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Gene: Ctsa (cathepsin A) Rattus norvegicus

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Symbol:

Ctsa

Name:

cathepsin A

RGD ID:

1309070

Description:

Predicted to enable serine-type carboxypeptidase activity. Predicted to be involved in negative regulation of chaperone-mediated autophagy; proteolysis; and regulation of protein stability. Human ortholog(s) of this gene implicated in galactosialidosis and lysosomal storage disease. Orthologous to human CTSA (cathepsin A); PARTICIPATES IN renin-angiotensin cascade pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC296370; lysosomal protective protein; Ppgb; protective protein for beta-galactosidase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CTSA (cathepsin A)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Ctsa (cathepsin A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ctsa (cathepsin A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CTSA (cathepsin A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CTSA (cathepsin A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ctsa (cathepsin A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CTSA (cathepsin A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CTSA (cathepsin A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ctsa (cathepsin A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ctsa (cathepsin A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CTSA (cathepsin A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CTSA (cathepsin A)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ctsa (cathepsin A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ctsa (cathepsin A)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ctsa (cathepsin A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ctsa (cathepsin A)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ATG42	Alliance	DIOPT (InParanoid\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F13D12.6	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F13D12.6	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F41C3.5	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F41C3.5	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PRC1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ctsa-1	Alliance	DIOPT (OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ctsa-1	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ctsa-2	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	C08H9.1	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F32A5.3	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	K10C2.1	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	Y16B4A.2	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ctsa	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	ctsa	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	173,988,443 - 173,994,320 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	173,988,460 - 173,995,539 (+)	Ensembl				GRCr8
mRatBN7.2	3	153,569,106 - 153,574,983 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	153,568,381 - 153,576,215 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	157,377,572 - 157,383,424 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	165,876,542 - 165,882,394 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	163,620,317 - 163,626,169 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	161,298,750 - 161,304,627 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	161,298,962 - 161,304,625 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	167,483,817 - 167,489,976 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	155,866,335 - 155,871,998 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	152,176,711 - 152,182,414 (+)	NCBI		Celera
RGSC_v3.1	3	155,772,370 - 155,778,034 (+)	NCBI
Cytogenetic Map	3	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brain Small Vessel Disease 6 (ISO)

Desbuquois dysplasia (ISO)

galactosialidosis (ISO)

genetic disease (ISO)

Hydrops Fetalis (ISO)

lysosomal storage disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (EXP)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3',5'-cyclic AMP (EXP)

4,4'-sulfonyldiphenol (EXP,ISO)

aconitine (EXP)

actinomycin D (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ampicillin (EXP)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (EXP,ISO)

bleomycin A2 (ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chloroquine (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

clofibrate (ISO)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

diethylstilbestrol (ISO)

divanadium pentaoxide (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

fenthion (ISO)

flutamide (EXP)

folic acid (ISO)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

glycidyl methacrylate (ISO)

ivermectin (ISO)

L-cysteine (EXP)

lead diacetate (EXP,ISO)

methidathion (ISO)

metronidazole (EXP)

N-methyl-4-phenylpyridinium (ISO)

neomycin (EXP)

Nutlin-3 (ISO)

ochratoxin A (EXP)

paracetamol (ISO)

paraquat (ISO)

perfluorododecanoic acid (EXP)

Pf-06840003 (ISO)

pirinixic acid (ISO)

quizartinib (ISO)

rac-lactic acid (ISO)

remdesivir (ISO)

selenium atom (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

Soman (EXP)

T-2 toxin (ISO)

tamibarotene (ISO)

temozolomide (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

triptonide (ISO)

valproic acid (EXP,ISO)

vancomycin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

negative regulation of chaperone-mediated autophagy (IEA,ISO)

proteolysis (IEA,ISO)

regulation of protein stability (IEA,ISO)

Cellular Component

lysosome (IEA,ISO)

Molecular Function

carboxypeptidase activity (IEA,ISO)

hydrolase activity (IEA)

peptidase activity (IEA)

protein binding (ISO)

serine-type carboxypeptidase activity (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

renin-angiotensin cascade pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor.	Cuervo AM, etal., EMBO J. 2003 Jan 2;22(1):47-59.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	Protective protein gene mutations in galactosialidosis.	Shimmoto M, etal., J Clin Invest. 1993 Jun;91(6):2393-8.

Additional References at PubMed

PMID:12477932	PMID:14651853	PMID:19056867	PMID:19946888	PMID:23376485	PMID:23533145	PMID:27032673

Genomics

Comparative Map Data

Ctsa
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	173,988,443 - 173,994,320 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	173,988,460 - 173,995,539 (+)	Ensembl				GRCr8
mRatBN7.2	3	153,569,106 - 153,574,983 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	153,568,381 - 153,576,215 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	157,377,572 - 157,383,424 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	165,876,542 - 165,882,394 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	163,620,317 - 163,626,169 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	161,298,750 - 161,304,627 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	161,298,962 - 161,304,625 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	167,483,817 - 167,489,976 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	155,866,335 - 155,871,998 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	152,176,711 - 152,182,414 (+)	NCBI		Celera
RGSC_v3.1	3	155,772,370 - 155,778,034 (+)	NCBI
Cytogenetic Map	3	q42	NCBI

CTSA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	45,891,335 - 45,898,820 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	45,890,144 - 45,898,949 (+)	Ensembl			hg38	GRCh38
GRCh37	20	44,519,974 - 44,527,459 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	43,952,998 - 43,960,866 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	20	43,953,612 - 43,960,863	NCBI
Celera	20	41,231,053 - 41,238,921 (+)	NCBI		Celera
Cytogenetic Map	20	q13.12	NCBI
HuRef	20	41,261,571 - 41,269,436 (+)	NCBI		HuRef
CHM1_1	20	44,422,715 - 44,430,579 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	47,627,833 - 47,635,315 (+)	NCBI		T2T-CHM13v2.0

Ctsa
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	164,674,792 - 164,682,952 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	164,674,793 - 164,682,952 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	164,832,872 - 164,841,032 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	164,832,873 - 164,841,032 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	164,658,373 - 164,666,532 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	164,524,078 - 164,532,237 (+)	NCBI		MGSCv36	mm8
Celera	2	170,770,535 - 170,778,698 (+)	NCBI		Celera
Cytogenetic Map	2	H3	NCBI
cM Map	2	85.27	NCBI

Ctsa
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	11,399,151 - 11,405,069 (-)	Ensembl
ChiLan1.0	NW_004955445	11,399,151 - 11,405,069 (-)	NCBI	ChiLan1.0	ChiLan1.0

CTSA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	51,631,610 - 51,640,169 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	51,625,703 - 51,633,277 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	42,229,064 - 42,237,627 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	43,315,722 - 43,324,671 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	43,316,530 - 43,324,671 (+)	Ensembl			panPan2	panpan1.1

CTSA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	33,183,090 - 33,189,248 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	33,183,090 - 33,189,248 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	32,710,110 - 32,716,269 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	33,893,407 - 33,899,565 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	33,893,230 - 33,902,559 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	33,151,886 - 33,158,036 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	33,267,003 - 33,273,167 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	33,806,176 - 33,812,343 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ctsa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	191,677,621 - 191,683,147 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936514	7,130,848 - 7,136,536 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936514	7,131,263 - 7,136,775 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CTSA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	48,082,448 - 48,089,971 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	17	48,082,480 - 48,089,971 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	53,729,009 - 53,736,612 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CTSA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	17,986,036 - 17,993,866 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	17,984,310 - 17,993,489 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666050	66,625,707 - 66,634,343 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ctsa
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624790	8,686,027 - 8,691,898 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624790	8,686,027 - 8,692,119 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ctsa
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	153,119,995 - 153,125,799 (-)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	455
Count of miRNA genes:	228
Interacting mature miRNAs:	262
Transcripts:	ENSRNOT00000066028
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
12879876	Bw182	Body weight QTL 182		0.003	body mass (VT:0001259)	body weight (CMO:0000012)	3	141555229	186555229	Rat
2301411	Bp320	Blood pressure QTL 320		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141555229	186555229	Rat
1582233	Insul10	Insulin level QTL 10	5.4	0.0015	blood insulin amount (VT:0001560)	serum insulin level times blood glucose level (CMO:0002040)	3	133259579	178259579	Rat
1300113	Bp176	Blood pressure QTL 176	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	166376089	177728348	Rat
12879872	Cm97	Cardiac mass QTL 97		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	141555229	186555229	Rat
12879873	Cm96	Cardiac mass QTL 96		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	141555229	186555229	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	151075912	189428310	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	129154923	182114333	Rat
12879874	Cm98	Cardiac mass QTL 98		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	141555229	186555229	Rat
12879875	Kidm64	Kidney mass QTL 64		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	141555229	186555229	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	161492708	189428310	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
8552791	Vie2	Viral induced encephalitis QTL 2	4.1		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	3	166376089	189428310	Rat
61335	Bp20	Blood pressure QTL 20	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	161799493	176036425	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	133134628	178134628	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	161799270	187311134	Rat
1582213	Insul6	Insulin level QTL 6	3.7	0.0009	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	3	155759447	189428310	Rat
1598854	Memor10	Memory QTL 10	2		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	3	166376089	189428310	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	152055202	189428310	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	142898802	187898802	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	145335553	189428310	Rat
1582256	Insul9	Insulin level QTL 9	4.4	0.0016	blood insulin amount (VT:0001560)	absolute change in serum insulin level (CMO:0002038)	3	155759447	189428310	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	139299381	184299381	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	141508991	177728348	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	131036586	176036586	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	137114333	182114333	Rat
1582248	Insul7	Insulin level QTL 7	3.9	0.0041	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	3	155759447	189428310	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	131036586	176036586	Rat
1578666	Vnigr1	Vascular neointimal growth QTL 1	4.6		artery morphology trait (VT:0002191)	artery lumen area (CMO:0001409)	3	151075912	189428310	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	151075912	189428310	Rat
12879871	Am7	Aortic mass QTL 7		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	141555229	186555229	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	144575244	189428310	Rat

Markers in Region

AA891893

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	3	173,993,661 - 173,994,060 (+)	Marker Load Pipeline
mRatBN7.2	3	153,574,324 - 153,574,723 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	161,303,969 - 161,304,367	NCBI	Rnor6.0
Rnor_5.0	3	167,489,318 - 167,489,716	UniSTS	Rnor5.0
RGSC_v3.4	3	155,871,342 - 155,871,740	UniSTS	RGSC3.4
Celera	3	152,181,930 - 152,182,328	UniSTS
RH 3.4 Map	3	1424.1	UniSTS
Cytogenetic Map	3	q42	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001011959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC105815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078934	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212992	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219992	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229081	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000066028 ⟹ ENSRNOP00000062425

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	173,988,532 - 173,994,319 (+)	Ensembl
mRatBN7.2 Ensembl	3	153,568,381 - 153,574,978 (+)	Ensembl
Rnor_6.0 Ensembl	3	161,298,962 - 161,304,625 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105075 ⟹ ENSRNOP00000097812

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	173,988,460 - 173,995,539 (+)	Ensembl
mRatBN7.2 Ensembl	3	153,568,837 - 153,576,215 (+)	Ensembl

RefSeq Acc Id:

NM_001011959 ⟹ NP_001011959

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	173,988,443 - 173,994,320 (+)	NCBI
mRatBN7.2	3	153,569,106 - 153,574,983 (+)	NCBI
Rnor_6.0	3	161,298,750 - 161,304,627 (+)	NCBI
Rnor_5.0	3	167,483,817 - 167,489,976 (+)	NCBI
RGSC_v3.4	3	155,866,335 - 155,871,998 (+)	RGD
Celera	3	152,176,711 - 152,182,414 (+)	NCBI

Sequence:

show sequence

AACACCAAAATCATCTGATTTCTGGCACCCTGACTGTGCACTTTGGGCTGTGCACTTTGACCTG
GTAATTGACCGCCCCCGACCCTCAGATAAAAAAAGTGAACGCTGAGCAAGCTGTCACGTGCTGC
AGAAGCTCACGTGACCAGAACTACACATGACTTCCAGTCCAAAGGCGGCTCCAGGAGAGCAAGG
ACACAAGGAAGCAGAGATGCCCCGAGCAGCACTGTCTCCACTGCTCCTGCTGCTGCTCCTATCC
TGGGCGTCCCGGGACGAAGCAGCTCCGGACCAGGATGAAATCGATTGCCTCCCGGGCCTGGCCA
AGCAGCCCTCTTTCCGGCAGTACTCCGGCTATCTCAAAGCATCGGATTCCAAGCACTTCCACTA
CTGGTTTGTGGAATCGCAGAACGACCCTAAGAACAGCCCCGTGGTGCTTTGGCTCAATGGGGGT
CCTGGCTGCAGCTCCCTAGATGGGTTACTTACAGAGCACGGTCCCTTCCTGATCCAGCCAGATG
GTGTCACCCTGGAGTACAACCCCTATTCTTGGAACCTGATTGCCAACATGCTGTATATCGAGTC
CCCAGCTGGGGTGGGCTTCTCCTACTCGGATGACAAGATGTATGTGACCAATGACACAGAGGTG
GCTGAGAACAATTATCAAGCCCTTAAAGACTTCTACCACCTCTTTCCGGAGTACAAGGACAACA
AACTTTTCCTGACCGGAGAGAGCTATGCTGGCATCTACATCCCCACCTTGGCTGTACTGGTCAT
GCAGGATCCCAGCATGAACCTTCAGGGGCTGGCTGTGGGCAATGGACTCTCCTCCTATGAGCAG
AATGACAACTCCCTGGTCTACTTTGCCTACTACCATGGTCTTCTGGGGAACAGGCTTTGGACTT
CACTCCAGACCCACTGCTGTTCTCAGAACAAGTGTAACTTCTATGACAACAAAGATCCAGATTG
TGTAAACAATCTCCAGGAAGTGTCTCGAATTGTGGGCAAATCTGGCCTCAACATATACAATCTC
TACGCCCCGTGTGCTGGTGGGGTACCCGGCCGTGATAGGTCTGAGGACACACTTGTAGTCCAGG
ATTTTGGCAATATCTTCACTCGCTTGCCACTCAAGAGGAGATTTCCTGAGGCTCTACTGCTTCG
GTCTGGGGACAAGGTACGCTTGGATCCTCCATGCACCAACACCACAGCCCCCTCCACCTACCTC
AACAACCCATATGTTCGGAAGGCTCTCCACATCCCGGAGTCGCTGCCCCGCTGGGACATGTGCA
ACCTCATGGTGAACTTACAGTACCGCCGTCTCTACGAAAGCATGAACTCCCAGTACCTGAAGTT
GCTCAGCTCACAGAAATACCAGATCCTGCTTTACAATGGCGATGTGGACATGGCCTGCAACTTC
ATGGGGGATGAGTGGTTTGTGGATTCCCTCAACCAGAAGATGGAGGTGCAGCGCCGGCCCTGGC
TAGTGGACTACGGGGAGAGTGGAGAGCAGGTAGCTGGCTTTGTGAAGGAATGCTCACACATTAC
CTTCCTCACCATCAAGGGTGCCGGACACATGGTCCCCACGGACAAGCCTCGAGCTGCTTTTACC
ATGTTCTCTCGATTCCTGAACAAGGAGCCTTACTGATAGCTTCGAGGACCCATGGAAGTCCTCA
GCACCTGATCAGACCCTCAAAGCCTCTCTCGATGTCGAGGACTCCTCCTTTATGCAAAGTGCTC
CCGTGGGGCAAGTCCTGCTTTAAAAATGCCCAGGCTTCCTACAGCCCTGTGCATCCCAGCCTGG
GCCTTGGGGCTTCACAGACAGTCTGGGACCAAATGAACACTTTGTTCTGGCTTTGATAGGATGG
CTTTCCCTGGTCTGCATAAAAAATGCCCCATCCCAGGACCCCAACAGAGCTCTAGAGAAGCCCA
AGGAGAGGGTTGGATGGATTGTAATTGATGGTTGACTGATTATGGAATTAAATCGGGTATAGCT
TCCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001011959	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH78934	(Get FASTA)	NCBI Sequence Viewer
	EDL96486	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000062425
	ENSRNOP00000062425.2
	ENSRNOP00000097812.2

RefSeq Acc Id:	NP_001011959 ⟸ NM_001011959
- Peptide Label:	precursor
- UniProtKB:	F7EU44 (UniProtKB/TrEMBL), A6JXC2 (UniProtKB/TrEMBL), A6JXC3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTSSPKAAPGEQGHKEAEMPRAALSPLLLLLLLSWASRDEAAPDQDEIDCLPGLAKQPSFRQYS GYLKASDSKHFHYWFVESQNDPKNSPVVLWLNGGPGCSSLDGLLTEHGPFLIQPDGVTLEYNPY SWNLIANMLYIESPAGVGFSYSDDKMYVTNDTEVAENNYQALKDFYHLFPEYKDNKLFLTGESY AGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWTSLQTHCCSQ NKCNFYDNKDPDCVNNLQEVSRIVGKSGLNIYNLYAPCAGGVPGRDRSEDTLVVQDFGNIFTRL PLKRRFPEALLLRSGDKVRLDPPCTNTTAPSTYLNNPYVRKALHIPESLPRWDMCNLMVNLQYR RLYESMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVDYGESGE QVAGFVKECSHITFLTIKGAGHMVPTDKPRAAFTMFSRFLNKEPY hide sequence

Ensembl Acc Id:

ENSRNOP00000062425 ⟸ ENSRNOT00000066028

Ensembl Acc Id:

ENSRNOP00000097812 ⟸ ENSRNOT00000105075

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AYS3-F1-model_v2	AlphaFold	Q6AYS3	1-456	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692668

Promoter ID:

EPDNEW_R3193

Type:

initiation region

Name:

Ctsa_1

Description:

cathepsin A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	161,298,913 - 161,298,973	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309070	AgrOrtholog
BioCyc Gene	G2FUF-46822	BioCyc
Ensembl Genes	ENSRNOG00000015857	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000066028	ENTREZGENE
	ENSRNOT00000066028.3	UniProtKB/TrEMBL
	ENSRNOT00000105075.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1820	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7108104	IMAGE-MGC_LOAD
InterPro	AB_hydrolase	UniProtKB/TrEMBL
	Peptidase_S10	UniProtKB/TrEMBL
	Ser_caboxypep_his_AS	UniProtKB/TrEMBL
	Ser_caboxypep_ser_AS	UniProtKB/TrEMBL
KEGG Report	rno:296370	UniProtKB/TrEMBL
MGC_CLONE	MGC:93743	IMAGE-MGC_LOAD
NCBI Gene	296370	ENTREZGENE
PANTHER	LYSOSOMAL PROTECTIVE PROTEIN	UniProtKB/TrEMBL
	PTHR11802	UniProtKB/TrEMBL
Pfam	Peptidase_S10	UniProtKB/TrEMBL
PhenoGen	Ctsa	PhenoGen
PRINTS	CRBOXYPTASEC	UniProtKB/TrEMBL
PROSITE	CARBOXYPEPT_SER_HIS	UniProtKB/TrEMBL
	CARBOXYPEPT_SER_SER	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000015857	RatGTEx
Superfamily-SCOP	SSF53474	UniProtKB/TrEMBL
UniProt	A0A8I6ARV9_RAT	UniProtKB/TrEMBL
	A6JXC2	ENTREZGENE, UniProtKB/TrEMBL
	A6JXC3	ENTREZGENE, UniProtKB/TrEMBL
	F7EU44	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2009-08-05	Ctsa	cathepsin A	Ppgb	protective protein for beta-galactosidase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Ppgb	protective protein for beta-galactosidase	Ppgb_predicted	protective protein for beta-galactosidase (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Ppgb_predicted	protective protein for beta-galactosidase (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)