Tfeb (transcription factor EB) - Rat Genome Database

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Gene: Tfeb (transcription factor EB) Rattus norvegicus
Analyze
Symbol: Tfeb
Name: transcription factor EB
RGD ID: 1309583
Description: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; defense response to bacterium; and positive regulation of metabolic process. Predicted to act upstream of or within lysosome organization and positive regulation of DNA-templated transcription. Predicted to be located in cytosol and lysosomal membrane. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human TFEB (transcription factor EB); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC316214; MGC116240; Tcfeb
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,696,440 - 20,752,265 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl920,696,441 - 20,727,863 (-)EnsemblGRCr8
mRatBN7.2913,198,890 - 13,254,726 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl913,198,891 - 13,254,714 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx921,778,959 - 21,785,655 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,844,786 - 26,851,514 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0925,142,350 - 25,149,046 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0915,208,141 - 15,264,101 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl915,207,822 - 15,214,596 (-)Ensemblrn6Rnor6.0
Rnor_5.0914,132,621 - 14,188,412 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.498,665,061 - 8,671,743 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera910,951,098 - 10,957,780 (-)NCBICelera
RGSC_v3.198,664,602 - 8,671,285 (-)NCBI
Cytogenetic Map9q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-methyladenine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
alpha,alpha-trehalose  (EXP,ISO)
alpha-D-galactose  (ISO)
amiodarone  (ISO)
antimycin A  (ISO)
apilimod  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-cyclodextrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (EXP)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium acetate  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
CHIR 99021  (ISO)
cisplatin  (ISO)
copper(II) chloride  (ISO)
corosolic acid  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diethyl maleate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
elemental selenium  (ISO)
entinostat  (ISO)
ethanol  (EXP)
fluphenazine  (ISO)
FR900359  (ISO)
galactose  (ISO)
gallic acid  (EXP)
gentamycin  (EXP)
ginsenoside Rb1  (EXP,ISO)
hesperidin  (EXP)
lactulose  (ISO)
lithocholic acid  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melibiose  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
okadaic acid  (ISO)
oligomycin A  (ISO)
oxidopamine  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
prochlorperazine  (ISO)
progesterone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
swainsonine  (EXP)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
titanium dioxide  (ISO)
torin 1  (ISO)
triclosan  (ISO)
trifluoperazine  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zidovudine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
lysosomal membrane  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
transcription regulator complex  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9806910   PMID:12477932   PMID:15994295   PMID:16936731   PMID:19556463   PMID:21617040   PMID:22343943   PMID:22576015   PMID:22692423   PMID:23434374   PMID:26601776   PMID:27184844  
PMID:27278822   PMID:28002813   PMID:29146937   PMID:32085781   PMID:32306793   PMID:32716134   PMID:34071043   PMID:34482051   PMID:35739666   PMID:35758908   PMID:36217215   PMID:36608573  
PMID:37210406   PMID:37609444   PMID:37683766   PMID:38358580   PMID:39168657   PMID:39375262  


Genomics

Comparative Map Data
Tfeb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,696,440 - 20,752,265 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl920,696,441 - 20,727,863 (-)EnsemblGRCr8
mRatBN7.2913,198,890 - 13,254,726 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl913,198,891 - 13,254,714 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx921,778,959 - 21,785,655 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,844,786 - 26,851,514 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0925,142,350 - 25,149,046 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0915,208,141 - 15,264,101 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl915,207,822 - 15,214,596 (-)Ensemblrn6Rnor6.0
Rnor_5.0914,132,621 - 14,188,412 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.498,665,061 - 8,671,743 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera910,951,098 - 10,957,780 (-)NCBICelera
RGSC_v3.198,664,602 - 8,671,285 (-)NCBI
Cytogenetic Map9q12NCBI
TFEB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,683,978 - 41,736,223 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,683,978 - 41,736,259 (-)Ensemblhg38GRCh38
GRCh37641,651,716 - 41,703,961 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,759,694 - 41,810,776 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34641,759,694 - 41,810,776NCBI
Celera643,205,150 - 43,257,434 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef641,370,592 - 41,422,827 (-)NCBIHuRef
CHM1_1641,655,195 - 41,707,480 (-)NCBICHM1_1
T2T-CHM13v2.0641,512,540 - 41,564,779 (-)NCBIT2T-CHM13v2.0
Tfeb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391748,047,962 - 48,103,341 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1748,047,955 - 48,103,344 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381747,737,037 - 47,792,416 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1747,737,030 - 47,792,419 (+)Ensemblmm10GRCm38
MGSCv371747,873,986 - 47,929,365 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361747,248,935 - 47,255,607 (+)NCBIMGSCv36mm8
Celera1751,174,084 - 51,229,512 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1723.99NCBI
Tfeb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554378,098,976 - 8,141,001 (-)Ensembl
ChiLan1.0NW_0049554378,102,241 - 8,141,001 (-)NCBIChiLan1.0ChiLan1.0
TFEB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2556,176,926 - 56,228,643 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1652,046,000 - 52,098,651 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0641,268,169 - 41,320,822 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1642,574,416 - 42,596,615 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,574,416 - 42,627,031 (-)EnsemblpanPan2panpan1.1
TFEB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11210,367,979 - 10,423,478 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1210,368,599 - 10,452,619 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1210,397,632 - 10,453,009 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01210,848,131 - 10,903,700 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1210,848,131 - 10,868,839 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11210,378,806 - 10,434,436 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01210,462,511 - 10,517,872 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01210,556,169 - 10,611,532 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tfeb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,726,580 - 45,771,013 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647618,189,041 - 18,233,701 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647618,189,096 - 18,233,622 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TFEB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,870,242 - 36,920,865 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1736,870,240 - 36,920,887 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2742,165,273 - 42,189,485 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TFEB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11730,425,893 - 30,478,954 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1730,426,260 - 30,479,124 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604441,678,714 - 41,731,770 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tfeb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475417,321,162 - 17,358,524 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475417,321,179 - 17,358,402 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tfeb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1482,084,476 - 82,140,295 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tfeb
495 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:83
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000039102
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9360535521031556Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat

Markers in Region
REN60515  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2913,199,495 - 13,199,742 (+)MAPPERmRatBN7.2
Rnor_6.0915,208,747 - 15,208,993NCBIRnor6.0
Rnor_5.0914,133,227 - 14,133,473UniSTSRnor5.0
RGSC_v3.498,665,667 - 8,665,913UniSTSRGSC3.4
Celera910,951,704 - 10,951,950UniSTS
Cytogenetic Map9q12UniSTS
REN60529  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2913,202,786 - 13,203,036 (+)MAPPERmRatBN7.2
Rnor_6.0915,212,036 - 15,212,285NCBIRnor6.0
Rnor_5.0914,136,516 - 14,136,765UniSTSRnor5.0
RGSC_v3.498,668,956 - 8,669,205UniSTSRGSC3.4
Celera910,954,993 - 10,955,242UniSTS
Cytogenetic Map9q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000039102   ⟹   ENSRNOP00000037517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl920,696,441 - 20,727,863 (-)Ensembl
mRatBN7.2 Ensembl913,198,891 - 13,206,466 (-)Ensembl
Rnor_6.0 Ensembl915,207,822 - 15,214,596 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112521   ⟹   ENSRNOP00000096641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl920,696,441 - 20,703,334 (-)Ensembl
mRatBN7.2 Ensembl913,201,984 - 13,254,714 (-)Ensembl
RefSeq Acc Id: NM_001025707   ⟹   NP_001020878
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,696,440 - 20,703,124 (-)NCBI
mRatBN7.2913,198,890 - 13,205,576 (-)NCBI
Rnor_6.0915,208,141 - 15,214,823 (-)NCBI
Rnor_5.0914,132,621 - 14,188,412 (-)NCBI
RGSC_v3.498,665,061 - 8,671,743 (-)RGD
Celera910,951,098 - 10,957,780 (-)RGD
Sequence:
RefSeq Acc Id: XM_006244442   ⟹   XP_006244504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,696,443 - 20,752,193 (-)NCBI
mRatBN7.2913,198,893 - 13,254,726 (-)NCBI
Rnor_6.0915,208,144 - 15,264,101 (-)NCBI
Rnor_5.0914,132,621 - 14,188,412 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006244446   ⟹   XP_006244508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,696,443 - 20,721,628 (-)NCBI
mRatBN7.2913,198,893 - 13,223,161 (-)NCBI
Rnor_6.0915,208,144 - 15,232,418 (-)NCBI
Rnor_5.0914,132,621 - 14,188,412 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083486   ⟹   XP_038939414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,696,443 - 20,752,265 (-)NCBI
mRatBN7.2913,198,893 - 13,254,721 (-)NCBI
RefSeq Acc Id: XM_039083488   ⟹   XP_038939416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,696,443 - 20,751,306 (-)NCBI
mRatBN7.2913,198,893 - 13,253,166 (-)NCBI
RefSeq Acc Id: XM_063267087   ⟹   XP_063123157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,696,443 - 20,717,702 (-)NCBI
RefSeq Acc Id: NP_001020878   ⟸   NM_001025707
- UniProtKB: A6JII3 (UniProtKB/TrEMBL),   A6JII2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244504   ⟸   XM_006244442
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006244508   ⟸   XM_006244446
- Peptide Label: isoform X2
- UniProtKB: A6JII3 (UniProtKB/TrEMBL),   A6JII2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000037517   ⟸   ENSRNOT00000039102
RefSeq Acc Id: XP_038939414   ⟸   XM_039083486
- Peptide Label: isoform X2
- UniProtKB: A6JII3 (UniProtKB/TrEMBL),   A6JII2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939416   ⟸   XM_039083488
- Peptide Label: isoform X2
- UniProtKB: A6JII3 (UniProtKB/TrEMBL),   A6JII2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096641   ⟸   ENSRNOT00000112521
RefSeq Acc Id: XP_063123157   ⟸   XM_063267087
- Peptide Label: isoform X1
- UniProtKB: A6JII2 (UniProtKB/TrEMBL)
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7F5J1-F1-model_v2 AlphaFold F7F5J1 1-476 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309583 AgrOrtholog
BioCyc Gene G2FUF-28283 BioCyc
Ensembl Genes ENSRNOG00000014666 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039102 ENTREZGENE
  ENSRNOT00000039102.7 UniProtKB/TrEMBL
  ENSRNOT00000112521 ENTREZGENE
  ENSRNOT00000112521.2 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7460021 IMAGE-MGC_LOAD
InterPro bHLH_ZIP_TF_MiT/TFE UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  HLH_DNA_bd UniProtKB/TrEMBL
  MiT/TFE_N UniProtKB/TrEMBL
  TFEB UniProtKB/TrEMBL
KEGG Report rno:316214 UniProtKB/TrEMBL
MGC_CLONE MGC:116240 IMAGE-MGC_LOAD
NCBI Gene 316214 ENTREZGENE
PANTHER MIP04163P UniProtKB/TrEMBL
  PTHR45776:SF5 UniProtKB/TrEMBL
Pfam DUF3371 UniProtKB/TrEMBL
  HLH UniProtKB/TrEMBL
  MITF_TFEB_C_3_N UniProtKB/TrEMBL
PhenoGen Tfeb PhenoGen
PROSITE HLH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014666 RatGTEx
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP HLH_basic UniProtKB/TrEMBL
UniProt A0A8I6ATP3_RAT UniProtKB/TrEMBL
  A6JII2 ENTREZGENE, UniProtKB/TrEMBL
  A6JII3 ENTREZGENE, UniProtKB/TrEMBL
  F7F5J1_RAT UniProtKB/TrEMBL
  Q4KLM8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tfeb  transcription factor EB  Tcfeb  transcription factor EB  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Tcfeb  transcription factor EB  Tcfeb_predicted  transcription factor EB (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Tcfeb_predicted  transcription factor EB (predicted)      Symbol and Name status set to approved 70820 APPROVED