Api5 (apoptosis inhibitor 5) - Rat Genome Database

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Gene: Api5 (apoptosis inhibitor 5) Rattus norvegicus
Analyze
Symbol: Api5
Name: apoptosis inhibitor 5
RGD ID: 1309772
Description: Predicted to enable RNA binding activity and fibroblast growth factor binding activity. Predicted to be involved in negative regulation of apoptotic process. Predicted to act upstream of or within negative regulation of fibroblast apoptotic process. Predicted to be located in nuclear speck. Predicted to be part of spliceosomal complex. Predicted to be active in nucleus. Orthologous to human API5 (apoptosis inhibitor 5); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC362170; MGC187857
RGD Orthologs
Human
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83100,833,417 - 100,858,580 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3100,833,417 - 100,858,580 (-)EnsemblGRCr8
mRatBN7.2380,378,096 - 80,403,259 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl380,378,096 - 80,403,264 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx383,847,551 - 83,871,239 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0392,446,619 - 92,470,303 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0390,289,305 - 90,312,964 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0383,310,878 - 83,336,053 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl383,310,884 - 83,335,960 (-)Ensemblrn6Rnor6.0
Rnor_5.0390,010,495 - 90,035,670 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4378,819,632 - 78,844,710 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera379,572,457 - 79,597,535 (-)NCBICelera
RGSC_v3.1378,716,055 - 78,741,216 (-)NCBI
Cytogenetic Map3q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis. Kim JW, etal., Lab Invest. 2000 Apr;80(4):587-94.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:9307294   PMID:11075807   PMID:11555636   PMID:12477932   PMID:19946888   PMID:22658674   PMID:22681889   PMID:31505169  


Genomics

Comparative Map Data
Api5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83100,833,417 - 100,858,580 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3100,833,417 - 100,858,580 (-)EnsemblGRCr8
mRatBN7.2380,378,096 - 80,403,259 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl380,378,096 - 80,403,264 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx383,847,551 - 83,871,239 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0392,446,619 - 92,470,303 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0390,289,305 - 90,312,964 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0383,310,878 - 83,336,053 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl383,310,884 - 83,335,960 (-)Ensemblrn6Rnor6.0
Rnor_5.0390,010,495 - 90,035,670 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4378,819,632 - 78,844,710 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera379,572,457 - 79,597,535 (-)NCBICelera
RGSC_v3.1378,716,055 - 78,741,216 (-)NCBI
Cytogenetic Map3q31NCBI
API5P1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X116,104,366 - 116,108,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX116,106,921 - 116,108,430 (-)Ensemblhg38GRCh38
GRCh37X115,235,619 - 115,239,750 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361143,290,109 - 43,322,655 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341143,290,108 - 43,322,655NCBI
Celera1143,480,519 - 43,513,094 (+)NCBICelera
Cytogenetic MapXq23NCBI
HuRef1143,043,693 - 43,076,275 (+)NCBIHuRef
CHM1_1X115,146,490 - 115,150,617 (-)NCBICHM1_1
T2T-CHM13v2.0X114,513,939 - 114,518,074 (-)NCBIT2T-CHM13v2.0
API5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11826,326,387 - 26,355,580 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1826,327,920 - 26,355,585 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1826,016,307 - 26,045,407 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01826,950,978 - 26,980,076 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1826,950,978 - 26,980,114 (-)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.01826,106,836 - 26,135,908 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01826,718,679 - 26,747,755 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0

Variants

.
Variants in Api5
85 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:466
Count of miRNA genes:243
Interacting mature miRNAs:302
Transcripts:ENSRNOT00000013914
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
AI196452  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2380,378,265 - 80,378,358 (+)MAPPERmRatBN7.2
mRatBN7.2516,046,131 - 16,046,224 (+)MAPPERmRatBN7.2
Rnor_6.0383,311,048 - 83,311,140NCBIRnor6.0
Rnor_6.0515,876,789 - 15,876,881NCBIRnor6.0
Rnor_5.0520,659,973 - 20,660,065UniSTSRnor5.0
Rnor_5.0390,010,665 - 90,010,757UniSTSRnor5.0
RGSC_v3.4516,303,193 - 16,303,285UniSTSRGSC3.4
RGSC_v3.4378,819,798 - 78,819,890UniSTSRGSC3.4
Celera515,416,892 - 15,416,984UniSTS
Celera379,572,623 - 79,572,715UniSTS
Cytogenetic Map3q31UniSTS
Cytogenetic Map5q12UniSTS
RH132195  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2380,381,499 - 80,381,708 (+)MAPPERmRatBN7.2
Rnor_6.0383,314,282 - 83,314,490NCBIRnor6.0
Rnor_5.0390,013,899 - 90,014,107UniSTSRnor5.0
RGSC_v3.4378,823,032 - 78,823,240UniSTSRGSC3.4
Celera379,575,857 - 79,576,065UniSTS
RH 3.4 Map3691.6UniSTS
Cytogenetic Map3q31UniSTS
RH134450  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2380,378,248 - 80,378,451 (+)MAPPERmRatBN7.2
Rnor_6.0383,311,031 - 83,311,233NCBIRnor6.0
Rnor_5.0390,010,648 - 90,010,850UniSTSRnor5.0
RGSC_v3.4378,819,781 - 78,819,983UniSTSRGSC3.4
Celera379,572,606 - 79,572,808UniSTS
RH 3.4 Map3694.9UniSTS
Cytogenetic Map3q31UniSTS
AA850535  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2380,378,472 - 80,378,674 (+)MAPPERmRatBN7.2
Rnor_6.0383,311,255 - 83,311,456NCBIRnor6.0
Rnor_5.0390,010,872 - 90,011,073UniSTSRnor5.0
RGSC_v3.4378,820,005 - 78,820,206UniSTSRGSC3.4
Celera379,572,830 - 79,573,031UniSTS
RH 3.4 Map3706.5UniSTS
Cytogenetic Map3q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000013914   ⟹   ENSRNOP00000013914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3100,833,417 - 100,858,580 (-)Ensembl
mRatBN7.2 Ensembl380,378,096 - 80,403,257 (-)Ensembl
Rnor_6.0 Ensembl383,310,884 - 83,335,960 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097889   ⟹   ENSRNOP00000080371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3100,838,062 - 100,858,580 (-)Ensembl
mRatBN7.2 Ensembl380,382,150 - 80,403,264 (-)Ensembl
RefSeq Acc Id: NM_001127379   ⟹   NP_001120851
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83100,833,417 - 100,858,580 (-)NCBI
mRatBN7.2380,378,096 - 80,403,259 (-)NCBI
Rnor_6.0383,310,882 - 83,335,960 (-)NCBI
Rnor_5.0390,010,495 - 90,035,670 (-)NCBI
RGSC_v3.4378,819,632 - 78,844,710 (-)RGD
Celera379,572,457 - 79,597,535 (-)RGD
Sequence:
RefSeq Acc Id: NM_001399729   ⟹   NP_001386658
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83100,833,417 - 100,858,580 (-)NCBI
mRatBN7.2380,378,096 - 80,403,259 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001120851 (Get FASTA)   NCBI Sequence Viewer  
  NP_001386658 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI62003 (Get FASTA)   NCBI Sequence Viewer  
  EDL79612 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013914
  ENSRNOP00000013914.5
  ENSRNOP00000080371
  ENSRNOP00000080371.1
RefSeq Acc Id: NP_001120851   ⟸   NM_001127379
- Peptide Label: isoform 2
- UniProtKB: B1WC49 (UniProtKB/TrEMBL),   F7EZ33 (UniProtKB/TrEMBL),   A0A8I5ZQJ6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013914   ⟸   ENSRNOT00000013914
Ensembl Acc Id: ENSRNOP00000080371   ⟸   ENSRNOT00000097889
RefSeq Acc Id: NP_001386658   ⟸   NM_001399729
- Peptide Label: isoform 1
- UniProtKB: A0A8I5ZQJ6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1WC49-F1-model_v2 AlphaFold B1WC49 1-504 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692237
Promoter ID:EPDNEW_R2762
Type:initiation region
Name:Api5_1
Description:apoptosis inhibitor 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0383,336,025 - 83,336,085EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309772 AgrOrtholog
BioCyc Gene G2FUF-48652 BioCyc
Ensembl Genes ENSRNOG00000009689 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013914 ENTREZGENE
  ENSRNOT00000013914.6 UniProtKB/TrEMBL
  ENSRNOT00000097889 ENTREZGENE
  ENSRNOT00000097889.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9089120 IMAGE-MGC_LOAD
InterPro API5 UniProtKB/TrEMBL
  ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
KEGG Report rno:362170 UniProtKB/TrEMBL
MGC_CLONE MGC:187857 IMAGE-MGC_LOAD
NCBI Gene 362170 ENTREZGENE
PANTHER APOPTOSIS INHIBITOR 5 UniProtKB/TrEMBL
  PTHR12758 UniProtKB/TrEMBL
Pfam API5 UniProtKB/TrEMBL
PhenoGen Api5 PhenoGen
RatGTEx ENSRNOG00000009689 RatGTEx
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt A0A8I5ZQJ6 ENTREZGENE, UniProtKB/TrEMBL
  B1WC49 ENTREZGENE, UniProtKB/TrEMBL
  F7EZ33 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Api5  apoptosis inhibitor 5   Api5_predicted  apoptosis inhibitor 5 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Api5_predicted  apoptosis inhibitor 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED