Enkur (enkurin, TRPC channel interacting protein) - Rat Genome Database

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Gene: Enkur (enkurin, TRPC channel interacting protein) Rattus norvegicus
Analyze
Symbol: Enkur
Name: enkurin, TRPC channel interacting protein
RGD ID: 1309839
Description: Predicted to enable calmodulin binding activity. Predicted to act upstream of or within establishment of left/right asymmetry and flagellated sperm motility. Predicted to be located in 9+0 motile cilium and sperm principal piece. Predicted to be active in acrosomal vesicle; axonemal B tubule inner sheath; and sperm flagellum. Orthologous to human ENKUR (enkurin, TRPC channel interacting protein); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: enkurin; LOC291354; RGD1309839; similar to hypothetical protein MGC26778
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81788,599,057 - 88,622,668 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1788,599,057 - 88,622,668 (-)EnsemblGRCr8
mRatBN7.21783,690,105 - 83,714,756 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1783,690,797 - 83,714,408 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1787,163,349 - 87,186,973 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01790,998,723 - 91,022,347 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01785,015,657 - 85,039,281 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1789,928,498 - 89,952,102 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1789,226,538 - 89,250,142 (-)NCBILyon_Normotensive
Lyon_Hypertensive1787,014,644 - 87,038,248 (-)NCBILyon_Hypertensive
F344_StmMcwi1788,195,662 - 88,219,266 (-)NCBIF344_StmMcwi
Rnor_6.01788,071,794 - 88,095,444 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1788,071,757 - 88,095,729 (-)Ensemblrn6Rnor6.0
Rnor_5.01789,759,584 - 89,782,791 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41795,178,267 - 95,201,846 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1782,943,601 - 82,967,089 (-)NCBICelera
RGSC_v3.11795,189,321 - 95,212,473 (-)NCBI
Cytogenetic Map17q12.3NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15385169  


Genomics

Comparative Map Data
Enkur
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81788,599,057 - 88,622,668 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1788,599,057 - 88,622,668 (-)EnsemblGRCr8
mRatBN7.21783,690,105 - 83,714,756 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1783,690,797 - 83,714,408 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1787,163,349 - 87,186,973 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01790,998,723 - 91,022,347 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01785,015,657 - 85,039,281 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1789,928,498 - 89,952,102 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1789,226,538 - 89,250,142 (-)NCBILyon_Normotensive
Lyon_Hypertensive1787,014,644 - 87,038,248 (-)NCBILyon_Hypertensive
F344_StmMcwi1788,195,662 - 88,219,266 (-)NCBIF344_StmMcwi
Rnor_6.01788,071,794 - 88,095,444 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1788,071,757 - 88,095,729 (-)Ensemblrn6Rnor6.0
Rnor_5.01789,759,584 - 89,782,791 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41795,178,267 - 95,201,846 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1782,943,601 - 82,967,089 (-)NCBICelera
RGSC_v3.11795,189,321 - 95,212,473 (-)NCBI
Cytogenetic Map17q12.3NCBI
ENKUR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381024,981,985 - 25,062,327 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1024,981,979 - 25,062,279 (-)Ensemblhg38GRCh38
GRCh371025,270,914 - 25,351,256 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361025,310,923 - 25,345,036 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341025,310,922 - 25,345,036NCBI
Celera1024,971,786 - 25,006,443 (-)NCBICelera
Cytogenetic Map10p12.1NCBI
HuRef1024,931,919 - 25,012,056 (-)NCBIHuRef
CHM1_11025,271,433 - 25,351,929 (-)NCBICHM1_1
T2T-CHM13v2.01025,000,242 - 25,080,555 (-)NCBIT2T-CHM13v2.0
Enkur
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39221,185,542 - 21,210,176 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl221,185,542 - 21,210,176 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38221,180,731 - 21,205,365 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl221,180,731 - 21,205,365 (-)Ensemblmm10GRCm38
MGSCv37221,102,358 - 21,126,992 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36221,098,485 - 21,123,119 (-)NCBIMGSCv36mm8
Celera221,062,063 - 21,086,735 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map214.82NCBI
Enkur
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554294,182,715 - 4,204,077 (+)Ensembl
ChiLan1.0NW_0049554294,182,507 - 4,203,275 (+)NCBIChiLan1.0ChiLan1.0
ENKUR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2837,680,559 - 37,714,756 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11037,685,888 - 37,720,082 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01025,156,234 - 25,236,620 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11025,526,548 - 25,606,817 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1025,526,548 - 25,606,709 (-)EnsemblpanPan2panpan1.1
ENKUR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.128,497,252 - 8,522,302 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl28,497,726 - 8,522,294 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha27,191,779 - 7,216,813 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.026,696,396 - 6,721,436 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl26,696,892 - 6,721,428 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.126,066,321 - 6,091,359 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.026,144,423 - 6,169,486 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.026,311,130 - 6,336,653 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Enkur
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934424,512,670 - 24,535,805 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936484677,833 - 701,038 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936484679,541 - 700,898 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENKUR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1050,310,984 - 50,341,238 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11050,310,497 - 50,364,311 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21055,747,194 - 55,759,689 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ENKUR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1924,710,588 - 24,740,173 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl924,707,109 - 24,740,516 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605130,669,028 - 30,700,878 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Enkur
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247963,961,538 - 3,980,952 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247963,961,148 - 3,980,197 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Enkur
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1142,906,861 - 2,930,906 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:94
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000025140
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176855004093515804Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)176515487293515804Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 16 10 119 249 90 89 64 137 58 21 445 296 11 228 77 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025140   ⟹   ENSRNOP00000025140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1788,599,057 - 88,622,668 (-)Ensembl
mRatBN7.2 Ensembl1783,690,797 - 83,714,408 (-)Ensembl
Rnor_6.0 Ensembl1788,071,757 - 88,095,729 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000122266   ⟹   ENSRNOP00000108397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1788,599,057 - 88,622,668 (-)Ensembl
RefSeq Acc Id: NM_001106126   ⟹   NP_001099596
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81788,599,057 - 88,622,668 (-)NCBI
mRatBN7.21783,690,797 - 83,714,408 (-)NCBI
Dahl_SR_JrHsd1789,928,498 - 89,952,102 (-)NCBI
Lyon_Normotensive1789,226,538 - 89,250,142 (-)NCBI
Lyon_Hypertensive1787,014,644 - 87,038,248 (-)NCBI
F344_StmMcwi1788,195,662 - 88,219,266 (-)NCBI
Rnor_6.01788,071,794 - 88,095,444 (-)NCBI
Rnor_5.01789,759,584 - 89,782,791 (-)NCBI
RGSC_v3.41795,178,267 - 95,201,846 (-)RGD
Celera1782,943,601 - 82,967,089 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099596 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL78800 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025140
  ENSRNOP00000025140.5
  ENSRNOP00000108397.1
RefSeq Acc Id: NP_001099596   ⟸   NM_001106126
- UniProtKB: D3ZWN6 (UniProtKB/TrEMBL),   A6JMC3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025140   ⟸   ENSRNOT00000025140
Ensembl Acc Id: ENSRNOP00000108397   ⟸   ENSRNOT00000122266
Protein Domains
Enkurin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZWN6-F1-model_v2 AlphaFold D3ZWN6 1-255 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309839 AgrOrtholog
BioCyc Gene G2FUF-8502 BioCyc
Ensembl Genes ENSRNOG00000018631 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025140 ENTREZGENE
  ENSRNOT00000025140.8 UniProtKB/TrEMBL
  ENSRNOT00000122266.1 UniProtKB/TrEMBL
InterPro Enkurin-like_dom UniProtKB/TrEMBL
  Enkurin_domain-protein UniProtKB/TrEMBL
KEGG Report rno:291354 UniProtKB/TrEMBL
NCBI Gene 291354 ENTREZGENE
PANTHER PTHR21490:SF0 UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam Enkurin UniProtKB/TrEMBL
PhenoGen Enkur PhenoGen
PROSITE ENKURIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018631 RatGTEx
UniProt A0ABK0LXP7_RAT UniProtKB/TrEMBL
  A6JMC3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZWN6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-06-12 Enkur  enkurin, TRPC channel interacting protein  RGD1309839  similar to hypothetical protein MGC26778   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1309839  similar to hypothetical protein MGC26778   RGD1309839_predicted  similar to hypothetical protein MGC26778 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1309839_predicted  similar to hypothetical protein MGC26778 (predicted)  LOC291354_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC291354_predicted  similar to hypothetical protein MGC26778 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL