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Gene: Srsf9 (serine and arginine rich splicing factor 9) Rattus norvegicus

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Symbol:

Srsf9

Name:

serine and arginine rich splicing factor 9

RGD ID:

1309495

Description:

Predicted to enable mRNA binding activity and protein domain specific binding activity. Involved in response to alkaloid and response to toxic substance. Predicted to be located in nucleus. Predicted to be active in nuclear speck. Orthologous to human SRSF9 (serine and arginine rich splicing factor 9); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amitrole; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC288701; MGC105562; serine/arginine-rich splicing factor 9; Sfrs9; splicing factor, arginine/serine rich 9; splicing factor, arginine/serine-rich 9

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SRSF9 (serine and arginine rich splicing factor 9)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Mus musculus (house mouse):	Srsf9 (serine and arginine-rich splicing factor 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Srsf9 (serine and arginine rich splicing factor 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SRSF9 (serine and arginine rich splicing factor 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SRSF9 (serine and arginine rich splicing factor 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Srsf9 (serine and arginine rich splicing factor 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SRSF9 (serine and arginine rich splicing factor 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SRSF9 (serine and arginine rich splicing factor 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Srsf9 (serine and arginine rich splicing factor 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Srsf9 (serine and arginine rich splicing factor 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GATC (glutamyl-tRNA amidotransferase subunit C)	HGNC	PhylomeDB, Treefam
Homo sapiens (human):	CPSF4 (cleavage and polyadenylation specific factor 4)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SRSF9 (serine and arginine rich splicing factor 9)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Srsf9 (serine and arginine-rich splicing factor 9)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	srsf9 (serine and arginine rich splicing factor 9)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	NPL3	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	SF2	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	SF2	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	rsp-3	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rsp-3	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	srsf9	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	srsf9	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	46,938,948 - 46,945,213 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	46,938,950 - 46,945,283 (-)	Ensembl				GRCr8
mRatBN7.2	12	41,278,225 - 41,284,502 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	41,275,687 - 41,284,499 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	42,445,022 - 42,451,223 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	43,058,690 - 43,064,891 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	42,119,244 - 42,125,445 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	47,039,714 - 47,046,022 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	47,039,716 - 47,046,022 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	48,833,030 - 48,839,338 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	42,546,330 - 42,552,590 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	42,899,173 - 42,905,366 (-)	NCBI		Celera
RGSC_v3.1	12	42,409,719 - 42,415,978 (-)	NCBI
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Autoimmune Encephalomyelitis (ISO)

human immunodeficiency virus infectious disease (ISO)

urinary bladder cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3',5'-cyclic UMP (ISO)

amitrole (EXP)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzene-1,2,4-triol (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (EXP)

cadmium dichloride (ISO)

CGP 52608 (ISO)

chloropicrin (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

cyclosporin A (ISO)

deoxynivalenol (ISO)

diarsenic trioxide (ISO)

elemental selenium (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

fenthion (ISO)

folic acid (ISO)

FR900359 (ISO)

gentamycin (EXP)

Heptachlor epoxide (ISO)

ivermectin (ISO)

lead(0) (ISO)

leflunomide (EXP)

lipopolysaccharide (ISO)

methoxychlor (EXP)

nitrates (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

rotenone (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

tetrachloromethane (ISO)

thapsigargin (EXP)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vitamin E (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mRNA processing (IEA)

negative regulation of mRNA splicing, via spliceosome (IEA,ISO,ISS)

regulation of alternative mRNA splicing, via spliceosome (IBA)

response to alkaloid (IEP)

response to toxic substance (IEP)

RNA splicing (IEA)

Cellular Component

nuclear speck (IBA)

nucleoplasm (IEA,ISO)

nucleus (IEA)

Molecular Function

mRNA binding (IBA)

nucleic acid binding (IEA)

protein binding (IPI,ISO)

protein domain specific binding (IEA,ISO)

RNA binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

spliceosome pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.	Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements.	Nayler O, etal., Nucleic Acids Res 1998 Aug 1;26(15):3542-9.
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites.	Stoss O, etal., J Biol Chem 2001 Mar 23;276(12):8665-73.
10.	RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation.	Tariq A, etal., Nucleic Acids Res. 2013 Feb 1;41(4):2581-93. doi: 10.1093/nar/gks1353. Epub 2012 Dec 28.
11.	The spliceosome: design principles of a dynamic RNP machine.	Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.
12.	Super-high-dose methylprednisolone does not improve efficacy or induce glucocorticoid resistance in experimental allergic encephalomyelitis.	Wei ZS, etal., Neuroimmunomodulation. 2011;18(1):28-36. doi: 10.1159/000314736. Epub 2010 Jul 8.
13.	Tumor suppressive microRNA-1 mediated novel apoptosis pathways through direct inhibition of splicing factor serine/arginine-rich 9 (SRSF9/SRp30c) in bladder cancer.	Yoshino H, etal., Biochem Biophys Res Commun. 2012 Jan 6;417(1):588-93. doi: 10.1016/j.bbrc.2011.12.011. Epub 2011 Dec 9.

Additional References at PubMed

PMID:10749975	PMID:12477932	PMID:15009664	PMID:15489334	PMID:16396499	PMID:22658674	PMID:22681889

Genomics

Comparative Map Data

Srsf9
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	46,938,948 - 46,945,213 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	46,938,950 - 46,945,283 (-)	Ensembl				GRCr8
mRatBN7.2	12	41,278,225 - 41,284,502 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	41,275,687 - 41,284,499 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	42,445,022 - 42,451,223 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	43,058,690 - 43,064,891 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	42,119,244 - 42,125,445 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	47,039,714 - 47,046,022 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	47,039,716 - 47,046,022 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	48,833,030 - 48,839,338 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	42,546,330 - 42,552,590 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	42,899,173 - 42,905,366 (-)	NCBI		Celera
RGSC_v3.1	12	42,409,719 - 42,415,978 (-)	NCBI
Cytogenetic Map	12	q16	NCBI

SRSF9
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	120,461,672 - 120,469,748 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	120,456,138 - 120,495,946 (-)	Ensembl			hg38	GRCh38
GRCh37	12	120,899,475 - 120,907,551 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	119,383,854 - 119,391,941 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	119,362,191 - 119,370,278	NCBI
Celera	12	120,534,186 - 120,542,273 (-)	NCBI		Celera
Cytogenetic Map	12	q24.31	NCBI
HuRef	12	117,908,257 - 117,917,448 (-)	NCBI		HuRef
CHM1_1	12	120,867,963 - 120,876,363 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	120,450,186 - 120,458,930 (-)	NCBI		T2T-CHM13v2.0

Srsf9
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	115,465,236 - 115,471,139 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	115,465,236 - 115,471,139 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	115,327,163 - 115,333,843 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	115,327,177 - 115,333,080 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	115,777,186 - 115,783,089 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	115,588,176 - 115,594,079 (+)	NCBI		MGSCv36	mm8
Celera	5	112,424,239 - 112,430,116 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	56.05	NCBI

Srsf9
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	11,175,760 - 11,183,597 (+)	Ensembl
ChiLan1.0	NW_004955455	11,175,760 - 11,183,597 (+)	NCBI	ChiLan1.0	ChiLan1.0

SRSF9
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	128,530,009 - 128,538,799 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	128,526,386 - 128,535,176 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	118,043,325 - 118,052,107 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	121,417,557 - 121,425,708 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	121,417,557 - 121,425,708 (-)	Ensembl			panPan2	panpan1.1

SRSF9
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	16,363,275 - 16,369,699 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	16,363,475 - 16,369,666 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	16,366,878 - 16,373,300 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	16,630,436 - 16,636,863 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	16,626,148 - 16,636,878 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	16,590,501 - 16,596,923 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	16,667,211 - 16,673,632 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	16,709,046 - 16,715,469 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Srsf9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	145,986,030 - 145,992,687 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936668	484,917 - 495,699 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936668	484,922 - 491,576 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SRSF9
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	40,419,093 - 40,434,047 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	40,425,412 - 40,433,950 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	42,892,690 - 42,901,227 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SRSF9
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	115,813,964 - 115,822,753 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	115,810,642 - 115,822,700 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	129,277,674 - 129,286,477 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Srsf9
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	13,201,217 - 13,209,481 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	13,202,014 - 13,212,611 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Srsf9
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	38,489,549 - 38,495,673 (-)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	73
Count of miRNA genes:	61
Interacting mature miRNAs:	65
Transcripts:	ENSRNOT00000001539
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	50386405	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	37764145	51558799	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	33700432	51558799	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	49212240	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	44139558	52308831	Rat

Markers in Region

D12Got215

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	12	46,942,864 - 46,943,104 (+)	Marker Load Pipeline
mRatBN7.2	12	41,282,141 - 41,282,381 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	47,043,740 - 47,043,979	NCBI	Rnor6.0
Rnor_5.0	12	48,837,056 - 48,837,295	UniSTS	Rnor5.0
RGSC_v3.4	12	42,550,247 - 42,550,486	UniSTS	RGSC3.4
Celera	12	42,903,090 - 42,903,329	UniSTS
Cytogenetic Map	12	q16	UniSTS

RH141055

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	41,278,246 - 41,278,445 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	47,039,736 - 47,039,934	NCBI	Rnor6.0
Rnor_5.0	12	48,833,052 - 48,833,250	UniSTS	Rnor5.0
RGSC_v3.4	12	42,546,352 - 42,546,550	UniSTS	RGSC3.4
Celera	12	42,899,195 - 42,899,393	UniSTS
Cytogenetic Map	12	q16	UniSTS

AU046359

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	41,282,188 - 41,282,363 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	47,043,787 - 47,043,961	NCBI	Rnor6.0
Rnor_5.0	12	48,837,103 - 48,837,277	UniSTS	Rnor5.0
RGSC_v3.4	12	42,550,294 - 42,550,468	UniSTS	RGSC3.4
Celera	12	42,903,137 - 42,903,311	UniSTS
Cytogenetic Map	12	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001009255	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010056379	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC087684	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001536 ⟹ ENSRNOP00000001536

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	41,275,687 - 41,284,499 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000001539 ⟹ ENSRNOP00000001539

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	46,938,950 - 46,945,283 (-)	Ensembl
mRatBN7.2 Ensembl	12	41,278,227 - 41,284,499 (-)	Ensembl
Rnor_6.0 Ensembl	12	47,039,716 - 47,046,022 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106311 ⟹ ENSRNOP00000095591

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	46,938,950 - 46,945,134 (-)	Ensembl
mRatBN7.2 Ensembl	12	41,278,232 - 41,284,412 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112601 ⟹ ENSRNOP00000081626

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	46,938,950 - 46,945,091 (-)	Ensembl
mRatBN7.2 Ensembl	12	41,278,402 - 41,284,029 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000115290 ⟹ ENSRNOP00000092881

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	41,278,227 - 41,283,115 (-)	Ensembl

RefSeq Acc Id:

NM_001009255 ⟹ NP_001009255

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,938,948 - 46,945,147 (-)	NCBI
mRatBN7.2	12	41,278,225 - 41,284,424 (-)	NCBI
Rnor_6.0	12	47,039,714 - 47,046,022 (-)	NCBI
Rnor_5.0	12	48,833,030 - 48,839,338 (-)	NCBI
RGSC_v3.4	12	42,546,330 - 42,552,590 (-)	RGD
Celera	12	42,899,173 - 42,905,366 (-)	RGD

Sequence:

show sequence

CCGGGCTGAGGAGGCGGCTGCGGGAAGTGGGCTGCGGCGGGCCCGCGGCGTCGGGTGGTGCGGA
TGTCGGGCTGGGCGGACGAGCGCGGCGGTGAGGGCGACGGGCGCATCTACGTGGGCAACCTTCC
GACCGACGTGCGTGAGAAGGACCTCGAGGATCTGTTTTACAAGTACGGTCGCATCCGCGAGATT
GAGCTCAAGAACCGGCACGGCCTCGTGCCCTTCGCCTTCGTGCGCTTCGAGGACCCGCGAGATG
CTGAGGATGCCATCTATGGAAGAAACGGTTATGACTACGGCCAGTGTCGACTCCGGGTGGAATT
CCCCAGGGCTTACGGAGGTCGGGGAGGGTGGCCCCGAGCCTCGAGGAACGGGCCTCCTACAAGA
CGATCAGATTTCCGAGTTCTTGTTTCAGGGCTTCCTCCATCCGGCAGCTGGCAGGACCTGAAGG
ATCACATGCGCGAAGCTGGGGATGTCTGTTACGCAGACGTACAGAAGGACGGAATGGGGATGGT
TGAATATTTGAGGAAAGAAGACATGGAATATGCTCTGCGGAAACTGGATGACACCAAATTCCGC
TCTCACGAGGGTGAGACTTCGTACATCCGGGTGTATCCTGAGAGGGGCACCAGCTATGGCTGCT
CGAGGTCGCGGTCGGGGTCCAGGGGCCGTGACTCTCCATACCAAAGCCGGGGCTCGCCACACTA
CTTCTCTCCGTTCAGGCCCTACTGAGGAGGCGGCGGGAGGGCTCTCTTCAGGTTTTTTTGAAGA
GCTGAGCTGCTTTGTGCTCAGTGTCTACATTCCAGATCGATAACTTAGTGTCTTAGGAAAGTCC
TTAATTTCTCCTCCCCCCCCCTTTTTTTTTTCTTTTTTAAGGAGCTACGTAATTTCGACCAGAG
CCACTGTGCTAGCAGGGACATGTTTTAGACTGCAGAGATAGAAGTCATGGCTTTGGTTCAGGGA
CAAGTTGTATATTTTTCACCCCTGATTATGGGACAGAGATCAGTGCTGCATCTTTATGGGCTGC
TCTGCTCTGGACATCAGCAGCCACACGGCCGAGTCGCCCACTGTGTTTAGAAATATATTTTAAA
TGTTTAGTAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XR_010056379

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,939,741 - 46,945,213 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001009255	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH87684	(Get FASTA)	NCBI Sequence Viewer
	EDM13891	(Get FASTA)	NCBI Sequence Viewer
	EDM13892	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001539.3
	ENSRNOP00000095591
GenBank Protein	Q5PPI1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001009255 ⟸ NM_001009255

- UniProtKB:

Q5PPI1 (UniProtKB/Swiss-Prot), A6J1V2 (UniProtKB/TrEMBL), A0A8I6B311 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGWADERGGEGDGRIYVGNLPTDVREKDLEDLFYKYGRIREIELKNRHGLVPFAFVRFEDPRD
AEDAIYGRNGYDYGQCRLRVEFPRAYGGRGGWPRASRNGPPTRRSDFRVLVSGLPPSGSWQDLK
DHMREAGDVCYADVQKDGMGMVEYLRKEDMEYALRKLDDTKFRSHEGETSYIRVYPERGTSYGC
SRSRSGSRGRDSPYQSRGSPHYFSPFRPY

hide sequence

Ensembl Acc Id:

ENSRNOP00000001539 ⟸ ENSRNOT00000001539

Ensembl Acc Id:

ENSRNOP00000095591 ⟸ ENSRNOT00000106311

Ensembl Acc Id:

ENSRNOP00000092881 ⟸ ENSRNOT00000115290

Ensembl Acc Id:

ENSRNOP00000081626 ⟸ ENSRNOT00000112601

Ensembl Acc Id:

ENSRNOP00000001536 ⟸ ENSRNOT00000001536

Protein Domains

RRM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5PPI1-F1-model_v2	AlphaFold	Q5PPI1	1-221	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698694

Promoter ID:

EPDNEW_R9219

Type:

initiation region

Name:

Srsf9_1

Description:

serine and arginine rich splicing factor 9

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	47,046,077 - 47,046,137	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309495	AgrOrtholog
BioCyc Gene	G2FUF-18985	BioCyc
Ensembl Genes	ENSRNOG00000001163	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000001539.5	UniProtKB/Swiss-Prot
	ENSRNOT00000106311	ENTREZGENE
Gene3D-CATH	3.30.70.330	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7309111	IMAGE-MGC_LOAD
InterPro	Nucleotide-bd_a/b_plait_sf	UniProtKB/Swiss-Prot
	RBD_domain_sf	UniProtKB/Swiss-Prot
	RRM_dom	UniProtKB/Swiss-Prot
	RRT5_SRSF_SR	UniProtKB/Swiss-Prot
	SRSF9_RRM1	UniProtKB/Swiss-Prot
	SRSF9_RRM2	UniProtKB/Swiss-Prot
KEGG Report	rno:288701	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105562	IMAGE-MGC_LOAD
NCBI Gene	288701	ENTREZGENE
PANTHER	RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN	UniProtKB/Swiss-Prot
	RRM DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot
Pfam	RRM_1	UniProtKB/Swiss-Prot
PhenoGen	Srsf9	PhenoGen
PROSITE	RRM	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000001163	RatGTEx
SMART	RRM	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF54928	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZVE6_RAT	UniProtKB/TrEMBL
	A0A8I6B311	ENTREZGENE, UniProtKB/TrEMBL
	A6J1V2	ENTREZGENE, UniProtKB/TrEMBL
	Q5PPI1	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-15	Srsf9	serine and arginine rich splicing factor 9	Srsf9	serine/arginine-rich splicing factor 9	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-01	Srsf9	serine/arginine-rich splicing factor 9	Sfrs9	splicing factor, arginine/serine-rich 9	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-09-20	Sfrs9	splicing factor, arginine/serine-rich 9	Srsf9	serine/arginine-rich splicing factor 9	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-09-14	Srsf9	serine/arginine-rich splicing factor 9	Sfrs9	splicing factor, arginine/serine rich 9	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Sfrs9	splicing factor, arginine/serine rich 9	Sfrs9_predicted	splicing factor, arginine/serine rich 9 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Sfrs9_predicted	splicing factor, arginine/serine rich 9 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

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Imported Disease Annotations - CTD

RGD Manual Annotations