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Gene: Rnf10 (ring finger protein 10) Rattus norvegicus

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Symbol:

Rnf10

Name:

ring finger protein 10

RGD ID:

1309282

Description:

Enables transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II; postsynapse to nucleus signaling pathway; and regulation of nervous system development. Located in nucleus. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Orthologous to human RNF10 (ring finger protein 10); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E3 ubiquitin-protein ligase RNF10; LOC288710

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RNF10 (ring finger protein 10)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Rnf10 (ring finger protein 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rnf10 (ring finger protein 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RNF10 (ring finger protein 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RNF10 (ring finger protein 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rnf10 (ring finger protein 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RNF10 (ring finger protein 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RNF10 (ring finger protein 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rnf10 (ring finger protein 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rnf10 (ring finger protein 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RNF10 (ring finger protein 10)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rnf10 (ring finger protein 10)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rnf10 (ring finger protein 10)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG12099	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG12099	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MAG2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MAG2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rnf10	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	47,002,409 - 47,036,201 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	47,002,409 - 47,036,201 (+)	Ensembl				GRCr8
mRatBN7.2	12	41,341,708 - 41,375,505 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	41,341,717 - 41,375,504 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	42,508,613 - 42,542,554 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	43,122,279 - 43,156,219 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	42,182,832 - 42,216,776 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	47,103,313 - 47,137,096 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	47,103,314 - 47,138,128 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	48,896,967 - 48,930,787 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	42,609,879 - 42,643,662 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	42,961,374 - 42,995,153 (+)	NCBI		Celera
RGSC_v3.1	12	42,473,266 - 42,507,049 (+)	NCBI
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cardiotoxicity (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

acrylamide (EXP)

alpha-pinene (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

CGP 52608 (ISO)

chlordecone (ISO)

ciglitazone (ISO)

cobalt dichloride (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

epoxiconazole (ISO)

flutamide (EXP)

folic acid (ISO)

nefazodone (EXP)

ozone (ISO)

paracetamol (ISO)

pirarubicin (EXP)

pirinixic acid (ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP)

trichloroethene (EXP)

triphenyl phosphate (ISO)

tungsten (ISO)

uranium atom (ISO)

urethane (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of Schwann cell proliferation (IDA)

nonfunctional rRNA decay (IEA,ISO,ISS)

positive regulation of DNA-templated transcription (IEA,ISO)

positive regulation of myelination (IBA,IMP)

positive regulation of transcription by RNA polymerase II (IDA)

postsynapse to nucleus signaling pathway (IDA,IEP,IMP)

protein autoubiquitination (IEA,ISO)

protein monoubiquitination (IEA,ISO,ISS)

protein ubiquitination (IEA)

ribosome disassembly (IEA,ISO,ISS)

ribosome-associated ubiquitin-dependent protein catabolic process (IBA,IEA,ISO,ISS)

Cellular Component

cytoplasm (IEA,ISO)

cytosol (IBA)

cytosolic ribosome (IEA,ISO,ISS)

extrinsic component of postsynaptic density membrane (IDA,IEP,IMP)

glutamatergic synapse (IDA,IEP,IMP)

nucleus (IDA,IEA)

Molecular Function

DNA binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

transcription cis-regulatory region binding (IDA)

transferase activity (IEA)

ubiquitin protein ligase activity (IBA,IEA,ISO,ISS)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus.	Dinamarca MC, etal., Elife. 2016 Mar 15;5:e12430. doi: 10.7554/eLife.12430.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	A novel function of RING finger protein 10 in transcriptional regulation of the myelin-associated glycoprotein gene and myelin formation in Schwann cells.	Hoshikawa S, etal., PLoS One. 2008;3(10):e3464. doi: 10.1371/journal.pone.0003464. Epub 2008 Oct 21.
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:16335786	PMID:24105792	PMID:29723537	PMID:31069631	PMID:31173254	PMID:36713029

Genomics

Comparative Map Data

Rnf10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	47,002,409 - 47,036,201 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	47,002,409 - 47,036,201 (+)	Ensembl				GRCr8
mRatBN7.2	12	41,341,708 - 41,375,505 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	41,341,717 - 41,375,504 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	42,508,613 - 42,542,554 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	43,122,279 - 43,156,219 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	42,182,832 - 42,216,776 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	47,103,313 - 47,137,096 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	47,103,314 - 47,138,128 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	48,896,967 - 48,930,787 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	42,609,879 - 42,643,662 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	42,961,374 - 42,995,153 (+)	NCBI		Celera
RGSC_v3.1	12	42,473,266 - 42,507,049 (+)	NCBI
Cytogenetic Map	12	q16	NCBI

RNF10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	120,534,356 - 120,577,588 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	120,533,480 - 120,577,588 (+)	Ensembl			hg38	GRCh38
GRCh37	12	120,972,159 - 121,015,391 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	119,456,515 - 119,499,780 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	119,434,874 - 119,478,077	NCBI
Celera	12	120,606,443 - 120,649,686 (+)	NCBI		Celera
Cytogenetic Map	12	q24.31	NCBI
HuRef	12	117,981,628 - 118,024,812 (+)	NCBI		HuRef
CHM1_1	12	120,940,932 - 120,984,162 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	120,523,536 - 120,566,717 (+)	NCBI		T2T-CHM13v2.0

Rnf10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	115,379,829 - 115,410,951 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	115,379,471 - 115,410,957 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	115,241,770 - 115,272,921 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	115,241,412 - 115,272,898 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	115,691,779 - 115,722,904 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	115,502,770 - 115,533,893 (-)	NCBI		MGSCv36	mm8
Celera	5	112,340,985 - 112,370,451 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	56.01	NCBI

Rnf10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	11,074,344 - 11,119,752 (-)	Ensembl
ChiLan1.0	NW_004955455	11,074,118 - 11,119,771 (-)	NCBI	ChiLan1.0	ChiLan1.0

RNF10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	128,604,207 - 128,647,065 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	128,600,790 - 128,643,440 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	118,117,486 - 118,160,341 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	121,491,665 - 121,533,548 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	121,492,170 - 121,532,623 (+)	Ensembl			panPan2	panpan1.1

RNF10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	16,426,220 - 16,461,478 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	16,426,234 - 16,547,119 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	16,429,396 - 16,465,372 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	16,693,386 - 16,728,782 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	16,693,372 - 16,728,782 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	16,653,398 - 16,689,445 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	16,729,688 - 16,765,114 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	16,771,763 - 16,807,186 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rnf10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	145,891,072 - 145,928,330 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936668	389,343 - 427,258 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936668	389,961 - 427,213 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RNF10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	40,481,249 - 40,519,886 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	40,481,239 - 40,521,998 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	42,969,793 - 42,989,462 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RNF10
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	115,888,359 - 115,930,790 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	115,893,457 - 115,930,848 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	129,166,194 - 129,210,481 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rnf10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624747	13,094,084 - 13,134,360 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rnf10
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	38,554,815 - 38,588,338 (+)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	45
Count of miRNA genes:	40
Interacting mature miRNAs:	45
Transcripts:	ENSRNOT00000064910
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	50386405	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	37764145	51558799	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	33700432	51558799	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	49212240	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	44139558	52308831	Rat

Markers in Region

RH129378

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	41,375,240 - 41,375,437 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	47,136,832 - 47,137,028	NCBI	Rnor6.0
Rnor_5.0	12	48,930,521 - 48,930,717	UniSTS	Rnor5.0
RGSC_v3.4	12	42,643,398 - 42,643,594	UniSTS	RGSC3.4
Celera	12	42,994,889 - 42,995,085	UniSTS
RH 3.4 Map	12	777.02	UniSTS
Cytogenetic Map	12	q16	UniSTS

RH144528

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	41,348,285 - 41,348,429 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	47,109,879 - 47,110,022	NCBI	Rnor6.0
Rnor_5.0	12	48,903,568 - 48,903,711	UniSTS	Rnor5.0
RGSC_v3.4	12	42,616,445 - 42,616,588	UniSTS	RGSC3.4
Celera	12	42,967,946 - 42,968,089	UniSTS
RH 3.4 Map	12	777.93	UniSTS
Cytogenetic Map	12	q16	UniSTS

BF397929

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	41,344,867 - 41,345,006 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	47,106,462 - 47,106,600	NCBI	Rnor6.0
Rnor_5.0	12	48,900,151 - 48,900,289	UniSTS	Rnor5.0
RGSC_v3.4	12	42,613,028 - 42,613,166	UniSTS	RGSC3.4
Celera	12	42,964,529 - 42,964,667	UniSTS
RH 3.4 Map	12	774.12	UniSTS
Cytogenetic Map	12	q16	UniSTS

BF405038

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	41,364,144 - 41,364,263 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	47,125,736 - 47,125,854	NCBI	Rnor6.0
Rnor_5.0	12	48,919,425 - 48,919,543	UniSTS	Rnor5.0
RGSC_v3.4	12	42,632,302 - 42,632,420	UniSTS	RGSC3.4
Celera	12	42,983,803 - 42,983,921	UniSTS
Cytogenetic Map	12	q16	UniSTS

RH135502

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	41,375,378 - 41,375,471 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	47,136,970 - 47,137,062	NCBI	Rnor6.0
Rnor_5.0	12	48,930,659 - 48,930,751	UniSTS	Rnor5.0
RGSC_v3.4	12	42,643,536 - 42,643,628	UniSTS	RGSC3.4
Celera	12	42,995,027 - 42,995,119	UniSTS
Cytogenetic Map	12	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001011904	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001415782	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC121426	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC083831	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230316	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000064910 ⟹ ENSRNOP00000063855

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	47,002,409 - 47,036,201 (+)	Ensembl
mRatBN7.2 Ensembl	12	41,341,717 - 41,375,504 (+)	Ensembl
Rnor_6.0 Ensembl	12	47,103,314 - 47,138,128 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000140599 ⟹ ENSRNOP00000106011

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	47,002,409 - 47,036,197 (+)	Ensembl

RefSeq Acc Id:

NM_001011904 ⟹ NP_001011904

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	47,002,409 - 47,036,201 (+)	NCBI
mRatBN7.2	12	41,341,708 - 41,375,505 (+)	NCBI
Rnor_6.0	12	47,103,313 - 47,137,096 (+)	NCBI
Rnor_5.0	12	48,896,967 - 48,930,787 (+)	NCBI
RGSC_v3.4	12	42,609,879 - 42,643,662 (+)	RGD
Celera	12	42,961,374 - 42,995,153 (+)	RGD

Sequence:

show sequence

CGACTCGTCGCCATTCCCGGAGCAGCTCGGCCTCGGCCCAGAGGCGAGTGTCGGTCGCTGTGTC
GGAGACCCCGGTCCCCGGCACCGAGACAACCAGCCCTCTCTCCTGCCCCGCGGCGGGAGAGCGT
GTCCGGCCGGCCGGCGGGGCTCGCGACCCTCCCGCGCCTCCCCTTTCCCCTCAGCCTCCGCCCC
GCCAGGCCCGGCCCGGACCTCCGAGCCCCGGCCTCCTCCTCCTCCTCTTCGGTCACCGCCGCCT
CTGGGCCCCACAGCCCCACCTGCCGCTTCTCCTTCCATTTTGAGAAGCTGAGGAAGGAAACAAG
GAAAAATGTCGCCATGAAGGCCGAGAACCGCTGCCGCCGCCGACCCCCGCCGGCCCTGAACGCC
ATGAGCCTGGGTCCCCGCCGCGCCCGCTCCGCTCCGACCGCCGTCGCCGCCGAGGCCCCCTTTG
ATGCCGCAGAGCTCCCCCAGCACCGCCGCCACCGCCTCCGACATGGACAAGAACAGCGGCTCCA
ACAGCTCCTCCGCCTCCTCGGGCAGCAGCAAAGGGCAACAGCCGCCCCGCTCCGCCTCGGCGGG
GCCGGCCGGCGAGTCTAAACCCAAGAGCGATGGAAAGAACTCAAATGGATCCAAGCGTTACAAT
CGCAAGCGTGAACCTTCCTACCCCAAAAATGAGAATTTTAGCAACCAGTCCCGTCGCTCCAATT
CACAGAAAAGCAAAACTTTTAACAAGACGCCTCCTCAAAGGGGCGGTGGCAGCAGCAAACCCTT
TAGCTCTTCTTCTAATGGTGGAAGACGGGATGAGGTAGCAGAGGCTCAGCGGGCAGAGTTTAGC
CCTGCCCAGTTCTCCGGCCCTAAGAAGATCAACCTGAACCACTTGTTAAATTTCACCTTTGAAC
CCCGTGGCCAGGCAGGTCACTTTGAAGGCAGTGGACATGGCAGCTGGGGGAAAAGAAACAAGTG
GGGACACAAGCCTTTCAACAAGGAACTCTTTTTACAGGCCAACTGCCAATTTGTGGTGTCTGAA
GACCAAGATTACACAGCTAACTTTGCTGACCCTGACACCTTAGTCAACTGGGACTTTGTGGAAC
AAGTGCGCATCTGTAGCCATGAAGTGCCATCTTGTCCAATATGCCTCTACCCACCCACTGCAGC
CAAGATAACCCGCTGTGGACACATTTTCTGCTGGGCCTGCATCCTGCACTATCTCTCACTCAGT
GAGAGAACCTGGAGCAAATGTCCCATCTGCTACAGCTCTGTGCACAAGAAGGATCTCAAGAGTG
TTGTTGCCACAGAGTCTCGACAGTATGTTGTGGGTGACACCATTACGATGCAGCTGATGAAGAG
AGAGAAAGGAGTGTTGGTGGCCCTGCCCAAATCCAAGTGGATGAATGTAGACCATCCTATTAGT
CTAGGAGACGAGCAGCACAGCCAGTACTCCAAGCTGCTGCTGGCCTCTAAGGAGCAGGTGCTGC
ACCGGGTGGTTCTGGAGGAGAAAGTCGCGCTGGAGCAGCAGCTTGCCGAAGAGAAGCACACTCC
TGAGTCCTGCTTTATTGAGGCTGCTCTCCAGGAGGTCAAGATTCGGGAAGAAGCTCTGTCAGGA
GTGGCTGGAGGCAGAGCGGAGGTCACTGGTGTTGTGACTGCTCTGGAACAACTGGTGCTGATGG
CTCCCCTGGCCAAGGAGTCTGCTTTTCAACCCAGGAAGGGTGTGCTAGAGTATCTGTCTGCTTT
TGATGAAGAAGCTGCACAAGTTTGTTCTCTGGACCCCCCTGGTCCTCTCGCTCTCCCTTTGGTA
GAAGAAGAGGAAGCAGTGTCTGAGCCAGAAGCCTGTGAGGACTTAATAGCTGATGACAGTCTTG
GAGAGGGGACCGTCTGTGCCGAGTTGAGCCAGGAGGAGCCCATCGCTAAGCCAGGCTTCACACA
GCTGAGCAGCTCTCCCTGTTACTACTTCTACCAAGCGGAGGATGGACAGCACATGTTCCTGCAC
CCTGTCAACGTGCGCTGCCTTGTGCGGGAGTATGGCAGCCTGGAGCAGAGCCCGGAGAAGATCT
CAGCAACCGTGGTAGAGATTGCTGGGTATTCCATGTCTGAGGATGTTCGACAGCGTCACAGGTA
TCTCTCTCACTTGCCACTCACCTGTGAGTTCAGCATCTGTGAACTGGCTCTGCAGCCTCCTGTG
GTCTCTAAGGAAACCCTAGAGATGTTCTCAGATGACATTGAGAAAAGGAAGCGTCAGCGCCAAA
AGAAGGCTCGCGAGGAGCGGCGCAGAGAGCGCAGAATTGAACTGGAGGAGAACAAGAGACAGGG
CAGGTATCCCGAGGTCCACATTCCCCTCGAGAACCTTCAGCAGTTTCCTGCCTTCAATTCCTAC
ACCTGTTCCTCTGATTCTGCTTTGGGACCCACCAGCACCGAGGGCCACGGGGCCCTATCCCTGT
CTCCTCTGAGCAGAAGTCCAGGTTCCCATGCAGACTTTCTGCTGACCCCTCTGTCACCCACTGC
CAGTCAGGGCAGTCCCTCCTTCTGCGTTGGGAGTCTGGAAGAAGACTCTCCCTTCCTTTCCTTT
GCCCAGATGCTGAGGGTTGGCAAAGCAAAAGCAGACGGGTGGCCCAAAGCTGCTCCAAAGAAAG
ACGACAATAGCCTGGCTCCTCCCGCCCCGGTGGACAGTGATGGGGAGAGTGACAATTCTGACCG
TGTTCCTGTGCCCAGTTTCCAAAATTCCTTCAGCCAAGCTATCGAAGCCGCCTTCATGAAATTG
GACACACCAGCTACTTCAGACCCCCTCTCTGACAGAGGAGGGAGGAAGAGGAAGAGGCAGAAGC
AGAAGCTGCTGTTCAGCACCTCGGTCGTCCACACCAAGTGACTACTGCCCAGGCGCCTTCTCCA
TCGGGTTTCTTCTGTGCTTTGGTTTGCTGCTGCTGTAATTTTTAAGTGTTTGAGTTTGAACAGA
TTGATTAGCTTGGGGCGGGGGGAGGGGCTTTCCACAAAGTGAGGGAACCAAGAAAATTTTAAAT
ACAGTGTATTTTCCAGCTTCCCTCTTTACACCAAAATAAAGTATTGACACTCACATGAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_001415782 ⟹ NP_001402711

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	47,002,409 - 47,036,201 (+)	NCBI
mRatBN7.2	12	41,341,708 - 41,375,505 (+)	NCBI

RefSeq Acc Id:

XM_063271215 ⟹ XP_063127285

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	47,016,482 - 47,036,201 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001011904	(Get FASTA)	NCBI Sequence Viewer
	NP_001402711	(Get FASTA)	NCBI Sequence Viewer
	XP_063127285	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83831	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000063855
	ENSRNOP00000063855.3
	ENSRNOP00000106011
GenBank Protein	Q5XI59	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001011904 ⟸ NM_001011904
- Peptide Label:	isoform 1
- UniProtKB:	Q5XI59 (UniProtKB/Swiss-Prot), A6J1V7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPQSSPSTAATASDMDKNSGSNSSSASSGSSKGQQPPRSASAGPAGESKPKSDGKNSNGSKRYN RKREPSYPKNENFSNQSRRSNSQKSKTFNKTPPQRGGGSSKPFSSSSNGGRRDEVAEAQRAEFS PAQFSGPKKINLNHLLNFTFEPRGQAGHFEGSGHGSWGKRNKWGHKPFNKELFLQANCQFVVSE DQDYTANFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLS ERTWSKCPICYSSVHKKDLKSVVATESRQYVVGDTITMQLMKREKGVLVALPKSKWMNVDHPIS LGDEQHSQYSKLLLASKEQVLHRVVLEEKVALEQQLAEEKHTPESCFIEAALQEVKIREEALSG VAGGRAEVTGVVTALEQLVLMAPLAKESAFQPRKGVLEYLSAFDEEAAQVCSLDPPGPLALPLV EEEEAVSEPEACEDLIADDSLGEGTVCAELSQEEPIAKPGFTQLSSSPCYYFYQAEDGQHMFLH PVNVRCLVREYGSLEQSPEKISATVVEIAGYSMSEDVRQRHRYLSHLPLTCEFSICELALQPPV VSKETLEMFSDDIEKRKRQRQKKAREERRRERRIELEENKRQGRYPEVHIPLENLQQFPAFNSY TCSSDSALGPTSTEGHGALSLSPLSRSPGSHADFLLTPLSPTASQGSPSFCVGSLEEDSPFLSF AQMLRVGKAKADGWPKAAPKKDDNSLAPPAPVDSDGESDNSDRVPVPSFQNSFSQAIEAAFMKL DTPATSDPLSDRGGRKRKRQKQKLLFSTSVVHTK hide sequence

Ensembl Acc Id:

ENSRNOP00000063855 ⟸ ENSRNOT00000064910

RefSeq Acc Id:	NP_001402711 ⟸ NM_001415782
- Peptide Label:	isoform 2
- UniProtKB:	A0A0H2UI24 (UniProtKB/TrEMBL), A6J1V7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127285 ⟸ XM_063271215
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000106011 ⟸ ENSRNOT00000140599

Protein Domains

RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5XI59-F1-model_v2	AlphaFold	Q5XI59	1-802	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698697

Promoter ID:

EPDNEW_R9222

Type:

multiple initiation site

Name:

Rnf10_1

Description:

ring finger protein 10

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	47,103,304 - 47,103,364	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309282	AgrOrtholog
BioCyc Gene	G2FUF-18979	BioCyc
Ensembl Genes	ENSRNOG00000001172	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000064910	ENTREZGENE
	ENSRNOT00000064910.3	UniProtKB/Swiss-Prot
	ENSRNOT00000140599	ENTREZGENE
Gene3D-CATH	3.30.40.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7112480	IMAGE-MGC_LOAD
InterPro	Mag2/Rnf10	UniProtKB/Swiss-Prot
	Znf_C3HC4_RING-type	UniProtKB/Swiss-Prot
	Znf_RING	UniProtKB/Swiss-Prot
	Znf_RING/FYVE/PHD	UniProtKB/Swiss-Prot
	Znf_RING_CS	UniProtKB/Swiss-Prot
KEGG Report	rno:288710	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94926	IMAGE-MGC_LOAD
NCBI Gene	288710	ENTREZGENE
PANTHER	PTHR12983	UniProtKB/Swiss-Prot
	RING FINGER PROTEIN 10	UniProtKB/Swiss-Prot
Pfam	zf-C3HC4	UniProtKB/Swiss-Prot
PhenoGen	Rnf10	PhenoGen
PROSITE	ZF_RING_1	UniProtKB/Swiss-Prot
	ZF_RING_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000001172	RatGTEx
SMART	RING	UniProtKB/Swiss-Prot
Superfamily-SCOP	RING/U-box	UniProtKB/Swiss-Prot
UniProt	A0A0H2UI24	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LWC1_RAT	UniProtKB/TrEMBL
	A6J1V7	ENTREZGENE, UniProtKB/TrEMBL
	Q5XI59	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Rnf10	ring finger protein 10	Rnf10_predicted	ring finger protein 10 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Rnf10_predicted	ring finger protein 10 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD