Hells (helicase, lymphoid specific) - Rat Genome Database

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Gene: Hells (helicase, lymphoid specific) Rattus norvegicus
Analyze
Symbol: Hells
Name: helicase, lymphoid specific
RGD ID: 1309820
Description: Predicted to enable ATP-dependent chromatin remodeler activity; chromatin binding activity; and chromatin-protein adaptor activity. Predicted to be involved in several processes, including double-strand break repair via homologous recombination; lymphocyte proliferation; and negative regulation of gene expression, epigenetic. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; chromosomal DNA methylation maintenance following DNA replication; and negative regulation of intrinsic apoptotic signaling pathway. Predicted to be located in chromosome, centromeric region and site of double-strand break. Predicted to be active in nucleus and pericentric heterochromatin. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific); INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC100911660; LOC294071; lymphocyte-specific helicase-like; lymphoid-specific helicase; similar to helicase, lymphoid specific; Tbc1d12; TBC1D12: TBC1 domain family, member 12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,113,580 - 246,159,230 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1246,114,096 - 246,159,228 (+)EnsemblGRCr8
mRatBN7.21236,701,704 - 236,748,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1236,701,758 - 236,746,844 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1245,125,577 - 245,167,789 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01252,018,896 - 252,061,072 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01244,857,143 - 244,899,325 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01257,901,856 - 257,953,889 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1257,614,731 - 257,791,728 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1257,766,691 - 257,949,183 (+)Ensemblrn6Rnor6.0
Rnor_5.01265,357,043 - 265,402,172 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41243,246,843 - 243,262,459 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1233,793,113 - 233,835,276 (+)NCBICelera
Cytogenetic Map1q53NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,4-dioxane  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
anthracene-1,8,9-triol  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
bazedoxifene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
butylated hydroxyanisole  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (ISO)
cholic acid  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
Enterolactone  (ISO)
flurbiprofen  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycerol 2-phosphate  (ISO)
GSK-J4  (ISO)
indole-3-methanol  (EXP)
irinotecan  (ISO)
iron dichloride  (ISO)
iron trichloride  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
Lasiocarpine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
Mezerein  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
palytoxin  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
saccharin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium nitrite  (ISO)
styrene oxide  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
6. Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Sun LQ, etal., Genes Dev. 2004 May 1;18(9):1035-46. Epub 2004 Apr 22.
7. Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3ß-E2F1 Axis Linking Reversely with Survival in Gliomas. Xiao D, etal., Theranostics. 2017 Jan 1;7(1):132-143. doi: 10.7150/thno.17032. eCollection 2017.
Additional References at PubMed
PMID:10781083   PMID:11325543   PMID:11555636   PMID:11711429   PMID:14612388   PMID:15448183   PMID:15647320   PMID:20439489  


Genomics

Comparative Map Data
Hells
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,113,580 - 246,159,230 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1246,114,096 - 246,159,228 (+)EnsemblGRCr8
mRatBN7.21236,701,704 - 236,748,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1236,701,758 - 236,746,844 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1245,125,577 - 245,167,789 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01252,018,896 - 252,061,072 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01244,857,143 - 244,899,325 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01257,901,856 - 257,953,889 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1257,614,731 - 257,791,728 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1257,766,691 - 257,949,183 (+)Ensemblrn6Rnor6.0
Rnor_5.01265,357,043 - 265,402,172 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41243,246,843 - 243,262,459 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1233,793,113 - 233,835,276 (+)NCBICelera
Cytogenetic Map1q53NCBI
HELLS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381094,545,788 - 94,613,905 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1094,545,329 - 94,613,905 (+)Ensemblhg38GRCh38
GRCh371096,305,545 - 96,361,856 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361096,295,564 - 96,351,846 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341096,295,563 - 96,351,845NCBI
Celera1090,045,660 - 90,101,938 (+)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1089,932,081 - 89,988,296 (+)NCBIHuRef
CHM1_11096,587,374 - 96,643,612 (+)NCBICHM1_1
T2T-CHM13v2.01095,424,900 - 95,493,015 (+)NCBIT2T-CHM13v2.0
Hells
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391938,913,282 - 38,958,914 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1938,919,359 - 38,959,495 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381938,930,262 - 38,970,470 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1938,930,915 - 38,971,051 (+)Ensemblmm10GRCm38
MGSCv371939,005,480 - 39,042,767 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361938,996,134 - 39,033,421 (+)NCBIMGSCv36mm8
Celera1939,732,380 - 39,769,659 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1933.57NCBI
Hells
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955507990,429 - 1,034,852 (+)Ensembl
ChiLan1.0NW_004955507995,389 - 1,034,852 (+)NCBIChiLan1.0ChiLan1.0
HELLS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28106,573,712 - 106,642,121 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110106,579,467 - 106,647,438 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01091,282,330 - 91,344,156 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11094,790,137 - 94,847,209 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1094,790,292 - 94,847,209 (+)EnsemblpanPan2panpan1.1
HELLS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1288,660,866 - 8,705,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl288,661,008 - 8,705,580 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha288,837,652 - 8,882,362 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0288,924,517 - 8,969,255 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl288,924,655 - 8,969,265 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1288,640,526 - 8,685,234 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0288,671,482 - 8,716,173 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0288,842,995 - 8,887,709 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hells
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721338,989,077 - 39,029,670 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936601626,823 - 662,465 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936601626,354 - 662,477 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HELLS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14105,924,536 - 105,955,430 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114105,923,727 - 105,967,003 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214115,770,403 - 115,812,864 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HELLS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1987,780,897 - 87,835,087 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl987,796,502 - 87,834,619 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604848,579,766 - 48,645,153 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hells
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247375,892,705 - 5,954,364 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hells
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1234,811,112 - 34,852,777 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hells
232 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:384
Count of miRNA genes:197
Interacting mature miRNAs:219
Transcripts:ENSRNOT00000073015, ENSRNOT00000075680
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
AI323785  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01265,281,565 - 265,281,855NCBIRnor5.0
Rnor_5.01265,398,721 - 265,399,011NCBIRnor5.0
RGSC_v3.41243,261,941 - 243,262,230UniSTSRGSC3.4
Celera1233,834,758 - 233,835,047UniSTS
Cytogenetic Map1q53UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 9 61 134 57 60 41 85 41 293 165 11 125 70 73 19 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000073015   ⟹   ENSRNOP00000064061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1257,901,985 - 257,949,183 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000075680   ⟹   ENSRNOP00000064734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1246,114,096 - 246,159,228 (+)Ensembl
mRatBN7.2 Ensembl1236,701,758 - 236,746,844 (+)Ensembl
Rnor_6.0 Ensembl1257,614,731 - 257,657,252 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083183   ⟹   ENSRNOP00000074269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1246,114,096 - 246,159,228 (+)Ensembl
mRatBN7.2 Ensembl1236,701,758 - 236,746,844 (+)Ensembl
Rnor_6.0 Ensembl1257,615,088 - 257,791,728 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088148   ⟹   ENSRNOP00000070054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1246,118,703 - 246,159,228 (+)Ensembl
mRatBN7.2 Ensembl1236,706,322 - 236,746,844 (+)Ensembl
Rnor_6.0 Ensembl1257,766,691 - 257,949,180 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000145501   ⟹   ENSRNOP00000102830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1246,118,511 - 246,159,228 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000157251   ⟹   ENSRNOP00000109566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1246,114,096 - 246,159,228 (+)Ensembl
RefSeq Acc Id: NM_001106371   ⟹   NP_001099841
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,114,129 - 246,156,298 (+)NCBI
mRatBN7.21236,701,748 - 236,743,924 (+)NCBI
Rnor_6.01257,901,899 - 257,949,747 (+)NCBI
Rnor_5.01265,357,043 - 265,402,172 (+)NCBI
RGSC_v3.41243,246,843 - 243,262,459 (+)RGD
Celera1233,793,113 - 233,835,276 (+)RGD
Sequence:
RefSeq Acc Id: XM_017589048   ⟹   XP_017444537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,113,580 - 246,159,230 (+)NCBI
mRatBN7.21236,701,704 - 236,748,239 (+)NCBI
Rnor_6.01257,901,856 - 257,953,889 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099841 (Get FASTA)   NCBI Sequence Viewer  
  XP_017444537 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM13225 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064734.2
  ENSRNOP00000070054.2
  ENSRNOP00000074269
  ENSRNOP00000074269.2
  ENSRNOP00000102830.1
  ENSRNOP00000109566.1
RefSeq Acc Id: NP_001099841   ⟸   NM_001106371
- UniProtKB: M0R3Y7 (UniProtKB/TrEMBL),   A6I194 (UniProtKB/TrEMBL),   A0A0G2K7M6 (UniProtKB/TrEMBL),   M0R5Q8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444537   ⟸   XM_017589048
- Peptide Label: isoform X1
- UniProtKB: M0R3Y7 (UniProtKB/TrEMBL),   A6I194 (UniProtKB/TrEMBL),   A0A0G2K7M6 (UniProtKB/TrEMBL),   M0R5Q8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064734   ⟸   ENSRNOT00000075680
Ensembl Acc Id: ENSRNOP00000064061   ⟸   ENSRNOT00000073015
Ensembl Acc Id: ENSRNOP00000070054   ⟸   ENSRNOT00000088148
Ensembl Acc Id: ENSRNOP00000074269   ⟸   ENSRNOT00000083183
Ensembl Acc Id: ENSRNOP00000109566   ⟸   ENSRNOT00000157251
Ensembl Acc Id: ENSRNOP00000102830   ⟸   ENSRNOT00000145501
Protein Domains
Helicase ATP-binding   Helicase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R3Y7-F1-model_v2 AlphaFold M0R3Y7 1-837 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690888
Promoter ID:EPDNEW_R1413
Type:initiation region
Name:LOC100911660_1
Description:lymphocyte-specific helicase-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01257,901,909 - 257,901,969EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309820 AgrOrtholog
BioCyc Gene G2FUF-55772 BioCyc
Ensembl Genes ENSRNOG00000047104 Ensembl
  ENSRNOG00000047692 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075680.4 UniProtKB/TrEMBL
  ENSRNOT00000083183 ENTREZGENE
  ENSRNOT00000083183.3 UniProtKB/TrEMBL
  ENSRNOT00000088148.3 UniProtKB/TrEMBL
  ENSRNOT00000145501.1 UniProtKB/TrEMBL
  ENSRNOT00000157251.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10810 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro Helicase_ATP-bd UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  HELLS_N UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  SNF2-like_sf UniProtKB/TrEMBL
  SNF2/RAD54-like_C UniProtKB/TrEMBL
  SNF2_N UniProtKB/TrEMBL
KEGG Report rno:294071 UniProtKB/TrEMBL
NCBI Gene 294071 ENTREZGENE
PANTHER LYMPHOID-SPECIFIC HELICASE UniProtKB/TrEMBL
  LYMPHOID-SPECIFIC HELICASE UniProtKB/TrEMBL
Pfam Helicase_C UniProtKB/TrEMBL
  SNF2_N UniProtKB/TrEMBL
PhenoGen Hells PhenoGen
PROSITE HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047104 RatGTEx
  ENSRNOG00000047692 RatGTEx
SMART DEXDc UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2JWX6_RAT UniProtKB/TrEMBL
  A0A0G2K7M6 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LDF8_RAT UniProtKB/TrEMBL
  A0ABK0LYM9_RAT UniProtKB/TrEMBL
  A6I194 ENTREZGENE, UniProtKB/TrEMBL
  M0R3Y7 ENTREZGENE
  M0R5Q8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary M0R3Y7 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Hells  helicase, lymphoid specific  LOC100911660  lymphocyte-specific helicase-like  Data merged from RGD:6491699 737654 PROVISIONAL
2013-05-24 Hells  helicase, lymphoid specific  LOC361781  similar to helicase, lymphoid specific  Data merged from RGD:1594521 1643240 APPROVED
2012-07-05 LOC100911660  lymphocyte-specific helicase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-04 Hells  helicase, lymphoid specific  Tbc1d12_predicted  TBC1D12: TBC1 domain family, member 12 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC361781  similar to helicase, lymphoid specific      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Tbc1d12_predicted  TBC1D12: TBC1 domain family, member 12 (predicted)      Symbol and Name status set to approved 70820 APPROVED