Abhd16b (abhydrolase domain containing 16B) - Rat Genome Database

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Gene: Abhd16b (abhydrolase domain containing 16B) Rattus norvegicus
Analyze
Symbol: Abhd16b (Ensembl: Tpd52l2)
Name: abhydrolase domain containing 16B (Ensembl:TPD52 like 2)
RGD ID: 1309726
Description: Predicted to enable acylglycerol lipase activity and phospholipase activity. Predicted to be involved in monoacylglycerol catabolic process and phosphatidylserine catabolic process. Predicted to be located in nucleoplasm. Orthologous to human ABHD16B (abhydrolase domain containing 16B); INTERACTS WITH bisphenol A; paracetamol; trichloroethene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: abhydrolase domain-containing protein 16B; alpha/beta hydrolase domain-containing protein 16B; hypothetical protein LOC311720; LOC311720; RGD1309726; similar to Hypothetical protein C20orf135
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,972,198 - 188,974,095 (+)NCBIGRCr8
mRatBN7.23168,594,677 - 168,596,574 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,594,609 - 168,619,762 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,974,992 - 172,976,889 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,934,087 - 181,935,984 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,595,602 - 178,597,499 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,985,900 - 176,987,797 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,985,900 - 176,987,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,696,183 - 180,698,080 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,627,853 - 170,629,750 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,533,888 - 170,535,785 (+)NCBI
Celera3163,990,474 - 163,992,371 (-)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334  


Genomics

Comparative Map Data
Abhd16b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,972,198 - 188,974,095 (+)NCBIGRCr8
mRatBN7.23168,594,677 - 168,596,574 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,594,609 - 168,619,762 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,974,992 - 172,976,889 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,934,087 - 181,935,984 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,595,602 - 178,597,499 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,985,900 - 176,987,797 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,985,900 - 176,987,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,696,183 - 180,698,080 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,627,853 - 170,629,750 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,533,888 - 170,535,785 (+)NCBI
Celera3163,990,474 - 163,992,371 (-)NCBICelera
Cytogenetic Map3q43NCBI
ABHD16B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382063,861,498 - 63,862,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2063,861,498 - 63,862,988 (+)EnsemblGRCh38hg38GRCh38
GRCh372062,492,851 - 62,494,341 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,963,010 - 61,964,785 (+)NCBINCBI36Build 36hg18NCBI36
Build 342061,963,009 - 61,964,785NCBI
Celera2059,176,749 - 59,178,524 (+)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2059,225,182 - 59,226,958 (+)NCBIHuRef
CHM1_12062,393,380 - 62,395,155 (+)NCBICHM1_1
T2T-CHM13v2.02065,681,341 - 65,682,831 (+)NCBIT2T-CHM13v2.0
Abhd16b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392181,134,999 - 181,136,773 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2181,134,999 - 181,136,773 (+)EnsemblGRCm39 Ensembl
GRCm382181,493,206 - 181,494,980 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,493,206 - 181,494,980 (+)EnsemblGRCm38mm10GRCm38
MGSCv372181,227,911 - 181,229,685 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362181,422,617 - 181,424,384 (+)NCBIMGSCv36mm8
Celera2185,574,847 - 185,576,621 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.63NCBI
Abhd16b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955528391,749 - 395,181 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955528391,749 - 395,181 (-)NCBIChiLan1.0ChiLan1.0
ABHD16B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22169,669,175 - 69,674,709 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12069,663,001 - 69,664,410 (+)NCBINHGRI_mPanPan1
PanPan1.12061,783,164 - 61,784,933 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2061,783,486 - 61,784,895 (+)Ensemblpanpan1.1panPan2
ABHD16B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2446,483,287 - 46,484,804 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02448,488,223 - 48,489,742 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2448,488,223 - 48,489,655 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12447,332,979 - 47,334,491 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02447,457,849 - 47,459,357 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02448,196,124 - 48,197,634 (+)NCBIUU_Cfam_GSD_1.0
Abhd16b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,614,944 - 195,616,808 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651411,068,762 - 11,070,162 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651411,068,762 - 11,070,162 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABHD16B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1762,730,062 - 62,731,474 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11762,729,995 - 62,732,060 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ABHD16B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12367,344 - 370,151 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2367,423 - 368,832 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605047,907,700 - 47,909,463 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abhd16b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474129,487,951 - 29,490,234 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:36
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000020210
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat

Markers in Region
RH142555  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,596,177 - 168,596,432 (+)MAPPERmRatBN7.2
Rnor_6.03176,987,401 - 176,987,655NCBIRnor6.0
Rnor_5.03180,697,684 - 180,697,938UniSTSRnor5.0
RGSC_v3.43170,629,354 - 170,629,608UniSTSRGSC3.4
Celera3163,990,616 - 163,990,870UniSTS
RH 3.4 Map31549.6UniSTS
Cytogenetic Map3q43UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 5 1 3 1
Below cutoff 3 13 2 19 2 6 7 10 9 6 10 6

Sequence


RefSeq Acc Id: ENSRNOT00000020210   ⟹   ENSRNOP00000020210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,594,609 - 168,619,762 (+)Ensembl
Rnor_6.0 Ensembl3176,985,900 - 176,987,796 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100247   ⟹   ENSRNOP00000082032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,594,761 - 168,619,762 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114404   ⟹   ENSRNOP00000084244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,594,761 - 168,619,762 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114740   ⟹   ENSRNOP00000080130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,594,761 - 168,619,762 (+)Ensembl
RefSeq Acc Id: NM_001014052   ⟹   NP_001014074
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,972,198 - 188,974,095 (+)NCBI
mRatBN7.23168,594,677 - 168,596,574 (+)NCBI
Rnor_6.03176,985,900 - 176,987,797 (+)NCBI
Rnor_5.03180,696,183 - 180,698,080 (+)NCBI
RGSC_v3.43170,627,853 - 170,629,750 (+)RGD
Celera3163,990,474 - 163,992,371 (-)RGD
Sequence:
RefSeq Acc Id: NP_001014074   ⟸   NM_001014052
- UniProtKB: Q5XIL6 (UniProtKB/Swiss-Prot),   A6KM09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020210   ⟸   ENSRNOT00000020210
RefSeq Acc Id: ENSRNOP00000080130   ⟸   ENSRNOT00000114740
RefSeq Acc Id: ENSRNOP00000082032   ⟸   ENSRNOT00000100247
RefSeq Acc Id: ENSRNOP00000084244   ⟸   ENSRNOT00000114404
Protein Domains
AB hydrolase-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIL6-F1-model_v2 AlphaFold Q5XIL6 1-474 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309726 AgrOrtholog
BioCyc Gene G2FUF-46282 BioCyc
Ensembl Genes ENSRNOG00000015067 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055001190 UniProtKB/Swiss-Prot
  ENSRNOG00060001344 UniProtKB/Swiss-Prot
  ENSRNOG00065013953 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020210 ENTREZGENE
  ENSRNOT00000020210.6 UniProtKB/Swiss-Prot
  ENSRNOT00000100247.1 UniProtKB/Swiss-Prot
  ENSRNOT00000114404.1 UniProtKB/Swiss-Prot
  ENSRNOT00000114740.1 UniProtKB/Swiss-Prot
  ENSRNOT00055001977 UniProtKB/Swiss-Prot
  ENSRNOT00055001979 UniProtKB/Swiss-Prot
  ENSRNOT00055001983 UniProtKB/Swiss-Prot
  ENSRNOT00055001988 UniProtKB/Swiss-Prot
  ENSRNOT00060001952 UniProtKB/Swiss-Prot
  ENSRNOT00060001953 UniProtKB/Swiss-Prot
  ENSRNOT00060001956 UniProtKB/Swiss-Prot
  ENSRNOT00060001960 UniProtKB/Swiss-Prot
  ENSRNOT00065023034 UniProtKB/Swiss-Prot
  ENSRNOT00065023042 UniProtKB/Swiss-Prot
  ENSRNOT00065023047 UniProtKB/Swiss-Prot
  ENSRNOT00065023060 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135476 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AB_hydrolase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:311720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94505 IMAGE-MGC_LOAD
NCBI Gene 311720 ENTREZGENE
PANTHER ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN ABHD16B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Abhydrolase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Abhd16b PhenoGen
RatGTEx ENSRNOG00000015067 RatGTEx
  ENSRNOG00055001190 RatGTEx
  ENSRNOG00060001344 RatGTEx
  ENSRNOG00065013953 RatGTEx
Superfamily-SCOP alpha/beta-Hydrolases UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6KM09 ENTREZGENE, UniProtKB/TrEMBL
  ABHGB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-05-26 Abhd16b   abhydrolase domain containing 16B   RGD1309726  similar to Hypothetical protein C20orf135  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1309726  similar to Hypothetical protein C20orf135  RGD1309726_predicted  similar to Hypothetical protein C20orf135 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1309726_predicted  similar to Hypothetical protein C20orf135 (predicted)  LOC311720_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC311720_predicted  similar to Hypothetical protein C20orf135 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL