Tmprss9 (transmembrane serine protease 9) - Rat Genome Database

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Gene: Tmprss9 (transmembrane serine protease 9) Rattus norvegicus
Analyze
Symbol: Tmprss9
Name: transmembrane serine protease 9
RGD ID: 1309581
Description: Predicted to enable serine-type peptidase activity. Predicted to be involved in plasminogen activation. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TMPRSS9 (transmembrane serine protease 9); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC314636; polyserase-1; polyserase-I; polyserine protease 1; serase-1b; transmembrane protease serine 9; transmembrane protease, serine 9
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,460,998 - 9,481,854 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl79,460,998 - 9,481,854 (-)EnsemblGRCr8
mRatBN7.278,810,321 - 8,831,177 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,810,320 - 8,831,177 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx711,694,234 - 11,715,157 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,569,742 - 13,590,661 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,436,265 - 11,457,194 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,678,591 - 11,710,581 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,678,591 - 11,699,448 (-)Ensemblrn6Rnor6.0
Rnor_5.0711,846,111 - 11,876,500 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4710,321,210 - 10,341,746 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera76,994,667 - 7,015,204 (-)NCBICelera
RGSC_v3.1710,321,364 - 10,341,746 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
plasminogen activation  (IBA,ISO)
proteolysis  (IEA,ISO)

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12886014   PMID:15057822   PMID:16872279  


Genomics

Comparative Map Data
Tmprss9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,460,998 - 9,481,854 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl79,460,998 - 9,481,854 (-)EnsemblGRCr8
mRatBN7.278,810,321 - 8,831,177 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,810,320 - 8,831,177 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx711,694,234 - 11,715,157 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,569,742 - 13,590,661 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,436,265 - 11,457,194 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,678,591 - 11,710,581 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,678,591 - 11,699,448 (-)Ensemblrn6Rnor6.0
Rnor_5.0711,846,111 - 11,876,500 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4710,321,210 - 10,341,746 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera76,994,667 - 7,015,204 (-)NCBICelera
RGSC_v3.1710,321,364 - 10,341,746 (-)NCBI
Cytogenetic Map7q11NCBI
TMPRSS9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,360,265 - 2,426,261 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,360,238 - 2,426,261 (+)Ensemblhg38GRCh38
GRCh37192,360,263 - 2,426,259 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,340,784 - 2,377,086 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34192,340,783 - 2,377,086NCBI
Celera192,325,619 - 2,363,578 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,161,023 - 2,198,137 (+)NCBIHuRef
CHM1_1192,389,526 - 2,425,585 (+)NCBICHM1_1
T2T-CHM13v2.0192,333,932 - 2,402,052 (+)NCBIT2T-CHM13v2.0
Tmprss9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,706,951 - 80,735,329 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,707,682 - 80,735,326 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381080,871,117 - 80,899,495 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,871,848 - 80,899,492 (+)Ensemblmm10GRCm38
MGSCv371080,342,561 - 80,362,239 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361080,282,945 - 80,302,623 (+)NCBIMGSCv36mm8
Celera1081,898,636 - 81,918,315 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Tmprss9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,782,929 - 5,800,980 (-)Ensembl
ChiLan1.0NW_0049554955,782,817 - 5,800,988 (-)NCBIChiLan1.0ChiLan1.0
TMPRSS9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2206,743,435 - 6,811,339 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1196,003,127 - 6,040,904 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,402,052 - 1,438,710 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1192,373,618 - 2,404,564 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,373,815 - 2,404,215 (+)EnsemblpanPan2panpan1.1
TMPRSS9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,666,201 - 56,694,655 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,676,936 - 56,686,218 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2056,462,516 - 56,490,261 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02057,399,900 - 57,427,681 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,399,910 - 57,427,881 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,452,113 - 56,479,887 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,937,329 - 56,964,998 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,137,567 - 57,165,342 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmprss9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,389,845 - 216,425,979 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,422,783 - 1,444,770 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,422,783 - 1,444,938 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMPRSS9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,158,045 - 76,224,446 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1276,158,059 - 76,228,444 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,709,502 - 76,779,732 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMPRSS9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,148,025 - 2,205,398 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660816,454,828 - 6,500,409 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmprss9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,531,482 - 6,548,605 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248286,530,911 - 6,560,640 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmprss9
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11153,984,824 - 154,005,995 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmprss9
101 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:72
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000049221, ENSRNOT00000066037
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 6 64 157 81 80 49 79 49 6 322 174 10 134 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000049221   ⟹   ENSRNOP00000041782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl79,460,998 - 9,481,854 (-)Ensembl
mRatBN7.2 Ensembl78,810,320 - 8,831,177 (-)Ensembl
Rnor_6.0 Ensembl711,678,591 - 11,699,436 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000066037   ⟹   ENSRNOP00000062691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl711,687,853 - 11,699,448 (-)Ensembl
RefSeq Acc Id: NM_001395516   ⟹   NP_001382445
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,460,998 - 9,481,854 (-)NCBI
mRatBN7.278,810,321 - 8,831,177 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001382445 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAF02297 (Get FASTA)   NCBI Sequence Viewer  
  EDL89212 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000041782
GenBank Protein P69526 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000062691   ⟸   ENSRNOT00000066037
Ensembl Acc Id: ENSRNOP00000041782   ⟸   ENSRNOT00000049221
RefSeq Acc Id: NP_001382445   ⟸   NM_001395516
- UniProtKB: P69526 (UniProtKB/Swiss-Prot),   A0A8L2QMN2 (UniProtKB/TrEMBL)
Protein Domains
LDL-receptor class A   Peptidase S1   SEA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P69526-F1-model_v2 AlphaFold P69526 1-1061 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309581 AgrOrtholog
BioCyc Gene G2FUF-34977 BioCyc
Ensembl Genes ENSRNOG00000032429 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000049221 ENTREZGENE
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
  4.10.400.10 UniProtKB/Swiss-Prot
InterPro LDL_receptor-like_sf UniProtKB/Swiss-Prot
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot
  Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Tmprss9 UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
NCBI Gene 314636 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/Swiss-Prot
  TRANSMEMBRANE SERINE PROTEASE 9 UniProtKB/Swiss-Prot
Pfam Ldl_recept_a UniProtKB/Swiss-Prot
  Trypsin UniProtKB/Swiss-Prot
PhenoGen Tmprss9 PhenoGen
PIRSF TMPRSS9_polyserase-1 UniProtKB/Swiss-Prot
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE LDLRA_1 UniProtKB/Swiss-Prot
  LDLRA_2 UniProtKB/Swiss-Prot
  TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032429 RatGTEx
SMART LDLa UniProtKB/Swiss-Prot
  Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
  SSF57424 UniProtKB/Swiss-Prot
UniProt A0A8L2QMN2 ENTREZGENE, UniProtKB/TrEMBL
  P69526 ENTREZGENE
  Q0X0F0_RAT UniProtKB/TrEMBL
  TMPS9_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-26 Tmprss9  transmembrane serine protease 9  Tmprss9  transmembrane protease, serine 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Tmprss9  transmembrane protease, serine 9  Tmprss9_predicted  transmembrane serine protease 9 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Tmprss9_predicted  transmembrane serine protease 9 (predicted)      Symbol and Name status set to approved 70820 APPROVED