Guk1 (guanylate kinase 1) - Rat Genome Database

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Gene: Guk1 (guanylate kinase 1) Rattus norvegicus
Analyze
Symbol: Guk1
Name: guanylate kinase 1
RGD ID: 1309638
Description: Enables guanylate kinase activity. Involved in glycoprotein transport; nucleobase-containing small molecule metabolic process; and phosphorylation. Predicted to be located in photoreceptor inner segment. Predicted to be active in cytosol. Orthologous to human GUK1 (guanylate kinase 1); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP:GMP-phosphotransferase; guanylate kinase; LOC303179
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81044,471,075 - 44,488,332 (-)NCBIGRCr8
mRatBN7.21043,971,514 - 43,988,658 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1043,971,509 - 43,980,107 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1048,665,329 - 48,673,594 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,155,687 - 48,163,952 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01043,659,284 - 43,667,549 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01045,535,617 - 45,552,455 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,535,627 - 45,543,897 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,291,702 - 45,308,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,489,304 - 45,497,364 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11045,502,968 - 45,510,938 (-)NCBI
Celera1043,234,788 - 43,243,045 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A microsomal GTPase is required for glycopeptide export from the mammalian endoplasmic reticulum. Ali BR, etal., J Biol Chem. 2000 Oct 27;275(43):33222-30.
2. Partial purification and properties of ATP:GMP phosphransferase from rat liver. Buccino RJ Jr and Roth JS, Arch Biochem Biophys. 1969 Jun;132(1):49-61.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Differences in expression of retinal proteins between diabetic and normal rats. Liu SQ, etal., World J Gastroenterol. 2007 Apr 14;13(14):2118-24.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1383219   PMID:6306664   PMID:8663313   PMID:12036965   PMID:29515371   PMID:31201273  


Genomics

Comparative Map Data
Guk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81044,471,075 - 44,488,332 (-)NCBIGRCr8
mRatBN7.21043,971,514 - 43,988,658 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1043,971,509 - 43,980,107 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1048,665,329 - 48,673,594 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,155,687 - 48,163,952 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01043,659,284 - 43,667,549 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01045,535,617 - 45,552,455 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,535,627 - 45,543,897 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,291,702 - 45,308,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,489,304 - 45,497,364 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11045,502,968 - 45,510,938 (-)NCBI
Celera1043,234,788 - 43,243,045 (-)NCBICelera
Cytogenetic Map10q22NCBI
GUK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381228,140,084 - 228,148,955 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1228,139,962 - 228,148,984 (+)EnsemblGRCh38hg38GRCh38
GRCh371228,327,785 - 228,336,656 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361226,394,605 - 226,403,275 (+)NCBINCBI36Build 36hg18NCBI36
Build 341224,634,716 - 224,643,387NCBI
Celera1201,518,174 - 201,526,898 (+)NCBICelera
Cytogenetic Map1q42.13NCBI
HuRef1198,842,817 - 198,851,685 (+)NCBIHuRef
CHM1_11229,600,114 - 229,608,980 (+)NCBICHM1_1
T2T-CHM13v2.01227,329,084 - 227,337,952 (+)NCBIT2T-CHM13v2.0
Guk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,074,696 - 59,083,068 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,074,701 - 59,083,069 (-)EnsemblGRCm39 Ensembl
GRCm381159,183,855 - 59,192,207 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,183,875 - 59,192,212 (-)EnsemblGRCm38mm10GRCm38
MGSCv371158,997,357 - 59,005,454 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361159,000,070 - 59,008,011 (-)NCBIMGSCv36mm8
Celera1163,948,962 - 63,956,989 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1137.05NCBI
Guk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955581299,280 - 305,032 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955581299,010 - 305,032 (-)NCBIChiLan1.0ChiLan1.0
GUK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2121,457,697 - 21,466,641 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1121,395,997 - 21,404,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01203,541,866 - 203,550,827 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11208,753,419 - 208,762,252 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1208,753,657 - 208,765,857 (+)Ensemblpanpan1.1panPan2
GUK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.114820,048 - 826,694 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl14820,093 - 827,250 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha14324,908 - 331,250 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.014540,816 - 547,155 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl14540,822 - 547,116 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.114731,629 - 737,964 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.014512,458 - 518,788 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.014498,337 - 504,677 (-)NCBIUU_Cfam_GSD_1.0
Guk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721387,735,431 - 87,745,573 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493686476,128 - 79,520 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493686476,707 - 86,479 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl251,241,952 - 51,257,485 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1251,247,665 - 51,257,481 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2253,854,695 - 53,864,531 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GUK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1251,579,382 - 1,587,623 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl251,579,610 - 1,587,419 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660551,459,801 - 1,467,918 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Guk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624937892,854 - 898,799 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624937892,840 - 898,799 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Guk1
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:30
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000003926
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat

Markers in Region
RH129753  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21043,971,537 - 43,971,732 (+)MAPPERmRatBN7.2
Rnor_6.01045,535,641 - 45,535,835NCBIRnor6.0
Rnor_5.01045,291,726 - 45,291,920UniSTSRnor5.0
RH 3.4 Map10500.29UniSTS
Cytogenetic Map10q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001013115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC142478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF354443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AT006427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM065046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000003926   ⟹   ENSRNOP00000003926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1043,971,509 - 43,975,441 (-)Ensembl
Rnor_6.0 Ensembl1045,535,627 - 45,543,897 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095132   ⟹   ENSRNOP00000081629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1043,971,509 - 43,979,909 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114145   ⟹   ENSRNOP00000085799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1043,971,509 - 43,980,107 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116629   ⟹   ENSRNOP00000095535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1043,971,509 - 43,979,909 (-)Ensembl
RefSeq Acc Id: NM_001013115   ⟹   NP_001013133
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,471,085 - 44,479,355 (-)NCBI
mRatBN7.21043,971,524 - 43,979,794 (-)NCBI
Rnor_6.01045,535,627 - 45,543,897 (-)NCBI
Rnor_5.01045,291,702 - 45,308,540 (-)NCBI
RGSC_v3.41045,489,304 - 45,497,364 (-)RGD
Celera1043,234,788 - 43,243,045 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246477   ⟹   XP_006246539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,471,075 - 44,479,589 (-)NCBI
mRatBN7.21043,971,514 - 43,979,866 (-)NCBI
Rnor_6.01045,535,617 - 45,543,922 (-)NCBI
Rnor_5.01045,291,702 - 45,308,540 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063268989   ⟹   XP_063125059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,471,075 - 44,479,487 (-)NCBI
RefSeq Acc Id: XM_063268990   ⟹   XP_063125060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,471,075 - 44,479,610 (-)NCBI
RefSeq Acc Id: XM_063268991   ⟹   XP_063125061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,471,075 - 44,488,332 (-)NCBI
RefSeq Acc Id: XM_063268992   ⟹   XP_063125062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,471,075 - 44,488,221 (-)NCBI
RefSeq Acc Id: XM_063268993   ⟹   XP_063125063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,471,075 - 44,479,488 (-)NCBI
RefSeq Acc Id: XM_063268994   ⟹   XP_063125064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,471,682 - 44,479,496 (-)NCBI
RefSeq Acc Id: XM_063268995   ⟹   XP_063125065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,471,075 - 44,479,554 (-)NCBI
RefSeq Acc Id: XM_063268996   ⟹   XP_063125066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,471,075 - 44,479,484 (-)NCBI
RefSeq Acc Id: XM_063268997   ⟹   XP_063125067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,471,683 - 44,479,610 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001013133   ⟸   NM_001013115
- UniProtKB: A6HEY0 (UniProtKB/TrEMBL),   A0A8I5ZT32 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246539   ⟸   XM_006246477
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A2B3 (UniProtKB/TrEMBL),   A0A8I6GLP0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003926   ⟸   ENSRNOT00000003926
RefSeq Acc Id: ENSRNOP00000085799   ⟸   ENSRNOT00000114145
RefSeq Acc Id: ENSRNOP00000095535   ⟸   ENSRNOT00000116629
RefSeq Acc Id: ENSRNOP00000081629   ⟸   ENSRNOT00000095132
RefSeq Acc Id: XP_063125061   ⟸   XM_063268991
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063125062   ⟸   XM_063268992
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063125060   ⟸   XM_063268990
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063125065   ⟸   XM_063268995
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063125063   ⟸   XM_063268993
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063125059   ⟸   XM_063268989
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063125066   ⟸   XM_063268996
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063125064   ⟸   XM_063268994
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063125067   ⟸   XM_063268997
- Peptide Label: isoform X9
Protein Domains
Guanylate kinase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PTV0-F1-model_v2 AlphaFold E9PTV0 1-219 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697231
Promoter ID:EPDNEW_R7755
Type:initiation region
Name:Guk1_1
Description:guanylate kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01045,543,888 - 45,543,948EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309638 AgrOrtholog
BioCyc Gene G2FUF-24909 BioCyc
BioCyc Pathway PWY-7221 [guanosine ribonucleotides de novo biosynthesis] BioCyc
BioCyc Pathway Image PWY-7221 BioCyc
Ensembl Genes ENSRNOG00000002928 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003926.7 UniProtKB/TrEMBL
  ENSRNOT00000095132.1 UniProtKB/TrEMBL
  ENSRNOT00000114145.1 UniProtKB/TrEMBL
  ENSRNOT00000116629 ENTREZGENE
  ENSRNOT00000116629.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  Guanylate Kinase phosphate binding domain UniProtKB/TrEMBL
InterPro Guanylate_kin UniProtKB/TrEMBL
  Guanylate_kin/L-typ_Ca_channel UniProtKB/TrEMBL
  Guanylate_kinase_CS UniProtKB/TrEMBL
  Guanylate_kinase_sub UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:303179 UniProtKB/TrEMBL
NCBI Gene 303179 ENTREZGENE
PANTHER GUANYLATE KINASE UniProtKB/TrEMBL
  GUANYLATE KINASE-RELATED UniProtKB/TrEMBL
Pfam Guanylate_kin UniProtKB/TrEMBL
PhenoGen Guk1 PhenoGen
PROSITE GUANYLATE_KINASE_1 UniProtKB/TrEMBL
  GUANYLATE_KINASE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002928 RatGTEx
SMART GuKc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I5ZT32 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A2B3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLP0 ENTREZGENE, UniProtKB/TrEMBL
  A6HEY0 ENTREZGENE, UniProtKB/TrEMBL
  A6HEY2_RAT UniProtKB/TrEMBL
  E9PTV0_RAT UniProtKB/TrEMBL
  Q71RR7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Guk1  guanylate kinase 1  Guk1_predicted  guanylate kinase 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Guk1_predicted  guanylate kinase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED