Pi15 (peptidase inhibitor 15) - Rat Genome Database

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Gene: Pi15 (peptidase inhibitor 15) Rattus norvegicus
Analyze
Symbol: Pi15
Name: peptidase inhibitor 15
RGD ID: 1309577
Description: Predicted to enable peptidase inhibitor activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human PI15 (peptidase inhibitor 15); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC301489; protease inhibitor 15
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Vetf3
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr856,178,427 - 6,206,548 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl56,174,963 - 6,247,841 (-)EnsemblGRCr8
mRatBN7.251,395,094 - 1,423,213 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl51,395,094 - 1,423,213 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx53,511,849 - 3,539,976 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.055,150,722 - 5,178,855 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.054,837,833 - 4,865,958 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05791,137 - 819,233 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5790,833 - 819,326 (-)Ensemblrn6Rnor6.0
Rnor_5.05786,324 - 814,420 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45463,937 - 492,169 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera51,039,264 - 1,067,408 (-)NCBICelera
RGSC_v3.15464,435 - 491,572 (-)NCBI
Cytogenetic Map5q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23533145   PMID:24790086  


Genomics

Comparative Map Data
Pi15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr856,178,427 - 6,206,548 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl56,174,963 - 6,247,841 (-)EnsemblGRCr8
mRatBN7.251,395,094 - 1,423,213 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl51,395,094 - 1,423,213 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx53,511,849 - 3,539,976 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.055,150,722 - 5,178,855 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.054,837,833 - 4,865,958 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05791,137 - 819,233 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5790,833 - 819,326 (-)Ensemblrn6Rnor6.0
Rnor_5.05786,324 - 814,420 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45463,937 - 492,169 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera51,039,264 - 1,067,408 (-)NCBICelera
RGSC_v3.15464,435 - 491,572 (-)NCBI
Cytogenetic Map5q11NCBI
PI15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38874,824,534 - 74,855,029 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl874,824,534 - 74,855,029 (+)Ensemblhg38GRCh38
GRCh37875,736,769 - 75,767,264 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36875,899,327 - 75,929,819 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34875,899,999 - 75,929,817NCBI
Celera871,730,974 - 71,761,463 (+)NCBICelera
Cytogenetic Map8q21.13NCBI
HuRef871,227,247 - 71,257,719 (+)NCBIHuRef
CHM1_1875,788,390 - 75,818,882 (+)NCBICHM1_1
T2T-CHM13v2.0875,254,011 - 75,284,508 (+)NCBIT2T-CHM13v2.0
Pi15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39117,672,064 - 17,701,169 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl117,672,125 - 17,701,163 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38117,601,901 - 17,630,939 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl117,601,901 - 17,630,939 (+)Ensemblmm10GRCm38
MGSCv37117,591,982 - 17,621,020 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36117,587,209 - 17,610,661 (+)NCBIMGSCv36mm8
Celera117,513,609 - 17,542,652 (+)NCBICelera
Cytogenetic Map1A3NCBI
cM Map15.32NCBI
Pi15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554445,653,301 - 5,674,557 (-)Ensembl
ChiLan1.0NW_0049554445,647,862 - 5,674,470 (-)NCBIChiLan1.0ChiLan1.0
PI15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2790,355,507 - 90,597,713 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1866,193,732 - 66,225,488 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0871,146,241 - 71,388,401 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1873,002,748 - 73,033,221 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl873,001,482 - 73,027,431 (+)EnsemblpanPan2panpan1.1
PI15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12923,231,073 - 23,259,556 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2923,231,812 - 23,256,540 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2923,494,453 - 23,525,690 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02923,341,330 - 23,372,588 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2923,341,322 - 23,366,796 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12923,399,968 - 23,431,203 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02923,435,403 - 23,466,660 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02923,786,852 - 23,818,091 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pi15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530356,066,591 - 56,093,818 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366483,354,702 - 3,376,562 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366483,354,750 - 3,381,987 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PI15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl461,114,497 - 61,142,811 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1461,114,490 - 61,142,869 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2466,778,162 - 66,802,978 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PI15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1870,397,468 - 70,441,438 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl870,398,656 - 70,422,307 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603970,924,926 - 70,967,826 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pi15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474416,380,316 - 16,401,611 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474416,374,544 - 16,401,611 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pi15
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11151,543,718 - 151,571,468 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pi15
271 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:50
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000023899
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)519895442Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 10 60 106 80 79 48 25 48 6 232 115 9 84 51 88 31 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000023899   ⟹   ENSRNOP00000023899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl56,178,427 - 6,247,841 (-)Ensembl
mRatBN7.2 Ensembl51,395,094 - 1,423,213 (-)Ensembl
Rnor_6.0 Ensembl5790,833 - 819,326 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140487   ⟹   ENSRNOP00000108073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl56,174,963 - 6,206,548 (-)Ensembl
RefSeq Acc Id: NM_001106917   ⟹   NP_001100387
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr856,178,427 - 6,206,548 (-)NCBI
mRatBN7.251,395,094 - 1,423,213 (-)NCBI
Rnor_6.05791,137 - 819,233 (-)NCBI
Rnor_5.05786,324 - 814,420 (-)NCBI
RGSC_v3.45463,937 - 492,169 (-)RGD
Celera51,039,264 - 1,067,408 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100387 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11483 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023899
  ENSRNOP00000023899.6
  ENSRNOP00000108073.1
RefSeq Acc Id: NP_001100387   ⟸   NM_001106917
- Peptide Label: precursor
- UniProtKB: F1M2W7 (UniProtKB/TrEMBL),   A6JF87 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023899   ⟸   ENSRNOT00000023899
Ensembl Acc Id: ENSRNOP00000108073   ⟸   ENSRNOT00000140487
Protein Domains
SCP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M2W7-F1-model_v2 AlphaFold F1M2W7 1-258 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693520
Promoter ID:EPDNEW_R4044
Type:single initiation site
Name:Pi15_1
Description:peptidase inhibitor 15
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05819,326 - 819,386EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309577 AgrOrtholog
BioCyc Gene G2FUF-42329 BioCyc
Ensembl Genes ENSRNOG00000017686 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023899 ENTREZGENE
  ENSRNOT00000023899.7 UniProtKB/TrEMBL
  ENSRNOT00000140487.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.33.10 UniProtKB/TrEMBL
InterPro Allrgn_V5/Tpx1 UniProtKB/TrEMBL
  Allrgn_V5/Tpx1_CS UniProtKB/TrEMBL
  CAP_domain UniProtKB/TrEMBL
  CAP_sf UniProtKB/TrEMBL
  PI15_CAP UniProtKB/TrEMBL
KEGG Report rno:301489 UniProtKB/TrEMBL
NCBI Gene 301489 ENTREZGENE
PANTHER Allrgn_V5/Tpx1 UniProtKB/TrEMBL
Pfam CAP UniProtKB/TrEMBL
PhenoGen Pi15 PhenoGen
PRINTS V5TPXLIKE UniProtKB/TrEMBL
PROSITE CRISP_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017686 RatGTEx
SMART SCP UniProtKB/TrEMBL
Superfamily-SCOP SCP-like_extracellular UniProtKB/TrEMBL
UniProt A0ABK0LWZ0_RAT UniProtKB/TrEMBL
  A6JF87 ENTREZGENE, UniProtKB/TrEMBL
  F1M2W7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Pi15  peptidase inhibitor 15  Pi15_predicted  protease inhibitor 15 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Pi15_predicted  protease inhibitor 15 (predicted)      Symbol and Name status set to approved 70820 APPROVED