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Gene: Rasal3 (RAS protein activator like 3) Rattus norvegicus

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Symbol:

Rasal3

Name:

RAS protein activator like 3

RGD ID:

1309019

Description:

Predicted to enable GTPase activator activity and identical protein binding activity. Predicted to be involved in negative regulation of Ras protein signal transduction and positive regulation of NK T cell proliferation. Predicted to be located in cytoplasm and cytoplasmic side of membrane. Orthologous to human RASAL3 (RAS protein activator like 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC314596; RAS protein activator like-3; RGD1309019; similar to Ras GTPase-activating protein nGAP (RAS protein activator like 1)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RASAL3 (RAS protein activator like 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Rasal3 (RAS protein activator like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rasal3 (RAS protein activator like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RASAL3 (RAS protein activator like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RASAL3 (RAS protein activator like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rasal3 (RAS protein activator like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RASAL3 (RAS protein activator like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RASAL3 (RAS protein activator like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rasal3 (RAS protein activator like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Rasal3 (RAS protein activator like 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	RASAL3 (RAS protein activator like 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rasal3 (RAS protein activator like 3)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	BUD2	Alliance	DIOPT (Hieranoid\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	BUD2	Alliance	DIOPT (OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG42684	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG42684	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	gap-2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	rasal3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	12,047,090 - 12,061,883 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	12,047,090 - 12,061,883 (-)	Ensembl				GRCr8
mRatBN7.2	7	11,396,554 - 11,411,347 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	11,396,090 - 11,411,465 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	14,214,565 - 14,229,763 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	16,091,987 - 16,107,185 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	13,963,524 - 13,978,783 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	14,403,592 - 14,419,570 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	14,403,592 - 14,418,950 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	14,557,751 - 14,573,109 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	12,953,506 - 12,968,785 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	9,507,312 - 9,522,488 (-)	NCBI		Celera
RGSC_v3.1	7	12,953,969 - 13,036,520 (-)	NCBI
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute megakaryocytic leukemia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-palmitoylglycerol (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

alpha-Zearalanol (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

buta-1,3-diene (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

chloroprene (ISO)

chlorpyrifos (EXP)

chromium(6+) (ISO)

Cuprizon (EXP)

decabromodiphenyl ether (EXP)

Dibutyl phosphate (ISO)

dimethylarsinic acid (ISO)

dioxygen (EXP)

diquat (ISO)

diuron (ISO)

epoxiconazole (ISO)

gentamycin (EXP)

ivermectin (ISO)

methylarsonic acid (ISO)

N-nitrosodiethylamine (ISO)

nickel atom (ISO)

ozone (ISO)

paracetamol (ISO)

pentachlorophenol (ISO)

phorbol 13-acetate 12-myristate (ISO)

piperonyl butoxide (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

T-2 toxin (EXP)

tetrachloromethane (EXP)

titanium dioxide (ISO)

tungsten (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of Ras protein signal transduction (IEA,ISO)

positive regulation of NK T cell proliferation (IEA,ISO)

regulation of intracellular signal transduction (IBA)

Cellular Component

cytoplasm (IEA,ISO)

cytoplasmic side of membrane (IEA,ISO)

plasma membrane (IEA,ISO)

Molecular Function

GTPase activator activity (IBA,IEA)

identical protein binding (IEA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:19946888	PMID:20458337	PMID:25652366

Genomics

Comparative Map Data

Rasal3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	12,047,090 - 12,061,883 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	12,047,090 - 12,061,883 (-)	Ensembl				GRCr8
mRatBN7.2	7	11,396,554 - 11,411,347 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	11,396,090 - 11,411,465 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	14,214,565 - 14,229,763 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	16,091,987 - 16,107,185 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	13,963,524 - 13,978,783 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	14,403,592 - 14,419,570 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	14,403,592 - 14,418,950 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	14,557,751 - 14,573,109 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	12,953,506 - 12,968,785 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	9,507,312 - 9,522,488 (-)	NCBI		Celera
RGSC_v3.1	7	12,953,969 - 13,036,520 (-)	NCBI
Cytogenetic Map	7	q11	NCBI

RASAL3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	15,451,624 - 15,464,544 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	15,451,624 - 15,464,583 (-)	Ensembl			hg38	GRCh38
GRCh37	19	15,562,435 - 15,575,355 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	15,423,438 - 15,436,382 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	19	15,459,253 - 15,472,196 (-)	NCBI		Celera
Cytogenetic Map	19	p13.12	NCBI
HuRef	19	15,130,271 - 15,143,115 (-)	NCBI		HuRef
CHM1_1	19	15,562,083 - 15,575,024 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	15,576,612 - 15,589,556 (-)	NCBI		T2T-CHM13v2.0

Rasal3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	32,609,633 - 32,622,586 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	32,609,633 - 32,622,557 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	32,390,659 - 32,403,582 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	32,390,659 - 32,403,583 (-)	Ensembl			mm10	GRCm38
MGSCv37	17	32,527,606 - 32,540,526 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	32,121,906 - 32,136,226 (-)	NCBI		MGSCv36	mm8
Celera	17	33,304,546 - 33,317,468 (-)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	17.55	NCBI

Rasal3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	7,795,842 - 7,808,511 (+)	Ensembl
ChiLan1.0	NW_004955495	7,795,619 - 7,808,674 (+)	NCBI	ChiLan1.0	ChiLan1.0

RASAL3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	20,364,784 - 20,377,718 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	19,367,558 - 19,380,483 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	14,982,964 - 14,995,889 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	15,969,412 - 15,981,800 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	15,969,582 - 15,981,800 (-)	Ensembl			panPan2	panpan1.1

RASAL3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	46,733,072 - 46,743,657 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	46,732,952 - 46,743,924 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	46,580,801 - 46,591,492 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	47,219,876 - 47,230,567 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	47,218,828 - 47,230,702 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	46,454,750 - 46,465,438 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	46,871,406 - 46,882,096 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	47,144,900 - 47,155,591 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rasal3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	205,497,560 - 205,504,782 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936596	5,048,068 - 5,059,074 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RASAL3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	62,142,769 - 62,153,799 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	62,142,368 - 62,153,812 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	61,716,444 - 61,725,472 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RASAL3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	14,054,517 - 14,068,423 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	14,054,522 - 14,064,590 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666074	5,439,480 - 5,453,339 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rasal3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624901	2,538,550 - 2,550,327 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624901	2,538,131 - 2,550,540 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Rasal3
233 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	319
Count of miRNA genes:	193
Interacting mature miRNAs:	221
Transcripts:	ENSRNOT00000066722
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1669658	46669658	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	1	23748937	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	7216097	52216097	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	10517086	62346019	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	10112916	99900612	Rat
2290372	Gluco33	Glucose level QTL 33	2.71		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	1	31777942	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	1	104117804	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1709527	46709527	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	32612984	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	10112916	60150541	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	9460877	54460877	Rat
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	29716167	Rat
1300138	Hrtrt9	Heart rate QTL 9	4.72		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	10498820	55498820	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34650782	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	32612984	Rat

Markers in Region

RH144044

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	11,399,398 - 11,399,526 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	14,406,901 - 14,407,028	NCBI	Rnor6.0
Rnor_5.0	7	14,561,060 - 14,561,187	UniSTS	Rnor5.0
RGSC_v3.4	7	12,956,815 - 12,956,942	UniSTS	RGSC3.4
Celera	7	9,510,619 - 9,510,746	UniSTS
RH 3.4 Map	7	67.4	UniSTS
Cytogenetic Map	7	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	161	91	90	59	92	59	6	356	192	11	140	81	91	31	13	13

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001134562	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001414936	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000066722 ⟹ ENSRNOP00000059964

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	12,047,090 - 12,061,883 (-)	Ensembl
mRatBN7.2 Ensembl	7	11,396,090 - 11,411,349 (-)	Ensembl
Rnor_6.0 Ensembl	7	14,403,592 - 14,418,950 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094712 ⟹ ENSRNOP00000077890

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	12,047,090 - 12,061,883 (-)	Ensembl
mRatBN7.2 Ensembl	7	11,396,090 - 11,411,349 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104813 ⟹ ENSRNOP00000086442

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	12,047,090 - 12,061,883 (-)	Ensembl
mRatBN7.2 Ensembl	7	11,396,090 - 11,411,465 (-)	Ensembl

RefSeq Acc Id:

NM_001134562 ⟹ NP_001128034

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	12,047,090 - 12,061,883 (-)	NCBI
mRatBN7.2	7	11,396,554 - 11,411,347 (-)	NCBI
Rnor_6.0	7	14,403,592 - 14,418,950 (-)	NCBI
Rnor_5.0	7	14,557,751 - 14,573,109 (-)	NCBI
RGSC_v3.4	7	12,953,506 - 12,968,785 (-)	RGD
Celera	7	9,507,312 - 9,522,488 (-)	RGD

Sequence:

show sequence

GTACAGACGGCTGCTGGTTCTGGACTGGCCAGGAAATCAAGCAGAGACTCCGCCATGGACCCAC
CGCTGCAGAATGAAGATTCCCAAACGCAGCCCTCGCCGCTGACGTCCTATCGTTGGCACACTGG
AGGCAGAGGGGAGAAGATTGCTGGAGGGTTCCGCTGGGGCCGCTTCGCAGGCTGGGGAAGGGCC
CTGAGCCATCAGGAGCCCATGGTGAGCAGCCAGCCAGCCCCTAGATCTCTGTTTCGTCGGGTCC
TCTCTGCACCTCCTAAGGAGTCACGACCCAATCGCCTCCGGTTTTCCAAGAGCCTGTGGGGGAG
GCACAAGAACGTGGTACCGCTGGAACCCAAGCTAAATCCGAAGGCCCCAGAGCCAGAGCTGGAG
TTGGAGGGAGCCCCAGACCTGCGCGCTGCACATATCCCTGAGCCTCCCGCCCCTGACATGCCTG
TTTGGAACATTGATGGCTTTGCCCTGCTCGAAGGAAGACTGGTGATGCTCGGTGAGGAGGAGGG
TCCTCGCCAAATCCGAATGGGAAGTGCCAGCTCGGAAAGCAGCATGCAGGCAGCCTTGGGGAAC
CTCAAAGACCCAGTTCGGACTCCTGGGAAAATTGAGCCGGAAGCTACTGGTTCCAACCAGGTCC
ACAATGTTCGGAAGTTACTCAAGAGGCTGAAGGAGAAGAAAAGGGCCAAGTCGGAACTGGGAGC
CCACACTCCTCGAGATGGACCCTCCAGTGCTCTTGGTTCCAGAGAATCGCTGGCCACACTCTCT
GAGCTGGACCTAGGCGTTGAGAGGGATGTGAGAGTCTGGCCGCTGCATCCTAGCCTCCTGGGGG
AGCCATATTGCTTCCAGGTAACGTGGGCAGGTGGGAGCCGCTGTTTCTCTTGTCGCTCGAGCGC
TGAGAGAGACCGTTGGATTGAGGACCTTCGTCGGCAGTTCCAGCCTAGCCAGGACAATGTGGAA
CGACAAGAGACCTGGCTGACAGTGTGGGTGCACGAAGCCAAAGGGCTTCCCCGAGCAGCTGCAC
CCGGAGTGCGTGCGGAGCTGTGGTTGGACGGCGCGCTACTGGCGCGCACTGCCCCTCGGGCGGG
CCCTGACCAACTCTTCTGGGCCGAACGCTTCCACTTCGAGGCGTTGCCACCTGCCCGTCGCCTG
TCGCTGCGGCTGCGCGGAGCAGGCCCGGCAGGGGCAACCGTGGGCAGGGTGGTACTAGAACTGG
ACGAGGTGAGCATCCCCCGCGCGCCTGCCGCAGGCCTGGAGCGCTGGTTCCCCGTGCTCGGGGC
TCCGGCGGGTGCGGTGCTACGGGCGCGGATCAGGGTACGATGTCTGCGCGTGCTGCCGTCGGAG
CGCTATAAGGAGTTAGCGGAGTTCCTCACCTTCCACTACGCGCGCCTGTGCATGGCGCTGGAGC
CCGCGCTGTCTGCTCAGGCCAAGGAGGAGCTGGCAGCAGCCATGGTGCGCGTGCTACGAGCCAC
TGGCCGAGCGCAGGCATTGGTGACAGACCTAGGAACCGCAGAGCTGGAGCGCTGTGGAGGCCGT
GAAGCGCTGCTATTCCGAGAAAATACCTTAGCCACAAAGGCCATTGATGAATACATGAAACTGG
TGGCACAGGAGTACCTCCAGGAGACCCTGGGCCAGGTTGTGCGGAGTCTCTGTGCCTCCACCGA
GGACTGTGAAGTGGACCCCAGCAAGTGCCCAACACCGGAGCTGCCAAAATGCCAAGCTAGACTG
CGAAGCAGTTGTGAGGAGGTTTTTGAAAACATCATCCACTCTTACAACTATTTCCCAGCAGAGC
TGGGCACCGTGTTCTCAAATTGGCGGGAAGCATGCAAAGCACGAGGCTCTGAGGCACTGGGCCC
CCGGCTGGTGTGTGCTTCTCTCTTCCTAAGGCTCCTATGCCCCGCCATCTTGGCACCTAGCCTC
TTTGGCCTGGCACCAGAGCACCCCGCCCCAGGCCCAGCCAGAACTCTTACACTCATCGCCAAGG
TCATCCAGAATCTTGCCAACTGTGCTCCGTTTGGTGAGAAGGAAGCCTACATGGTCTTTATGAA
TAGCTTCCTGGAAGATCATGGACCGGCCATGCGACACTTCCTGGATCAGGTAGCTATGGTGGAC
ACAGATACCACACCCAGTGGCTACCAGGGAAGTGGAGACCTGGCCCTCCAGTTGGCAGTTCTTC
ATGTCCAGCTCTGCACAATCTTTGCTGAACTTGACCAGAAAACTCGAGACAGCTTGGAACCACT
ACCCACCATCCTTCAAGCCATTGAGGAGGGTCGGCCTGTCCCAGTGTCTGTACCAATGCGTCTT
CCCCTGAACACTGCTCATGTCCAATCCAGCTTCTCTTCAGGGGAGAAACCCGGCTTCCTGGCAC
CCCGAGACCTCCCCAAGCACACTCCTCTCATTTCCAAGAGCCAGTCTTTGCGCAGCTTTCAAGG
GGCAGGAAGCTGGGCCCGTCGGCGGCCAGATGGGGAGCGGCCCCAGCGGCGGCCGCGGCCAGTG
CTGCGCACACAGAGCGTCCCTGCCAGACGCCCTACCCACCATCGCCCTGCTGCGGGTTCCAAGC
CTCGACCCAAAGGCTCTCTACGCACTGGTCCTGCGACTTCCGGACGGGCCTGGGCTAGGACTTC
CACCTCTCTACCTCGGAAGCCATCGGTGCCTTGGCAGCGCCAACTGGACCAGCCCGGGGACCGA
TACCAAACTCCGGGAACGCACCGACCAGTGGGCAAGCTAGCAGAGATACAATGCGAGGTAGCTG
CACTCCGCGAGGAACAGAAAGCCCTGTCCCATCTGGTGGAGTCGCTGAGTACCCACATCCAGGC
CTTGACGGAGCAGCAAGAGCAGCTCCGCTGTCAGCTGCAGGATCTGGACTCCAGACTGGGAGCT
GGGATCTCAAAGTTGGATTCTAAGGGTGGTCTCCCAAGCAACGGTAGCCTCGGGCTGAAAAGTC
TGGAGCACCGCATGACTGAGATGGAATGTTCTCAGAACCAGCTGAGGGATACCCTCCAAAGCCT
ACAGCTTCTTTCAAAAACTCCAGGATCTCGGAGCCAGCCCCCGCCTCTCAAAGCACCATGTGTC
AATGGAGCTGATCTGTCGATGGGCACCTGAGTATTTCACCCCACTCCATACAGTCTGGAAGCCA
GGAGAGCCACTACAGAGGATTTTCTGACTACCTCAGTCCTTCATGGCCCTTAGTAGGGGACAGA
GTGGGAGGTGTCAATCACTCTGGTAACTGTGAGGTTGCCCAGTAAATCTCCATTTCAGAAAATC
ACTGGTTTCTCTGCCCCTACAAAGATTAATGCAAGAGCATACCCAGTTCTCTACTCAGCTCCCC
CAAATTCTTACCTAATTTGAAGTCTCCCGAAGATGAAAATGATTAGCAAAATTGTCCTCACTAT
TGGTGTGATCTAAGGTCATCACTCTAAAAGACTCCATTCTCTCTTCTGTATCTAAAAATTCTCT
GCATAGTTAAAGGTATTCAATAAAAGGTATTTATCATTGTTGTGGGAACCACCTGCTTTTCCAT
GATGCACAGATCTCCCGCCCACCTATCCCACCTCATCCCCTGCCAATACCTCAAGTTCTGAGTG
ACAGAATCTTTCTAGACTTTGTCTAGAAAGACAATGCAGGTACCTTTATGGCAGGGAGAGCAAT
GGGTCTGAGAGGCAGATGAAGGAACGGACTGTGCATGAGAACACGGTTGAGTTCTATGGCTGGT
TGAGTAAGGTGGATGAACCAATAGGCAGGTGACTAGGTTAGCTAATTCACTGAACATTTGACCT
GCTGTAAGGCAGATCATGAATCAAAATAGACAGGTCTACTTAGAGAAGGCTGACACAAAATAGG
AAATTAACACTTGAACTAAATGAGTAAACACGCACACACACACACACACACACACACACACACA
CACACACACACACACCTCACGTTTATCGAGGTCTTTTGGGACTCCCAAATGAGTCATGGGAA

hide sequence

RefSeq Acc Id:

NM_001414936 ⟹ NP_001401865

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	12,047,090 - 12,061,883 (-)	NCBI
mRatBN7.2	7	11,396,554 - 11,411,347 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001128034	(Get FASTA)	NCBI Sequence Viewer
	NP_001401865	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL89468	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000059964
	ENSRNOP00000059964.1
	ENSRNOP00000077890.2
	ENSRNOP00000086442
	ENSRNOP00000086442.1

RefSeq Acc Id:	NP_001128034 ⟸ NM_001134562
- Peptide Label:	isoform 2
- UniProtKB:	D3ZWW3 (UniProtKB/TrEMBL), A6K948 (UniProtKB/TrEMBL), A0A8I5ZJL7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDPPLQNEDSQTQPSPLTSYRWHTGGRGEKIAGGFRWGRFAGWGRALSHQEPMVSSQPAPRSLF RRVLSAPPKESRPNRLRFSKSLWGRHKNVVPLEPKLNPKAPEPELELEGAPDLRAAHIPEPPAP DMPVWNIDGFALLEGRLVMLGEEEGPRQIRMGSASSESSMQAALGNLKDPVRTPGKIEPEATGS NQVHNVRKLLKRLKEKKRAKSELGAHTPRDGPSSALGSRESLATLSELDLGVERDVRVWPLHPS LLGEPYCFQVTWAGGSRCFSCRSSAERDRWIEDLRRQFQPSQDNVERQETWLTVWVHEAKGLPR AAAPGVRAELWLDGALLARTAPRAGPDQLFWAERFHFEALPPARRLSLRLRGAGPAGATVGRVV LELDEVSIPRAPAAGLERWFPVLGAPAGAVLRARIRVRCLRVLPSERYKELAEFLTFHYARLCM ALEPALSAQAKEELAAAMVRVLRATGRAQALVTDLGTAELERCGGREALLFRENTLATKAIDEY MKLVAQEYLQETLGQVVRSLCASTEDCEVDPSKCPTPELPKCQARLRSSCEEVFENIIHSYNYF PAELGTVFSNWREACKARGSEALGPRLVCASLFLRLLCPAILAPSLFGLAPEHPAPGPARTLTL IAKVIQNLANCAPFGEKEAYMVFMNSFLEDHGPAMRHFLDQVAMVDTDTTPSGYQGSGDLALQL AVLHVQLCTIFAELDQKTRDSLEPLPTILQAIEEGRPVPVSVPMRLPLNTAHVQSSFSSGEKPG FLAPRDLPKHTPLISKSQSLRSFQGAGSWARRRPDGERPQRRPRPVLRTQSVPARRPTHHRPAA GSKPRPKGSLRTGPATSGRAWARTSTSLPRKPSVPWQRQLDQPGDRYQTPGTHRPVGKLAEIQC EVAALREEQKALSHLVESLSTHIQALTEQQEQLRCQLQDLDSRLGAGISKLDSKGGLPSNGSLG LKSLEHRMTEMECSQNQLRDTLQSLQLLSKTPGSRSQPPPLKAPCVNGADLSMGT hide sequence

Ensembl Acc Id:

ENSRNOP00000059964 ⟸ ENSRNOT00000066722

Ensembl Acc Id:

ENSRNOP00000086442 ⟸ ENSRNOT00000104813

Ensembl Acc Id:

ENSRNOP00000077890 ⟸ ENSRNOT00000094712

RefSeq Acc Id:	NP_001401865 ⟸ NM_001414936
- Peptide Label:	isoform 1
- UniProtKB:	A0A8I6GE24 (UniProtKB/TrEMBL), A0A8I5ZJL7 (UniProtKB/TrEMBL)

Protein Domains

C2 Ras-GAP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZWW3-F1-model_v2	AlphaFold	D3ZWW3	1-1015	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695069

Promoter ID:

EPDNEW_R5593

Type:

single initiation site

Name:

Rasal3_1

Description:

RAS protein activator like 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	14,418,948 - 14,419,008	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309019	AgrOrtholog
BioCyc Gene	G2FUF-34826	BioCyc
Ensembl Genes	ENSRNOG00000006167	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000066722	ENTREZGENE
	ENSRNOT00000066722.3	UniProtKB/TrEMBL
	ENSRNOT00000094712.2	UniProtKB/TrEMBL
	ENSRNOT00000104813	ENTREZGENE
	ENSRNOT00000104813.2	UniProtKB/TrEMBL
Gene3D-CATH	GTPase Activation - p120gap, domain 1	UniProtKB/TrEMBL
InterPro	C2_dom	UniProtKB/TrEMBL
	C2_domain_sf	UniProtKB/TrEMBL
	Ras_GTPase	UniProtKB/TrEMBL
	RasGAP	UniProtKB/TrEMBL
	RasGAP_CS	UniProtKB/TrEMBL
	Rho_GTPase_activation_prot	UniProtKB/TrEMBL
KEGG Report	rno:314596	UniProtKB/TrEMBL
NCBI Gene	314596	ENTREZGENE
PANTHER	PTHR10194	UniProtKB/TrEMBL
	RAS PROTEIN ACTIVATOR LIKE-3	UniProtKB/TrEMBL
Pfam	PH_RASGAP	UniProtKB/TrEMBL
	RasGAP	UniProtKB/TrEMBL
PhenoGen	Rasal3	PhenoGen
PROSITE	PS50004	UniProtKB/TrEMBL
	RAS_GTPASE_ACTIV_1	UniProtKB/TrEMBL
	RAS_GTPASE_ACTIV_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006167	RatGTEx
SMART	RasGAP	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
	Rho_GAP	UniProtKB/TrEMBL
	SSF49562	UniProtKB/TrEMBL
UniProt	A0A8I5ZJL7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GE24	ENTREZGENE, UniProtKB/TrEMBL
	A6K948	ENTREZGENE, UniProtKB/TrEMBL
	D3ZWW3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-12-30	Rasal3	RAS protein activator like 3	RGD1309019	similar to Ras GTPase-activating protein nGAP (RAS protein activator like 1)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1309019	similar to Ras GTPase-activating protein nGAP (RAS protein activator like 1)	RGD1309019_predicted	similar to Ras GTPase-activating protein nGAP (RAS protein activator like 1) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1309019_predicted	similar to Ras GTPase-activating protein nGAP (RAS protein activator like 1) (predicted)	LOC314596_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC314596_predicted	similar to Ras GTPase-activating protein nGAP (RAS protein activator like 1) (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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