Trem1 (triggering receptor expressed on myeloid cells 1) - Rat Genome Database

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Gene: Trem1 (triggering receptor expressed on myeloid cells 1) Rattus norvegicus
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Symbol: Trem1
Name: triggering receptor expressed on myeloid cells 1
RGD ID: 1309467
Description: Predicted to enable receptor decoy activity; scaffold protein binding activity; and transmembrane signaling receptor activity. Involved in several processes, including cellular response to lipopolysaccharide; cellular response to vitamin D; and positive regulation of macrophage chemotaxis. Predicted to be located in plasma membrane. Predicted to be active in cell surface and extracellular space. Used to study several diseases, including acute pancreatitis; bacterial sepsis; mesenteric vascular occlusion; middle cerebral artery infarction; and pleural empyema. Biomarker of congestive heart failure; depressive disorder; periodontitis; and rheumatoid arthritis. Human ortholog(s) of this gene implicated in bacterial sepsis and malaria. Orthologous to human TREM1 (triggering receptor expressed on myeloid cells 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC301229
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,259,227 - 20,276,879 (-)NCBIGRCr8
mRatBN7.2912,763,819 - 12,779,285 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,763,819 - 12,779,203 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx921,277,179 - 21,288,238 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,343,405 - 26,354,464 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0924,732,622 - 24,743,689 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0914,727,887 - 14,743,371 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,727,976 - 14,809,447 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0913,649,246 - 13,664,645 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.498,175,081 - 8,186,142 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.198,175,083 - 8,193,441 (-)NCBI
Celera910,535,490 - 10,546,547 (-)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Triggering receptor expressed on myeloid cells 1 (TREM-1) and cytokine gene variants in complicated and uncomplicated malaria. Adukpo S, etal., Trop Med Int Health. 2016 Dec;21(12):1592-1601. doi: 10.1111/tmi.12787. Epub 2016 Oct 24.
2. TREM-1 Mediates Inflammatory Injury and Cardiac Remodeling Following Myocardial Infarction. Boufenzer A, etal., Circ Res. 2015 May 22;116(11):1772-82. doi: 10.1161/CIRCRESAHA.116.305628. Epub 2015 Apr 3.
3. Triggering receptor expressed on myeloid cells-1 (TREM-1) modulates immune responses to Aspergillus fumigatus during fungal asthma in mice. Buckland KF, etal., Immunol Invest. 2011;40(7-8):692-722. doi: 10.3109/08820139.2011.578270. Epub 2011 May 19.
4. Triggering receptor expressed on myeloid cells (TREM)-1 participates in Schistosoma mansoni inflammatory responses. Cheng PC, etal., Parasite Immunol. 2011 May;33(5):276-86. doi: 10.1111/j.1365-3024.2011.01284.x.
5. Soluble triggering receptor expressed on myeloid cells 1: a biomarker for bacterial meningitis. Determann RM, etal., Intensive Care Med. 2006 Aug;32(8):1243-7. doi: 10.1007/s00134-006-0240-4. Epub 2006 Jun 20.
6. Triptolide Modulates TREM-1 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis. Fan D, etal., Int J Mol Sci. 2016 Apr 2;17(4):498. doi: 10.3390/ijms17040498.
7. Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats via Regulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in the Hippocampus and PFC. Fang K, etal., Front Pharmacol. 2020 Jan 17;10:1544. doi: 10.3389/fphar.2019.01544. eCollection 2019.
8. Role of TREM-1 in pulmonary tuberculosis patients- analysis of serum soluble TREM-1 levels. Feng JY, etal., Sci Rep. 2018 May 29;8(1):8223. doi: 10.1038/s41598-018-26478-2.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Effects of the TREM-1 pathway modulation during mesenteric ischemia-reperfusion in rats. Gibot S, etal., Crit Care Med. 2008 Feb;36(2):504-10. doi: 10.1097/01.CCM.0B013E318161FAF3.
11. TREM-1 promotes survival during septic shock in mice. Gibot S, etal., Eur J Immunol. 2007 Feb;37(2):456-66. doi: 10.1002/eji.200636387.
12. Modulation of the triggering receptor expressed on myeloid cells-1 pathway during pneumonia in rats. Gibot S, etal., J Infect Dis. 2006 Oct 1;194(7):975-83. doi: 10.1086/506950. Epub 2006 Aug 29.
13. Effects of the TREM 1 pathway modulation during hemorrhagic shock in rats. Gibot S, etal., Shock. 2009 Dec;32(6):633-7. doi: 10.1097/SHK.0b013e3181a53842.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. In familial Mediterranean fever, soluble TREM-1 plasma level is higher in case of amyloidosis. Gorlier C, etal., Innate Immun. 2019 Nov;25(8):487-490. doi: 10.1177/1753425919870847. Epub 2019 Aug 31.
16. Triggering receptor expressed on myeloid cells-1 (TREM-1) improves host defence in pneumococcal pneumonia. Hommes TJ, etal., J Pathol. 2014 Aug;233(4):357-67. doi: 10.1002/path.4361. Epub 2014 Jun 3.
17. HIV and HCV augments inflammatory responses through increased TREM-1 expression and signaling in Kupffer and Myeloid cells. Hyun J, etal., PLoS Pathog. 2019 Jul 1;15(7):e1007883. doi: 10.1371/journal.ppat.1007883. eCollection 2019 Jul.
18. Forsythoside B protects against experimental sepsis by modulating inflammatory factors. Jiang WL, etal., Phytother Res. 2012 Jul;26(7):981-7. doi: 10.1002/ptr.3668. Epub 2011 Dec 6.
19. Role of triggering receptor expressed on myeloid cells-1 in experimental severe acute pancreatitis. Kamei K, etal., J Hepatobiliary Pancreat Sci. 2010 May;17(3):305-12. doi: 10.1007/s00534-009-0191-6. Epub 2009 Sep 29.
20. Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia. Knapp S, etal., J Immunol. 2004 Dec 15;173(12):7131-4. doi: 10.4049/jimmunol.173.12.7131.
21. Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils. Kozik JH, etal., Sci Rep. 2016 Jun 22;6:28556. doi: 10.1038/srep28556.
22. Amniotic fluid sTREM-1 in normal pregnancy, spontaneous parturition at term and preterm, and intra-amniotic infection/inflammation. Kusanovic JP, etal., J Matern Fetal Neonatal Med. 2010 Jan;23(1):34-47. doi: 10.3109/14767050903009248.
23. TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia. Lagler H, etal., J Immunol. 2009 Aug 1;183(3):2027-36. doi: 10.4049/jimmunol.0803862. Epub 2009 Jul 13.
24. TREM-1-targeting LP17 attenuates cerebral ischemia-induced neuronal injury by inhibiting oxidative stress and pyroptosis. Liang YB, etal., Biochem Biophys Res Commun. 2020 Aug 27;529(3):554-561. doi: 10.1016/j.bbrc.2020.05.056. Epub 2020 Jul 15.
25. TREM-1 promotes survival during Klebsiella pneumoniae liver abscess in mice. Lin YT, etal., Infect Immun. 2014 Mar;82(3):1335-42. doi: 10.1128/IAI.01347-13. Epub 2014 Jan 6.
26. High Expression Levels of Trigger Receptor Expressed on Myeloid Cells-1 on Neutrophils Associated with Increased Severity of Acute Pancreatitis in Mice. Liu M, etal., Biol Pharm Bull. 2015;38(10):1450-7. doi: 10.1248/bpb.b15-00057. Epub 2015 Aug 5.
27. Etomidate Mitigates Lipopolysaccharide-Induced CD14 and TREM-1 Expression, NF-κB Activation, and Pro-inflammatory Cytokine Production in Rat Macrophages. Liu M, etal., Inflammation. 2016 Feb;39(1):327-335. doi: 10.1007/s10753-015-0253-7.
28. Effects of the TREM-1 pathway modulation during empyema in rats. Luo L, etal., Chin Med J (Engl). 2010 Jun;123(12):1561-5.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Triggering receptor expressed on myeloid cells-1 (TREM-1) expression on gastric epithelium: implication for a role of TREM-1 in Helicobacter pylori infection. Schmausser B, etal., Clin Exp Immunol. 2008 Apr;152(1):88-94. doi: 10.1111/j.1365-2249.2008.03608.x.
32. Value of soluble TREM-1, procalcitonin, and C-reactive protein serum levels as biomarkers for detecting bacteremia among sepsis patients with new fever in intensive care units: a prospective cohort study. Su L, etal., BMC Infect Dis. 2012 Jul 18;12:157. doi: 10.1186/1471-2334-12-157.
33. Role of TREM-1 in the development of early brain injury after subarachnoid hemorrhage. Sun XG, etal., Exp Neurol. 2021 Jul;341:113692. doi: 10.1016/j.expneurol.2021.113692. Epub 2021 Mar 13.
34. Inhibition of TREM-1 attenuates early brain injury after subarachnoid hemorrhage via downregulation of p38MAPK/MMP-9 and preservation of ZO-1. Sun XG, etal., Neuroscience. 2019 May 15;406:369-375. doi: 10.1016/j.neuroscience.2019.03.032. Epub 2019 Mar 23.
35. Association of Inflammatory Responses and ECM Disorganization with HMGB1 Upregulation and NLRP3 Inflammasome Activation in the Injured Rotator Cuff Tendon. Thankam FG, etal., Sci Rep. 2018 Jun 11;8(1):8918. doi: 10.1038/s41598-018-27250-2.
36. Azithromycin acts as an immunomodulatory agent to suppress the expression of TREM-1 in Bacillus pyocyaneus-induced sepsis. Tong J, etal., Immunol Lett. 2011 Aug 30;138(2):137-43. doi: 10.1016/j.imlet.2011.04.001. Epub 2011 Apr 9.
37. Gene expression analysis of TREM1 and GRK2 in polymorphonuclear leukocytes as the surrogate biomarkers of acute bacterial infections. Ubagai T, etal., Int J Med Sci. 2014 Jan 10;11(2):215-21. doi: 10.7150/ijms.7231. eCollection 2014.
38. Evaluation of TREM1 gene expression in circulating polymorphonuclear leukocytes and its inverse correlation with the severity of pathophysiological conditions in patients with acute bacterial infections. Ubagai T, etal., Jpn J Infect Dis. 2012;65(5):376-82. doi: 10.7883/yoken.65.376.
39. TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance. Weber B, etal., PLoS Pathog. 2014 Jan;10(1):e1003900. doi: 10.1371/journal.ppat.1003900. Epub 2014 Jan 16.
40. [The effect of signal transduction pathway of triggering receptor-1 expressed on myeloid cells in acute lung injury induced by paraquat in rats]. Wei M, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2015 Sep;33(9):646-51.
41. Expression profile and function of triggering receptor expressed on myeloid cells-1 during melioidosis. Wiersinga WJ, etal., J Infect Dis. 2007 Dec 1;196(11):1707-16. doi: 10.1086/522141. Epub 2007 Oct 25.
42. [Temporal expression of triggering receptors expressed by myeloid cells-1 during the development of experimental periodontitis in rat]. Wu WC, etal., Zhonghua Kou Qiang Yi Xue Za Zhi. 2018 Mar 9;53(3):157-163. doi: 10.3760/cma.j.issn.1002-0098.2018.03.003.
43. Shengxian decoction decreases doxorubicin‑induced cardiac apoptosis by regulating the TREM1/NF‑κB signaling pathway. Yao L, etal., Mol Med Rep. 2021 Mar;23(3). pii: 219. doi: 10.3892/mmr.2021.11858. Epub 2021 Jan 26.
44. Active vitamin D regulates macrophage M1/M2 phenotypes via the STAT-1-TREM-1 pathway in diabetic nephropathy. Zhang X, etal., J Cell Physiol. 2019 May;234(5):6917-6926. doi: 10.1002/jcp.27450. Epub 2018 Nov 27.
45. Vitamin D suppresses macrophage infiltration by down-regulation of TREM-1 in diabetic nephropathy rats. Zhao Y, etal., Mol Cell Endocrinol. 2018 Sep 15;473:44-52. doi: 10.1016/j.mce.2018.01.001. Epub 2018 Jan 10.
46. Inhibition of TREM-1 and Dectin-1 Alleviates the Severity of Fungal Keratitis by Modulating Innate Immune Responses. Zhong J, etal., PLoS One. 2016 Mar 10;11(3):e0150114. doi: 10.1371/journal.pone.0150114. eCollection 2016.
47. Inhibition of triggering receptor expressed on myeloid cells-1 ameliorates experimental autoimmune neuritis. Zhou X, etal., Mol Med Rep. 2017 Apr;15(4):1565-1570. doi: 10.3892/mmr.2017.6167. Epub 2017 Feb 6.
48. TREM-1 deficiency attenuates the inflammatory responses in LPS-induced murine endometritis. Zhu H, etal., Microb Biotechnol. 2019 Nov;12(6):1337-1345. doi: 10.1111/1751-7915.13467. Epub 2019 Jul 31.
Additional References at PubMed
PMID:11602640   PMID:22883093   PMID:23241959  


Genomics

Comparative Map Data
Trem1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,259,227 - 20,276,879 (-)NCBIGRCr8
mRatBN7.2912,763,819 - 12,779,285 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,763,819 - 12,779,203 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx921,277,179 - 21,288,238 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,343,405 - 26,354,464 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0924,732,622 - 24,743,689 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0914,727,887 - 14,743,371 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,727,976 - 14,809,447 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0913,649,246 - 13,664,645 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.498,175,081 - 8,186,142 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.198,175,083 - 8,193,441 (-)NCBI
Celera910,535,490 - 10,546,547 (-)NCBICelera
Cytogenetic Map9q12NCBI
TREM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,267,385 - 41,286,682 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,267,100 - 41,286,682 (-)EnsemblGRCh38hg38GRCh38
GRCh37641,235,123 - 41,254,420 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,351,690 - 41,362,435 (-)NCBINCBI36Build 36hg18NCBI36
Build 34641,351,689 - 41,362,435NCBI
Celera642,797,142 - 42,807,885 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef640,961,518 - 40,972,978 (-)NCBIHuRef
CHM1_1641,246,251 - 41,257,709 (-)NCBICHM1_1
T2T-CHM13v2.0641,096,688 - 41,115,965 (-)NCBIT2T-CHM13v2.0
Trem1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391748,539,763 - 48,553,955 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1748,539,796 - 48,553,952 (+)EnsemblGRCm39 Ensembl
GRCm381748,232,713 - 48,246,927 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1748,232,768 - 48,246,924 (+)EnsemblGRCm38mm10GRCm38
MGSCv371748,371,922 - 48,386,091 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361747,698,178 - 47,712,333 (+)NCBIMGSCv36mm8
Celera1751,668,001 - 51,682,161 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1723.99NCBI
TREM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2555,770,728 - 55,782,228 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1651,639,052 - 51,652,228 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0640,861,283 - 40,874,446 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1642,168,992 - 42,182,134 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,163,337 - 42,183,091 (-)Ensemblpanpan1.1panPan2
TREM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1129,990,678 - 10,000,195 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl129,990,679 - 10,000,236 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1210,020,952 - 10,030,132 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01210,470,281 - 10,479,802 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1210,470,277 - 10,479,839 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11210,002,655 - 10,011,845 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01210,084,374 - 10,093,559 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01210,179,448 - 10,188,597 (-)NCBIUU_Cfam_GSD_1.0
Trem1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,374,752 - 45,385,967 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647618,574,381 - 18,583,647 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647618,577,825 - 18,583,675 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TREM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,510,253 - 36,531,796 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1736,510,253 - 36,531,796 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2741,804,122 - 41,825,672 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TREM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11730,873,647 - 30,885,292 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1730,873,666 - 30,886,967 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604441,275,669 - 41,288,974 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Trem1
144 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:182
Count of miRNA genes:135
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000049193
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9336865213533896Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 43 55 89 89 58 25 58 6 201 90 36 36 51 31

Sequence


Ensembl Acc Id: ENSRNOT00000049193   ⟹   ENSRNOP00000040482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl912,763,819 - 12,779,203 (-)Ensembl
Rnor_6.0 Ensembl914,727,976 - 14,809,447 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106823   ⟹   ENSRNOP00000084138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl912,763,819 - 12,779,176 (-)Ensembl
RefSeq Acc Id: NM_001106885   ⟹   NP_001100355
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,261,408 - 20,272,469 (-)NCBI
mRatBN7.2912,763,819 - 12,774,880 (-)NCBI
Rnor_6.0914,727,887 - 14,738,948 (-)NCBI
Rnor_5.0913,649,246 - 13,664,645 (-)NCBI
RGSC_v3.498,175,081 - 8,186,142 (-)RGD
Celera910,535,490 - 10,546,547 (-)RGD
Sequence:
RefSeq Acc Id: XM_039083174   ⟹   XP_038939102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,259,227 - 20,276,879 (-)NCBI
mRatBN7.2912,763,822 - 12,779,285 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100355 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939102 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18917 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000040482.4
  ENSRNOP00000084138.1
RefSeq Acc Id: NP_001100355   ⟸   NM_001106885
- UniProtKB: A6JIG5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000040482   ⟸   ENSRNOT00000049193
RefSeq Acc Id: XP_038939102   ⟸   XM_039083174
- Peptide Label: isoform X1
- UniProtKB: D4ABU7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084138   ⟸   ENSRNOT00000106823
Protein Domains
Ig-like   Immunoglobulin V-set

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ABU7-F1-model_v2 AlphaFold D4ABU7 1-226 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309467 AgrOrtholog
BioCyc Gene G2FUF-28296 BioCyc
Ensembl Genes ENSRNOG00000022859 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049193.5 UniProtKB/TrEMBL
  ENSRNOT00000106823.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
KEGG Report rno:301229 UniProtKB/TrEMBL
NCBI Gene 301229 ENTREZGENE
PANTHER PTHR19357:SF0 UniProtKB/TrEMBL
  TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1 UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
PhenoGen Trem1 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022859 RatGTEx
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A8I5ZYI0_RAT UniProtKB/TrEMBL
  A6JIG5 ENTREZGENE, UniProtKB/TrEMBL
  D4ABU7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Trem1  triggering receptor expressed on myeloid cells 1   Trem1_predicted  triggering receptor expressed on myeloid cells 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Trem1_predicted  triggering receptor expressed on myeloid cells 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED