Tmem192 (transmembrane protein 192) - Rat Genome Database

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Gene: Tmem192 (transmembrane protein 192) Rattus norvegicus
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Symbol: Tmem192
Name: transmembrane protein 192
RGD ID: 1309341
Description: Predicted to enable protein homodimerization activity. Predicted to be located in several cellular components, including endosome; lysosome; and perinuclear region of cytoplasm. Predicted to be active in late endosome and lysosomal membrane. Orthologous to human TMEM192 (transmembrane protein 192); INTERACTS WITH 2,5-hexanedione; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC361137; RGD1309341; similar to hypothetical protein FLJ38482
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81629,506,658 - 29,527,553 (-)NCBIGRCr8
mRatBN7.21624,740,166 - 24,760,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1624,740,124 - 24,761,021 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1628,105,543 - 28,126,379 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01631,539,895 - 31,560,731 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01627,495,104 - 27,515,930 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01626,620,525 - 26,642,537 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1626,619,598 - 26,633,796 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01626,503,237 - 26,515,689 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41626,481,058 - 26,494,314 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11626,481,056 - 26,494,312 (-)NCBI
Celera1624,825,265 - 24,846,005 (-)NCBICelera
Cytogenetic Map16p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:20370317   PMID:22736246   PMID:23376485  


Genomics

Comparative Map Data
Tmem192
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81629,506,658 - 29,527,553 (-)NCBIGRCr8
mRatBN7.21624,740,166 - 24,760,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1624,740,124 - 24,761,021 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1628,105,543 - 28,126,379 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01631,539,895 - 31,560,731 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01627,495,104 - 27,515,930 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01626,620,525 - 26,642,537 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1626,619,598 - 26,633,796 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01626,503,237 - 26,515,689 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41626,481,058 - 26,494,314 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11626,481,056 - 26,494,312 (-)NCBI
Celera1624,825,265 - 24,846,005 (-)NCBICelera
Cytogenetic Map16p13NCBI
TMEM192
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384165,070,608 - 165,112,860 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4165,070,608 - 165,208,549 (-)EnsemblGRCh38hg38GRCh38
GRCh374165,991,760 - 166,034,012 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364166,216,680 - 166,253,474 (-)NCBINCBI36Build 36hg18NCBI36
Celera4163,328,647 - 163,365,196 (-)NCBICelera
Cytogenetic Map4q32.3NCBI
HuRef4161,750,449 - 161,784,815 (-)NCBIHuRef
CHM1_14165,973,696 - 166,010,477 (-)NCBICHM1_1
T2T-CHM13v2.04168,418,071 - 168,457,901 (-)NCBIT2T-CHM13v2.0
Tmem192
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39865,399,801 - 65,421,688 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl865,399,837 - 65,421,685 (+)EnsemblGRCm39 Ensembl
GRCm38864,947,149 - 64,969,036 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl864,947,185 - 64,969,033 (+)EnsemblGRCm38mm10GRCm38
MGSCv37867,471,084 - 67,492,935 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36867,876,174 - 67,898,022 (+)NCBIMGSCv36mm8
Celera867,509,201 - 67,530,946 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map832.44NCBI
Tmem192
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540340,199,850 - 40,212,765 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540340,202,180 - 40,211,747 (+)NCBIChiLan1.0ChiLan1.0
TMEM192
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23162,820,364 - 162,858,325 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14163,178,415 - 163,216,390 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04157,269,816 - 157,304,743 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14169,320,974 - 169,352,166 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4169,318,179 - 169,427,945 (-)Ensemblpanpan1.1panPan2
TMEM192
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11561,088,944 - 61,110,426 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1561,090,399 - 61,110,762 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1561,398,375 - 61,424,725 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01561,947,230 - 61,977,993 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1561,949,936 - 61,977,938 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11561,110,372 - 61,140,899 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01561,172,080 - 61,202,976 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01561,583,010 - 61,596,317 (-)NCBIUU_Cfam_GSD_1.0
Tmem192
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494317,679,474 - 17,715,443 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936555855,063 - 893,624 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936555855,096 - 891,525 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM192
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl843,960,709 - 43,990,093 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1843,960,670 - 43,994,286 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2845,924,110 - 45,944,995 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM192
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17111,440,985 - 111,472,196 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7111,443,197 - 111,472,123 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603791,279,622 - 91,315,082 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem192
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475811,887,780 - 11,903,854 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475811,887,968 - 11,900,581 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem192
157 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:153
Count of miRNA genes:127
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000042181
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638712345387123Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat

Markers in Region
D16Got30  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1624,842,207 - 24,842,461UniSTS
RH 3.4 Map16319.0UniSTS
RH 3.4 Map16319.0RGD
RH 2.0 Map16350.3RGD
Cytogenetic Map16p13UniSTS
D16Got28  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1624,847,086 - 24,847,239UniSTS
RH 2.0 Map16352.5RGD
Cytogenetic Map16p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000042181   ⟹   ENSRNOP00000050426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1624,740,124 - 24,753,448 (-)Ensembl
Rnor_6.0 Ensembl1626,619,598 - 26,633,796 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097782   ⟹   ENSRNOP00000084072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1624,740,124 - 24,761,021 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102211   ⟹   ENSRNOP00000083809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1624,742,270 - 24,760,982 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104426   ⟹   ENSRNOP00000084423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1624,740,124 - 24,761,021 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115229   ⟹   ENSRNOP00000091094
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1624,740,124 - 24,753,701 (-)Ensembl
RefSeq Acc Id: NM_001014141   ⟹   NP_001014163
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81629,506,658 - 29,527,484 (-)NCBI
mRatBN7.21624,740,166 - 24,760,994 (-)NCBI
Rnor_6.01626,620,525 - 26,642,537 (-)NCBI
Rnor_5.01626,503,237 - 26,515,689 (-)NCBI
RGSC_v3.41626,481,058 - 26,494,314 (-)RGD
Celera1624,825,265 - 24,846,005 (-)RGD
Sequence:
RefSeq Acc Id: XM_063275514   ⟹   XP_063131584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81629,506,658 - 29,527,553 (-)NCBI
RefSeq Acc Id: NP_001014163   ⟸   NM_001014141
- UniProtKB: Q5U1Y0 (UniProtKB/Swiss-Prot),   A6KFN6 (UniProtKB/TrEMBL),   A0A8I6AEY9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050426   ⟸   ENSRNOT00000042181
Ensembl Acc Id: ENSRNOP00000084072   ⟸   ENSRNOT00000097782
Ensembl Acc Id: ENSRNOP00000091094   ⟸   ENSRNOT00000115229
Ensembl Acc Id: ENSRNOP00000084423   ⟸   ENSRNOT00000104426
Ensembl Acc Id: ENSRNOP00000083809   ⟸   ENSRNOT00000102211
RefSeq Acc Id: XP_063131584   ⟸   XM_063275514
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U1Y0-F1-model_v2 AlphaFold Q5U1Y0 1-266 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309341 AgrOrtholog
BioCyc Gene G2FUF-11633 BioCyc
Ensembl Genes ENSRNOG00000030199 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042181.6 UniProtKB/TrEMBL
  ENSRNOT00000097782.1 UniProtKB/TrEMBL
  ENSRNOT00000102211.1 UniProtKB/TrEMBL
  ENSRNOT00000104426.1 UniProtKB/Swiss-Prot
  ENSRNOT00000115229.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7304126 IMAGE-MGC_LOAD
InterPro TMEM192 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361137 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105668 IMAGE-MGC_LOAD
NCBI Gene 361137 ENTREZGENE
PANTHER PTHR31592 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 192 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TMEM192 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmem192 PhenoGen
RatGTEx ENSRNOG00000030199 RatGTEx
UniProt A0A8I5ZX83_RAT UniProtKB/TrEMBL
  A0A8I5ZZY4_RAT UniProtKB/TrEMBL
  A0A8I6AEY9 ENTREZGENE, UniProtKB/TrEMBL
  A6KFN6 ENTREZGENE, UniProtKB/TrEMBL
  F1LLW0_RAT UniProtKB/TrEMBL
  Q5U1Y0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-26 Tmem192  transmembrane protein 192  RGD1309341  similar to hypothetical protein FLJ38482  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1309341  similar to hypothetical protein FLJ38482  RGD1309341_predicted  similar to hypothetical protein FLJ38482 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1309341_predicted  similar to hypothetical protein FLJ38482 (predicted)  LOC361137_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361137_predicted  similar to hypothetical protein FLJ38482 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL