Ak7 (adenylate kinase 7) - Rat Genome Database

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Gene: Ak7 (adenylate kinase 7) Rattus norvegicus
Analyze
Symbol: Ak7
Name: adenylate kinase 7
RGD ID: 1309600
Description: Predicted to enable AMP kinase activity; dCMP kinase activity; and nucleoside diphosphate kinase activity. Predicted to be involved in nucleoside monophosphate phosphorylation. Predicted to act upstream of or within several processes, including axoneme assembly; epithelial cilium movement involved in extracellular fluid movement; and inflammatory response to antigenic stimulus. Predicted to be located in extracellular region. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in spermatogenic failure 27. Orthologous to human AK7 (adenylate kinase 7); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH 6-propyl-2-thiouracil; acetamide; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC314416; putative adenylate kinase 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86130,376,499 - 130,444,674 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6130,376,550 - 130,444,677 (+)EnsemblGRCr8
mRatBN7.26124,611,789 - 124,679,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6124,611,902 - 124,679,961 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6124,734,223 - 124,803,198 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06125,029,490 - 125,098,470 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06124,389,700 - 124,457,780 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06129,538,648 - 129,606,960 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,538,982 - 129,606,932 (+)Ensemblrn6Rnor6.0
Rnor_5.06138,732,026 - 138,805,327 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46129,861,499 - 129,933,903 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6122,178,930 - 122,246,130 (+)NCBICelera
RGSC_v3.16129,865,370 - 129,939,804 (+)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10215863   PMID:18776131   PMID:21080915   PMID:21746835   PMID:23416111  


Genomics

Comparative Map Data
Ak7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86130,376,499 - 130,444,674 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6130,376,550 - 130,444,677 (+)EnsemblGRCr8
mRatBN7.26124,611,789 - 124,679,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6124,611,902 - 124,679,961 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6124,734,223 - 124,803,198 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06125,029,490 - 125,098,470 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06124,389,700 - 124,457,780 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06129,538,648 - 129,606,960 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,538,982 - 129,606,932 (+)Ensemblrn6Rnor6.0
Rnor_5.06138,732,026 - 138,805,327 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46129,861,499 - 129,933,903 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6122,178,930 - 122,246,130 (+)NCBICelera
RGSC_v3.16129,865,370 - 129,939,804 (+)NCBI
Cytogenetic Map6q32NCBI
AK7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381496,392,128 - 96,489,427 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1496,392,128 - 96,490,031 (+)Ensemblhg38GRCh38
GRCh371496,858,465 - 96,955,764 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361495,928,201 - 96,024,865 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341495,928,200 - 96,024,866NCBI
Celera1476,914,175 - 77,010,845 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1477,043,535 - 77,140,413 (+)NCBIHuRef
CHM1_11496,797,289 - 96,894,524 (+)NCBICHM1_1
T2T-CHM13v2.01490,623,724 - 90,721,030 (+)NCBIT2T-CHM13v2.0
Ak7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912105,670,115 - 105,748,706 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12105,672,235 - 105,748,706 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812105,703,858 - 105,782,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12105,705,976 - 105,782,447 (+)Ensemblmm10GRCm38
MGSCv3712106,944,192 - 107,020,657 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612106,107,032 - 106,183,497 (+)NCBIMGSCv36mm8
Celera12106,940,507 - 107,017,130 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1255.95NCBI
Ak7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543818,178,822 - 18,233,051 (+)Ensembl
ChiLan1.0NW_00495543818,178,822 - 18,233,051 (+)NCBIChiLan1.0ChiLan1.0
AK7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21597,552,083 - 97,651,326 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11496,768,587 - 96,867,830 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01477,021,880 - 77,119,037 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11496,344,219 - 96,440,415 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1496,344,240 - 96,440,384 (+)EnsemblpanPan2panpan1.1
AK7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1865,136,750 - 65,213,589 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl865,136,705 - 65,213,555 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha864,653,322 - 64,730,381 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0865,409,508 - 65,486,864 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl865,409,456 - 65,486,388 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1865,082,340 - 65,159,573 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0865,143,563 - 65,220,637 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0865,467,259 - 65,544,215 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ak7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086409,339,422 - 9,402,271 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936604680,329 - 742,284 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936604680,237 - 742,580 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AK7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7117,609,840 - 117,667,455 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.17117,609,791 - 117,667,247 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27124,867,883 - 124,925,586 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AK7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12474,275,451 - 74,376,032 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2474,275,637 - 74,377,562 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605361,426,946 - 61,526,079 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ak7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247346,942,374 - 7,001,212 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247346,942,786 - 7,000,453 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ak7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17123,365,779 - 123,433,946 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ak7
443 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:136
Count of miRNA genes:107
Interacting mature miRNAs:113
Transcripts:ENSRNOT00000050752
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 8 33 147 90 89 59 68 59 6 283 133 11 124 70 89 30 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000082522   ⟹   ENSRNOP00000073263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6130,376,615 - 130,444,677 (+)Ensembl
mRatBN7.2 Ensembl6124,611,902 - 124,679,961 (+)Ensembl
Rnor_6.0 Ensembl6129,539,075 - 129,606,930 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083626   ⟹   ENSRNOP00000070935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6130,376,550 - 130,444,673 (+)Ensembl
mRatBN7.2 Ensembl6124,611,902 - 124,679,961 (+)Ensembl
Rnor_6.0 Ensembl6129,538,982 - 129,606,932 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000171648   ⟹   ENSRNOP00000105834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6130,376,550 - 130,444,673 (+)Ensembl
RefSeq Acc Id: NM_001108055   ⟹   NP_001101525
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,376,604 - 130,444,666 (+)NCBI
mRatBN7.26124,611,902 - 124,679,970 (+)NCBI
Rnor_6.06129,539,075 - 129,606,939 (+)NCBI
Rnor_5.06138,732,026 - 138,805,327 (+)NCBI
RGSC_v3.46129,861,499 - 129,933,903 (+)RGD
Celera6122,178,930 - 122,246,130 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594182   ⟹   XP_017449671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,376,499 - 130,444,674 (+)NCBI
mRatBN7.26124,611,795 - 124,679,978 (+)NCBI
Rnor_6.06129,538,649 - 129,606,960 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063262001   ⟹   XP_063118071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,376,502 - 130,444,674 (+)NCBI
RefSeq Acc Id: XM_063262002   ⟹   XP_063118072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,376,502 - 130,444,674 (+)NCBI
RefSeq Acc Id: XM_063262003   ⟹   XP_063118073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,376,503 - 130,444,674 (+)NCBI
RefSeq Acc Id: NP_001101525   ⟸   NM_001108055
- UniProtKB: A0A0G2K524 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449671   ⟸   XM_017594182
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K524 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073263   ⟸   ENSRNOT00000082522
Ensembl Acc Id: ENSRNOP00000070935   ⟸   ENSRNOT00000083626
RefSeq Acc Id: XP_063118071   ⟸   XM_063262001
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063118072   ⟸   XM_063262002
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063118073   ⟸   XM_063262003
- Peptide Label: isoform X3
- UniProtKB: A6KBD4 (UniProtKB/TrEMBL),   A0A0G2JZ71 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105834   ⟸   ENSRNOT00000171648

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZ71-F1-model_v2 AlphaFold A0A0G2JZ71 1-724 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309600 AgrOrtholog
BioCyc Gene G2FUF-36329 BioCyc
BioCyc Pathway PWY-7219 [adenosine ribonucleotides de novo biosynthesis] BioCyc
BioCyc Pathway Image PWY-7219 BioCyc
Ensembl Genes ENSRNOG00000055714 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082522 ENTREZGENE
  ENSRNOT00000082522.3 UniProtKB/TrEMBL
  ENSRNOT00000083626 ENTREZGENE
  ENSRNOT00000083626.3 UniProtKB/TrEMBL
  ENSRNOT00000171648 ENTREZGENE
  ENSRNOT00000171648.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Adenylate_kin UniProtKB/TrEMBL
  DD_AK7 UniProtKB/TrEMBL
  Dpy-30_motif UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:314416 UniProtKB/TrEMBL
NCBI Gene 314416 ENTREZGENE
PANTHER Adenylate_kin UniProtKB/TrEMBL
Pfam ADK UniProtKB/TrEMBL
  Dpy-30 UniProtKB/TrEMBL
PhenoGen Ak7 PhenoGen
RatGTEx ENSRNOG00000055714 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2JZ71 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K524 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LVX3_RAT UniProtKB/TrEMBL
  A6KBD4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ak7  adenylate kinase 7   Ak7_predicted  adenylate kinase 7 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ak7_predicted  adenylate kinase 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED