Klf12 (KLF transcription factor 12) - Rat Genome Database

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Gene: Klf12 (KLF transcription factor 12) Rattus norvegicus
Analyze
Symbol: Klf12
Name: KLF transcription factor 12
RGD ID: 1309204
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human KLF12 (KLF transcription factor 12); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Krueppel-like factor 12; Kruppel-like factor 12; LOC306110
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81583,037,548 - 83,469,998 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1583,045,463 - 83,670,640 (-)EnsemblGRCr8
mRatBN7.21576,628,778 - 77,062,000 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1576,637,654 - 77,062,056 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1580,623,760 - 80,973,738 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01581,700,349 - 82,050,323 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01578,647,950 - 78,997,925 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01584,316,986 - 84,748,549 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1584,324,470 - 84,748,525 (-)Ensemblrn6Rnor6.0
Rnor_5.01588,087,725 - 88,517,300 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41583,686,143 - 84,046,291 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1575,877,048 - 76,225,583 (-)NCBICelera
RGSC_v3.11583,824,681 - 83,885,689 (-)NCBI
Cytogenetic Map15q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
amphotericin B  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dicyclanil  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
Heptachlor epoxide  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
melphalan  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
paracetamol  (EXP)
PCB138  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
rofecoxib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
versicolorin A  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9858544   PMID:16615998  


Genomics

Comparative Map Data
Klf12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81583,037,548 - 83,469,998 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1583,045,463 - 83,670,640 (-)EnsemblGRCr8
mRatBN7.21576,628,778 - 77,062,000 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1576,637,654 - 77,062,056 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1580,623,760 - 80,973,738 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01581,700,349 - 82,050,323 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01578,647,950 - 78,997,925 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01584,316,986 - 84,748,549 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1584,324,470 - 84,748,525 (-)Ensemblrn6Rnor6.0
Rnor_5.01588,087,725 - 88,517,300 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41583,686,143 - 84,046,291 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1575,877,048 - 76,225,583 (-)NCBICelera
RGSC_v3.11583,824,681 - 83,885,689 (-)NCBI
Cytogenetic Map15q21NCBI
KLF12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381373,686,089 - 74,306,045 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1373,686,089 - 74,134,922 (-)Ensemblhg38GRCh38
GRCh371374,260,226 - 74,880,182 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361373,158,150 - 73,606,067 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341373,284,706 - 73,606,043NCBI
Celera1355,158,964 - 55,607,803 (-)NCBICelera
Cytogenetic Map13q22.1NCBI
HuRef1354,957,615 - 55,405,960 (-)NCBIHuRef
CHM1_11374,227,338 - 74,675,586 (-)NCBICHM1_1
T2T-CHM13v2.01372,907,694 - 73,528,039 (-)NCBIT2T-CHM13v2.0
Klf12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914100,103,617 - 100,719,681 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14100,108,068 - 100,522,115 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381499,866,181 - 100,285,891 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1499,870,632 - 100,284,679 (-)Ensemblmm10GRCm38
MGSCv3714100,269,851 - 100,549,015 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361498,753,766 - 99,032,930 (-)NCBIMGSCv36mm8
Celera1498,543,645 - 98,822,073 (-)NCBICelera
Cytogenetic Map14E2.2- E2.3NCBI
cM Map1450.9NCBI
Klf12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540432,854,754 - 33,118,361 (+)Ensembl
ChiLan1.0NW_00495540432,715,636 - 33,127,525 (+)NCBIChiLan1.0ChiLan1.0
KLF12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21475,267,675 - 75,717,201 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11373,867,629 - 74,309,095 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01354,916,443 - 55,535,131 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11373,688,429 - 74,136,126 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1373,697,912 - 73,996,956 (-)EnsemblpanPan2panpan1.1
KLF12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12227,695,017 - 28,264,813 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2227,704,686 - 28,123,099 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2227,545,323 - 28,120,406 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02228,028,356 - 28,604,139 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2228,042,396 - 28,462,397 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12227,683,490 - 28,257,505 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02227,722,157 - 28,312,161 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02227,794,427 - 28,385,703 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Klf12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945131,272,121 - 131,875,349 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365116,854,995 - 7,283,347 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365116,992,131 - 7,292,484 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLF12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1145,985,564 - 46,459,791 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11145,981,096 - 46,655,472 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21150,573,347 - 50,616,802 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLF12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1352,817,588 - 53,153,414 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660468,926,353 - 9,374,326 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klf12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475126,508,490 - 26,798,125 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475126,363,475 - 26,807,430 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Klf12
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11224,277,617 - 24,641,015 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Klf12
2687 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:424
Count of miRNA genes:227
Interacting mature miRNAs:267
Transcripts:ENSRNOT00000012424
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1582194914108192169Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1574735564106469153Rat
1358354Srcrt5Stress Responsive Cort QTL 53.38blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1582503470108192169Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1582714037106778197Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)154367724488677244Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1572716871101425383Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)1561710951106710951Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1575928947101425383Rat
2317050Aia24Adjuvant induced arthritis QTL 242.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1559257087104257087Rat
2313080Bss65Bone structure and strength QTL 653.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1567399137108192169Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1582194914108192169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)154367724488677244Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)1560213984105213984Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)156244089297773284Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)1572716871101425383Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
1581555Eae19Experimental allergic encephalomyelitis QTL 194.7nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)158271393186775589Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1564571127108192169Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)154367724488677244Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat

Markers in Region
D15Rat40  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1576,226,865 - 76,227,019UniSTS
RH 2.0 Map15404.7RGD
SHRSP x BN Map1549.5298RGD
FHH x ACI Map1563.69RGD
Cytogenetic Map15q21UniSTS
BF403686  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21576,796,664 - 76,796,833 (+)MAPPERmRatBN7.2
Rnor_6.01584,484,522 - 84,484,690NCBIRnor6.0
Rnor_5.01588,255,667 - 88,255,835UniSTSRnor5.0
RGSC_v3.41583,846,822 - 83,846,990UniSTSRGSC3.4
Celera1576,036,340 - 76,036,508UniSTS
RH 3.4 Map15516.3UniSTS
Cytogenetic Map15q21UniSTS
BI298444  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81583,074,436 - 83,074,727 (+)Marker Load Pipeline
mRatBN7.21576,666,627 - 76,666,918 (+)MAPPERmRatBN7.2
Rnor_6.01584,353,646 - 84,353,936NCBIRnor6.0
Rnor_5.01588,124,791 - 88,125,081UniSTSRnor5.0
RGSC_v3.41583,716,640 - 83,716,930UniSTSRGSC3.4
Celera1575,906,297 - 75,906,587UniSTS
RH 3.4 Map15517.0UniSTS
Cytogenetic Map15q21UniSTS
AU048543  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21576,958,441 - 76,958,730 (+)MAPPERmRatBN7.2
Rnor_6.01584,646,840 - 84,647,128NCBIRnor6.0
Rnor_5.01588,416,325 - 88,416,613UniSTSRnor5.0
RGSC_v3.41584,016,768 - 84,017,056UniSTSRGSC3.4
Celera1576,196,344 - 76,196,632UniSTS
Cytogenetic Map15q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001443893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001443894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001443895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001443896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005493737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000012424   ⟹   ENSRNOP00000012424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1583,045,463 - 83,281,267 (-)Ensembl
mRatBN7.2 Ensembl1576,637,654 - 76,873,465 (-)Ensembl
Rnor_6.0 Ensembl1584,324,470 - 84,676,125 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090009   ⟹   ENSRNOP00000073633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1583,045,463 - 83,463,385 (-)Ensembl
mRatBN7.2 Ensembl1576,637,654 - 77,062,056 (-)Ensembl
Rnor_6.0 Ensembl1584,325,468 - 84,748,525 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115385   ⟹   ENSRNOP00000094732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1583,045,463 - 83,469,781 (-)Ensembl
mRatBN7.2 Ensembl1576,637,654 - 77,062,056 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000136791   ⟹   ENSRNOP00000104842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1583,070,388 - 83,670,640 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000150382   ⟹   ENSRNOP00000109863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1583,045,463 - 83,282,231 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000152113   ⟹   ENSRNOP00000099671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1583,045,463 - 83,446,179 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000162907   ⟹   ENSRNOP00000109858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1583,045,463 - 83,469,480 (-)Ensembl
RefSeq Acc Id: NM_001107281   ⟹   NP_001100751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,045,463 - 83,395,562 (-)NCBI
mRatBN7.21576,637,654 - 76,987,740 (-)NCBI
Rnor_6.01584,324,470 - 84,676,125 (-)NCBI
Rnor_5.01588,087,725 - 88,517,300 (-)NCBI
RGSC_v3.41583,686,143 - 84,046,291 (-)RGD
Celera1575,877,048 - 76,225,583 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252409   ⟹   XP_006252471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,037,979 - 83,469,442 (-)NCBI
mRatBN7.21576,630,170 - 77,061,626 (-)NCBI
Rnor_6.01584,316,986 - 84,748,549 (-)NCBI
Rnor_5.01588,087,725 - 88,517,300 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006252410   ⟹   XP_006252472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,037,979 - 83,469,996 (-)NCBI
mRatBN7.21576,630,170 - 77,062,000 (-)NCBI
Rnor_6.01584,316,986 - 84,748,549 (-)NCBI
Rnor_5.01588,087,725 - 88,517,300 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599716   ⟹   XP_017455205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,037,979 - 83,469,442 (-)NCBI
mRatBN7.21576,630,170 - 77,061,626 (-)NCBI
Rnor_6.01584,316,986 - 84,748,549 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599718   ⟹   XP_017455207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,037,979 - 83,469,442 (-)NCBI
mRatBN7.21576,630,170 - 77,061,626 (-)NCBI
Rnor_6.01584,316,986 - 84,748,549 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093383   ⟹   XP_038949311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,037,979 - 83,451,187 (-)NCBI
mRatBN7.21576,630,170 - 77,043,274 (-)NCBI
RefSeq Acc Id: XM_039093384   ⟹   XP_038949312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,037,979 - 83,451,194 (-)NCBI
mRatBN7.21576,630,170 - 77,043,275 (-)NCBI
RefSeq Acc Id: XM_039093386   ⟹   XP_038949314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,037,979 - 83,469,442 (-)NCBI
mRatBN7.21576,630,170 - 77,061,626 (-)NCBI
RefSeq Acc Id: XM_039093388   ⟹   XP_038949316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,037,979 - 83,284,956 (-)NCBI
mRatBN7.21576,630,170 - 76,877,156 (-)NCBI
RefSeq Acc Id: XM_039093390   ⟹   XP_038949318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,037,979 - 83,469,996 (-)NCBI
mRatBN7.21576,630,170 - 77,062,000 (-)NCBI
RefSeq Acc Id: XM_039093393   ⟹   XP_038949321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,037,979 - 83,469,998 (-)NCBI
mRatBN7.21576,630,170 - 77,062,000 (-)NCBI
RefSeq Acc Id: XM_039093394   ⟹   XP_038949322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,037,979 - 83,280,206 (-)NCBI
mRatBN7.21576,630,170 - 76,798,339 (-)NCBI
RefSeq Acc Id: XM_039093395   ⟹   XP_038949323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,037,979 - 83,469,442 (-)NCBI
mRatBN7.21576,630,170 - 77,061,626 (-)NCBI
RefSeq Acc Id: XM_063274326   ⟹   XP_063130396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,349,731 - 83,469,442 (-)NCBI
RefSeq Acc Id: XM_063274327   ⟹   XP_063130397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,349,731 - 83,469,427 (-)NCBI
RefSeq Acc Id: XM_063274328   ⟹   XP_063130398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,349,731 - 83,469,460 (-)NCBI
RefSeq Acc Id: XM_063274329   ⟹   XP_063130399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,350,502 - 83,469,442 (-)NCBI
RefSeq Acc Id: XM_063274331   ⟹   XP_063130401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,037,979 - 83,469,442 (-)NCBI
RefSeq Acc Id: XM_063274333   ⟹   XP_063130403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,037,979 - 83,469,442 (-)NCBI
RefSeq Acc Id: XM_063274334   ⟹   XP_063130404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,037,979 - 83,469,442 (-)NCBI
RefSeq Acc Id: XR_005493737
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81583,037,548 - 83,451,187 (-)NCBI
mRatBN7.21576,628,778 - 77,043,274 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100751 (Get FASTA)   NCBI Sequence Viewer  
  NP_001430822 (Get FASTA)   NCBI Sequence Viewer  
  NP_001430823 (Get FASTA)   NCBI Sequence Viewer  
  NP_001430824 (Get FASTA)   NCBI Sequence Viewer  
  NP_001430825 (Get FASTA)   NCBI Sequence Viewer  
  XP_006252471 (Get FASTA)   NCBI Sequence Viewer  
  XP_006252472 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455205 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455207 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949311 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949312 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949314 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949316 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949318 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949321 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949322 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949323 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130396 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130397 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130398 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130399 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130401 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130403 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130404 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM02426 (Get FASTA)   NCBI Sequence Viewer  
  EDM02427 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012424.8
  ENSRNOP00000073633
  ENSRNOP00000073633.1
  ENSRNOP00000094732
  ENSRNOP00000094732.2
  ENSRNOP00000099671
  ENSRNOP00000099671.1
  ENSRNOP00000104842.1
  ENSRNOP00000109858
  ENSRNOP00000109858.1
  ENSRNOP00000109863
  ENSRNOP00000109863.1
RefSeq Acc Id: NP_001100751   ⟸   NM_001107281
- Sequence:
RefSeq Acc Id: XP_006252472   ⟸   XM_006252410
- Peptide Label: isoform X5
- UniProtKB: A0A0G2K610 (UniProtKB/TrEMBL),   A6HU63 (UniProtKB/TrEMBL),   D3ZG44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252471   ⟸   XM_006252409
- Peptide Label: isoform X5
- UniProtKB: A0A0G2K610 (UniProtKB/TrEMBL),   A6HU63 (UniProtKB/TrEMBL),   D3ZG44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455205   ⟸   XM_017599716
- Peptide Label: isoform X6
- UniProtKB: D3ZG44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455207   ⟸   XM_017599718
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AMS3 (UniProtKB/TrEMBL),   D3ZG44 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073633   ⟸   ENSRNOT00000090009
Ensembl Acc Id: ENSRNOP00000012424   ⟸   ENSRNOT00000012424
RefSeq Acc Id: XP_038949318   ⟸   XM_039093390
- Peptide Label: isoform X6
- UniProtKB: D3ZG44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949321   ⟸   XM_039093393
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AMS3 (UniProtKB/TrEMBL),   D3ZG44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949323   ⟸   XM_039093395
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038949314   ⟸   XM_039093386
- Peptide Label: isoform X5
- UniProtKB: A0A0G2K610 (UniProtKB/TrEMBL),   A6HU63 (UniProtKB/TrEMBL),   D3ZG44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949312   ⟸   XM_039093384
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038949311   ⟸   XM_039093383
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038949316   ⟸   XM_039093388
- Peptide Label: isoform X6
- UniProtKB: D3ZG44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949322   ⟸   XM_039093394
- Peptide Label: isoform X8
Ensembl Acc Id: ENSRNOP00000094732   ⟸   ENSRNOT00000115385
RefSeq Acc Id: XP_063130404   ⟸   XM_063274334
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063130403   ⟸   XM_063274333
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AMS3 (UniProtKB/TrEMBL),   D3ZG44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130401   ⟸   XM_063274331
- Peptide Label: isoform X6
- UniProtKB: D3ZG44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130398   ⟸   XM_063274328
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063130396   ⟸   XM_063274326
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063130397   ⟸   XM_063274327
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063130399   ⟸   XM_063274329
- Peptide Label: isoform X2
- UniProtKB: A6JPT4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000104842   ⟸   ENSRNOT00000136791
Ensembl Acc Id: ENSRNOP00000099671   ⟸   ENSRNOT00000152113
Ensembl Acc Id: ENSRNOP00000109863   ⟸   ENSRNOT00000150382
Ensembl Acc Id: ENSRNOP00000109858   ⟸   ENSRNOT00000162907
Protein Domains
C2H2-type   Endonuclease/exonuclease/phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZG44-F1-model_v2 AlphaFold D3ZG44 1-419 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699867
Promoter ID:EPDNEW_R10385
Type:single initiation site
Name:Klf12_1
Description:Kruppel-like factor 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01584,748,484 - 84,748,544EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309204 AgrOrtholog
BioCyc Gene G2FUF-12770 BioCyc
Ensembl Genes ENSRNOG00000009145 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012424.9 UniProtKB/TrEMBL
  ENSRNOT00000090009 ENTREZGENE
  ENSRNOT00000090009.3 UniProtKB/TrEMBL
  ENSRNOT00000115385 ENTREZGENE
  ENSRNOT00000115385.2 UniProtKB/TrEMBL
  ENSRNOT00000136791.1 UniProtKB/TrEMBL
  ENSRNOT00000150382 ENTREZGENE
  ENSRNOT00000150382.1 UniProtKB/TrEMBL
  ENSRNOT00000152113 ENTREZGENE
  ENSRNOT00000152113.1 UniProtKB/TrEMBL
  ENSRNOT00000162907 ENTREZGENE
  ENSRNOT00000162907.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
  Endonuclease/exonuclease/phosphatase UniProtKB/TrEMBL
InterPro Endo/exonu/phosph_ase_sf UniProtKB/TrEMBL
  Endo/exonuclease/phosphatase UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:306110 UniProtKB/TrEMBL
NCBI Gene 306110 ENTREZGENE
PANTHER KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
  PTHR23235:SF56 UniProtKB/TrEMBL
  REVERSE TRANSCRIPTASES UniProtKB/TrEMBL
Pfam Exo_endo_phos UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Klf12 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009145 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP DNase I-like UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A0G2K610 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMS3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L550_RAT UniProtKB/TrEMBL
  A0ABK0L6R3_RAT UniProtKB/TrEMBL
  A0ABK0LXL5_RAT UniProtKB/TrEMBL
  A0ABK0M4N5_RAT UniProtKB/TrEMBL
  A6HU63 ENTREZGENE, UniProtKB/TrEMBL
  A6HU64_RAT UniProtKB/TrEMBL
  A6JPT4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZG44 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-03 Klf12  KLF transcription factor 12  Klf12  Kruppel-like factor 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Klf12  Kruppel-like factor 12   Klf12_predicted  Kruppel-like factor 12 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Klf12_predicted  Kruppel-like factor 12 (predicted)      Symbol and Name status set to approved 70820 APPROVED