Slc7a12 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 12) - Rat Genome Database

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Gene: Slc7a12 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 12) Rattus norvegicus
Analyze
Symbol: Slc7a12 (Ensembl: LOC361914)
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 (Ensembl:similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12)
RGD ID: 1309208
Description: Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to act upstream of or within amino acid transport. Predicted to be located in cytoplasm and plasma membrane; INTERACTS WITH acrylamide; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC294881
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8288,800,954 - 88,868,117 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl288,800,979 - 88,868,103 (-)EnsemblGRCr8
mRatBN7.2287,079,724 - 87,146,875 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl287,079,749 - 87,146,875 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx293,409,295 - 93,476,443 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0291,530,310 - 91,597,461 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0286,587,120 - 86,654,267 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0288,559,677 - 88,660,449 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl288,559,702 - 88,660,449 (-)Ensemblrn6Rnor6.0
Rnor_5.02108,364,359 - 108,366,610 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.02108,332,499 - 108,333,025 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.02108,432,230 - 108,432,980 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4288,429,238 - 88,496,893 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera282,670,076 - 82,737,132 (-)NCBICelera
RGSC_v3.1288,374,210 - 88,441,855 (-)NCBI
Cytogenetic Map2q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11591708   PMID:12477932   PMID:15632090  


Genomics

Comparative Map Data
Slc7a12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8288,800,954 - 88,868,117 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl288,800,979 - 88,868,103 (-)EnsemblGRCr8
mRatBN7.2287,079,724 - 87,146,875 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl287,079,749 - 87,146,875 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx293,409,295 - 93,476,443 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0291,530,310 - 91,597,461 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0286,587,120 - 86,654,267 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0288,559,677 - 88,660,449 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl288,559,702 - 88,660,449 (-)Ensemblrn6Rnor6.0
Rnor_5.02108,364,359 - 108,366,610 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.02108,332,499 - 108,333,025 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.02108,432,230 - 108,432,980 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4288,429,238 - 88,496,893 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera282,670,076 - 82,737,132 (-)NCBICelera
RGSC_v3.1288,374,210 - 88,441,855 (-)NCBI
Cytogenetic Map2q23NCBI
Slc7a12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39314,545,757 - 14,570,879 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl314,545,757 - 14,570,890 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38314,480,697 - 14,505,819 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl314,480,697 - 14,505,830 (+)Ensemblmm10GRCm38
MGSCv37314,480,697 - 14,505,819 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36314,455,795 - 14,482,563 (+)NCBIMGSCv36mm8
Celera314,489,110 - 14,514,234 (+)NCBICelera
Cytogenetic Map3A1NCBI
cM Map33.05NCBI

Variants

.
Variants in Slc7a12
356 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:103
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000051741
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)261556902106556902Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)278269809104744824Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)261051541105724065Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)261051883104684275Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)261051541105724065Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)260861391105861391Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 8 12 40 39 37 11 24 11 4 147 52 23 70 23 26 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000051741   ⟹   ENSRNOP00000050128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl288,800,979 - 88,868,103 (-)Ensembl
mRatBN7.2 Ensembl287,079,749 - 87,146,875 (-)Ensembl
Rnor_6.0 Ensembl288,559,702 - 88,660,449 (-)Ensembl
RefSeq Acc Id: NM_001011948   ⟹   NP_001011948
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8288,800,954 - 88,868,103 (-)NCBI
mRatBN7.2287,079,724 - 87,146,875 (-)NCBI
Rnor_6.0288,559,677 - 88,660,449 (-)NCBI
Rnor_5.02108,432,230 - 108,432,980 (-)NCBI
Rnor_5.02108,332,499 - 108,333,025 (-)NCBI
Rnor_5.02108,364,359 - 108,366,610 (-)NCBI
RGSC_v3.4288,429,238 - 88,496,893 (-)RGD
Celera282,670,076 - 82,737,132 (-)RGD
Sequence:
RefSeq Acc Id: XM_063281531   ⟹   XP_063137601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8288,800,954 - 88,868,117 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001011948 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137601 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH78940 (Get FASTA)   NCBI Sequence Viewer  
  EDM00969 (Get FASTA)   NCBI Sequence Viewer  
  EDM00970 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050128
  ENSRNOP00000050128.2
RefSeq Acc Id: NP_001011948   ⟸   NM_001011948
- UniProtKB: Q6AYR7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050128   ⟸   ENSRNOT00000051741
RefSeq Acc Id: XP_063137601   ⟸   XM_063281531
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYR7-F1-model_v2 AlphaFold Q6AYR7 1-472 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691228
Promoter ID:EPDNEW_R1751
Type:multiple initiation site
Name:Slc7a12_1
Description:solute carrier family 7 (cationic amino acid transporter, y+system), member 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0288,660,463 - 88,660,523EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309208 AgrOrtholog
BioCyc Gene G2FUF-53801 BioCyc
Ensembl Genes ENSRNOG00000033830 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051741 ENTREZGENE
  ENSRNOT00000051741.6 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109204 IMAGE-MGC_LOAD
InterPro AA/rel_permease1 UniProtKB/TrEMBL
  AminoAcid_Transporter UniProtKB/TrEMBL
KEGG Report rno:294881 UniProtKB/TrEMBL
MGC_CLONE MGC:93774 IMAGE-MGC_LOAD
NCBI Gene 294881 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/TrEMBL
  ASC-TYPE AMINO ACID TRANSPORTER 2 UniProtKB/TrEMBL
Pfam AA_permease_2 UniProtKB/TrEMBL
PhenoGen Slc7a12 PhenoGen
PIRSF AA_transporter UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033830 RatGTEx
UniProt Q6AYR7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Slc7a12  solute carrier family 7 (cationic amino acid transporter, y+ system), member 12  Slc7a12_predicted  solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Slc7a12_predicted  solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 (predicted)      Symbol and Name status set to approved 70820 APPROVED