 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	21
Count of miRNA genes:	21
Interacting mature miRNAs:	21
Transcripts:	ENSRNOT00000017892
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8693637	Alc29	Alcohol consumption QTL 29	2.7	0.258	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	217412367	243666627	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	160111531	262090437	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	160573753	266453731	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	207243873	252243873	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	186658830	266453731	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	210980612	255980612	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	181059071	226059071	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	181059071	226059071	Rat
61455	Niddm7	Non-insulin dependent diabetes mellitus QTL 7	5.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	223964326	248681945	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	182039247	227039247	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	183564652	228564652	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	205233991	267096252	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	218829748	263829748	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	186658830	266453731	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	176288899	270518180	Rat
631838	Niddm36	Non-insulin dependent diabetes mellitus QTL 36		0.01	insulin secretion trait (VT:0003564)	calculated pancreatic islet insulin release measurement (CMO:0001217)	1	193964073	238964073	Rat
8693661	Alc34	Alcohol consumption QTL 34	2.2	0.611	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	217412367	238041033	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	162548015	270518180	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	181059071	226059071	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	132966869	252856240	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	210980612	255980612	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	152919152	268496042	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	160111531	262090437	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	181059071	226059071	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	181059071	226059071	Rat
1300145	Rf7	Renal function QTL 7	2.96		urine creatinine amount (VT:0010540)	urine creatinine level (CMO:0000125)	1	194575422	239575422	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	193400541	238400541	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	200449456	256003563	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	182535316	227535316	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	146080545	243492863	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	207163993	269633915	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	210980612	255980612	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	181059071	226059071	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	153679879	232414077	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
724538	Kidm1	Kidney mass QTL 1	3.2		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	223134011	262090599	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	160574007	235238518	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	181059071	226059071	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	210980612	255980612	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	207243873	252243873	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	160111426	262090599	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	181059071	226059071	Rat
2314011	Gluco56	Glucose level QTL 56			blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	209203273	254203273	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	202543537	247543537	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	225108840	270108840	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	154961463	266453731	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	8e-07	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	205674651	250674651	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	207243873	252243873	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	208479811	269633915	Rat
634312	Bp143	Blood pressure QTL 143	3	0.0002	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	203300512	229359342	Rat
1358294	Bw37	Body weight QTL 37	5	0.000011	body mass (VT:0001259)	body weight (CMO:0000012)	1	180739993	225739993	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	224633915	269633915	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	172718770	228180370	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	186298393	231298393	Rat
1358916	Kidm22	Kidney mass QTL 22	3.32		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	212738576	257738576	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	194786607	262083703	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	188241285	250779312	Rat
2292218	Kidm35	Kidney mass QTL 35			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	208798288	253798288	Rat
1331790	Bp201	Blood pressure QTL 201	3.127		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	221820316	234540296	Rat
1300168	Bp170	Blood pressure QTL 170	2.76		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	192995199	237995199	Rat
61403	Niddm4	Non-insulin dependent diabetes mellitus QTL 4			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	201464383	246464383	Rat
2292222	Bp307	Blood pressure QTL 307	3.06	0.0014	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	186298393	231298393	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	186298393	231298393	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	203675682	248675682	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	205674651	250674651	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	185979875	230979875	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
1582206	Kidm33	Kidney mass QTL 33	6.9		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	197807365	233480676	Rat
2293700	Bmd27	Bone mineral density QTL 27	6.6	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	210980612	255980612	Rat
2293701	Bmd34	Bone mineral density QTL 34	8.3	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	1	210980612	255980612	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	193400541	238400541	Rat
634340	Hcar5	Hepatocarcinoma resistance QTL 5	8		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	223964326	236074012	Rat
6903303	Scl34	Serum cholesterol QTL 34	2.5	0.0033	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	173363824	227535316	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	207099883	252099883	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	210980612	255980612	Rat
8693618	Alc25	Alcohol consumption QTL 25	3	0.28	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	217412367	238041033	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	191260175	236260175	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	111949780	228180370	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	185857683	270518180	Rat
2325727	Pia41	Pristane induced arthritis QTL 41			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	188241285	233241285	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	210980612	255980612	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	8	54	143	77	76	45	92	45	6	323	174	11	118	81	92	31	10	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001432161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006223666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006223669	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006223670	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006223671	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006223673	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008774783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101381	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101382	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101383	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101384	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101385	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EF673693	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000017892 ⟹ ENSRNOP00000017892

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	225,596,652 - 225,747,108 (+)	Ensembl
mRatBN7.2 Ensembl	1	216,170,038 - 216,320,520 (+)	Ensembl
Rnor_6.0 Ensembl	1	234,479,289 - 234,596,971 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000131062 ⟹ ENSRNOP00000105982

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	225,596,652 - 225,731,934 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000132012 ⟹ ENSRNOP00000102743

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	225,576,872 - 225,747,108 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000135056 ⟹ ENSRNOP00000102082

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	225,596,652 - 225,747,108 (+)	Ensembl

RefSeq Acc Id:

XM_039101381 ⟹ XP_038957309

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	225,596,309 - 225,747,106 (+)	NCBI
mRatBN7.2	1	216,169,517 - 216,320,523 (+)	NCBI

RefSeq Acc Id:

XM_039101382 ⟹ XP_038957310

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	225,559,528 - 225,747,106 (+)	NCBI
mRatBN7.2	1	216,136,407 - 216,320,523 (+)	NCBI

RefSeq Acc Id:

XM_039101383 ⟹ XP_038957311

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	225,596,308 - 225,747,106 (+)	NCBI
mRatBN7.2	1	216,169,516 - 216,320,523 (+)	NCBI

RefSeq Acc Id:

XM_039101384 ⟹ XP_038957312

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	225,596,308 - 225,747,106 (+)	NCBI
mRatBN7.2	1	216,169,516 - 216,320,523 (+)	NCBI

RefSeq Acc Id:

XM_039101385 ⟹ XP_038957313

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	225,596,309 - 225,747,106 (+)	NCBI
mRatBN7.2	1	216,169,517 - 216,320,523 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001419090	(Get FASTA)	NCBI Sequence Viewer
	XP_038957309	(Get FASTA)	NCBI Sequence Viewer
	XP_038957310	(Get FASTA)	NCBI Sequence Viewer
	XP_038957311	(Get FASTA)	NCBI Sequence Viewer
	XP_038957312	(Get FASTA)	NCBI Sequence Viewer
	XP_038957313	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABS12241	(Get FASTA)	NCBI Sequence Viewer
	EDM12986	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017892
	ENSRNOP00000017892.8
	ENSRNOP00000102082
	ENSRNOP00000102082.1
	ENSRNOP00000102743
	ENSRNOP00000102743.1
	ENSRNOP00000105982.1

Ensembl Acc Id:

ENSRNOP00000017892 ⟸ ENSRNOT00000017892

RefSeq Acc Id:	XP_038957310 ⟸ XM_039101382
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038957311 ⟸ XM_039101383
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038957312 ⟸ XM_039101384
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038957309 ⟸ XM_039101381
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038957313 ⟸ XM_039101385
- Peptide Label:	isoform X5

Ensembl Acc Id:

ENSRNOP00000105982 ⟸ ENSRNOT00000131062

Ensembl Acc Id:

ENSRNOP00000102082 ⟸ ENSRNOT00000135056

Ensembl Acc Id:

ENSRNOP00000102743 ⟸ ENSRNOT00000132012

Protein Domains

Alpha-type protein kinase TRPM-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M7G0-F1-model_v2	AlphaFold	F1M7G0	1-2027	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309942	AgrOrtholog
BioCyc Gene	G2FUF-56195	BioCyc
Ensembl Genes	ENSRNOG00000013053	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000017892	ENTREZGENE
	ENSRNOT00000017892.9	UniProtKB/TrEMBL
	ENSRNOT00000131062.1	UniProtKB/TrEMBL
	ENSRNOT00000132012	ENTREZGENE
	ENSRNOT00000132012.1	UniProtKB/TrEMBL
	ENSRNOT00000135056	ENTREZGENE
	ENSRNOT00000135056.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.1010	UniProtKB/TrEMBL
	MHCK/EF2 kinase	UniProtKB/TrEMBL
	Phosphorylase Kinase, domain 1	UniProtKB/TrEMBL
InterPro	Ion_trans	UniProtKB/TrEMBL
	Kinase-like_dom	UniProtKB/TrEMBL
	MHCK_EF2_kinase	UniProtKB/TrEMBL
	TRPM	UniProtKB/TrEMBL
	TRPM-like	UniProtKB/TrEMBL
	TRPM_SLOG	UniProtKB/TrEMBL
	TRPM_tetra	UniProtKB/TrEMBL
	TRPM_tetra_sf	UniProtKB/TrEMBL
NCBI Gene	293874	ENTREZGENE
PANTHER	PTHR13800:SF15	UniProtKB/TrEMBL
	TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6	UniProtKB/TrEMBL
Pfam	Alpha_kinase	UniProtKB/TrEMBL
	Ion_trans	UniProtKB/TrEMBL
	LSDAT_euk	UniProtKB/TrEMBL
	TRPM2	UniProtKB/TrEMBL
	TRPM_tetra	UniProtKB/TrEMBL
PhenoGen	Trpm6	PhenoGen
PROSITE	ALPHA_KINASE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000013053	RatGTEx
SMART	Alpha_kinase	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
UniProt	A0ABK0L252_RAT	UniProtKB/TrEMBL
	A0ABK0LJM5_RAT	UniProtKB/TrEMBL
	A0ABK0LK30_RAT	UniProtKB/TrEMBL
	A6I0K5	ENTREZGENE, UniProtKB/TrEMBL
	A7L641_RAT	UniProtKB/TrEMBL
	F1M7G0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2007-02-12	Trpm6	transient receptor potential cation channel, subfamily M, member 6	Trpm6_predicted	transient receptor potential cation channel, subfamily M, member 6 (predicted)	Symbol and Name updated to reflect Human and Mouse nomenclature	1299863	APPROVED
2005-01-12	Trpm6_predicted	transient receptor potential cation channel, subfamily M, member 6 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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