Nlrp12 (NLR family, pyrin domain containing 12) - Rat Genome Database

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Gene: Nlrp12 (NLR family, pyrin domain containing 12) Rattus norvegicus
Analyze
Symbol: Nlrp12
Name: NLR family, pyrin domain containing 12
RGD ID: 1309415
Description: Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in negative regulation of inflammatory response; regulation of macromolecule biosynthetic process; and regulation of signal transduction. Predicted to act upstream of or within cellular response to cytokine stimulus; dendritic cell migration; and regulation of intracellular signal transduction. Predicted to be part of canonical inflammasome complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 2. Orthologous to human NLRP12 (NLR family pyrin domain containing 12); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC292541; NACHT, leucine rich repeat and PYD containing 12; NACHT, LRR and PYD domains-containing protein 12; Nalp12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Nlrp12em1Mcwi
Genetic Models: SS-Nlrp12em1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8174,848,020 - 74,885,945 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl174,848,063 - 74,876,341 (+)EnsemblGRCr8
mRatBN7.2165,932,610 - 65,969,873 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl165,932,595 - 65,960,934 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx171,380,449 - 71,408,567 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,803,424 - 79,831,544 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0173,136,593 - 73,164,746 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0164,506,750 - 64,543,908 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl164,506,735 - 64,534,912 (+)Ensemblrn6Rnor6.0
Rnor_5.0163,493,575 - 63,521,356 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4164,242,875 - 64,271,212 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera163,663,350 - 63,691,368 (+)NCBICelera
RGSC_v3.1164,320,985 - 64,349,047 (+)NCBI
Cytogenetic Map1q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
carnosic acid  (ISO)
choline  (ISO)
curcumin  (ISO)
cyanocob(III)alamin  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (EXP,ISO)
folic acid  (ISO)
genistein  (ISO)
glycine betaine  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
ozone  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
Ptaquiloside  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
XL147  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12019269   PMID:12759408   PMID:16203735   PMID:17237370   PMID:18230725   PMID:20861349   PMID:22503542   PMID:30212649  


Genomics

Comparative Map Data
Nlrp12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8174,848,020 - 74,885,945 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl174,848,063 - 74,876,341 (+)EnsemblGRCr8
mRatBN7.2165,932,610 - 65,969,873 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl165,932,595 - 65,960,934 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx171,380,449 - 71,408,567 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,803,424 - 79,831,544 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0173,136,593 - 73,164,746 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0164,506,750 - 64,543,908 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl164,506,735 - 64,534,912 (+)Ensemblrn6Rnor6.0
Rnor_5.0163,493,575 - 63,521,356 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4164,242,875 - 64,271,212 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera163,663,350 - 63,691,368 (+)NCBICelera
RGSC_v3.1164,320,985 - 64,349,047 (+)NCBI
Cytogenetic Map1q12NCBI
NLRP12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381953,793,584 - 53,824,403 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1953,792,139 - 53,824,403 (-)Ensemblhg38GRCh38
GRCh371954,296,838 - 54,327,657 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361958,988,650 - 59,019,404 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341958,988,668 - 59,019,405NCBI
Celera1951,337,923 - 51,368,731 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1950,616,403 - 50,647,262 (-)NCBIHuRef
CHM1_11954,298,613 - 54,329,404 (-)NCBICHM1_1
T2T-CHM13v2.01956,873,043 - 56,904,207 (-)NCBIT2T-CHM13v2.0
Nlrp12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3973,267,317 - 3,298,400 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl73,267,458 - 3,298,370 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3873,218,643 - 3,249,771 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl73,218,784 - 3,249,740 (-)Ensemblmm10GRCm38
MGSCv3773,221,511 - 3,249,741 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3673,221,511 - 3,249,741 (-)NCBIMGSCv36mm8
Celera73,172,140 - 3,200,874 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map71.88NCBI
Nlrp12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955604317,987 - 331,051 (+)NCBIChiLan1.0ChiLan1.0
NLRP12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22059,797,427 - 59,836,448 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11961,719,665 - 61,758,320 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01950,735,124 - 50,765,556 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11959,581,547 - 59,614,665 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1959,582,005 - 59,614,436 (-)EnsemblpanPan2panpan1.1
NLRP12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11103,571,756 - 103,605,692 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1103,437,738 - 103,470,619 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01104,026,723 - 104,061,018 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1104,026,630 - 104,058,744 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11103,658,372 - 103,692,595 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01103,420,767 - 103,454,359 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01104,139,804 - 104,174,064 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nlrp12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,900,786 - 2,931,614 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493699420,854 - 36,757 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493699420,848 - 36,757 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLRP12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl656,402,665 - 56,425,101 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1656,402,617 - 56,425,038 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2652,741,089 - 52,763,504 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NLRP12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1646,507,241 - 46,533,832 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl646,507,410 - 46,533,615 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607326,577,383 - 26,608,988 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nlrp12
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12177,856,986 - 177,883,542 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nlrp12
183 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:26
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000043650
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat

Markers in Region
D17S610  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21069,030,155 - 69,030,849 (+)MAPPERmRatBN7.2
mRatBN7.2165,931,532 - 65,932,178 (+)MAPPERmRatBN7.2
Rnor_6.0164,505,675 - 64,506,320NCBIRnor6.0
Rnor_6.01071,457,449 - 71,458,142NCBIRnor6.0
Rnor_5.01071,370,820 - 71,371,513UniSTSRnor5.0
Rnor_5.0163,492,445 - 63,493,090UniSTSRnor5.0
RGSC_v3.4164,241,600 - 64,242,245UniSTSRGSC3.4
RGSC_v3.41072,429,352 - 72,430,045UniSTSRGSC3.4
Celera1067,958,412 - 67,959,105UniSTS
Celera163,662,075 - 63,662,720UniSTS
Cytogenetic Map1q12UniSTS


Genetic Models
This gene Nlrp12 is modified in the following models/strains:
SS-Nlrp12em1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 4 26 68 77 78 47 83 47 6 241 138 11 41 40 67 31 5 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001169142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC106193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000086331   ⟹   ENSRNOP00000069711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl174,848,063 - 74,876,341 (+)Ensembl
mRatBN7.2 Ensembl165,932,595 - 65,960,934 (+)Ensembl
Rnor_6.0 Ensembl164,506,735 - 64,534,912 (+)Ensembl
RefSeq Acc Id: NM_001169142   ⟹   NP_001162613
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,848,222 - 74,876,341 (+)NCBI
mRatBN7.2165,932,808 - 65,960,934 (+)NCBI
Rnor_6.0164,506,950 - 64,534,991 (+)NCBI
Rnor_5.0163,493,575 - 63,521,356 (+)NCBI
RGSC_v3.4164,242,875 - 64,271,212 (+)RGD
Celera163,663,350 - 63,691,368 (+)RGD
Sequence:
RefSeq Acc Id: XM_017588882   ⟹   XP_017444371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,848,371 - 74,876,341 (+)NCBI
mRatBN7.2165,932,958 - 65,960,934 (+)NCBI
Rnor_6.0164,507,153 - 64,538,745 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103730   ⟹   XP_038959658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,848,025 - 74,876,341 (+)NCBI
mRatBN7.2165,932,610 - 65,960,934 (+)NCBI
RefSeq Acc Id: XM_039103733   ⟹   XP_038959661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,848,025 - 74,876,341 (+)NCBI
mRatBN7.2165,932,611 - 65,960,934 (+)NCBI
RefSeq Acc Id: XM_063282937   ⟹   XP_063139007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,848,024 - 74,876,341 (+)NCBI
RefSeq Acc Id: XM_063282938   ⟹   XP_063139008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,848,392 - 74,876,341 (+)NCBI
RefSeq Acc Id: XR_010064551
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,848,024 - 74,885,945 (+)NCBI
RefSeq Acc Id: XR_010064552
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,848,020 - 74,864,089 (+)NCBI
RefSeq Acc Id: NP_001162613   ⟸   NM_001169142
- UniProtKB: A0A0G2JW23 (UniProtKB/TrEMBL),   A6KS45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444371   ⟸   XM_017588882
- Peptide Label: isoform X3
- UniProtKB: A6KS45 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069711   ⟸   ENSRNOT00000086331
RefSeq Acc Id: XP_038959658   ⟸   XM_039103730
- Peptide Label: isoform X2
- UniProtKB: A6KS45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959661   ⟸   XM_039103733
- Peptide Label: isoform X4
- UniProtKB: A6KS45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139007   ⟸   XM_063282937
- Peptide Label: isoform X1
- UniProtKB: A6KS45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139008   ⟸   XM_063282938
- Peptide Label: isoform X3
- UniProtKB: A6KS45 (UniProtKB/TrEMBL)
Protein Domains
NACHT   Pyrin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JW23-F1-model_v2 AlphaFold A0A0G2JW23 1-1054 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309415 AgrOrtholog
BioCyc Gene G2FUF-61010 BioCyc
Ensembl Genes ENSRNOG00000060745 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000086331 ENTREZGENE
  ENSRNOT00000086331.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro DEATH-like UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/TrEMBL
  NATCH-assoc UniProtKB/TrEMBL
  NLRC_HD2 UniProtKB/TrEMBL
  NLRP_innate_immun_reg UniProtKB/TrEMBL
  NOD2_WH UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Pyrin UniProtKB/TrEMBL
KEGG Report rno:292541 UniProtKB/TrEMBL
NCBI Gene 292541 ENTREZGENE
PANTHER NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 UniProtKB/TrEMBL
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 UniProtKB/TrEMBL
Pfam FISNA UniProtKB/TrEMBL
  LRR_6 UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
  NLRC4_HD2 UniProtKB/TrEMBL
  NOD2_WH UniProtKB/TrEMBL
  PAAD_DAPIN UniProtKB/TrEMBL
PhenoGen Nlrp12 PhenoGen
PROSITE DAPIN UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060745 RatGTEx
SMART FISNA UniProtKB/TrEMBL
  LRR_RI UniProtKB/TrEMBL
  PYRIN UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  RNI-like UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2JW23 ENTREZGENE, UniProtKB/TrEMBL
  A6KS45 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Nlrp12  NLR family, pyrin domain containing 12  Nalp12  NACHT, leucine rich repeat and PYD containing 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Nalp12  NACHT, leucine rich repeat and PYD containing 12   Nalp12_predicted  NACHT, leucine rich repeat and PYD containing 12 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nalp12_predicted  NACHT, leucine rich repeat and PYD containing 12 (predicted)      Symbol and Name status set to approved 70820 APPROVED