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Gene: Sdsl (serine dehydratase-like) Rattus norvegicus

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Symbol:

Sdsl

Name:

serine dehydratase-like

RGD ID:

1309192

Description:

Enables ammonia-lyase activity; glutamate racemase activity; and pyridoxal phosphate binding activity. Predicted to be involved in L-serine catabolic process. Orthologous to human SDSL (serine dehydratase like); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

glutamate racemase; L-serine deaminase; L-serine dehydratase-like; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; LOC360816; Sdhl; TDH

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SDSL (serine dehydratase like)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Sds (serine dehydratase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sdsl (serine dehydratase like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SDSL (serine dehydratase like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SDSL (serine dehydratase like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sdsl (serine dehydratase like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SDSL (serine dehydratase like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SDSL (serine dehydratase like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sdsl (serine dehydratase like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Sdsl (serine dehydratase like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SDS (serine dehydratase)	HGNC	OrthoDB
Homo sapiens (human):	ZNF700 (zinc finger protein 700)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SDSL (serine dehydratase like)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SDSL (serine dehydratase like)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|OMA\|OrthoFinder\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sds (serine dehydratase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sds (serine dehydratase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sds (serine dehydratase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sds (serine dehydratase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sdsl (serine dehydratase-like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	sdsl (serine dehydratase-like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	CHA1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	CHA1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sdsl	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	sdsl	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	41,760,252 - 41,770,465 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	41,760,252 - 41,770,465 (+)	Ensembl				GRCr8
mRatBN7.2	12	36,099,693 - 36,109,914 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	36,099,693 - 36,109,906 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	37,278,879 - 37,289,146 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	37,890,098 - 37,900,365 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	36,942,571 - 36,952,838 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	41,636,994 - 41,647,205 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	41,636,994 - 41,647,205 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	43,487,966 - 43,497,281 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	37,297,342 - 37,307,847 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	37,757,811 - 37,767,910 (+)	NCBI		Celera
RGSC_v3.1	12	37,156,569 - 37,171,232 (+)	NCBI
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

(2E,4E)-hexa-2,4-dienoic acid (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,4-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

atrazine (EXP)

belinostat (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

chlorpyrifos (ISO)

ciguatoxin CTX1B (ISO)

copper(II) sulfate (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

fructose (ISO)

gallic acid (ISO)

hydrogen peroxide (ISO)

indometacin (EXP)

ivermectin (ISO)

ketamine (EXP)

leflunomide (EXP)

monosodium L-glutamate (ISO)

N-nitrosodiethylamine (ISO)

paracetamol (ISO)

parathion (ISO)

pentachlorophenol (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

phlorizin (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

resorcinol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tamoxifen (ISO)

tetrachloromethane (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

Triptolide (ISO)

triptonide (ISO)

tunicamycin (ISO)

valdecoxib (EXP)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

lipid metabolic process (IEA)

Molecular Function

glutamate racemase activity (IDA,IEA)

identical protein binding (ISO)

isomerase activity (IEA)

L-serine ammonia-lyase activity (IDA,IEA,ISO)

lyase activity (IEA)

pyridoxal phosphate binding (IDA)

threonine deaminase activity (IDA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Identification of an l-serine/l-threonine dehydratase with glutamate racemase activity in mammals.	Katane M, etal., Biochem J. 2020 Nov 13;477(21):4221-4241. doi: 10.1042/BCJ20200721.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:16189514	PMID:18614015	PMID:23376485	PMID:25416956	PMID:31515488

Genomics

Comparative Map Data

Sdsl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	41,760,252 - 41,770,465 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	41,760,252 - 41,770,465 (+)	Ensembl				GRCr8
mRatBN7.2	12	36,099,693 - 36,109,914 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	36,099,693 - 36,109,906 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	37,278,879 - 37,289,146 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	37,890,098 - 37,900,365 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	36,942,571 - 36,952,838 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	41,636,994 - 41,647,205 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	41,636,994 - 41,647,205 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	43,487,966 - 43,497,281 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	37,297,342 - 37,307,847 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	37,757,811 - 37,767,910 (+)	NCBI		Celera
RGSC_v3.1	12	37,156,569 - 37,171,232 (+)	NCBI
Cytogenetic Map	12	q16	NCBI

SDSL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	113,422,380 - 113,438,276 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	113,418,087 - 113,438,386 (+)	Ensembl			hg38	GRCh38
GRCh37	12	113,860,185 - 113,876,081 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	112,344,599 - 112,360,464 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	112,322,935 - 112,338,800	NCBI
Celera	12	113,487,476 - 113,503,320 (+)	NCBI		Celera
Cytogenetic Map	12	q24.13	NCBI
HuRef	12	110,871,400 - 110,887,228 (+)	NCBI		HuRef
CHM1_1	12	113,828,434 - 113,844,299 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	113,399,004 - 113,414,868 (+)	NCBI		T2T-CHM13v2.0

Sds
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	120,614,612 - 120,621,997 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	120,614,591 - 120,621,997 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	120,476,547 - 120,483,932 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	120,458,186 - 120,472,810 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	120,908,211 - 120,922,772 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	120,718,819 - 120,733,380 (-)	NCBI		MGSCv36	mm8
Celera	5	117,542,665 - 117,557,130 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	60.63	NCBI

Sdsl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	9,659,999 - 9,675,618 (+)	Ensembl
ChiLan1.0	NW_004955482	9,656,563 - 9,670,951 (+)	NCBI	ChiLan1.0	ChiLan1.0

SDSL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	121,509,056 - 121,524,998 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	121,505,454 - 121,521,396 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	111,024,957 - 111,040,900 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	114,406,590 - 114,422,347 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	114,406,738 - 114,422,347 (+)	Ensembl			panPan2	panpan1.1

SDSL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	10,731,972 - 10,759,768 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	10,743,947 - 10,759,777 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	10,855,844 - 10,883,608 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	10,977,874 - 11,010,015 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	10,990,071 - 11,015,079 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	10,951,813 - 10,979,463 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	11,014,470 - 11,042,112 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	11,063,615 - 11,091,344 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Sdsl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	148,723,917 - 148,735,377 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936668	3,222,904 - 3,232,626 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936668	3,222,894 - 3,232,736 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SDSL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	38,471,165 - 38,484,155 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	38,471,162 - 38,484,459 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	40,882,862 - 40,895,856 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SDSL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	108,673,058 - 108,693,748 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	108,673,075 - 108,693,815 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	136,399,423 - 136,420,348 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sdsl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	19,109,587 - 19,116,244 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	19,110,425 - 19,131,161 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Sdsl
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	33,365,688 - 33,376,175 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Sdsl
54 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	90
Count of miRNA genes:	70
Interacting mature miRNAs:	74
Transcripts:	ENSRNOT00000001882
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	50386405	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	37764145	51558799	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
70169	Eae13	Experimental allergic encephalomyelitis QTL 13		0.032	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	12	29775522	42298555	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	33700432	51558799	Rat
631829	Alc6	Alcohol consumption QTL 6	4.7		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	34243475	43352593	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	49212240	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	9	63	160	89	88	59	58	59	6	311	154	11	136	77	92	29	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108336	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	LC552948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001882 ⟹ ENSRNOP00000001882

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	41,760,252 - 41,770,465 (+)	Ensembl
mRatBN7.2 Ensembl	12	36,099,693 - 36,109,906 (+)	Ensembl
Rnor_6.0 Ensembl	12	41,636,994 - 41,647,205 (+)	Ensembl

RefSeq Acc Id:

NM_001108336 ⟹ NP_001101806

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	41,760,252 - 41,770,465 (+)	NCBI
mRatBN7.2	12	36,099,693 - 36,109,906 (+)	NCBI
Rnor_6.0	12	41,636,994 - 41,647,205 (+)	NCBI
Rnor_5.0	12	43,487,966 - 43,497,281 (+)	NCBI
RGSC_v3.4	12	37,297,342 - 37,307,847 (+)	RGD
Celera	12	37,757,811 - 37,767,910 (+)	RGD

Sequence:

show sequence

ATGAGCACGGGTCATTCATGAGCCGTGAGCTGCATGAGGAAGGCAGAGAGGGTTGCATATCCCC
ACGAGTTCATCTTGATCACTTTTTGTTGTGAGTCCTCACCAGGACCCCAGAATCAAGAGCTGTC
CCTTTAACAAGGAGGAGGGGCCAGGGCCTGATAGCGGAAGCTGATCTGGTAGCCTGTGAGTTCA
GATTGATCCTGGCTGGGCTGTGCTGGTCTTGGACTGTCTTTCGGGGAAGGTCGTCAGCGTTCTG
TTGGAATGGAGGGAGCCTCGGCAGAGTGTGTCAGGGCAGAGCCTTTCCACAGGGTCACACCCCT
GCTGGAGAGCTGGGCGCTGTCTCAGGTGGCAGGCATGCCTGTCTTCCTCAAATATGAGAACGTG
CAGATAGCTGGCTCCTTTAAGATCCGGGGCATCGGACATTTCTGTCAGCAGATGGCCAAGAGGG
GATGCAGACATCTGGTGTGCTCCTCAGGGGGCAACGCAGGCATTGCGGCCGCATACTCCGCTCA
GAAGCTGGGCATCCCCGTCACCATCGTGCTCCCAGAGAGCACCTCCAAGCAGGTGGTGAGGCGG
CTGGAGGGAGAGGGGGCCGAGGTCCAGCTGACTGGGAAGGTCTGGGATGAAGCCAATGTAAGGG
CACAAGAACTGGCCACCAGGGACGGCTGGGTGAACGTCTCCCCGTTTGACCATCCCCTGATATG
GGAAGGCAATGCCAGCCTAGTGCGGGAGCTCAAGGAGTCCCTGAGGACGCCTCCAGGTGCCGTG
GTGCTGGCCGTGGGGGGTGGAGGGCTCCTGGCCGGTGTGGTTGCTGGCTTACTGGAGGTAGGCT
GGCAGCATGTGCCCATCGTTGCCATGGAGACCCGGGGGGCACACAGTTTCAACGCGGCTTTGCT
GGCGGGCAGGCTGGTCACTCTGCCAGACATCACCAGCGTAGCCAGGAGCCTGGGAGCCAAGACT
GTGGCTGCACGGACCTTGGAGTGTGCAAAGGAGTGTGAAGTCCTCTCTGAGGTGGTAGAAGACC
GGGAGGCTGTCAGAGCTGTGCAGAGGTTCCTGGACGATGAGCGCATGCTGGTGGAGCCTGCCTG
CGGTGCTGCCCTGGCTGCTGTCTACTCAGGCATCCTGGGGAGGCTCCAGACTGAGGGCCGCCTG
AGCCCTGCCCTGGATTCCGTCGTGGTCATCGTGTGTGGTGGCAACAACATCAGTAGCCAACAGC
TTCAGGAGCTGAAAACACAGCTGAACTGCAGCTGAAGGATCCCAGGGACCTCGGAGGCTACTGG
ACACCTTGGTCCTGTCCTCTTCCTTCAGGCAGCCCTCCTGGATTGCTCCCTGTGGCTCCCTGCA
GTCCAATGAATAAACCTGCCTGACTGGAGCATGT

hide sequence

RefSeq Acc Id:

XM_039089600 ⟹ XP_038945528

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	41,765,362 - 41,770,459 (+)	NCBI
mRatBN7.2	12	36,105,150 - 36,109,914 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101806	(Get FASTA)	NCBI Sequence Viewer
	XP_038945528	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	A0A6N3IN21	(Get FASTA)	NCBI Sequence Viewer
	BCG52828	(Get FASTA)	NCBI Sequence Viewer
	EDM13784	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001882

RefSeq Acc Id:

NP_001101806 ⟸ NM_001108336

- UniProtKB:

D3ZHV7 (UniProtKB/Swiss-Prot), A0A6N3IN21 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEGASAECVRAEPFHRVTPLLESWALSQVAGMPVFLKYENVQIAGSFKIRGIGHFCQQMAKRGC
RHLVCSSGGNAGIAAAYSAQKLGIPVTIVLPESTSKQVVRRLEGEGAEVQLTGKVWDEANVRAQ
ELATRDGWVNVSPFDHPLIWEGNASLVRELKESLRTPPGAVVLAVGGGGLLAGVVAGLLEVGWQ
HVPIVAMETRGAHSFNAALLAGRLVTLPDITSVARSLGAKTVAARTLECAKECEVLSEVVEDRE
AVRAVQRFLDDERMLVEPACGAALAAVYSGILGRLQTEGRLSPALDSVVVIVCGGNNISSQQLQ
ELKTQLNCS

hide sequence

Ensembl Acc Id:

ENSRNOP00000001882 ⟸ ENSRNOT00000001882

RefSeq Acc Id:	XP_038945528 ⟸ XM_039089600
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZHV7-F1-model_v2	AlphaFold	D3ZHV7	1-329	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309192	AgrOrtholog
BioCyc Gene	G2FUF-19170	BioCyc
BioCyc Pathway	PWY-3661 [glycine betaine degradation I]	BioCyc
	SERDEG-PWY [L-serine degradation]	BioCyc
BioCyc Pathway Image	PWY-3661	BioCyc
	SERDEG-PWY	BioCyc
Ensembl Genes	ENSRNOG00000001391	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000001882	ENTREZGENE
Gene3D-CATH	3.40.50.1100	UniProtKB/Swiss-Prot
InterPro	Ser/Thr_Dehydratase	UniProtKB/Swiss-Prot
	TrpB-like_PALP	UniProtKB/Swiss-Prot
	TrpB-like_PALP_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:360816	UniProtKB/Swiss-Prot
NCBI Gene	360816	ENTREZGENE
PANTHER	SERINE DEHYDRATASE-LIKE	UniProtKB/Swiss-Prot
	THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED	UniProtKB/Swiss-Prot
Pfam	PALP	UniProtKB/Swiss-Prot
PhenoGen	Sdsl	PhenoGen
RatGTEx	ENSRNOG00000001391	RatGTEx
Superfamily-SCOP	Tryptophan synthase beta subunit-like PLP-dependent enzymes	UniProtKB/Swiss-Prot
UniProt	A0A6N3IN21	ENTREZGENE
	A0AAR3BP33_RAT	UniProtKB/TrEMBL
	D3ZHV7	ENTREZGENE
	SDSL_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	D3ZHV7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Sdsl	serine dehydratase-like	Sdsl_predicted	serine dehydratase-like (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Sdsl_predicted	serine dehydratase-like (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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