Mss51 (MSS51 mitochondrial translational activator) - Rat Genome Database

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Pathways
Gene: Mss51 (MSS51 mitochondrial translational activator) Rattus norvegicus
Analyze
Symbol: Mss51
Name: MSS51 mitochondrial translational activator
RGD ID: 1309408
Description: Predicted to enable zinc ion binding activity. Orthologous to human MSS51 (MSS51 mitochondrial translational activator); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC289904; MSS51 mitochondrial translational activator homolog; MSS51 mitochondrial translational activator homolog (S. cerevisiae); putative protein MSS51 homolog, mitochondrial; zinc finger MYND domain-containing protein 17; zinc finger, MYND domain containing 17; zinc finger, MYND-type containing 17; Zmynd17
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8153,855,094 - 3,868,614 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl153,855,478 - 3,868,611 (+)EnsemblGRCr8
mRatBN7.2153,805,240 - 3,819,385 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl153,807,516 - 3,819,385 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx153,817,674 - 3,829,543 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,204,098 - 5,215,967 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,816,491 - 3,828,360 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0154,240,203 - 4,252,072 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl154,240,203 - 4,252,072 (+)Ensemblrn6Rnor6.0
Rnor_5.0158,341,460 - 8,353,330 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4154,033,660 - 4,045,529 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera15775,583 - 787,452 (-)NCBICelera
RGSC_v3.1154,041,547 - 4,045,564 (+)NCBI
Cytogenetic Map15p16NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21531385  


Genomics

Comparative Map Data
Mss51
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8153,855,094 - 3,868,614 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl153,855,478 - 3,868,611 (+)EnsemblGRCr8
mRatBN7.2153,805,240 - 3,819,385 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl153,807,516 - 3,819,385 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx153,817,674 - 3,829,543 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,204,098 - 5,215,967 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,816,491 - 3,828,360 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0154,240,203 - 4,252,072 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl154,240,203 - 4,252,072 (+)Ensemblrn6Rnor6.0
Rnor_5.0158,341,460 - 8,353,330 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4154,033,660 - 4,045,529 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera15775,583 - 787,452 (-)NCBICelera
RGSC_v3.1154,041,547 - 4,045,564 (+)NCBI
Cytogenetic Map15p16NCBI
MSS51
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381073,423,579 - 73,433,561 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1073,423,579 - 73,433,561 (-)Ensemblhg38GRCh38
GRCh371075,183,337 - 75,193,319 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361074,853,343 - 74,863,325 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341074,853,344 - 74,863,324NCBI
Celera1068,468,933 - 68,478,915 (-)NCBICelera
Cytogenetic Map10q22.2NCBI
HuRef1069,177,050 - 69,187,032 (-)NCBIHuRef
CHM1_11075,465,098 - 75,475,085 (-)NCBICHM1_1
T2T-CHM13v2.01074,294,994 - 74,304,976 (-)NCBIT2T-CHM13v2.0
Mss51
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391420,532,925 - 20,546,969 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1420,532,935 - 20,546,969 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381420,482,857 - 20,496,901 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1420,482,867 - 20,496,901 (-)Ensemblmm10GRCm38
MGSCv371421,302,086 - 21,316,123 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361419,271,419 - 19,285,453 (-)NCBIMGSCv36mm8
Celera1416,864,286 - 16,878,323 (-)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.53NCBI
Mss51
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543718,380,026 - 18,390,840 (+)NCBIChiLan1.0ChiLan1.0
MSS51
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2885,599,377 - 85,611,239 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11085,601,695 - 85,617,707 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01069,971,015 - 69,983,208 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11072,429,833 - 72,439,963 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1072,429,833 - 72,439,963 (-)EnsemblpanPan2panpan1.1
MSS51
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1423,965,952 - 23,974,053 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl423,966,009 - 23,973,191 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha424,103,748 - 24,111,813 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0424,246,143 - 24,254,198 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl424,246,319 - 24,253,381 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1424,143,664 - 24,151,719 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0424,344,087 - 24,352,117 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0424,699,000 - 24,707,057 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mss51
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721357,128,998 - 57,133,471 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365215,617,218 - 5,625,778 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365215,616,325 - 5,625,647 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSS51
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1476,239,500 - 76,247,672 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11476,239,497 - 76,247,414 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21482,365,033 - 82,375,464 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MSS51
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1957,843,295 - 57,854,142 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl957,849,820 - 57,853,166 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604818,424,693 - 18,436,476 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mss51
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247547,032,550 - 7,042,222 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mss51
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11290,290,868 - 90,295,182 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mss51
95 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:18
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000010178
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
1300142Bp191Blood pressure QTL 1913.14arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)15115177511Rat

Markers in Region
BF397380  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2153,806,200 - 3,806,325 (+)MAPPERmRatBN7.2
Rnor_6.0154,238,888 - 4,239,012NCBIRnor6.0
Rnor_5.0158,340,145 - 8,340,269UniSTSRnor5.0
RGSC_v3.4154,032,345 - 4,032,469UniSTSRGSC3.4
Celera15788,643 - 788,767UniSTS
RH 3.4 Map1565.8UniSTS
Cytogenetic Map15p16UniSTS
RH141169  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8153,867,880 - 3,868,375 (+)Marker Load Pipeline
mRatBN7.2153,818,652 - 3,819,147 (+)MAPPERmRatBN7.2
Rnor_6.0154,251,340 - 4,251,834NCBIRnor6.0
Rnor_5.0158,352,597 - 8,353,091UniSTSRnor5.0
RGSC_v3.4154,044,797 - 4,045,291UniSTSRGSC3.4
Celera15775,821 - 776,315UniSTS
RH 3.4 Map1566.2UniSTS
Cytogenetic Map15p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 163 91 90 59 90 59 6 353 189 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010178   ⟹   ENSRNOP00000010179
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl153,855,478 - 3,868,611 (+)Ensembl
mRatBN7.2 Ensembl153,807,516 - 3,819,385 (+)Ensembl
Rnor_6.0 Ensembl154,240,203 - 4,252,072 (+)Ensembl
RefSeq Acc Id: NM_001106025   ⟹   NP_001099495
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8153,856,744 - 3,868,613 (+)NCBI
mRatBN7.2153,807,516 - 3,819,385 (+)NCBI
Rnor_6.0154,240,203 - 4,252,072 (+)NCBI
Rnor_5.0158,341,460 - 8,353,330 (+)NCBI
RGSC_v3.4154,033,660 - 4,045,529 (+)RGD
Celera15775,583 - 787,452 (-)RGD
Sequence:
RefSeq Acc Id: XM_039093085   ⟹   XP_038949013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8153,855,094 - 3,868,433 (+)NCBI
mRatBN7.2153,805,240 - 3,819,204 (+)NCBI
RefSeq Acc Id: XM_063274068   ⟹   XP_063130138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8153,855,094 - 3,868,614 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001099495 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949013 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130138 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZKV9 (Get FASTA)   NCBI Sequence Viewer  
  EDL86227 (Get FASTA)   NCBI Sequence Viewer  
  EDL86228 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010179
  ENSRNOP00000010179.3
RefSeq Acc Id: NP_001099495   ⟸   NM_001106025
- UniProtKB: D3ZKV9 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010179   ⟸   ENSRNOT00000010178
RefSeq Acc Id: XP_038949013   ⟸   XM_039093085
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063130138   ⟸   XM_063274068
- Peptide Label: isoform X1
- UniProtKB: D3ZKV9 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZKV9-F1-model_v2 AlphaFold D3ZKV9 1-467 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699563
Promoter ID:EPDNEW_R10087
Type:multiple initiation site
Name:Mss51_1
Description:MSS51 mitochondrial translational activator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0154,240,201 - 4,240,261EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309408 AgrOrtholog
BioCyc Gene G2FUF-14540 BioCyc
Ensembl Genes ENSRNOG00000007632 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010178 ENTREZGENE
  ENSRNOT00000010178.4 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.140.2220 UniProtKB/Swiss-Prot
InterPro Mito_gene_expr_regulator UniProtKB/Swiss-Prot
  Mss51-like_C UniProtKB/Swiss-Prot
  Znf_MYND UniProtKB/Swiss-Prot
KEGG Report rno:289904 UniProtKB/Swiss-Prot
NCBI Gene 289904 ENTREZGENE
PANTHER PROTEIN MSS51 HOMOLOG, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot
  PTHR46920 UniProtKB/Swiss-Prot
Pfam MSS51_C UniProtKB/Swiss-Prot
  zf-MYND UniProtKB/Swiss-Prot
PhenoGen Mss51 PhenoGen
PROSITE ZF_MYND_1 UniProtKB/Swiss-Prot
  ZF_MYND_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007632 RatGTEx
Superfamily-SCOP HIT/MYND zinc finger-like UniProtKB/Swiss-Prot
UniProt D3ZKV9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-17 Mss51  MSS51 mitochondrial translational activator  Mss51  MSS51 mitochondrial translational activator homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-26 Mss51  MSS51 mitochondrial translational activator homolog (S. cerevisiae)  Zmynd17  zinc finger, MYND-type containing 17  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Zmynd17  zinc finger, MYND-type containing 17  Zmynd17  zinc finger, MYND domain containing 17   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Zmynd17  zinc finger, MYND domain containing 17   Zmynd17_predicted  zinc finger, MYND domain containing 17 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Zmynd17_predicted  zinc finger, MYND domain containing 17 (predicted)      Symbol and Name status set to approved 70820 APPROVED