Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Efs | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Efs (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of EFS mRNA | CTD | PMID:22206623 | Efs | Rat | 1,2-dimethylhydrazine | affects expression | ISO | Efs (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine affects the expression of EFS mRNA | CTD | PMID:22206623 | Efs | Rat | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of EFS mRNA | CTD | PMID:30723492 | Efs | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Efs (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of EFS mRNA | CTD | PMID:17555576 | Efs | Rat | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of EFS mRNA | CTD | PMID:17557909 | Efs | Rat | 17beta-estradiol | multiple interactions | ISO | EFS (Homo sapiens) | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of EFS mRNA | CTD | PMID:17404688 | Efs | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Efs (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of EFS mRNA | CTD | PMID:21354282 | Efs | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EFS mRNA | CTD | PMID:32109520|PMID:33387578 | Efs | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | EFS (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Efs | Rat | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ... | CTD | PMID:36041667 | Efs | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Efs (Mus musculus) | 6480464 | Fenretinide results in decreased expression of EFS mRNA | CTD | PMID:28973697 | Efs | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of EFS mRNA | CTD | PMID:24780913 | Efs | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of EFS mRNA | CTD | PMID:31881176 | Efs | Rat | all-trans-retinoic acid | decreases expression | ISO | EFS (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of EFS mRNA | CTD | PMID:21934132 | Efs | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of EFS mRNA | CTD | PMID:16483693 | Efs | Rat | amphetamine | increases expression | EXP | | 6480464 | Amphetamine results in increased expression of EFS mRNA | CTD | PMID:30779732 | Efs | Rat | antirheumatic drug | increases expression | ISO | EFS (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of EFS mRNA | CTD | PMID:24449571 | Efs | Rat | arsane | multiple interactions | ISO | EFS (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of EFS more ... | CTD | PMID:32525701 | Efs | Rat | arsenic atom | multiple interactions | ISO | EFS (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of EFS more ... | CTD | PMID:32525701 | Efs | Rat | benzo[a]pyrene | decreases methylation | ISO | EFS (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of EFS exon; Benzo(a)pyrene results in decreased methylation of EFS more ... | CTD | PMID:27901495 | Efs | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of EFS mRNA | CTD | PMID:25181051 | Efs | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ... | CTD | PMID:36041667 | Efs | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of EFS mRNA | CTD | PMID:30816183|PMID:32528016|PMID:34947998 | Efs | Rat | bisphenol A | multiple interactions | ISO | EFS (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Efs | Rat | bisphenol F | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ... | CTD | PMID:36041667 | Efs | Rat | Butylbenzyl phthalate | increases methylation | ISO | Efs (Mus musculus) | 6480464 | butylbenzyl phthalate results in increased methylation of EFS intron | CTD | PMID:28392331 | Efs | Rat | cadmium atom | multiple interactions | ISO | Efs (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of EFS more ... | CTD | PMID:37325564 | Efs | Rat | cadmium dichloride | multiple interactions | ISO | Efs (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of EFS more ... | CTD | PMID:37325564 | Efs | Rat | carbamazepine | affects expression | ISO | EFS (Homo sapiens) | 6480464 | Carbamazepine affects the expression of EFS mRNA | CTD | PMID:25979313 | Efs | Rat | carbon nanotube | increases expression | ISO | Efs (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in increased expression of EFS mRNA; Nanotubes, Carbon results in increased more ... | CTD | PMID:25554681 | Efs | Rat | CGP 52608 | multiple interactions | ISO | EFS (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to EFS gene] | CTD | PMID:28238834 | Efs | Rat | chlorpyrifos | affects expression | ISO | Efs (Mus musculus) | 6480464 | Chlorpyrifos affects the expression of EFS mRNA | CTD | PMID:37019170 | Efs | Rat | chrysene | increases expression | ISO | Efs (Mus musculus) | 6480464 | chrysene results in increased expression of EFS mRNA | CTD | PMID:26377693 | Efs | Rat | clothianidin | decreases expression | ISO | EFS (Homo sapiens) | 6480464 | clothianidin results in decreased expression of EFS mRNA | CTD | PMID:31626844 | Efs | Rat | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of EFS mRNA | CTD | PMID:26577399 | Efs | Rat | dexamethasone | multiple interactions | ISO | EFS (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Efs | Rat | dibutyl phthalate | increases expression | ISO | Efs (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of EFS mRNA | CTD | PMID:17361019|PMID:21266533 | Efs | Rat | dorsomorphin | multiple interactions | ISO | EFS (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Efs | Rat | ethanol | increases expression | ISO | Efs (Mus musculus) | 6480464 | Ethanol results in increased expression of EFS mRNA | CTD | PMID:30319688 | Efs | Rat | etoposide | increases expression | ISO | Efs (Mus musculus) | 6480464 | Etoposide results in increased expression of EFS mRNA | CTD | PMID:25270620 | Efs | Rat | folic acid | multiple interactions | ISO | Efs (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of EFS mRNA | CTD | PMID:22206623 | Efs | Rat | formaldehyde | increases expression | ISO | EFS (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of EFS mRNA | CTD | PMID:27905399 | Efs | Rat | furan | increases expression | EXP | | 6480464 | furan results in increased expression of EFS mRNA | CTD | PMID:27387713 | Efs | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of EFS mRNA | CTD | PMID:22061828 | Efs | Rat | hydroquinone O-beta-D-glucopyranoside | decreases expression | ISO | EFS (Homo sapiens) | 6480464 | Arbutin results in decreased expression of EFS mRNA | CTD | PMID:17103032 | Efs | Rat | indometacin | multiple interactions | ISO | EFS (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Efs | Rat | mitomycin C | increases expression | ISO | Efs (Mus musculus) | 6480464 | Mitomycin results in increased expression of EFS mRNA | CTD | PMID:25270620 | Efs | Rat | N-methyl-N-nitrosourea | increases expression | ISO | Efs (Mus musculus) | 6480464 | Methylnitrosourea results in increased expression of EFS mRNA | CTD | PMID:25270620 | Efs | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of EFS mRNA | CTD | PMID:33387578 | Efs | Rat | PCB138 | increases expression | EXP | | 6480464 | 2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of EFS mRNA | CTD | PMID:23829299 | Efs | Rat | perfluorohexanesulfonic acid | decreases expression | ISO | Efs (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in decreased expression of EFS mRNA | CTD | PMID:37995155 | Efs | Rat | phenylmercury acetate | decreases expression | ISO | EFS (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of EFS mRNA | CTD | PMID:26272509 | Efs | Rat | phenylmercury acetate | multiple interactions | ISO | EFS (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Efs | Rat | progesterone | multiple interactions | ISO | EFS (Homo sapiens) | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of EFS mRNA | CTD | PMID:17404688 | Efs | Rat | propionic acid | decreases expression | ISO | EFS (Homo sapiens) | 6480464 | propionic acid results in decreased expression of EFS mRNA | CTD | PMID:31526819 | Efs | Rat | SB 431542 | multiple interactions | ISO | EFS (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Efs | Rat | sodium arsenate | multiple interactions | ISO | EFS (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of EFS more ... | CTD | PMID:32525701 | Efs | Rat | sunitinib | decreases expression | ISO | EFS (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of EFS mRNA | CTD | PMID:31533062 | Efs | Rat | tert-butyl hydroperoxide | increases expression | ISO | EFS (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in increased expression of EFS mRNA | CTD | PMID:15336504 | Efs | Rat | titanium dioxide | increases expression | ISO | Efs (Mus musculus) | 6480464 | titanium dioxide results in increased expression of EFS mRNA | CTD | PMID:23557971 | Efs | Rat | titanium dioxide | increases methylation | ISO | Efs (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of EFS gene; titanium dioxide results in increased methylation more ... | CTD | PMID:35295148 | Efs | Rat | titanium dioxide | decreases methylation | ISO | Efs (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of EFS gene | CTD | PMID:35295148 | Efs | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of EFS mRNA | CTD | PMID:33387578 | Efs | Rat | trimellitic anhydride | decreases expression | ISO | Efs (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of EFS mRNA | CTD | PMID:19042947 | Efs | Rat | tunicamycin | decreases expression | ISO | EFS (Homo sapiens) | 6480464 | Tunicamycin results in decreased expression of EFS mRNA | CTD | PMID:22378314 | Efs | Rat | valproic acid | decreases expression | ISO | Efs (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of EFS mRNA | CTD | PMID:19136453|PMID:20546886|PMID:21427059 | Efs | Rat | valproic acid | increases methylation | ISO | EFS (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of EFS gene | CTD | PMID:29154799 | Efs | Rat | valproic acid | affects expression | ISO | EFS (Homo sapiens) | 6480464 | Valproic Acid affects the expression of EFS mRNA | CTD | PMID:25979313 | Efs | Rat | valproic acid | decreases expression | ISO | EFS (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of EFS mRNA | CTD | PMID:19101580|PMID:23179753|PMID:24383497|PMID:24935251|PMID:26272509|PMID:28001369 | Efs | Rat | valproic acid | multiple interactions | ISO | EFS (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Efs | Rat | WIN 55212-2 | decreases expression | ISO | Efs (Mus musculus) | 6480464 | (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in decreased expression of EFS mRNA | CTD | PMID:12237329 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















