Rig1 (RNA sensor RIG-1) - Rat Genome Database

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Gene: Rig1 (RNA sensor RIG-1) Rattus norvegicus
Analyze
Symbol: Rig1
Name: RNA sensor RIG-1
RGD ID: 1309460
Description: Predicted to enable several functions, including ATP hydrolysis activity; GTP binding activity; and RNA binding activity. Predicted to be involved in several processes, including positive regulation of cytokine production; regulation of defense response; and response to virus. Predicted to act upstream of or within mRNA transcription and response to exogenous dsRNA. Predicted to be located in actin cytoskeleton; bicellular tight junction; and ruffle membrane. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm. Orthologous to human RIGI (RNA sensor RIG-I); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: antiviral innate immune response receptor RIG-I; Ddx58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; DEXD/H-box helicase 58; LOC297989; probable ATP-dependent RNA helicase DDX58; Rigi
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8560,117,398 - 60,165,995 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl560,117,398 - 60,165,995 (-)EnsemblGRCr8
mRatBN7.2555,321,351 - 55,369,947 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl555,321,235 - 55,370,819 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx557,286,594 - 57,336,136 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0559,105,729 - 59,155,277 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0559,077,158 - 59,126,758 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0556,486,584 - 56,536,898 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl556,500,734 - 56,536,772 (-)Ensemblrn6Rnor6.0
Rnor_5.0561,033,071 - 61,080,788 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4557,597,131 - 57,645,147 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera553,939,534 - 53,986,275 (-)NCBICelera
RGSC_v3.1557,599,100 - 57,645,200 (-)NCBI
Cytogenetic Map5q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
aconitine  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-phellandrene  (ISO)
amphetamine  (EXP)
aripiprazole  (ISO)
Aroclor 1254  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
cyclosporin A  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethyl malate  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
hydroxychloroquine  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
metam  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP,ISO)
methotrexate  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
Soman  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin cytoskeleton  (IEA,ISO)
bicellular tight junction  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
plasma membrane  (IEA,ISO)
ribonucleoprotein complex  (IEA,ISO)
ruffle membrane  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west Nile virus encephalitis. Noçon AL, etal., J Virol. 2014 Jan;88(1):679-89. doi: 10.1128/JVI.02094-13. Epub 2013 Oct 30.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17079289   PMID:17190814   PMID:17942531   PMID:18243112   PMID:19122199   PMID:19158679   PMID:19211564   PMID:19576794   PMID:19609254   PMID:19631370   PMID:20581823   PMID:21076616  
PMID:21102435   PMID:21478870   PMID:21703541   PMID:21957149   PMID:22314235   PMID:22745163   PMID:23950712   PMID:24409285   PMID:24590070   PMID:26471729   PMID:28469175   PMID:31006531  


Genomics

Comparative Map Data
Rig1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8560,117,398 - 60,165,995 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl560,117,398 - 60,165,995 (-)EnsemblGRCr8
mRatBN7.2555,321,351 - 55,369,947 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl555,321,235 - 55,370,819 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx557,286,594 - 57,336,136 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0559,105,729 - 59,155,277 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0559,077,158 - 59,126,758 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0556,486,584 - 56,536,898 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl556,500,734 - 56,536,772 (-)Ensemblrn6Rnor6.0
Rnor_5.0561,033,071 - 61,080,788 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4557,597,131 - 57,645,147 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera553,939,534 - 53,986,275 (-)NCBICelera
RGSC_v3.1557,599,100 - 57,645,200 (-)NCBI
Cytogenetic Map5q22NCBI
RIGI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38932,455,302 - 32,526,196 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl932,455,302 - 32,526,348 (-)Ensemblhg38GRCh38
GRCh37932,455,300 - 32,526,194 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36932,445,300 - 32,516,322 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34932,445,704 - 32,516,322NCBI
Celera932,385,259 - 32,456,256 (-)NCBICelera
Cytogenetic Map9p21.1NCBI
HuRef932,411,092 - 32,481,542 (-)NCBIHuRef
CHM1_1932,455,159 - 32,526,318 (-)NCBICHM1_1
T2T-CHM13v2.0932,471,227 - 32,542,369 (-)NCBIT2T-CHM13v2.0
Rigi
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39440,203,775 - 40,239,843 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl440,203,773 - 40,239,828 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38440,203,777 - 40,239,825 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl440,203,773 - 40,239,828 (-)Ensemblmm10GRCm38
MGSCv37440,150,810 - 40,186,858 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36440,394,461 - 40,428,372 (-)NCBIMGSCv36mm8
Celera439,866,998 - 39,902,804 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map420.24NCBI
Rigi
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554723,093,939 - 3,133,987 (+)Ensembl
ChiLan1.0NW_0049554723,093,895 - 3,135,524 (+)NCBIChiLan1.0ChiLan1.0
RIGI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21192,088,681 - 92,164,571 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1992,091,345 - 92,178,669 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0932,230,012 - 32,302,159 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1933,040,000 - 33,110,557 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl933,040,000 - 33,110,557 (-)EnsemblpanPan2panpan1.1
RIGI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11149,764,252 - 49,799,626 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1149,764,267 - 49,799,527 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1148,386,814 - 48,422,172 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01150,702,778 - 50,718,163 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11149,368,434 - 49,403,794 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01149,234,998 - 49,270,344 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01149,993,647 - 50,029,015 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rigi
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947164,594,226 - 164,653,026 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365241,140,971 - 1,200,638 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365241,141,840 - 1,200,638 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RIGI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1033,891,763 - 33,933,455 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11033,891,720 - 33,976,151 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21038,145,289 - 38,189,016 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RIGI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11247,729,040 - 47,800,995 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1247,729,076 - 47,799,570 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603844,621,500 - 44,694,693 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rigi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473637,133,059 - 37,197,218 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473637,134,718 - 37,204,543 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rigi
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11117,962,791 - 118,007,380 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rig1
143 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:132
Interacting mature miRNAs:140
Transcripts:ENSRNOT00000060765
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1578774Tcas8Tongue tumor susceptibility QTL 83.47tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)51570745160707451Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000060765   ⟹   ENSRNOP00000057492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl560,117,398 - 60,165,995 (-)Ensembl
mRatBN7.2 Ensembl555,322,103 - 55,369,947 (-)Ensembl
Rnor_6.0 Ensembl556,500,734 - 56,536,772 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107881   ⟹   ENSRNOP00000090460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl560,117,398 - 60,165,864 (-)Ensembl
mRatBN7.2 Ensembl555,322,103 - 55,370,819 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107968   ⟹   ENSRNOP00000094775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl560,117,398 - 60,165,995 (-)Ensembl
mRatBN7.2 Ensembl555,321,235 - 55,369,942 (-)Ensembl
RefSeq Acc Id: NM_001395071   ⟹   NP_001382000
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8560,117,398 - 60,165,995 (-)NCBI
mRatBN7.2555,321,351 - 55,369,947 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001382000 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98628 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057492.6
  ENSRNOP00000090460.1
  ENSRNOP00000094775
  ENSRNOP00000094775.2
Ensembl Acc Id: ENSRNOP00000057492   ⟸   ENSRNOT00000060765
Ensembl Acc Id: ENSRNOP00000090460   ⟸   ENSRNOT00000107881
Ensembl Acc Id: ENSRNOP00000094775   ⟸   ENSRNOT00000107968
RefSeq Acc Id: NP_001382000   ⟸   NM_001395071
- UniProtKB: D4ADT5 (UniProtKB/TrEMBL),   A0A8I6AN81 (UniProtKB/TrEMBL)
Protein Domains
Helicase ATP-binding   Helicase C-terminal   RLR CTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADT5-F1-model_v2 AlphaFold D4ADT5 1-598 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693628
Promoter ID:EPDNEW_R4153
Type:initiation region
Name:Ddx58_1
Description:DEXD/H-box helicase 58
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0556,536,868 - 56,536,928EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309460 AgrOrtholog
BioCyc Gene G2FUF-41606 BioCyc
Ensembl Genes ENSRNOG00000006384 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060765.6 UniProtKB/TrEMBL
  ENSRNOT00000107881.2 UniProtKB/TrEMBL
  ENSRNOT00000107968 ENTREZGENE
  ENSRNOT00000107968.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  1.20.1320.30 UniProtKB/TrEMBL
  2.170.150.30 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro CARD_dom UniProtKB/TrEMBL
  CARD_RIG-I_r2 UniProtKB/TrEMBL
  DEAD-like_N UniProtKB/TrEMBL
  DEAD/DEAH_box_helicase_dom UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RIG-I_C UniProtKB/TrEMBL
  RLR_C_sf UniProtKB/TrEMBL
  RLR_CTR UniProtKB/TrEMBL
  RLR_Helicase UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene 297989 ENTREZGENE
PANTHER ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I UniProtKB/TrEMBL
  HELICASE WITH DEATH DOMAIN-RELATED UniProtKB/TrEMBL
Pfam CARD_2 UniProtKB/TrEMBL
  DEAD UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  RIG-I_C UniProtKB/TrEMBL
  RIG-I_C-RD UniProtKB/TrEMBL
PhenoGen Rig1 PhenoGen
PROSITE HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
  RLR_CTR UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006384 RatGTEx
SMART DEXDc UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6AN81 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GKW7_RAT UniProtKB/TrEMBL
  D4ADT5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-15 Rig1  RNA sensor RIG-1  Ddx58  DEXD/H-box helicase 58  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-13 Ddx58  DEXD/H-box helicase 58  Ddx58  DEAD (Asp-Glu-Ala-Asp) box polypeptide 58  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ddx58  DEAD (Asp-Glu-Ala-Asp) box polypeptide 58   Ddx58_predicted  DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ddx58_predicted  DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (predicted)      Symbol and Name status set to approved 70820 APPROVED