Zcchc14 (zinc finger CCHC-type containing 14) - Rat Genome Database

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Pathways
Gene: Zcchc14 (zinc finger CCHC-type containing 14) Rattus norvegicus
Analyze
Symbol: Zcchc14
Name: zinc finger CCHC-type containing 14
RGD ID: 1309494
Description: Predicted to enable nucleic acid binding activity; phosphatidylinositol binding activity; and zinc ion binding activity. Orthologous to human ZCCHC14 (zinc finger CCHC-type containing 14); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC365018; RGD1309494; similar to M-BDG29; zinc finger CCHC domain-containing protein 14; zinc finger, CCHC domain containing 14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81966,582,800 - 66,627,136 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1966,582,800 - 66,627,136 (-)EnsemblGRCr8
mRatBN7.21949,674,185 - 49,718,004 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1949,674,195 - 49,718,029 (-)EnsemblmRatBN7.2
Rnor_6.01953,644,500 - 53,688,624 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1953,647,815 - 53,688,597 (-)Ensemblrn6Rnor6.0
Rnor_5.01964,381,938 - 64,426,070 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41951,858,907 - 51,899,663 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1948,921,002 - 48,964,690 (-)NCBICelera
RGSC_v3.11951,863,747 - 51,904,544 (-)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
stroke  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Zcchc14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81966,582,800 - 66,627,136 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1966,582,800 - 66,627,136 (-)EnsemblGRCr8
mRatBN7.21949,674,185 - 49,718,004 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1949,674,195 - 49,718,029 (-)EnsemblmRatBN7.2
Rnor_6.01953,644,500 - 53,688,624 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1953,647,815 - 53,688,597 (-)Ensemblrn6Rnor6.0
Rnor_5.01964,381,938 - 64,426,070 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41951,858,907 - 51,899,663 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1948,921,002 - 48,964,690 (-)NCBICelera
RGSC_v3.11951,863,747 - 51,904,544 (-)NCBI
Cytogenetic Map19q12NCBI
ZCCHC14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381687,406,248 - 87,493,024 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1687,406,246 - 87,493,024 (-)Ensemblhg38GRCh38
GRCh371687,439,854 - 87,526,630 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361685,997,353 - 86,082,961 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341685,997,363 - 86,082,966NCBI
Celera1671,736,619 - 71,822,230 (-)NCBICelera
Cytogenetic Map16q24.2NCBI
HuRef1673,182,266 - 73,267,848 (-)NCBIHuRef
CHM1_11688,851,639 - 88,937,191 (-)NCBICHM1_1
T2T-CHM13v2.01693,477,129 - 93,563,941 (-)NCBIT2T-CHM13v2.0
Zcchc14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398122,325,442 - 122,379,662 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8122,325,442 - 122,379,640 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388121,598,697 - 121,652,791 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8121,598,703 - 121,652,901 (-)Ensemblmm10GRCm38
MGSCv378124,122,603 - 124,175,833 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368124,485,528 - 124,538,023 (-)NCBIMGSCv36mm8
Celera8125,820,046 - 125,873,474 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map870.67NCBI
Zcchc14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555411,872,624 - 1,909,779 (-)Ensembl
ChiLan1.0NW_0049555411,872,624 - 1,909,723 (-)NCBIChiLan1.0ChiLan1.0
ZCCHC14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21897,165,154 - 97,251,845 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116103,079,289 - 103,168,696 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01668,078,237 - 68,165,406 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11687,401,184 - 87,486,124 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1687,401,184 - 87,486,124 (-)EnsemblpanPan2panpan1.1
ZCCHC14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1565,611,032 - 65,667,162 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl565,611,026 - 65,664,923 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha565,622,560 - 65,679,884 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0565,832,428 - 65,889,740 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl565,830,308 - 65,887,136 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1565,857,317 - 65,914,597 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0565,689,172 - 65,746,484 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0566,103,133 - 66,160,629 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Zcchc14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934925,975,048 - 26,030,891 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366411,728,592 - 1,781,896 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366411,728,596 - 1,783,710 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZCCHC14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl61,850,051 - 1,918,704 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.161,849,974 - 1,917,601 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.261,937,818 - 2,005,535 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZCCHC14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1572,776,249 - 72,863,957 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl572,780,300 - 72,863,860 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660472,832,207 - 2,920,201 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zcchc14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247463,097,565 - 3,138,799 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247463,096,644 - 3,138,825 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Zcchc14
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11741,261,426 - 41,306,726 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:92
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000058486, ENSRNOT00000074448
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
BF393292  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21949,782,583 - 49,782,699 (+)MAPPERmRatBN7.2
Rnor_6.01954,541,965 - 54,542,080NCBIRnor6.0
Rnor_5.01965,257,497 - 65,257,612UniSTSRnor5.0
RGSC_v3.41951,964,744 - 51,964,859UniSTSRGSC3.4
Celera1949,029,216 - 49,029,331UniSTS
RH 3.4 Map19682.8UniSTS
Cytogenetic Map19q12UniSTS
RH137961  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21949,785,460 - 49,785,699 (+)MAPPERmRatBN7.2
Rnor_6.01954,544,842 - 54,545,080NCBIRnor6.0
Rnor_5.01965,260,374 - 65,260,612UniSTSRnor5.0
RGSC_v3.41951,967,621 - 51,967,859UniSTSRGSC3.4
Celera1949,032,093 - 49,032,331UniSTS
RH 3.4 Map19682.8UniSTS
Cytogenetic Map19q12UniSTS
RH140237  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2269,249,793 - 69,249,977 (+)MAPPERmRatBN7.2
mRatBN7.21949,675,973 - 49,676,157 (+)MAPPERmRatBN7.2
Rnor_6.0270,037,784 - 70,037,967NCBIRnor6.0
Rnor_6.01953,646,289 - 53,646,472NCBIRnor6.0
Rnor_5.01964,383,724 - 64,383,907UniSTSRnor5.0
Rnor_5.0289,761,299 - 89,761,482UniSTSRnor5.0
RGSC_v3.4270,110,996 - 70,111,179UniSTSRGSC3.4
RGSC_v3.41951,857,182 - 51,857,365UniSTSRGSC3.4
Celera1948,922,792 - 48,922,975UniSTS
Celera265,106,837 - 65,107,020UniSTS
RH 3.4 Map19696.5UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000074448   ⟹   ENSRNOP00000064290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1966,582,800 - 66,627,136 (-)Ensembl
mRatBN7.2 Ensembl1949,674,195 - 49,718,029 (-)Ensembl
Rnor_6.0 Ensembl1953,647,815 - 53,688,597 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000153213   ⟹   ENSRNOP00000105060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1966,582,800 - 66,627,136 (-)Ensembl
RefSeq Acc Id: NM_001427306   ⟹   NP_001414235
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81966,582,800 - 66,627,136 (-)NCBI
RefSeq Acc Id: XM_006255732   ⟹   XP_006255794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81966,582,800 - 66,626,617 (-)NCBI
mRatBN7.21949,674,185 - 49,718,004 (-)NCBI
Rnor_6.01953,644,500 - 53,688,624 (-)NCBI
Rnor_5.01964,381,938 - 64,426,070 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098193   ⟹   XP_038954121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81966,582,800 - 66,626,617 (-)NCBI
mRatBN7.21949,674,185 - 49,718,004 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414235 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255794 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954121 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92728 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064290
  ENSRNOP00000064290.2
  ENSRNOP00000105060
  ENSRNOP00000105060.1
RefSeq Acc Id: XP_006255794   ⟸   XM_006255732
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000064290   ⟸   ENSRNOT00000074448
RefSeq Acc Id: XP_038954121   ⟸   XM_039098193
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001414235   ⟸   NM_001427306
- UniProtKB: M0R4K3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105060   ⟸   ENSRNOT00000153213
Protein Domains
CCHC-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R4K3-F1-model_v2 AlphaFold M0R4K3 1-1087 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309494 AgrOrtholog
BioCyc Gene G2FUF-5426 BioCyc
Ensembl Genes ENSRNOG00000018226 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074448 ENTREZGENE
  ENSRNOT00000074448.4 UniProtKB/TrEMBL
  ENSRNOT00000153213 ENTREZGENE
  ENSRNOT00000153213.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  3.30.1520.10 UniProtKB/TrEMBL
  Zinc finger, CCHC-type UniProtKB/TrEMBL
InterPro PX_dom_sf UniProtKB/TrEMBL
  SAM/pointed UniProtKB/TrEMBL
  Vts1_dom UniProtKB/TrEMBL
  ZCCH14_SAM UniProtKB/TrEMBL
  ZCCHC14 UniProtKB/TrEMBL
  Znf_CCHC UniProtKB/TrEMBL
  Znf_CCHC_sf UniProtKB/TrEMBL
NCBI Gene 365018 ENTREZGENE
PANTHER PTHR16195 UniProtKB/TrEMBL
  ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 14 UniProtKB/TrEMBL
Pfam Vts1 UniProtKB/TrEMBL
  zf-CCHC UniProtKB/TrEMBL
PhenoGen Zcchc14 PhenoGen
PROSITE ZF_CCHC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018226 RatGTEx
SMART ZnF_C2HC UniProtKB/TrEMBL
Superfamily-SCOP 64268 UniProtKB/TrEMBL
  SAM_homology UniProtKB/TrEMBL
  SSF57756 UniProtKB/TrEMBL
UniProt A0ABK0LSA9_RAT UniProtKB/TrEMBL
  M0R4K3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Zcchc14  zinc finger CCHC-type containing 14  Zcchc14  zinc finger, CCHC domain containing 14  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Zcchc14  zinc finger, CCHC domain containing 14   Zcchc14_predicted  zinc finger, CCHC domain containing 14 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Zcchc14_predicted  zinc finger, CCHC domain containing 14 (predicted)  RGD1309494_predicted  similar to M-BDG29 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1309494_predicted  similar to M-BDG29 (predicted)  LOC365018_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC365018_predicted  similar to M-BDG29 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL