Hltf (helicase-like transcription factor) - Rat Genome Database

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Gene: Hltf (helicase-like transcription factor) Rattus norvegicus
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Symbol: Hltf
Name: helicase-like transcription factor
RGD ID: 1309031
Description: Predicted to enable ATP-dependent activity, acting on DNA; ubiquitin protein ligase activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including mRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and regulation of neurogenesis. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Orthologous to human HLTF (helicase like transcription factor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC295568; Smarca3; Snf2l3; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82104,478,725 - 104,538,531 (+)NCBIGRCr8
mRatBN7.22102,549,724 - 102,609,492 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2102,549,724 - 102,609,327 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2109,063,231 - 109,122,470 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02107,184,391 - 107,243,629 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02102,148,291 - 102,207,981 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02104,854,571 - 104,914,338 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2104,854,572 - 104,914,173 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02124,574,548 - 124,634,389 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42105,202,487 - 105,262,107 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12105,148,839 - 105,205,382 (+)NCBI
Celera297,919,578 - 97,979,241 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HltfRataceruloplasminemia  ISOHLTF (Homo sapiens)8554872ClinVar Annotator: match by term: Deficiency of ferroxidaseClinVarPMID:16629161 and PMID:28492532
HltfRatglycogen storage disease XV  ISOHLTF (Homo sapiens)8554872ClinVar Annotator: match by term: Glycogen storage disease XVClinVarPMID:20357282 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HltfRatKidney Neoplasms  ISOHLTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16762066

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HltfRat(-)-epigallocatechin 3-gallate multiple interactionsISOHLTF (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HLTF mRNACTDPMID:22079256
HltfRat(S)-nicotine decreases expressionISOHLTF (Homo sapiens)6480464Nicotine results in decreased expression of HLTF mRNACTDPMID:18247414
HltfRat1,2-dimethylhydrazine increases expressionISOHltf (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of HLTF mRNACTDPMID:22206623
HltfRat17beta-estradiol decreases expressionISOHltf (Mus musculus)6480464Estradiol results in decreased expression of HLTF mRNACTDPMID:39298647
HltfRat2,3',4,4',5-Pentachlorobiphenyl increases expressionISOHltf (Mus musculus)64804642 more ...CTDPMID:31388691
HltfRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOHLTF (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of HLTF mRNACTDPMID:22574217
HltfRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of HLTF mRNACTDPMID:34747641
HltfRat2-methylcholine affects expressionISOHLTF (Homo sapiens)6480464beta-methylcholine affects the expression of HLTF mRNACTDPMID:21179406
HltfRat2-naphthylamine decreases expressionISOHLTF (Homo sapiens)64804642-Naphthylamine results in decreased expression of HLTF mRNACTDPMID:18247414
HltfRat2-palmitoylglycerol increases expressionISOHLTF (Homo sapiens)64804642-palmitoylglycerol results in increased expression of HLTF mRNACTDPMID:37199045
HltfRat4-hydroxyphenyl retinamide decreases expressionISOHltf (Mus musculus)6480464Fenretinide results in decreased expression of HLTF mRNACTDPMID:28973697
HltfRat5-aza-2'-deoxycytidine affects methylationISOHLTF (Homo sapiens)6480464Decitabine affects the methylation of HLTF promoterCTDPMID:17571247
HltfRatacetamide increases expressionEXP 6480464acetamide results in increased expression of HLTF mRNACTDPMID:31881176
HltfRataflatoxin B1 increases expressionISOHltf (Mus musculus)6480464Aflatoxin B1 results in increased expression of HLTF mRNACTDPMID:19770486
HltfRataflatoxin B1 increases expressionEXP 6480464Aflatoxin B1 results in increased expression of HLTF mRNACTDPMID:23630614
HltfRatall-trans-retinoic acid decreases expressionISOHltf (Mus musculus)6480464Tretinoin results in decreased expression of HLTF mRNACTDPMID:16604517
HltfRatall-trans-retinoic acid decreases expressionISOHLTF (Homo sapiens)6480464Tretinoin results in decreased expression of HLTF mRNACTDPMID:33167477
HltfRatantimonite multiple interactionsISOHLTF (Homo sapiens)6480464[Antimony Potassium Tartrate results in increased abundance of antimonite] which results in increased expression of HLTF mRNACTDPMID:32076005
HltfRatantirheumatic drug increases expressionISOHLTF (Homo sapiens)6480464Antirheumatic Agents results in increased expression of HLTF mRNACTDPMID:24449571
HltfRataristolochic acid A decreases expressionISOHLTF (Homo sapiens)6480464aristolochic acid I results in decreased expression of HLTF mRNACTDPMID:33212167

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Biological Process

  

Cellular Component
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Object Symbol
Species
Term
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Evidence
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Reference
Notes
Source
Original Reference(s)
HltfRatnucleoplasm located_inIEAUniProtKB:Q14527 and ensembl:ENSP000003089441600115GO_REF:0000107EnsemblGO_REF:0000107
HltfRatnucleoplasm located_inISOHLTF (Homo sapiens) and UniProtKB:Q14527-11624291 RGDGO_REF:0000052
HltfRatnucleus located_inIEAARBA:ARBA000263301600115GO_REF:0000117UniProtGO_REF:0000117
HltfRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
HltfRatnucleus is_active_inIBAFB:FBgn0002542 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
HltfRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
HltfRatRNA polymerase II transcription regulator complex part_ofISOHLTF (Homo sapiens)1624291 PMID:23415230RGDPMID:23415230
HltfRatRNA polymerase II transcription regulator complex part_ofISOHltf (Mus musculus)1624291 PMID:23415230RGDPMID:23415230
HltfRatRNA polymerase II transcription regulator complex part_ofIEAUniProtKB:Q6PCN7 and ensembl:ENSMUSP000000025021600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Object Symbol
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Qualifier
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Reference
Notes
Source
Original Reference(s)
HltfRatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
HltfRatATP binding enablesIEAInterPro:IPR0003301600115GO_REF:0000002InterProGO_REF:0000002
HltfRatATP-dependent activity, acting on DNA enablesISOHltf (Mus musculus)1624291 PMID:9427542RGDPMID:9427542
HltfRatATP-dependent activity, acting on DNA enablesIEAUniProtKB:Q6PCN7 and ensembl:ENSMUSP000000025021600115GO_REF:0000107EnsemblGO_REF:0000107
HltfRatATP-dependent activity, acting on DNA enablesIBAFB:FBgn0002542 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
HltfRathelicase activity enablesIEAUniProtKB-KW:KW-03471600115GO_REF:0000043UniProtGO_REF:0000043
HltfRathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
HltfRathydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides enablesIEAInterPro:IPR0149051600115GO_REF:0000002InterProGO_REF:0000002
HltfRatmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
HltfRatnucleic acid binding enablesIEAInterPro:IPR0149051600115GO_REF:0000002InterProGO_REF:0000002
HltfRatnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
HltfRatprotein binding enablesISOHLTF (Homo sapiens)1624291UniProtKB:P12004 more ...RGDPMID:10391891 more ...
HltfRatubiquitin protein ligase activity enablesISOHLTF (Homo sapiens)1624291 PMID:18316726 more ...RGDPMID:18316726 more ...
HltfRatubiquitin protein ligase binding enablesISOHLTF (Homo sapiens)1624291 PMID:25023518RGDPMID:25023518
HltfRatubiquitin protein ligase binding enablesIEAUniProtKB:Q14527 and ensembl:ENSP000003089441600115GO_REF:0000107EnsemblGO_REF:0000107
HltfRatzinc ion binding enablesIEAInterPro:IPR0149051600115GO_REF:0000002InterProGO_REF:0000002
HltfRatzinc ion binding enablesIEAUniProtKB-KW:KW-08631600115GO_REF:0000043UniProtGO_REF:0000043
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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:9427542   PMID:18316726   PMID:18719106   PMID:19723507   PMID:19946888   PMID:21396873   PMID:21507896   PMID:22658674   PMID:25023518   PMID:26350214  



Hltf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82104,478,725 - 104,538,531 (+)NCBIGRCr8
mRatBN7.22102,549,724 - 102,609,492 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2102,549,724 - 102,609,327 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2109,063,231 - 109,122,470 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02107,184,391 - 107,243,629 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02102,148,291 - 102,207,981 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02104,854,571 - 104,914,338 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2104,854,572 - 104,914,173 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02124,574,548 - 124,634,389 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42105,202,487 - 105,262,107 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12105,148,839 - 105,205,382 (+)NCBI
Celera297,919,578 - 97,979,241 (+)NCBICelera
Cytogenetic Map2q24NCBI
HLTF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383149,030,063 - 149,086,533 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3149,030,127 - 149,086,554 (-)EnsemblGRCh38hg38GRCh38
GRCh373148,747,850 - 148,804,320 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363150,230,594 - 150,287,031 (-)NCBINCBI36Build 36hg18NCBI36
Build 343150,230,611 - 150,287,015NCBI
Celera3147,158,179 - 147,214,609 (-)NCBICelera
Cytogenetic Map3q24NCBI
HuRef3146,119,870 - 146,176,257 (-)NCBIHuRef
CHM1_13148,710,947 - 148,767,418 (-)NCBICHM1_1
T2T-CHM13v2.03151,780,777 - 151,837,250 (-)NCBIT2T-CHM13v2.0
Hltf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39320,111,959 - 20,172,655 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl320,111,975 - 20,172,654 (+)EnsemblGRCm39 Ensembl
GRCm38320,057,808 - 20,118,491 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl320,057,811 - 20,118,490 (+)EnsemblGRCm38mm10GRCm38
MGSCv37319,957,811 - 20,018,376 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36320,249,962 - 20,310,527 (+)NCBIMGSCv36mm8
Celera320,047,166 - 20,107,713 (+)NCBICelera
Cytogenetic Map3A2NCBI
cM Map36.15NCBI
Hltf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554748,412,136 - 8,486,752 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554748,411,912 - 8,488,938 (+)NCBIChiLan1.0ChiLan1.0
HLTF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22146,925,896 - 146,982,742 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13146,930,616 - 146,987,472 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03146,054,371 - 146,111,150 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13153,632,319 - 153,688,951 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3153,632,319 - 153,688,951 (-)Ensemblpanpan1.1panPan2
HLTF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12343,868,896 - 43,918,616 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2343,870,939 - 43,918,436 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2343,734,282 - 43,783,354 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02344,498,185 - 44,547,255 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2344,498,189 - 44,547,213 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12344,086,465 - 44,136,026 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02344,134,925 - 44,184,505 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02344,389,026 - 44,438,712 (-)NCBIUU_Cfam_GSD_1.0
Hltf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560283,155,157 - 83,202,437 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365196,531,571 - 6,582,081 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365196,531,549 - 6,579,724 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HLTF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1389,261,205 - 89,333,011 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11389,261,199 - 89,333,020 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21397,254,690 - 97,326,863 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HLTF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11541,621,349 - 41,676,185 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1541,621,456 - 41,674,120 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604114,463,704 - 14,518,550 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hltf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473026,257,609 - 26,333,936 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473026,255,426 - 26,334,176 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Hltf
447 total Variants


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
2 102561518 102561519 G C snv ACI/EurMcwi (2019), ACI/N (2020), F344/DuCrl (2019), F344/NCrl (2019), F344/N (2020), F344/Stm (2019), FXLE16/Stm (2020), FXLE18/Stm (2020), LEXF11/Stm (2020), LEXF1A/Stm (2019), LEXF1C/Stm (2019), LEXF2B/Stm (2019), LEXF3/Stm (2020), LEXF4/Stm (2020), LE/Stm (2019), LH/MavRrrcAek (2020), LL/MavRrrcAek (2020), LN/MavRrrcAek (2020), LEXF10A/StmMcwi (2020), M520/NRrrcMcwi (2019), M520/N (2020), MWF/Hsd (2019), PVG/Seac (2019), SR/JrHsd (2020), SS/JrHsdMcwi (2019), WN/N (2020), ACI/EurMcwi (2019NG), BUF/MnaMcwi (2022), F344/DuCrl (2019NG), F344/DuCrl (2019NG), F344/DuCrl (2021), European Variation Archive Release 3, European Variation Archive Release 4, LEXF2A/StmMcwi (2023), FXLE26/StmMcwi (2023), FXLE22/StmMcwi (2023), FXLE20/StmMcwi (2023), LEXF8D/StmMcwi (2023), FXLE23/StmMcwi (2023), LEXF10C/StmMcwi (2023), FXLE17/StmMcwi (2023), LEXF6B/StmMcwi (2023), FXLE15/StmMcwi (2023), FXLE14/StmMcwi (2023), FXLE21/StmMcwi (2023), FXLE13/StmMcwi (2023), LEXF5/StmMcwi (2023), FXLE25/StmMcwi (2023), FXLE12/StmMcwi (2023), European Variation Archive Release 6, F344/NHsd (2021), F344/StmMcwi (2019), FXLE12/StmMcwi (2021), FXLE12/Stm (2019NG), FXLE13/Stm (2019NG), FXLE14/Stm (2019NG), FXLE15/StmMcwi (2021), FXLE15/Stm (2019NG), FXLE17/Stm (2019NG), FXLE19/StmMcwi (2022), FXLE20/Stm (2019NG), FXLE23/Stm (2022), FXLE25/Stm (2022), FXLE26/Stm (2022), LEXF10B/StmMcwi (2022), LEXF10C/Stm (2022), LEXF1C/StmMcwi (2021), LEXF2A/Stm (2022), LEXF2C/StmMcwi (2022), LEXF5/Stm (2019NG), LEXF6B/Stm (2019NG), LEXF7A/Stm (2019NG), LEXF7B/StmMcwi (2022), LEXF7C/StmMcwi (2022), LEXF8A/StmMcwi (2021), LEXF8D/Stm (2022), LEXF9/StmMcwi (2022), M520/NRrrcMcwi (2019NG), MWF/SimwMcwi (2019NG), MWF/SimwMcwi (2019), RCS/LavRrrcMcwi (2021), SS/HsdMcwiCrl (2021), SS/JrHsdMcwi (2019NG), SS/JrHsd (2021) View more Information


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
2 124586344 124586345 G C snv ACI/EurMcwi (MCW), ZFDM (KyushuU), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), LH/MavRrrc (KNAW), LL/MavRrrc (KNAW), LN/MavRrrc (KNAW), MHS/Gib (KNAW), MR/N (KNAW), SR/JrHsd (KNAW), SS/Jr (KNAW), SS/JrHsdMcwi (KNAW), ACI/N (KNAW), ACI/EurMcwi (KNAW), SBN/Ygl (KNAW), F344/NRrrc (Illumina) (KNAW), F344/NRrrc (SOLiD) (KNAW), F344/NCrl (KNAW), F344/NHsd (KNAW), LE/Stm (Illumina) (KNAW), LE/Stm (SOLiD) (KNAW), M520/N (KNAW), WN/N (KNAW), LE/OrlBarth (UDEL), IS/Kyo (KyushuU), BUF/MNa (KyushuU), NIG-III/Hok (KyushuU), F344/DuCrlCrlj (KyushuU), LE/Stm (KyushuU), F344/NSlc (KyushuU), RCS/Kyo (KyushuU), IS-Tlk/Kyo (KyushuU), F344/Stm (KyushuU), HWY/Slc (KyushuU), F344/Jcl (KyushuU), KFRS3B/Kyo (KyushuU), ZF (KyushuU), SBN/Ygl (MCW) View more Information


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
2 104866368 104866369 G C snv ACI/EurMcwi (MCW), European Variation Archive Release 6, SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), ACI/N (MCW), F344/NRrrc (MCW), M520/N (MCW), MR/N (MCW), WN/N (MCW), ACI/EurMcwi (RGD), F344/NCrl (RGD), LE/Stm (RGD), LH/MavRrrc (RGD), LN/MavRrrc (RGD), LL/MavRrrc (RGD), MHS/Gib (RGD), SBN/Ygl (RGD), SR/JrHsd (RGD), SS/Jr (RGD), SS/JrHsdMcwi (RGD), ACI/EurMcwi (2019), ACI/N (2020), F344/DuCrl (2019), F344/NCrl (2019), F344/N (2020), F344/Stm (2019), FXLE16/Stm (2020), FXLE18/Stm (2020), LEXF11/Stm (2020), LEXF1A/Stm (2019), LEXF1C/Stm (2019), LEXF2B/Stm (2019), LEXF3/Stm (2020), LEXF4/Stm (2020), LE/Stm (2019), LH/MavRrrcAek (2020), LL/MavRrrcAek (2020), LN/MavRrrcAek (2020), LEXF10A/StmMcwi (2020), M520/NRrrcMcwi (2019), M520/N (2020), MWF/Hsd (2019), PVG/Seac (2019), SR/JrHsd (2020), SS/JrHsdMcwi (2019), WN/N (2020), European Variation Archive Release 3, European Variation Archive Release 4, SBN/Ygl (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:414
Count of miRNA genes:241
Interacting mature miRNAs:293
Transcripts:ENSRNOT00000064828
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 60 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat

1 to 10 of 60 rows
RH127313  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22102,608,853 - 102,609,044 (+)MAPPERmRatBN7.2
Rnor_6.02104,913,700 - 104,913,890NCBIRnor6.0
Rnor_5.02124,633,751 - 124,633,941UniSTSRnor5.0
RGSC_v3.42105,261,622 - 105,261,812UniSTSRGSC3.4
Celera297,978,756 - 97,978,946UniSTS
RH 3.4 Map2729.6UniSTS
Cytogenetic Map2q24UniSTS
AU047370  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22102,560,975 - 102,561,122 (+)MAPPERmRatBN7.2
Rnor_6.02104,865,822 - 104,865,972NCBIRnor6.0
Rnor_5.02124,585,798 - 124,585,948UniSTSRnor5.0
RGSC_v3.42105,213,737 - 105,213,887UniSTSRGSC3.4
Celera297,930,809 - 97,930,973UniSTS
Cytogenetic Map2q24UniSTS
RH140388  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26116,967,420 - 116,967,609 (+)MAPPERmRatBN7.2
mRatBN7.22102,609,025 - 102,609,211 (+)MAPPERmRatBN7.2
Rnor_6.02104,913,872 - 104,914,057NCBIRnor6.0
Rnor_6.06121,687,222 - 121,687,410NCBIRnor6.0
Rnor_5.06130,907,420 - 130,907,608UniSTSRnor5.0
Rnor_5.02124,633,923 - 124,634,108UniSTSRnor5.0
RGSC_v3.46121,856,966 - 121,857,154UniSTSRGSC3.4
RGSC_v3.42105,261,794 - 105,261,979UniSTSRGSC3.4
Celera297,978,928 - 97,979,113UniSTS
Celera6114,547,864 - 114,548,052UniSTS
Cytogenetic Map2q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000064828   ⟹   ENSRNOP00000060341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2102,549,724 - 102,609,327 (+)Ensembl
Rnor_6.0 Ensembl2104,854,572 - 104,914,173 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090912   ⟹   ENSRNOP00000069487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2102,549,724 - 102,609,327 (+)Ensembl
Rnor_6.0 Ensembl2104,854,580 - 104,912,627 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106667   ⟹   ENSRNOP00000092944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2102,549,724 - 102,609,327 (+)Ensembl
RefSeq Acc Id: NM_001106478   ⟹   NP_001099948
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82104,478,765 - 104,538,378 (+)NCBI
mRatBN7.22102,549,724 - 102,609,339 (+)NCBI
Rnor_6.02104,854,572 - 104,914,185 (+)NCBI
Rnor_5.02124,574,548 - 124,634,389 (+)NCBI
RGSC_v3.42105,202,487 - 105,262,107 (+)RGD
Celera297,919,578 - 97,979,241 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232175   ⟹   XP_006232237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82104,478,725 - 104,538,531 (+)NCBI
mRatBN7.22102,549,734 - 102,609,492 (+)NCBI
Rnor_6.02104,854,571 - 104,914,338 (+)NCBI
Rnor_5.02124,574,548 - 124,634,389 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232176   ⟹   XP_006232238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82104,478,725 - 104,538,531 (+)NCBI
mRatBN7.22102,549,734 - 102,609,492 (+)NCBI
Rnor_6.02104,854,572 - 104,914,338 (+)NCBI
Rnor_5.02124,574,548 - 124,634,389 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232177   ⟹   XP_006232239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82104,478,775 - 104,538,531 (+)NCBI
mRatBN7.22102,549,734 - 102,609,492 (+)NCBI
Rnor_6.02104,854,571 - 104,914,338 (+)NCBI
Rnor_5.02124,574,548 - 124,634,389 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102120   ⟹   XP_038958048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82104,478,775 - 104,538,531 (+)NCBI
mRatBN7.22102,549,734 - 102,609,492 (+)NCBI
RefSeq Acc Id: NP_001099948   ⟸   NM_001106478
- UniProtKB: D3ZMQ9 (UniProtKB/TrEMBL),   A6IHC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232237   ⟸   XM_006232175
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AF43 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232239   ⟸   XM_006232177
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006232238   ⟸   XM_006232176
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JVH5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069487   ⟸   ENSRNOT00000090912
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVH5-F1-model_v2 AlphaFold A0A0G2JVH5 1-1003 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691262
Promoter ID:EPDNEW_R1782
Type:initiation region
Name:Hltf_1
Description:helicase-like transcription factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02104,854,601 - 104,854,661EPDNEW


1 to 40 of 47 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-53606 BioCyc
Ensembl Genes ENSRNOG00000000082 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064828 ENTREZGENE
  ENSRNOT00000064828.4 UniProtKB/TrEMBL
  ENSRNOT00000090912 ENTREZGENE
  ENSRNOT00000090912.2 UniProtKB/TrEMBL
  ENSRNOT00000106667 ENTREZGENE
  ENSRNOT00000106667.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
  3.30.70.2330 UniProtKB/TrEMBL
  3.40.50.10810 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro DEAD-like_helicase UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  HIP116_Rad5p_N UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  SNF2-like_sf UniProtKB/TrEMBL
  SNF2/RAD54-like_C UniProtKB/TrEMBL
  SNF2_N UniProtKB/TrEMBL
  SNF2_RAD54_helicase_TF UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report rno:295568 UniProtKB/TrEMBL
NCBI Gene 295568 ENTREZGENE
PANTHER HELICASE-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
  TRANSCRIPTION TERMINATION FACTOR 2-RELATED UniProtKB/TrEMBL
Pfam Helicase_C UniProtKB/TrEMBL
  HIRAN UniProtKB/TrEMBL
  SNF2_N UniProtKB/TrEMBL
  zf-C3HC4_2 UniProtKB/TrEMBL
PhenoGen Hltf PhenoGen
PROSITE HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000082 RatGTEx
SMART DEXDc UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
  HIRAN UniProtKB/TrEMBL
1 to 40 of 47 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Hltf  helicase-like transcription factor  Smarca3_predicted  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Smarca3_predicted  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED