Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Hycc2 | Rat | 1,2-dichloroethane | affects expression | ISO | Hycc2 (Mus musculus) | 6480464 | ethylene dichloride affects the expression of HYCC2 mRNA | CTD | PMID:28960355 | Hycc2 | Rat | 1,2-dichloroethane | decreases expression | ISO | Hycc2 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of HYCC2 mRNA | CTD | PMID:28189721 | Hycc2 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Hycc2 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of HYCC2 mRNA | CTD | PMID:22206623 | Hycc2 | Rat | 17beta-estradiol | decreases expression | ISO | Hycc2 (Mus musculus) | 6480464 | Estradiol results in decreased expression of HYCC2 mRNA | CTD | PMID:39298647 | Hycc2 | Rat | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of HYCC2 mRNA | CTD | PMID:32145629 | Hycc2 | Rat | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Hycc2 (Mus musculus) | 6480464 | 2,3',4,4',5-pentachlorobiphenyl results in increased expression of HYCC2 mRNA | CTD | PMID:31388691 | Hycc2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HYCC2 mRNA | CTD | PMID:21215274|PMID:32109520 | Hycc2 | Rat | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2,3,7,8-tetrachlorodibenzofuran results in decreased expression of HYCC2 mRNA | CTD | PMID:32109520 | Hycc2 | Rat | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Hycc2 (Mus musculus) | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of HYCC2 mRNA | CTD | PMID:26251327 | Hycc2 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | HYCC2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ... | CTD | PMID:28628672 | Hycc2 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | HYCC2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ... | CTD | PMID:28628672 | Hycc2 | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | Hycc2 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of HYCC2 mRNA | CTD | PMID:33297965 | Hycc2 | Rat | 4,4'-sulfonyldiphenol | affects expression | ISO | Hycc2 (Mus musculus) | 6480464 | bisphenol S affects the expression of HYCC2 mRNA | CTD | PMID:39298647 | Hycc2 | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Hycc2 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of HYCC2 mRNA | CTD | PMID:28973697 | Hycc2 | Rat | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of HYCC2 mRNA | CTD | PMID:31881176 | Hycc2 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of HYCC2 mRNA | CTD | PMID:28959563 | Hycc2 | Rat | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of HYCC2 mRNA | CTD | PMID:33354967 | Hycc2 | Rat | aflatoxin B1 | increases expression | ISO | Hycc2 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of HYCC2 mRNA | CTD | PMID:19770486 | Hycc2 | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of HYCC2 mRNA | CTD | PMID:30047161 | Hycc2 | Rat | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of HYCC2 mRNA | CTD | PMID:30779732 | Hycc2 | Rat | benzo[a]pyrene | increases methylation | ISO | HYCC2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of HYCC2 5' UTR | CTD | PMID:27901495 | Hycc2 | Rat | benzo[a]pyrene | increases methylation | ISO | Hycc2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased methylation of HYCC2 intron | CTD | PMID:27901495 | Hycc2 | Rat | benzo[b]fluoranthene | decreases expression | ISO | Hycc2 (Mus musculus) | 6480464 | benzo(b)fluoranthene results in decreased expression of HYCC2 mRNA | CTD | PMID:26377693 | Hycc2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of HYCC2 mRNA | CTD | PMID:25181051|PMID:32145629 | Hycc2 | Rat | bisphenol A | multiple interactions | ISO | HYCC2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of HYCC2 gene | CTD | PMID:31601247 | Hycc2 | Rat | bisphenol A | decreases methylation | ISO | HYCC2 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of HYCC2 gene | CTD | PMID:31601247 | Hycc2 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of HYCC2 mRNA | CTD | PMID:33296240 | Hycc2 | Rat | buspirone | increases expression | EXP | | 6480464 | Buspirone results in increased expression of HYCC2 mRNA | CTD | PMID:24136188 | Hycc2 | Rat | cadmium dichloride | decreases expression | ISO | HYCC2 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of HYCC2 mRNA | CTD | PMID:38568856 | Hycc2 | Rat | caffeine | decreases phosphorylation | ISO | HYCC2 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of HYCC2 protein | CTD | PMID:35688186 | Hycc2 | Rat | carbon nanotube | decreases expression | ISO | Hycc2 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of HYCC2 mRNA | CTD | PMID:25554681 | Hycc2 | Rat | chloroprene | increases expression | EXP | | 6480464 | Chloroprene results in increased expression of HYCC2 mRNA | CTD | PMID:23125180 | Hycc2 | Rat | chlorpyrifos | decreases expression | ISO | Hycc2 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of HYCC2 mRNA | CTD | PMID:37019170 | Hycc2 | Rat | cisplatin | multiple interactions | ISO | HYCC2 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of HYCC2 mRNA | CTD | PMID:27392435 | Hycc2 | Rat | clofibrate | increases expression | ISO | Hycc2 (Mus musculus) | 6480464 | Clofibrate results in increased expression of HYCC2 mRNA | CTD | PMID:23811191 | Hycc2 | Rat | copper(II) sulfate | increases expression | ISO | HYCC2 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of HYCC2 mRNA | CTD | PMID:19549813 | Hycc2 | Rat | coumestrol | decreases expression | ISO | HYCC2 (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of HYCC2 mRNA | CTD | PMID:19167446 | Hycc2 | Rat | crocidolite asbestos | decreases expression | ISO | Hycc2 (Mus musculus) | 6480464 | Asbestos, Crocidolite results in decreased expression of HYCC2 mRNA | CTD | PMID:29279043 | Hycc2 | Rat | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of HYCC2 mRNA | CTD | PMID:26577399 | Hycc2 | Rat | cyclosporin A | increases expression | ISO | HYCC2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of HYCC2 mRNA | CTD | PMID:21632981|PMID:25562108 | Hycc2 | Rat | dexamethasone | multiple interactions | ISO | HYCC2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ... | CTD | PMID:28628672 | Hycc2 | Rat | Dibutyl phosphate | affects expression | ISO | HYCC2 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of HYCC2 mRNA | CTD | PMID:37042841 | Hycc2 | Rat | diethyl maleate | decreases expression | EXP | | 6480464 | diethyl maleate results in decreased expression of HYCC2 mRNA | CTD | PMID:21161181 | Hycc2 | Rat | doxorubicin | decreases expression | ISO | HYCC2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of HYCC2 mRNA | CTD | PMID:29803840 | Hycc2 | Rat | entinostat | decreases expression | ISO | HYCC2 (Homo sapiens) | 6480464 | entinostat results in decreased expression of HYCC2 mRNA | CTD | PMID:27188386 | Hycc2 | Rat | ethanol | affects splicing | ISO | Hycc2 (Mus musculus) | 6480464 | Ethanol affects the splicing of HYCC2 mRNA | CTD | PMID:30319688 | Hycc2 | Rat | ethyl methanesulfonate | increases expression | ISO | HYCC2 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of HYCC2 mRNA | CTD | PMID:23649840 | Hycc2 | Rat | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of HYCC2 mRNA | CTD | PMID:30307764 | Hycc2 | Rat | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of HYCC2 mRNA | CTD | PMID:24136188 | Hycc2 | Rat | formaldehyde | decreases expression | ISO | HYCC2 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of HYCC2 mRNA | CTD | PMID:20655997 | Hycc2 | Rat | FR900359 | affects phosphorylation | ISO | HYCC2 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of HYCC2 protein | CTD | PMID:37730182 | Hycc2 | Rat | fulvestrant | multiple interactions | ISO | HYCC2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of HYCC2 gene | CTD | PMID:31601247 | Hycc2 | Rat | furan | increases expression | EXP | | 6480464 | furan results in increased expression of HYCC2 mRNA | CTD | PMID:26194646 | Hycc2 | Rat | indometacin | multiple interactions | ISO | HYCC2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ... | CTD | PMID:28628672 | Hycc2 | Rat | leflunomide | increases expression | ISO | HYCC2 (Homo sapiens) | 6480464 | Leflunomide results in increased expression of HYCC2 mRNA | CTD | PMID:28988120 | Hycc2 | Rat | methamphetamine | increases expression | EXP | | 6480464 | Methamphetamine results in increased expression of HYCC2 mRNA | CTD | PMID:19564919 | Hycc2 | Rat | methamphetamine | multiple interactions | EXP | | 6480464 | [Methamphetamine co-treated with SCH 23390] results in increased expression of HYCC2 mRNA | CTD | PMID:19564919 | Hycc2 | Rat | methapyrilene | decreases expression | EXP | | 6480464 | Methapyrilene results in decreased expression of HYCC2 mRNA | CTD | PMID:30467583 | Hycc2 | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of HYCC2 mRNA | CTD | PMID:30047161 | Hycc2 | Rat | methyl methanesulfonate | increases expression | ISO | HYCC2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of HYCC2 mRNA | CTD | PMID:23649840 | Hycc2 | Rat | methylmercury chloride | decreases expression | ISO | HYCC2 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of HYCC2 mRNA | CTD | PMID:28001369 | Hycc2 | Rat | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of HYCC2 mRNA | CTD | PMID:24136188 | Hycc2 | Rat | nimesulide | increases expression | EXP | | 6480464 | nimesulide results in increased expression of HYCC2 mRNA | CTD | PMID:24136188 | Hycc2 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [Oxaliplatin co-treated with Topotecan] results in decreased expression of HYCC2 mRNA | CTD | PMID:25729387 | Hycc2 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of HYCC2 mRNA | CTD | PMID:33387578 | Hycc2 | Rat | phenobarbital | increases expression | ISO | Hycc2 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of HYCC2 mRNA | CTD | PMID:19270015 | Hycc2 | Rat | phenobarbital | affects expression | ISO | Hycc2 (Mus musculus) | 6480464 | Phenobarbital affects the expression of HYCC2 mRNA | CTD | PMID:23091169 | Hycc2 | Rat | pirinixic acid | increases expression | ISO | Hycc2 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of HYCC2 mRNA | CTD | PMID:23811191 | Hycc2 | Rat | potassium dichromate | decreases expression | ISO | Hycc2 (Mus musculus) | 6480464 | Potassium Dichromate results in decreased expression of HYCC2 mRNA | CTD | PMID:23608068 | Hycc2 | Rat | rimonabant | affects expression | ISO | Hycc2 (Mus musculus) | 6480464 | Rimonabant affects the expression of HYCC2 mRNA | CTD | PMID:19030233 | Hycc2 | Rat | SCH 23390 | multiple interactions | EXP | | 6480464 | [Methamphetamine co-treated with SCH 23390] results in increased expression of HYCC2 mRNA | CTD | PMID:19564919 | Hycc2 | Rat | silicon dioxide | decreases expression | ISO | Hycc2 (Mus musculus) | 6480464 | Silicon Dioxide results in decreased expression of HYCC2 mRNA | CTD | PMID:19073995 | Hycc2 | Rat | sodium arsenate | increases expression | ISO | Hycc2 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of HYCC2 mRNA | CTD | PMID:21795629 | Hycc2 | Rat | sodium arsenite | increases expression | ISO | HYCC2 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of HYCC2 mRNA | CTD | PMID:38568856 | Hycc2 | Rat | succimer | multiple interactions | ISO | Hycc2 (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of HYCC2 mRNA | CTD | PMID:21641980 | Hycc2 | Rat | tetrachloroethene | increases expression | ISO | Hycc2 (Mus musculus) | 6480464 | Tetrachloroethylene results in increased expression of HYCC2 mRNA | CTD | PMID:28973375 | Hycc2 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of HYCC2 mRNA | CTD | PMID:34492290 | Hycc2 | Rat | thiram | increases expression | ISO | HYCC2 (Homo sapiens) | 6480464 | Thiram results in increased expression of HYCC2 mRNA | CTD | PMID:38568856 | Hycc2 | Rat | titanium dioxide | increases methylation | ISO | Hycc2 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of HYCC2 gene | CTD | PMID:35295148 | Hycc2 | Rat | titanium dioxide | decreases methylation | ISO | Hycc2 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of HYCC2 promoter alternative form | CTD | PMID:35295148 | Hycc2 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [Oxaliplatin co-treated with Topotecan] results in decreased expression of HYCC2 mRNA | CTD | PMID:25729387 | Hycc2 | Rat | trichostatin A | affects expression | ISO | HYCC2 (Homo sapiens) | 6480464 | trichostatin A affects the expression of HYCC2 mRNA | CTD | PMID:28542535 | Hycc2 | Rat | urethane | increases expression | ISO | HYCC2 (Homo sapiens) | 6480464 | Urethane results in increased expression of HYCC2 mRNA | CTD | PMID:28818685 | Hycc2 | Rat | valproic acid | increases expression | ISO | HYCC2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of HYCC2 mRNA | CTD | PMID:29154799 | Hycc2 | Rat | valproic acid | affects expression | ISO | Hycc2 (Mus musculus) | 6480464 | Valproic Acid affects the expression of HYCC2 mRNA | CTD | PMID:17292431 | Hycc2 | Rat | valproic acid | decreases expression | ISO | HYCC2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of HYCC2 mRNA | CTD | PMID:37505509 | Hycc2 | Rat | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of HYCC2 mRNA | CTD | PMID:29427782 | Hycc2 | Rat | valproic acid | decreases methylation | ISO | HYCC2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of HYCC2 gene | CTD | PMID:29154799 | Hycc2 | Rat | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of HYCC2 mRNA | CTD | PMID:19015723 | Hycc2 | Rat | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of HYCC2 mRNA | CTD | PMID:23034163 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















