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Gene: Mex3c (mex-3 RNA binding family member C) Rattus norvegicus

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Symbol:

Mex3c

Name:

mex-3 RNA binding family member C

RGD ID:

1309023

Description:

Predicted to enable RNA binding activity and ubiquitin protein ligase activity. Predicted to act upstream of or within chondrocyte hypertrophy; energy homeostasis; and regulation of fat cell differentiation. Predicted to be located in cytoplasm and nucleus. Orthologous to human MEX3C (mex-3 RNA binding family member C); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; chlorpyrifos.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC307271; mex-3 homolog C; mex-3 homolog C (C. elegans); ring finger and KH domain containing 2; Rkhd2; RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein MEX3C

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MEX3C (mex-3 RNA binding family member C)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Mex3c (mex3 RNA binding family member C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mex3c (mex-3 RNA binding family member C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MEX3C (mex-3 RNA binding family member C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MEX3C (mex-3 RNA binding family member C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mex3c (mex-3 RNA binding family member C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MEX3C (mex-3 RNA binding family member C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MEX3C (mex-3 RNA binding family member C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mex3c (mex-3 RNA binding family member C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Mex3c (mex-3 RNA binding family member C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MEX3C (mex-3 RNA binding family member C)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mex3c (mex3 RNA binding family member C)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG11360	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG11360	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mex-3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mex-3	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mex3c	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	69,442,850 - 69,463,843 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	69,442,152 - 69,463,846 (+)	Ensembl				GRCr8
mRatBN7.2	18	67,167,600 - 67,188,595 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	67,166,718 - 67,188,595 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	69,275,700 - 69,296,678 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	69,950,428 - 69,971,396 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	67,815,662 - 67,836,650 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	69,549,937 - 69,571,736 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	69,549,937 - 69,571,736 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	68,674,091 - 68,717,243 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	70,355,267 - 70,376,424 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	65,169,728 - 65,190,911 (+)	NCBI		Celera
RGSC_v3.1	18	70,428,370 - 70,449,630 (+)	NCBI
Cytogenetic Map	18	q12.2	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

atrial fibrillation (ISO)

juvenile rheumatoid arthritis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP)

chromium(6+) (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

ethanol (ISO)

fenvalerate (EXP)

flutamide (EXP)

FR900359 (ISO)

hydrogen peroxide (ISO)

leflunomide (ISO)

paracetamol (ISO)

phenobarbital (ISO)

potassium chromate (ISO)

rac-lactic acid (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chondrocyte hypertrophy (ISO)

energy homeostasis (ISO)

regulation of fat cell differentiation (ISO)

Cellular Component

cytoplasm (IEA)

nucleus (IEA)

Molecular Function

metal ion binding (IEA)

nucleic acid binding (IEA)

protein binding (ISO)

RNA binding (IEA,ISO)

ubiquitin protein ligase activity (IEA,ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	GOA pipeline	RGD automated data pipeline
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:22357625	PMID:22658674	PMID:22681889	PMID:22863774	PMID:22927639

Genomics

Comparative Map Data

Mex3c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	69,442,850 - 69,463,843 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	69,442,152 - 69,463,846 (+)	Ensembl				GRCr8
mRatBN7.2	18	67,167,600 - 67,188,595 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	67,166,718 - 67,188,595 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	69,275,700 - 69,296,678 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	69,950,428 - 69,971,396 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	67,815,662 - 67,836,650 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	69,549,937 - 69,571,736 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	69,549,937 - 69,571,736 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	68,674,091 - 68,717,243 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	70,355,267 - 70,376,424 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	65,169,728 - 65,190,911 (+)	NCBI		Celera
RGSC_v3.1	18	70,428,370 - 70,449,630 (+)	NCBI
Cytogenetic Map	18	q12.2	NCBI

MEX3C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	51,174,550 - 51,197,681 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	51,174,550 - 51,218,333 (-)	Ensembl			hg38	GRCh38
GRCh37	18	48,700,920 - 48,724,051 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	46,954,918 - 46,977,688 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	18	46,954,919 - 46,977,380	NCBI
Celera	18	45,557,653 - 45,580,784 (-)	NCBI		Celera
Cytogenetic Map	18	q21.2	NCBI
HuRef	18	45,556,322 - 45,579,835 (-)	NCBI		HuRef
CHM1_1	18	48,696,271 - 48,719,389 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	18	51,376,318 - 51,399,436 (-)	NCBI		T2T-CHM13v2.0

Mex3c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	73,705,710 - 73,725,649 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	73,706,115 - 73,725,646 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	18	73,572,637 - 73,592,578 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	73,573,044 - 73,592,575 (+)	Ensembl			mm10	GRCm38
MGSCv37	18	73,732,359 - 73,752,232 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	18	73,698,157 - 73,700,208 (+)	NCBI		MGSCv36	mm8
Celera	18	74,818,491 - 74,838,159 (+)	NCBI		Celera
Cytogenetic Map	18	E2	NCBI
cM Map	18	49.29	NCBI

Mex3c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	36,047,856 - 36,065,771 (-)	Ensembl
ChiLan1.0	NW_004955402	36,049,461 - 36,065,765 (-)	NCBI	ChiLan1.0	ChiLan1.0

MEX3C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	68,693,635 - 68,716,861 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	54,386,240 - 54,411,080 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	44,546,129 - 44,569,580 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	47,891,070 - 47,913,475 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

MEX3C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	23,818,790 - 23,838,106 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	23,818,099 - 23,836,297 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	24,805,803 - 24,825,631 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	23,709,603 - 23,730,449 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UMICH_Zoey_3.1	1	23,770,888 - 23,790,686 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	23,657,154 - 23,677,248 (+)	NCBI		UNSW_CanFamBas_1.0

Mex3c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	36,919,805 - 36,962,760 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936497	12,178,344 - 12,201,797 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936497	12,178,350 - 12,201,795 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MEX3C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	100,676,660 - 100,699,403 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	100,678,452 - 100,699,277 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	110,611,812 - 110,633,611 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MEX3C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	29,788,281 - 29,811,274 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	29,788,642 - 29,809,477 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666050	3,916,172 - 3,939,164 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mex3c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624778	14,685,172 - 14,701,122 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mex3c
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	15	58,484,676 - 58,510,450 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Mex3c
176 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	290
Count of miRNA genes:	162
Interacting mature miRNAs:	226
Transcripts:	ENSRNOT00000041227
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25071126	83910656	Rat
1331730	Scl27	Serum cholesterol level QTL 27	3.826		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	18	54490801	86134022	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	23494057	85487725	Rat
1331742	Bp228	Blood pressure QTL 228	3.88752		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
1298072	Cia26	Collagen induced arthritis QTL 26	3.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	64383762	79484311	Rat
631834	Sach3	Saccharin preference QTL 3	3.9	0.01	consumption behavior trait (VT:0002069)	calculated saccharin drink intake volume (CMO:0001600)	18	38575919	83575919	Rat
12904668	Bw188	Body weight QTL 188		0.03	body mass (VT:0001259)	body weight (CMO:0000012)	18	26822186	71822186	Rat
12904669	Cm125	Cardiac mass QTL 125		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	26822186	71822186	Rat
12904670	Cm126	Cardiac mass QTL 126		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	26822186	71822186	Rat
6893683	Bw110	Body weight QTL 110	2.7	0.002	body mass (VT:0001259)	body weight (CMO:0000012)	18	45620306	86134022	Rat
7794793	Mcs34	Mammary carcinoma susceptibility QTL 34	1.54		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	18	65635567	85897775	Rat
12904677	Kidm72	Kidney mass QTL 72		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	26822186	71822186	Rat
9589041	Epfw12	Epididymal fat weight QTL 12	17.08	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	18	48915737	86134022	Rat
8694432	Bw165	Body weight QTL 165	3.81	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	48915737	86134022	Rat
12904673	Cm127	Cardiac mass QTL 127		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	26822186	71822186	Rat
12904675	Am19	Aortic mass QTL 19		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	26822186	71822186	Rat
1331774	Bp226	Blood pressure QTL 226	4.41065		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
9589816	Gluco68	Glucose level QTL 68	7.25	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	31990891	76990891	Rat
1331770	Bp234	Blood pressure QTL 234	3.807		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	45620306	86134022	Rat
2301969	Bp324	Blood pressure QTL 324	4.05		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	61982204	76619168	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	12066482	85493247	Rat
2303120	Mamtr8	Mammary tumor resistance QTL 8		0.001	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	31610505	85493247	Rat
12880368	Bw187	Body weight QTL 187		0.045	body mass (VT:0001259)	body weight (CMO:0000012)	18	33379158	78379158	Rat
724542	Kidm2	Kidney mass QTL 2	2.6		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	18	61446853	86134022	Rat
61367	Iddm4	Insulin dependent diabetes mellitus QTL 4	2.33	0.0074	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	40462383	85462383	Rat
1359020	Ppulsi2	Prepulse inhibition QTL 2	2.71		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	18	54490801	76272247	Rat
2312600	Bp341	Blood pressure QTL 341		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	61600384	72538878	Rat
9590318	Scort22	Serum corticosterone level QTL 22	7.64	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	31990891	76990891	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	12066482	85493247	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	15642280	86134022	Rat
12904069	Cm123	Cardiac mass QTL 123		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	33379158	78379158	Rat
1331798	Bp224	Blood pressure QTL 224	3.53873		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
12904070	Cm124	Cardiac mass QTL 124		0.01	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	33379158	78379158	Rat
12904071	Am18	Aortic mass QTL 18		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	33379158	78379158	Rat
2303584	Gluco55	Glucose level QTL 55	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	18	50795212	86134022	Rat
2301413	Bp318	Blood pressure QTL 318		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	26822186	71822186	Rat
61383	Bp47	Blood pressure QTL 47	17.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	31522783	76522783	Rat
12904067	Cm122	Cardiac mass QTL 122		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	33379158	78379158	Rat
61384	Bp48	Blood pressure QTL 48	19.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	62892257	79484461	Rat
2301417	Bp319	Blood pressure QTL 319		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	33379158	78379158	Rat
12904073	Kidm71	Kidney mass QTL 71		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	33379158	78379158	Rat
738008	Hcar14	Hepatocarcinoma resistance QTL 14	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion number (CMO:0001462)	18	57825243	85493247	Rat
1331776	Bp225	Blood pressure QTL 225	2.829		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	31610505	77371277	Rat
631518	Bw11	Body weight QTL 11	2.8		body mass (VT:0001259)	body weight (CMO:0000012)	18	36121626	81121626	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	31990891	76990891	Rat
8694366	Abfw8	Abdominal fat weight QTL 8	6.38	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	18	48915737	86134022	Rat
631509	Sald2	Serum aldosterone level QTL 2	2.9		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	18	26415821	71415821	Rat
631274	Sprol1	Serum protein level QTL 1	5.3		blood total protein amount (VT:0005567)	serum total protein level (CMO:0000661)	18	31644508	79484311	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	65846447	86134022	Rat
1598832	Glom11	Glomerulus QTL 11	2.9		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	53266671	86134022	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19553532	85493247	Rat
8694378	Bw157	Body weight QTL 157	3.59	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	31990891	76990891	Rat
2303571	Bw92	Body weight QTL 92	3		body mass (VT:0001259)	body weight (CMO:0000012)	18	50795212	86134022	Rat
631675	Iddm15	Insulin dependent diabetes mellitus QTL 15			urine glucose amount (VT:0001758)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	18	62892257	79484461	Rat
61429	Cia17	Collagen induced arthritis QTL 17	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	31610505	72538878	Rat

Markers in Region

D18Got127

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	67,182,877 - 67,183,047 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	69,565,362 - 69,565,531	NCBI	Rnor6.0
Rnor_5.0	18	68,710,864 - 68,711,033	UniSTS	Rnor5.0
Celera	18	65,185,185 - 65,185,363	UniSTS
Celera	18	65,185,086 - 65,185,363	UniSTS
Cytogenetic Map	18	q12.2	UniSTS

BE111942

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	67,162,385 - 67,162,564 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	69,546,605 - 69,546,783	NCBI	Rnor6.0
Rnor_5.0	18	68,691,160 - 68,691,338	UniSTS	Rnor5.0
RGSC_v3.4	18	70,349,599 - 70,349,777	UniSTS	RGSC3.4
Celera	18	65,164,488 - 65,164,666	UniSTS
RH 3.4 Map	18	687.2	UniSTS
Cytogenetic Map	18	q12.2	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000041227 ⟹ ENSRNOP00000047441

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	69,442,152 - 69,463,846 (+)	Ensembl
mRatBN7.2 Ensembl	18	67,166,718 - 67,188,595 (+)	Ensembl
Rnor_6.0 Ensembl	18	69,549,937 - 69,571,736 (+)	Ensembl

RefSeq Acc Id:

NM_001107377 ⟹ NP_001100847

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	69,442,850 - 69,463,843 (+)	NCBI
mRatBN7.2	18	67,167,600 - 67,188,595 (+)	NCBI
Rnor_6.0	18	69,549,937 - 69,571,736 (+)	NCBI
Rnor_5.0	18	68,674,091 - 68,717,243 (+)	NCBI
RGSC_v3.4	18	70,355,267 - 70,376,424 (+)	RGD
Celera	18	65,169,728 - 65,190,911 (+)	RGD

Sequence:

show sequence

CGGCCGCGGCGGCGGGGGTGCTGTACGGAGGGGACGATGCCCAGGGCATGATGGCGGCGATGCT
GTCCCACGCCTACGGCCCCGGCGGCGGCGGGGCCGCCGCTGCCGCCCTGAACGGAGAGCAAGCG
GCCCTGCTGAGAAGGAAGAGCGTCAACACCACCGAGTGCGTCCCGGTGCCCAGTTCCGAACATG
TCGCTGAGATTGTCGGACGCCAGGGTTGTAAAATTAAAGCACTGAGAGCCAAGACAAACACGTA
TATCAAGACACCTGTCCGCGGTGAAGAGCCCATTTTTGTTGTCACTGGACGGAAAGAAGATGTT
GCCATGGCCAAGAGAGAAATCCTTTCGGCTGCAGAGCACTTCTCTATGATCCGTGCATCTCGGA
ACAAAAATGGCCCCGCGCTTGGAGGGTTATCGTGTAGTCCTAATCTGCCCGGTCAAACCACAGT
CCAAGTCAGGGTCCCCTATCGTGTGGTAGGGCTAGTGGTTGGACCAAAAGGAGCAACAATTAAG
AGAATTCAGCAACAGACCCACACATACATAGTTACTCCGAGCAGAGATAAGGAGCCAGTCTTTG
AAGTCACAGGGATGCCGGAAAATGTTGATCGAGCACGAGAAGAAATAGAAATGCATATTGCCAT
GCGTACAGGGAACTATATAGAGCTCAATGAAGAAAATGATTTCCACTATAACGGTACCGATGTG
AGCTTTGAAGGTGGCACTCTAGGCTCTGCGTGGCTCTCTTCCAATCCAGTTCCTCCAAGCCGAG
CAAGAATGATGTCCAACTATCGAAATGATAGTTCTAGTTCTCTAGGAAGTGGTTCCACTGATTC
CTATTTTGGAAGCAATAGGCTGGCTGACTTTAGTCCAACAAGCCCGTTTAGCACAGGAAACTTT
TGGTTTGGAGATACACTACCGTCTGTAGGCTCAGAAGACCTTGCAGTAGACTCTCCTGCCTTTG
ACTCTTTACCAACATCTGCTCAAACTATCTGGACTCCATTTGAACCAGTTAACCCACTCTCTGG
CTTTGGGAGTGATCCTTCTGGTAACATGAAGACTCAGCGTAGAGGAAGTCAGCCATCAACTCCT
CGTCTGTCTCCTACCTTTCCTGAGAGCATAGAACACCCACTTGCTCGAAGGGTTAGGAGCGACC
CACCTAGTACAGGCAACCATGTTGGCCTTCCAATATACATCCCTGCTTTTTCTAATGGTACCAA
TAGTTATTCCTCTTCCAATGGTGGTTCCACCTCTAGCTCACCTCCAGAATCAAGAAGAAAGCAC
GACTGTGTGATTTGCTTTGAGAATGAAGTTATTGCTGCCCTAGTTCCATGTGGCCACAACCTCT
TCTGCATGGAATGTGCCAACAAGATCTGTGAAAAGAGAACGCCATCATGTCCAGTTTGCCAGAC
AGCTGTTACTCAGGCAATCCAAATTCACTCTTAACTATATATATATACATAAATACTATATCTT
ATATGGACTCATAAAGGCATGGGTATAATGGTATACCCCAGTAAACTTCCTAATGAATTCTTAT
GACTGTTATCAGGCTTTATTGGGATTAGGCTAAAGTTGTTAGTACACTTATAAAAGGCTGCTAT
GGTAACACTAAACCTAAGTGGTCTCTTGTCTATTAGTTTGGTTTGAATTATTAATACTATCTTG
TAGACTCGGAGACATAGCTTGTATAGGAATTGTTAAAGCTGAAGTTCTACTTGGCTGTGTAACC
TATGAGCAAAATGTATCCATCTGAGGTTGTAGTCAGTGGGTCCCAAAGCCTAGCCGCATTAAGA
GTTTATGGAGGTGCCTGGCATCACAAATGACTGACACTCCAGCGCTGCCTTCTTCACACTGCCA
GTTTTGACAAAAACAGGTTTGTTTTTTATTTTACAACAACTTCTGCCTAATTCTGCAGGATTGC
AAGTAACTTTTTAAAGCATTGTGATTACTTACTAGTAATAATAGGGCTGATGGCAGTTTACTAG
ATCACTGGTTATAATTTGGGACAAAAACTGCTACATTGACTTTCATCTCGCCCAGAGTGCTCAA
GGCTGGTGTGTTCAGTGGATCAGGAGTACAATTGTCTTTGATTGTGAATTCCTACCCATTGCCT
CTCTCAGTGAATGTGGAAATGGCCGCCTGGGTTTTCCCATTTCTGGATGGGCTTTGGGAAACAC
CTATATTGGCTGAAAATTTGAGAATGTGAACATTCCATTCATTAGTCTGATCAAGATATTAATT
AATATTTAGACTGTAGCTCAAAATGTGAAACATTTTTTGTTCAATCCATATTTGTCTTGCACAT
TATAAATATATTTTTATTTTTTAGTAATGTAGGGGATGGGGAGGGAGACAATAATGCCCTTGGC
ATGATTCATGAAAGCAGCTGTGACAACCTCCAATCAGTTTACTTCATTTCAAACCTATTTCCAA
TCACAAGGAAAGATTTCTTTAAGACACTTGTCCATTTCACCTGTGGATGTTTTAACGTCATCCT
CAGTATGTCCCCAAATTTGCTGGTATTGAGAGGATAAAACATTATACTGGTGGGTTTTTCTACT
AATTATTTTTTGAAACGTTATTTTCCCAACACAAAAGAGCTTTTTTTCTCAGTATAACAAAAAT
TGAGATCTTATGTGTATTCAATAGTAAATAGACAAAATTTTATTTTTTATTTCCACTTGAAGAG
TTACATTTCGTATAAAGTTTACAAATAACAGTTTTTATTTTGATTTTTTTCAGTATAAAAAGTT
GCCTTGATGGCACATTATGAGGTAATGCTAATGGCTTGTAGGATAGTTGATTGTCTGTATTGAA
TCCTAATCTCTAGCTGCCGTCTTGTAGATATGGACGAATGTCACCCAGCATGTGTTTCGTATTT
TTTTGCATCGTACACTGCAACTAATAAGCCAAGGAATCGACATATATTAGGTGCGTGTACTATT
TCTAAAAACCACAAACTAAGAATGATAAATTATCAATATAGTTTAGTATTTGCTAATTTTACTA
CACTCTTTTGTTATGTATATGTAGGGAAGTCATAGGGATTATAAATTCAATTTGAGTAAAGTTT
AAAACCATATATTTTATGATAAAGGGCCTTTAACTTAAGATGGCCAAAGCACTGATATTATATA
TTTGCTGTAAAGAGAATTATAAGAGTTTTATTTTTCTGATATTAAAAGTTACTTAATAAAGACT
TGTTTCCATTAAC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100847	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM14794	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000047441.4

RefSeq Acc Id:

NP_001100847 ⟸ NM_001107377

- UniProtKB:

A6IY13 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MMAAMLSHAYGPGGGGAAAAALNGEQAALLRRKSVNTTECVPVPSSEHVAEIVGRQGCKIKALR
AKTNTYIKTPVRGEEPIFVVTGRKEDVAMAKREILSAAEHFSMIRASRNKNGPALGGLSCSPNL
PGQTTVQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEI
EMHIAMRTGNYIELNEENDFHYNGTDVSFEGGTLGSAWLSSNPVPPSRARMMSNYRNDSSSSLG
SGSTDSYFGSNRLADFSPTSPFSTGNFWFGDTLPSVGSEDLAVDSPAFDSLPTSAQTIWTPFEP
VNPLSGFGSDPSGNMKTQRRGSQPSTPRLSPTFPESIEHPLARRVRSDPPSTGNHVGLPIYIPA
FSNGTNSYSSSNGGSTSSSPPESRRKHDCVICFENEVIAALVPCGHNLFCMECANKICEKRTPS
CPVCQTAVTQAIQIHS

hide sequence

Ensembl Acc Id:

ENSRNOP00000047441 ⟸ ENSRNOT00000041227

Protein Domains

RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A2R5-F1-model_v2	AlphaFold	D4A2R5	1-464	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700858

Promoter ID:

EPDNEW_R11382

Type:

single initiation site

Name:

Mex3c_1

Description:

mex-3 RNA binding family member C

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	69,549,902 - 69,549,962	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309023	AgrOrtholog
BioCyc Gene	G2FUF-7059	BioCyc
Ensembl Genes	ENSRNOG00000015777	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000041227.5	UniProtKB/TrEMBL
Gene3D-CATH	3.30.1370.10	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
InterPro	IPR004087	UniProtKB/TrEMBL
	KH-I_MEX3_rpt1	UniProtKB/TrEMBL
	KH-I_MEX3_rpt2	UniProtKB/TrEMBL
	KH_dom_type_1_sf	UniProtKB/TrEMBL
	KH_type_1	UniProtKB/TrEMBL
	MEX3	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
KEGG Report	rno:307271	UniProtKB/TrEMBL
NCBI Gene	307271	ENTREZGENE
PANTHER	RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1	UniProtKB/TrEMBL
	RNA-BINDING E3 UBIQUITIN-PROTEIN LIGASE MEX3C	UniProtKB/TrEMBL
Pfam	KH_1	UniProtKB/TrEMBL
	zf-C3HC4_3	UniProtKB/TrEMBL
PhenoGen	Mex3c	PhenoGen
PROSITE	KH_TYPE_1	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000015777	RatGTEx
SMART	RING	UniProtKB/TrEMBL
	SM00322	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
	SSF54791	UniProtKB/TrEMBL
UniProt	A6IY13	ENTREZGENE, UniProtKB/TrEMBL
	D4A2R5_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-11-19	Mex3c	mex-3 RNA binding family member C	Mex3c	mex-3 homolog C (C. elegans)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-05-05	Mex3c	mex-3 homolog C (C. elegans)	Rkhd2	ring finger and KH domain containing 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Rkhd2	ring finger and KH domain containing 2	Rkhd2_predicted	ring finger and KH domain containing 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Rkhd2_predicted	ring finger and KH domain containing 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD