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Gene: Sh3tc2 (SH3 domain and tetratricopeptide repeats 2) Rattus norvegicus

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Symbol:

Sh3tc2

Name:

SH3 domain and tetratricopeptide repeats 2

RGD ID:

1309038

Description:

Predicted to be involved in regulation of ERBB signaling pathway; regulation of endocytic recycling; and regulation of intracellular protein transport. Predicted to act upstream of or within peripheral nervous system myelin maintenance. Predicted to be located in plasma membrane and recycling endosome. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4C. Orthologous to human SH3TC2 (SH3 domain and tetratricopeptide repeats 2); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; bis(2-ethylhexyl) phthalate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC102556165; LOC307393; RGD1309038; SH3 domain and tetratricopeptide repeat-containing protein 2; SH3 domain and tetratricopeptide repeats-containing protein 2; similar to RIKEN cDNA D430044G18; uncharacterized LOC102556165

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	57,686,701 - 57,747,735 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	57,686,735 - 57,800,541 (+)	Ensembl				GRCr8
mRatBN7.2	18	55,416,383 - 55,477,419 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	55,416,413 - 55,483,083 (+)	Ensembl				mRatBN7.2
Rnor_6.0	18	57,286,266 - 57,403,926 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	57,286,322 - 57,347,577 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	56,514,111 - 56,575,127 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	57,941,970 - 58,002,846 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	53,565,072 - 53,680,040 (+)	NCBI		Celera
RGSC_v3.1	18	57,990,670 - 58,074,424 (+)	NCBI
Cytogenetic Map	18	q12.1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

arthrogryposis multiplex congenita (ISO)

autosomal dominant distal hereditary motor neuronopathy 14 (ISO)

Charcot-Marie-Tooth disease (ISO)

Charcot-Marie-Tooth disease intermediate type (ISO)

Charcot-Marie-Tooth disease type 1 (ISO)

Charcot-Marie-Tooth disease type 1B (ISO)

Charcot-Marie-Tooth disease type 4 (ISO)

Charcot-Marie-Tooth disease type 4C (ISO,ISS)

Ependymomas (ISO)

genetic disease (ISO)

median neuropathy (ISO)

Mononeuropathy of the Median Nerve, Mild (ISO)

motor peripheral neuropathy (ISO)

schizophrenia (ISO)

scoliosis (ISO)

spinal muscular atrophy (ISO)

Talipes Cavus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',5,5'-tetrachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (EXP)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

Cuprizon (EXP)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

diethyl phthalate (EXP)

diisobutyl phthalate (EXP)

diisononyl phthalate (EXP)

dioxygen (ISO)

diquat (ISO)

FR900359 (ISO)

fulvestrant (ISO)

gentamycin (EXP)

lipopolysaccharide (ISO)

methotrexate (ISO)

methoxychlor (EXP)

N-methyl-4-phenylpyridinium (EXP)

naled (ISO)

niclosamide (ISO)

O-methyleugenol (ISO)

oxaliplatin (EXP)

paracetamol (EXP)

PCB138 (EXP)

perfluorohexanesulfonic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

sulforaphane (ISO)

sunitinib (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trametinib (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

urethane (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

myelination in peripheral nervous system (ISO)

peripheral nervous system myelin maintenance (ISO)

regulation of endocytic recycling (IEA,ISO)

regulation of ERBB signaling pathway (IBA,ISO)

regulation of intracellular protein transport (IBA,ISO)

Cellular Component

cytoplasmic vesicle (IEA,ISO)

plasma membrane (IEA,ISO)

recycling endosome (IEA,ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:14574644	PMID:19805030	PMID:20826437	PMID:23553667	PMID:27068304

Genomics

Comparative Map Data

Sh3tc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	57,686,701 - 57,747,735 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	57,686,735 - 57,800,541 (+)	Ensembl				GRCr8
mRatBN7.2	18	55,416,383 - 55,477,419 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	55,416,413 - 55,483,083 (+)	Ensembl				mRatBN7.2
Rnor_6.0	18	57,286,266 - 57,403,926 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	57,286,322 - 57,347,577 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	56,514,111 - 56,575,127 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	57,941,970 - 58,002,846 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	53,565,072 - 53,680,040 (+)	NCBI		Celera
RGSC_v3.1	18	57,990,670 - 58,074,424 (+)	NCBI
Cytogenetic Map	18	q12.1	NCBI

SH3TC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	148,982,150 - 149,063,062 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	148,923,639 - 149,063,163 (-)	Ensembl			hg38	GRCh38
GRCh37	5	148,361,713 - 148,442,625 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	148,341,906 - 148,422,930 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	148,364,376 - 148,422,880	NCBI
Celera	5	144,443,778 - 144,524,792 (-)	NCBI		Celera
Cytogenetic Map	5	q32	NCBI
HuRef	5	143,506,997 - 143,588,011 (-)	NCBI		HuRef
CHM1_1	5	147,794,201 - 147,875,232 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	149,516,997 - 149,597,907 (-)	NCBI		T2T-CHM13v2.0

Sh3tc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	62,086,002 - 62,148,790 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	62,086,146 - 62,157,473 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	18	61,952,928 - 62,015,719 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	61,953,075 - 62,024,402 (+)	Ensembl			mm10	GRCm38
MGSCv37	18	62,112,729 - 62,175,373 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	18	62,078,453 - 62,141,084 (+)	NCBI		MGSCv36	mm8
Celera	18	63,238,842 - 63,301,641 (+)	NCBI		Celera
Cytogenetic Map	18	E1	NCBI
cM Map	18	34.78	NCBI

Sh3tc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	5,303,311 - 5,355,672 (+)	Ensembl
ChiLan1.0	NW_004955415	5,286,475 - 5,354,880 (+)	NCBI	ChiLan1.0	ChiLan1.0

SH3TC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	144,216,609 - 144,294,434 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	142,356,158 - 142,433,983 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	144,412,449 - 144,490,183 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	150,439,183 - 150,498,467 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	150,438,976 - 150,498,354 (-)	Ensembl			panPan2	panpan1.1

SH3TC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	59,801,240 - 59,905,759 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	59,801,384 - 59,903,135 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	59,565,747 - 59,670,219 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	60,283,914 - 60,388,188 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	60,283,947 - 60,386,310 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	60,070,432 - 60,174,629 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	60,184,842 - 60,295,228 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	60,715,252 - 60,819,526 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Sh3tc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	144,189,964 - 144,245,205 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936504	5,763,984 - 5,871,143 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936504	5,763,929 - 5,817,309 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SH3TC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	150,183,485 - 150,247,637 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	150,183,480 - 150,247,747 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	156,973,044 - 157,004,306 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SH3TC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	51,615,754 - 51,677,650 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666034	26,070,743 - 26,139,032 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sh3tc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624774	8,398,925 - 8,454,774 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624774	8,391,285 - 8,454,828 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Sh3tc2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	15	69,927,502 - 69,995,839 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Sh3tc2
253 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	186
Count of miRNA genes:	141
Interacting mature miRNAs:	160
Transcripts:	ENSRNOT00000026174, ENSRNOT00000071911
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25071126	83910656	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	22015562	61600538	Rat
1331730	Scl27	Serum cholesterol level QTL 27	3.826		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	18	54490801	86134022	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	23494057	85487725	Rat
1331742	Bp228	Blood pressure QTL 228	3.88752		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
1331736	Bp227	Blood pressure QTL 227	2.791		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	48917054	60064728	Rat
1300125	Rf26	Renal function QTL 26	3.2		urine potassium amount (VT:0010539)	urine potassium excretion rate (CMO:0000761)	18	53350521	68120379	Rat
631834	Sach3	Saccharin preference QTL 3	3.9	0.01	consumption behavior trait (VT:0002069)	calculated saccharin drink intake volume (CMO:0001600)	18	38575919	83575919	Rat
12904668	Bw188	Body weight QTL 188		0.03	body mass (VT:0001259)	body weight (CMO:0000012)	18	26822186	71822186	Rat
12904669	Cm125	Cardiac mass QTL 125		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	26822186	71822186	Rat
12904670	Cm126	Cardiac mass QTL 126		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	26822186	71822186	Rat
6893683	Bw110	Body weight QTL 110	2.7	0.002	body mass (VT:0001259)	body weight (CMO:0000012)	18	45620306	86134022	Rat
1331727	Bp237	Blood pressure QTL 237	3.053		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	63968306	Rat
12904677	Kidm72	Kidney mass QTL 72		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	26822186	71822186	Rat
9589041	Epfw12	Epididymal fat weight QTL 12	17.08	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	18	48915737	86134022	Rat
8694432	Bw165	Body weight QTL 165	3.81	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	48915737	86134022	Rat
12904673	Cm127	Cardiac mass QTL 127		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	26822186	71822186	Rat
12904675	Am19	Aortic mass QTL 19		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	26822186	71822186	Rat
70185	BpQTLcluster15	Blood pressure QTL cluster 15	4.61		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	18	53845175	61982387	Rat
1331774	Bp226	Blood pressure QTL 226	4.41065		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
9589816	Gluco68	Glucose level QTL 68	7.25	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	31990891	76990891	Rat
1331770	Bp234	Blood pressure QTL 234	3.807		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	45620306	86134022	Rat
61360	Eaey	Experimental allergic encephalomyelitis QTL y	3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis duration (CMO:0001424)	18	49187226	62647720	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	12066482	85493247	Rat
2303120	Mamtr8	Mammary tumor resistance QTL 8		0.001	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	31610505	85493247	Rat
12880368	Bw187	Body weight QTL 187		0.045	body mass (VT:0001259)	body weight (CMO:0000012)	18	33379158	78379158	Rat
61367	Iddm4	Insulin dependent diabetes mellitus QTL 4	2.33	0.0074	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	40462383	85462383	Rat
1359020	Ppulsi2	Prepulse inhibition QTL 2	2.71		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	18	54490801	76272247	Rat
9590318	Scort22	Serum corticosterone level QTL 22	7.64	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	31990891	76990891	Rat
1331752	Bw27	Body weight QTL 27	2.963		body mass (VT:0001259)	body weight (CMO:0000012)	18	54490801	68120379	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	12066482	85493247	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	15642280	86134022	Rat
12904069	Cm123	Cardiac mass QTL 123		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	33379158	78379158	Rat
1331798	Bp224	Blood pressure QTL 224	3.53873		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
12904070	Cm124	Cardiac mass QTL 124		0.01	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	33379158	78379158	Rat
12904071	Am18	Aortic mass QTL 18		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	33379158	78379158	Rat
2303584	Gluco55	Glucose level QTL 55	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	18	50795212	86134022	Rat
2301413	Bp318	Blood pressure QTL 318		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	26822186	71822186	Rat
61383	Bp47	Blood pressure QTL 47	17.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	31522783	76522783	Rat
12904067	Cm122	Cardiac mass QTL 122		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	33379158	78379158	Rat
2301417	Bp319	Blood pressure QTL 319		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	33379158	78379158	Rat
1331806	Bp229	Blood pressure QTL 229	4.36484		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	48917054	60064728	Rat
12904073	Kidm71	Kidney mass QTL 71		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	33379158	78379158	Rat
1331780	Bp238	Blood pressure QTL 238	3.269		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	48917054	60064728	Rat
1331776	Bp225	Blood pressure QTL 225	2.829		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	31610505	77371277	Rat
631518	Bw11	Body weight QTL 11	2.8		body mass (VT:0001259)	body weight (CMO:0000012)	18	36121626	81121626	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	31990891	76990891	Rat
8694366	Abfw8	Abdominal fat weight QTL 8	6.38	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	18	48915737	86134022	Rat
631509	Sald2	Serum aldosterone level QTL 2	2.9		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	18	26415821	71415821	Rat
631274	Sprol1	Serum protein level QTL 1	5.3		blood total protein amount (VT:0005567)	serum total protein level (CMO:0000661)	18	31644508	79484311	Rat
1598832	Glom11	Glomerulus QTL 11	2.9		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	53266671	86134022	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19553532	85493247	Rat
8694378	Bw157	Body weight QTL 157	3.59	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	31990891	76990891	Rat
2303571	Bw92	Body weight QTL 92	3		body mass (VT:0001259)	body weight (CMO:0000012)	18	50795212	86134022	Rat
61429	Cia17	Collagen induced arthritis QTL 17	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	31610505	72538878	Rat
7411719	Strs5	Sensitivity to stroke QTL 5	9.4		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	18	52198059	68120379	Rat

Markers in Region

D18Got53

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	55,422,127 - 55,422,311 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	57,292,012 - 57,292,195	NCBI	Rnor6.0
Rnor_5.0	18	56,519,837 - 56,520,020	UniSTS	Rnor5.0
RGSC_v3.4	18	57,947,551 - 57,947,734	UniSTS	RGSC3.4
RGSC_v3.4	18	57,947,550 - 57,947,734	RGD	RGSC3.4
Celera	18	53,570,601 - 53,570,784	UniSTS
RGSC_v3.1	18	58,019,783 - 58,019,966	RGD
RH 3.4 Map	18	541.2	UniSTS
RH 3.4 Map	18	541.2	RGD
RH 2.0 Map	18	367.5	RGD
Cytogenetic Map	18	q12.1	UniSTS

RH139705

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	55,477,049 - 55,477,251 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	57,346,933 - 57,347,134	NCBI	Rnor6.0
Rnor_5.0	18	56,574,758 - 56,574,959	UniSTS	Rnor5.0
RGSC_v3.4	18	58,002,472 - 58,002,673	UniSTS	RGSC3.4
Celera	18	53,625,509 - 53,625,710	UniSTS
RH 3.4 Map	18	543.9	UniSTS
Cytogenetic Map	18	q12.1	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
15	12	67	146	90	89	58	38	58	6	300	138	11	125	81	92	31	12	12

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001427096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001059165	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006222580	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006222581	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006254817	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772199	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008774131	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008774132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008774133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097415	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097416	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097417	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277342	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277343	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277345	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC089936	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026174 ⟹ ENSRNOP00000026174

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	57,686,735 - 57,747,732 (+)	Ensembl
mRatBN7.2 Ensembl	18	55,416,413 - 55,477,416 (+)	Ensembl
Rnor_6.0 Ensembl	18	57,286,322 - 57,347,577 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098535 ⟹ ENSRNOP00000081796

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	57,686,735 - 57,753,411 (+)	Ensembl
mRatBN7.2 Ensembl	18	55,416,413 - 55,483,083 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000142112 ⟹ ENSRNOP00000099506

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	57,691,622 - 57,747,735 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000169979 ⟹ ENSRNOP00000104227

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	57,686,735 - 57,800,541 (+)	Ensembl

RefSeq Acc Id:

NM_001427096 ⟹ NP_001414025

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	57,686,828 - 57,747,735 (+)	NCBI

RefSeq Acc Id:

XM_006254817 ⟹ XP_006254879

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	57,686,702 - 57,747,034 (+)	NCBI
mRatBN7.2	18	55,416,384 - 55,476,721 (+)	NCBI
Rnor_6.0	18	57,286,267 - 57,346,554 (+)	NCBI
Rnor_5.0	18	56,514,111 - 56,575,127 (+)	NCBI

Sequence:

show sequence

CTCCCCACTGCAGGCCGGATATCAAAGGCTGCATTGTGCATTGAACTGCCTCGGTCCCCCTCGT
GTGCCAGGGAGGAGGCGGGAGGAGGGACACCACCGATGGGAGGCTCCCAAGGTTCTCCTGACTG
GCGTTCCCAGGGGCCTTGGCCCAGGGAGGATGGTGCACACATGGGTGGCTGCTTCTGTATCCCT
GGGGAGCGGAGTCTACCCTGGGGCCCAGGTAAAGAAGGTTCTTCCAAGGATCCGCCTGGATTGA
CTGAGGACATATCCTCACTTGAAAACAAGAGAAAATGTTTCCTGCCACAGAATATGACTCAAGA
CCTGGTGCTCTCATTCTGGGTGAGGAGTCGTTCCAGGAGGTGTGTCAACGCAGCCTTACAGGAA
GCTGCACGGAGGAGGCTCTGGGCCCTGGAGAATGAAGCCCACGAAGTCCATGCACTGTTTAAGG
ATCTCTCTGCAAGGTTGGTGAGTGTCCAGTCCCAGAAGGACCAGTTCCTCATCACCTTCAAGAC
CCTGGAGGAAATCTGGAAGTTTTCCACGTACCTGAACTTAGGCTATGTGTCTACATGTCTGGAA
CACCTCTTCTTTGACCACACGTACTGGCTCAACAGCAGACTGGTGGACGACACAGAGATCCAAG
TGTCTGTGGACGACACTCACTTGGAAAACATATACCTGGGCCTCCTGCTGCAGGAAGGTCACTT
CTTCTGCAGAGCCATGTGCTCTGTGACTCAGCCAGCTGACAAGGAAGGAGAATATTTGACATTG
TGTAAGAACGAGCTGATCTCCGTACTCTCTGGGGGCGAATCCGACTGGGAAGGCATGTCCTTAG
TGACGGGCCAGAGGGGCCTGGTGCCGGTGTCAGCCCTGGAACCCCTGCCTGTCTCTTTCCACCA
ATGGTTCCTAAAGAATCACCCAGGAATCTGTGGCCTTCCCAGGAAGAAAGACTGGACAGGCTCC
TGTCAGATCGGCAGAGGACGGTGCAAGGCTCTGATGGATTACCAACAGGAGGAAAGGGACGAAC
TGGGCTTCCTCCAGGGTGAAAGCATTGACGTCATCGGCTTTGTCATACCTGGGCTGCGGTGGTT
CATTGGGAAGTCAATGAGCTCAGGAAAAGTGGGCTTTGTCCCCACCAGGAGCATAGATCTCGAT
TCCTGCTCCCCGGTGAGCAAGAACTCTGTCTTTTTCAGTGATGAGGAAAGGTGTTCTCTCTGGT
CCCCAGGAGGTGACAGGAAGGCTGAGTGCTCTGGCTTCCTAAGCGCACTCGCTCATACTGACAT
CACCTCTGTCTACCGGCTGAGTGAGTTTGAATCCATCCAGAATCTTCAGAATGACTTGAGCGCA
TCTCAGCCCGAGGGCTTCAGGGAGGCCAGGTCTGGTGGGACCTGGATGGAGCGGAAGACCATGG
GCTCCAGACGTTCCAGCAGTTCTCTAGACTCCAGCCTTGAGGATGAGCTCATCTCAGCCTCCTC
AGACAGCTATCACCTTCCAGAGCCTGATGACCTCGATGACCCGGAACTGTTCATGGACCTAAGC
ACTAGCCTGGAAGAGGATGAGATGGAGCACTTTGCCCCCATCTTGGCTTTTCTAGATCATGAAG
GCTACACTGACCACTTCAAGAGCCTCTATGATTTCTCCTTCTCTTTTCTTACTTCGTCCTTTTA
CAGCTTCTCTGAGGAGGATGAGCTAGTGGCCTACCTAGAGACTTCAAGGAAGTGGGCCAAGATG
ACCCACAGGACGTGGGCCCATGCCCGGCTCTGCTTCCTCCTGGGCAGACTAAGCATCAGGAAGA
CCAAACTTTCCCAGGCCAGGGTATACTTTGAGGAGGCCATTCGAGTCCTTGACGGGGCGTTCGA
GGACCTCTCCCTGGTGGCTGCTCTGTACATCAACTTGGCAGCCATCTACCTGAGGCAGAGGCTA
AGACATAAAGGGCCAATCCTGCTGGAAAAGGCAGGTGCTCTGCTGGCCTGCCTGCCAGACCGTG
AGTTCAGTGCCAAGAATGAGCTTGACGTGGTGACTTATGTGCTTCGCCAAGGGATCGTGGCGGG
GAGTGGCCCTCTGGAGGCTAGGTCCTGCTTCCTGGCCATCCGGTTGCTCCTGAATCTTGGCCGG
CATGAGGAAGTTCTGCCATTTGCAGAGCGTCTGCAGCTCCTTTCTGGACACTCTCCTGCTTCGG
AGGTTACAGCCACCATGTTGAGTTCTCTGTATGACAAGAAATATCTTCCACATCTTGCAGTGGC
CTCCGTTCAGAAACGTGGTCCCCAGAGTGCCCGGGGGATGTCTGTTGCCATTTGGCAGGCTTAT
TTGGTTCTCCAGAATGCCACAAAGATCCTGGGTGTTCCTTTTTCAAGCTGGTGTGAAGTTTCTG
CACTGGCCTGCCCAACCCTCAGGCAGGCCCTGGCTGCCTGTGAGGAACAGACTGACCTGAACAT
CCAGAGGACCTTGTGTCTCCTCCTGTCCAAAATGTACCTCCAGCACAGGTCTCCTGATGGTTCT
GTCCAATACCTGAGTCAAGCACATGTGTTAGGGAAACTCCTGGGTGAAGAGGAAGCCTTTGAAT
CTTCTCTCTGTCTGGCATGGGCTTATCTCTTAGCCAGGCAGACGAAGAAGGCTTTGGAGATCCT
CGAACCGCTACTGTGTTCCTTGAGGGAGACAGAGTGTGTGACCCAGAGGGGAGTGGTCCATAAC
CTCCTGGGACTGGCCTTTCAAGATGAAGGTCGGACAAGCAGGGCAGCCAAGAGCTATCTCCGAG
CTTTGATCAGAGCTCGGGAGATGGGGAATATACGTAACCAGGCTGTGTCTATGGCCAATCTTGG
TCACTTGACCCTCAAGTCCTGTATGCAGCAGTCAGCCAGGGGTTATCTCCTGCAGGCTGTCCGA
CTGTATTCTGAAATCCAAGCCAGCAAGGAGACAGATATGGAATTGGTACAAGTGTTACTCTGGT
TGGGCCAAGCTCTGGTGTCTGGACACCAGCTGGTCCACAGCCGCCTTTGTTATGAAATGGCACT
GCTATTTGGCTTAAGGCACCGACACCTAAACAGTCAACTTCAGGTCACCAAATCCCTCTGCCAT
TTCTACAGCTCCGTGTCCCCAAACCCTGACGCGTGCATTACCTATCATGAACACTGGCTGGCCT
TGGCTCAACAACTCAGGGACCGGGAGATGGAGGGGCGGTTACTGGAGTCCCTTGGGCAGCTTTA
TAGGAACCTAAATACATCCAGGTCCCTCAGAAGGTCCCTCGCCTGCATCAAGGAGAGCCTGCGG
ATATTCGTCGACCTAGGGGAGAGAGACAAGGCTGCTGAGGCCTGGCTGGGGGCCGGGCGCCTGC
ACTACCTCATGCAGGAAGACGAGCTGGTGGAAGTGTATTTGCAGGAGGCCATCCAGACAGCCTT
GAGGTCAGAAGAGCTCTCCCTCGCTCTCAAGCTTTATGAAGAAGCAGGTGATGTGTTCTTCAAT
GGGACCCGCCATAGACATCGGGCTGTGGAGTATTACCGGGCTGGGGCTGTTCCTTTAGCGAGGA
GAATGAAGGCCCTGCGAACCGAGCTGCGGATCTTCAACAAGCTGACGGAGCTGCAGATCAGCCT
CCGGGGCTATGAAAAAGCTTTGGAATTTGCCACTCTGGCTGCCAGGCTGAGTGTCCTCACAGGA
GATCAGAAACAGGAGCTGGTGGCTTTTCACCGCCTGGCGACCGTGTACTTCTCTCTGAACATGT
ATGAGATGGCTGAAGACTGCTACCTGAAGACTCTATCCCTGTGCCCGCCATGGCTGCAGAGTCC
CAAGGAAGCGCTGTACTATGCCAAGGTGTATTGTCGCCTGGGCCGACTCACTTTCTACCAGCTG
AAGAGAGGGACAGGCGGCGAGGTGAAGGCCCACTTAACCACCATGCCAGAGCAAGTGGCTCAGG
GACAGAGAATGCATGGTCTGGTTGCATCAGCCAAGGAGTCTAGGTACCGCAAAGGGAAAACCTG
GAACAACTGTAAACAGAAGAGGCGGTTTACTGACTCCCATAACTGGAAGCTGAGGTGCAGATTT
AGTTTTGGGTACTTCTGGATTCTATTCCTCCTTCAACTTCATGAATACCTCTTATCTCCTCCTT
GACGCTGTGTGTTCCTACTTCTCTGTGACTCTTGGCCTCAATCTTTGCCAGCCCCTGGGAGACT
GATGCCATATTCAAAAGGAAATCGGCCATTTTCCTTGTTGGGTTACACCAAAAAGTCCCAGAGG
GGGGTGGACTGTCCAGTGCAATGTTGTATCTTGATTGGAGACGGGGAAGATGCCACCTCTGTGC
CTGAGGAGGAGGGACACTGTGATTGGTAATGCCATCAGAGCCTGAGTACATCAAGGGAAGACCT
CCTTTGAGGCATTGGGATGTGGGGATGGAGTAACTGAACAATGTCAATGATCTCAGCATAGAGC
TTAAGCCTGTCCTGTAAGTACTGCTAATGATGTCTCTTCTTTGCCCCATGGGGTTAGGATGCCC
ATGATGCTACTGAATACTTTTTGCTGGCACTAGCAGCTGCGGTCCTGGTGGGTGACGAGGAGCT
GCAGGACACCATTAAGAACAGG

hide sequence

RefSeq Acc Id:

XM_039097415 ⟹ XP_038953343

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	57,686,701 - 57,745,493 (+)	NCBI
mRatBN7.2	18	55,416,383 - 55,475,177 (+)	NCBI

RefSeq Acc Id:

XM_039097416 ⟹ XP_038953344

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	57,701,520 - 57,747,034 (+)	NCBI
mRatBN7.2	18	55,431,205 - 55,476,721 (+)	NCBI

RefSeq Acc Id:

XM_039097417 ⟹ XP_038953345

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	57,708,867 - 57,747,034 (+)	NCBI
mRatBN7.2	18	55,438,547 - 55,476,721 (+)	NCBI

RefSeq Acc Id:

XM_063277342 ⟹ XP_063133412

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	57,686,702 - 57,747,733 (+)	NCBI

RefSeq Acc Id:

XM_063277343 ⟹ XP_063133413

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	57,701,525 - 57,747,034 (+)	NCBI

RefSeq Acc Id:

XM_063277345 ⟹ XP_063133415

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	57,704,857 - 57,747,034 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001414025	(Get FASTA)	NCBI Sequence Viewer
	XP_006254879	(Get FASTA)	NCBI Sequence Viewer
	XP_038953343	(Get FASTA)	NCBI Sequence Viewer
	XP_038953344	(Get FASTA)	NCBI Sequence Viewer
	XP_038953345	(Get FASTA)	NCBI Sequence Viewer
	XP_063133412	(Get FASTA)	NCBI Sequence Viewer
	XP_063133413	(Get FASTA)	NCBI Sequence Viewer
	XP_063133415	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89936	(Get FASTA)	NCBI Sequence Viewer
	EDM14624	(Get FASTA)	NCBI Sequence Viewer
	EDM14625	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026174
	ENSRNOP00000026174.6
	ENSRNOP00000081796
	ENSRNOP00000081796.1
	ENSRNOP00000099506.1
	ENSRNOP00000104227.1

RefSeq Acc Id:	XP_006254879 ⟸ XM_006254817
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5ZSY8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGGSQGSPDWRSQGPWPREDGAHMGGCFCIPGERSLPWGPGKEGSSKDPPGLTEDISSLENKRK CFLPQNMTQDLVLSFWVRSRSRRCVNAALQEAARRRLWALENEAHEVHALFKDLSARLVSVQSQ KDQFLITFKTLEEIWKFSTYLNLGYVSTCLEHLFFDHTYWLNSRLVDDTEIQVSVDDTHLENIY LGLLLQEGHFFCRAMCSVTQPADKEGEYLTLCKNELISVLSGGESDWEGMSLVTGQRGLVPVSA LEPLPVSFHQWFLKNHPGICGLPRKKDWTGSCQIGRGRCKALMDYQQEERDELGFLQGESIDVI GFVIPGLRWFIGKSMSSGKVGFVPTRSIDLDSCSPVSKNSVFFSDEERCSLWSPGGDRKAECSG FLSALAHTDITSVYRLSEFESIQNLQNDLSASQPEGFREARSGGTWMERKTMGSRRSSSSLDSS LEDELISASSDSYHLPEPDDLDDPELFMDLSTSLEEDEMEHFAPILAFLDHEGYTDHFKSLYDF SFSFLTSSFYSFSEEDELVAYLETSRKWAKMTHRTWAHARLCFLLGRLSIRKTKLSQARVYFEE AIRVLDGAFEDLSLVAALYINLAAIYLRQRLRHKGPILLEKAGALLACLPDREFSAKNELDVVT YVLRQGIVAGSGPLEARSCFLAIRLLLNLGRHEEVLPFAERLQLLSGHSPASEVTATMLSSLYD KKYLPHLAVASVQKRGPQSARGMSVAIWQAYLVLQNATKILGVPFSSWCEVSALACPTLRQALA ACEEQTDLNIQRTLCLLLSKMYLQHRSPDGSVQYLSQAHVLGKLLGEEEAFESSLCLAWAYLLA RQTKKALEILEPLLCSLRETECVTQRGVVHNLLGLAFQDEGRTSRAAKSYLRALIRAREMGNIR NQAVSMANLGHLTLKSCMQQSARGYLLQAVRLYSEIQASKETDMELVQVLLWLGQALVSGHQLV HSRLCYEMALLFGLRHRHLNSQLQVTKSLCHFYSSVSPNPDACITYHEHWLALAQQLRDREMEG RLLESLGQLYRNLNTSRSLRRSLACIKESLRIFVDLGERDKAAEAWLGAGRLHYLMQEDELVEV YLQEAIQTALRSEELSLALKLYEEAGDVFFNGTRHRHRAVEYYRAGAVPLARRMKALRTELRIF NKLTELQISLRGYEKALEFATLAARLSVLTGDQKQELVAFHRLATVYFSLNMYEMAEDCYLKTL SLCPPWLQSPKEALYYAKVYCRLGRLTFYQLKRGTGGEVKAHLTTMPEQVAQGQRMHGLVASAK ESRYRKGKTWNNCKQKRRFTDSHNWKLRCRFSFGYFWILFLLQLHEYLLSPP hide sequence

Ensembl Acc Id:

ENSRNOP00000026174 ⟸ ENSRNOT00000026174

RefSeq Acc Id:	XP_038953343 ⟸ XM_039097415
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I5ZSY8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038953344 ⟸ XM_039097416
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I5ZSY8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038953345 ⟸ XM_039097417
- Peptide Label:	isoform X5

Ensembl Acc Id:

ENSRNOP00000081796 ⟸ ENSRNOT00000098535

RefSeq Acc Id:	XP_063133412 ⟸ XM_063277342
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZSY8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001414025 ⟸ NM_001427096
- UniProtKB:	A6IXJ3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133413 ⟸ XM_063277343
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I5ZSY8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133415 ⟸ XM_063277345
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I5ZSY8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000099506 ⟸ ENSRNOT00000142112

Ensembl Acc Id:

ENSRNOP00000104227 ⟸ ENSRNOT00000169979

Protein Domains

SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M9P6-F1-model_v2	AlphaFold	F1M9P6	1-1311	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700827

Promoter ID:

EPDNEW_R11347

Type:

multiple initiation site

Name:

Sh3tc2_1

Description:

SH3 domain and tetratricopeptide repeats 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	57,286,397 - 57,286,457	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309038	AgrOrtholog
BioCyc Gene	G2FUF-7297	BioCyc
Ensembl Genes	ENSRNOG00000019305	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000026174	ENTREZGENE
	ENSRNOT00000026174.9	UniProtKB/TrEMBL
	ENSRNOT00000098535	ENTREZGENE
	ENSRNOT00000098535.2	UniProtKB/TrEMBL
	ENSRNOT00000142112.1	UniProtKB/TrEMBL
	ENSRNOT00000169979.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.10	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7309469	IMAGE-MGC_LOAD
InterPro	SH3-like_dom	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	SH3TC1/SH3TC2	UniProtKB/TrEMBL
	TPR-like_helical	UniProtKB/TrEMBL
	TPR_repeat	UniProtKB/TrEMBL
MGC_CLONE	MGC:109233	IMAGE-MGC_LOAD
NCBI Gene	307393	ENTREZGENE
PANTHER	PTHR22647	UniProtKB/TrEMBL
	SH3 DOMAIN AND TETRATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2	UniProtKB/TrEMBL
Pfam	SH3_1	UniProtKB/TrEMBL
	SH3_2	UniProtKB/TrEMBL
	TPR_8	UniProtKB/TrEMBL
PhenoGen	Sh3tc2	PhenoGen
PROSITE	SH3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000019305	RatGTEx
SMART	SH3	UniProtKB/TrEMBL
	TPR	UniProtKB/TrEMBL
Superfamily-SCOP	SH3	UniProtKB/TrEMBL
	SSF48452	UniProtKB/TrEMBL
UniProt	A0A8I5ZSY8	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0L787_RAT	UniProtKB/TrEMBL
	A0ABK0LIL0_RAT	UniProtKB/TrEMBL
	A6IXJ3	ENTREZGENE, UniProtKB/TrEMBL
	F1M9P6_RAT	UniProtKB/TrEMBL
	Q5EB84_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-29	Sh3tc2	SH3 domain and tetratricopeptide repeats 2	LOC102556165	uncharacterized LOC102556165	Data merged from RGD:7587996	737654	PROVISIONAL
2013-12-18	LOC102556165	uncharacterized LOC102556165			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-02-26	Sh3tc2	SH3 domain and tetratricopeptide repeats 2	RGD1309038	similar to RIKEN cDNA D430044G18	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1309038	similar to RIKEN cDNA D430044G18	RGD1309038_predicted	similar to RIKEN cDNA D430044G18 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1309038_predicted	similar to RIKEN cDNA D430044G18 (predicted)	LOC307393_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC307393_predicted	similar to RIKEN cDNA D430044G18 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM