Mtf1 (metal-regulatory transcription factor 1) - Rat Genome Database

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Gene: Mtf1 (metal-regulatory transcription factor 1) Rattus norvegicus
Analyze
Symbol: Mtf1
Name: metal-regulatory transcription factor 1
RGD ID: 1308956
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone acetyltransferase binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human MTF1 (metal regulatory transcription factor 1); INTERACTS WITH 2,6-dinitrotoluene; acetamide; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC100909856; LOC362591; metal regulatory transcription factor 1; metal regulatory transcription factor 1-like; metal response element binding transcription factor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85142,347,024 - 142,391,810 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5142,347,054 - 142,391,810 (+)EnsemblGRCr8
mRatBN7.25137,062,319 - 137,107,136 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5137,062,376 - 137,107,136 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5139,767,233 - 139,812,075 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05141,537,246 - 141,582,093 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05141,544,424 - 141,589,269 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05142,797,340 - 142,843,896 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5142,332,607 - 142,376,370 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl5142,797,366 - 142,842,122 (+)Ensemblrn6Rnor6.0
Rnor_5.05146,567,984 - 146,614,540 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45144,135,674 - 144,180,430 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5135,585,105 - 135,629,881 (+)NCBICelera
RGSC_v3.15144,145,451 - 144,187,287 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+-)-suloctidil  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
2-tert-butylhydroquinone  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldosterone  (EXP)
alexidine  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
aluminium sulfate (anhydrous)  (ISO)
amiodarone  (ISO)
amlodipine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astemizole  (ISO)
bathocuproine disulfonic acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
busulfan  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
cerium  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cycloheximide  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
elemental selenium  (ISO)
ferroheme b  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
gallium nitrate  (ISO)
gentamycin  (EXP)
glutathione  (ISO)
heme b  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mefloquine  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metam  (ISO)
methylmercury chloride  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitroprusside  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylarsine oxide  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
spironolactone  (EXP)
succimer  (ISO)
TCEP  (ISO)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12). Chowanadisai W, etal., Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9903-8. doi: 10.1073/pnas.1222142110. Epub 2013 May 28.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9582278   PMID:10931824   PMID:10952993   PMID:15735762   PMID:16886906   PMID:18605988   PMID:24529376   PMID:33931586  


Genomics

Comparative Map Data
Mtf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85142,347,024 - 142,391,810 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5142,347,054 - 142,391,810 (+)EnsemblGRCr8
mRatBN7.25137,062,319 - 137,107,136 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5137,062,376 - 137,107,136 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5139,767,233 - 139,812,075 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05141,537,246 - 141,582,093 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05141,544,424 - 141,589,269 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05142,797,340 - 142,843,896 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5142,332,607 - 142,376,370 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl5142,797,366 - 142,842,122 (+)Ensemblrn6Rnor6.0
Rnor_5.05146,567,984 - 146,614,540 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45144,135,674 - 144,180,430 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5135,585,105 - 135,629,881 (+)NCBICelera
RGSC_v3.15144,145,451 - 144,187,287 (+)NCBI
Cytogenetic Map5q36NCBI
MTF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38137,809,574 - 37,859,592 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl137,809,574 - 37,859,614 (-)Ensemblhg38GRCh38
GRCh37138,275,246 - 38,325,264 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36138,047,826 - 38,097,879 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34137,948,943 - 37,994,324NCBI
Celera136,553,063 - 36,603,115 (-)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef136,393,522 - 36,443,287 (-)NCBIHuRef
CHM1_1138,391,063 - 38,441,086 (-)NCBICHM1_1
T2T-CHM13v2.0137,676,462 - 37,726,477 (-)NCBIT2T-CHM13v2.0
Mtf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Build 34136,271,267 - 36,284,160NCBI
GRCm394124,696,342 - 124,743,593 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4124,695,897 - 124,743,593 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384124,802,549 - 124,849,800 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4124,802,104 - 124,849,800 (+)Ensemblmm10GRCm38
MGSCv374124,479,793 - 124,527,044 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364124,304,876 - 124,349,954 (+)NCBIMGSCv36mm8
Celera4123,124,096 - 123,171,046 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map457.91NCBI
Mtf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545215,580,460 - 15,627,844 (-)Ensembl
ChiLan1.0NW_00495545215,580,460 - 15,627,844 (-)NCBIChiLan1.0ChiLan1.0
MTF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,977,327 - 189,027,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11188,106,469 - 188,152,667 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0137,088,744 - 37,134,318 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1138,432,716 - 38,482,142 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl138,438,294 - 38,482,142 (-)EnsemblpanPan2panpan1.1
MTF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1154,679,945 - 4,723,111 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl154,680,372 - 4,717,561 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha154,921,849 - 4,965,016 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0154,808,453 - 4,851,650 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl154,808,870 - 4,846,324 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1154,668,306 - 4,711,440 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0154,734,863 - 4,777,974 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0154,751,184 - 4,794,296 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mtf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505854,160,425 - 54,202,806 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647419,981,466 - 20,027,536 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647419,981,483 - 20,027,541 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl693,839,205 - 93,884,409 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1693,837,195 - 93,884,427 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2686,652,512 - 86,655,135 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12095,002,623 - 95,052,366 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2095,003,504 - 95,046,718 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603321,758,719 - 21,810,019 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mtf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476420,515,307 - 20,557,105 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476420,510,925 - 20,557,134 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mtf1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1133,451,190 - 33,493,028 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mtf1
251 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:583
Count of miRNA genes:266
Interacting mature miRNAs:361
Transcripts:ENSRNOT00000031928, ENSRNOT00000072841
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
7411722Strs6Sensitivity to stroke QTL 63.9cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)5140258140143398122Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
RH130361  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25137,064,835 - 137,065,020 (+)MAPPERmRatBN7.2
Rnor_6.05142,799,826 - 142,800,010NCBIRnor6.0
Rnor_6.05142,335,057 - 142,335,241NCBIRnor6.0
Rnor_5.05146,570,470 - 146,570,654UniSTSRnor5.0
Rnor_5.05146,109,874 - 146,110,058UniSTSRnor5.0
RGSC_v3.45144,138,134 - 144,138,318UniSTSRGSC3.4
Celera5135,587,566 - 135,587,750UniSTS
RH 3.4 Map5898.2UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 61 134 57 60 41 86 41 298 168 11 125 71 73 19 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000031928   ⟹   ENSRNOP00000031224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5142,347,054 - 142,391,810 (+)Ensembl
mRatBN7.2 Ensembl5137,062,376 - 137,107,136 (+)Ensembl
Rnor_6.0 Ensembl5142,797,366 - 142,842,122 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000072841   ⟹   ENSRNOP00000067792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5142,332,607 - 142,376,370 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000142529   ⟹   ENSRNOP00000103319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5142,347,054 - 142,391,810 (+)Ensembl
RefSeq Acc Id: NM_001108677   ⟹   NP_001102147
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85142,347,054 - 142,391,810 (+)NCBI
mRatBN7.25137,062,376 - 137,107,136 (+)NCBI
Rnor_6.05142,797,366 - 142,842,122 (+)NCBI
Rnor_5.05146,567,984 - 146,614,540 (+)NCBI
RGSC_v3.45144,135,674 - 144,180,430 (+)RGD
Celera5135,585,105 - 135,629,881 (+)RGD
Sequence:
RefSeq Acc Id: XM_006238884   ⟹   XP_006238946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85142,347,024 - 142,389,222 (+)NCBI
mRatBN7.25137,062,319 - 137,104,562 (+)NCBI
Rnor_6.05142,797,340 - 142,843,896 (+)NCBI
Rnor_5.05146,567,984 - 146,614,540 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110342   ⟹   XP_038966270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85142,361,218 - 142,389,222 (+)NCBI
mRatBN7.25137,074,368 - 137,104,562 (+)NCBI
RefSeq Acc Id: XM_039110343   ⟹   XP_038966271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85142,361,220 - 142,389,222 (+)NCBI
mRatBN7.25137,074,369 - 137,104,562 (+)NCBI
RefSeq Acc Id: XM_063288016   ⟹   XP_063144086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85142,347,189 - 142,389,222 (+)NCBI
RefSeq Acc Id: XM_063288017   ⟹   XP_063144087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85142,347,188 - 142,389,222 (+)NCBI
RefSeq Acc Id: NP_001102147   ⟸   NM_001108677
- UniProtKB: D3ZBT4 (UniProtKB/TrEMBL),   A6IS54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238946   ⟸   XM_006238884
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000031224   ⟸   ENSRNOT00000031928
RefSeq Acc Id: XP_038966270   ⟸   XM_039110342
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038966271   ⟸   XM_039110343
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000067792   ⟸   ENSRNOT00000072841
RefSeq Acc Id: XP_063144087   ⟸   XM_063288017
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063144086   ⟸   XM_063288016
- Peptide Label: isoform X1
- UniProtKB: A6IS54 (UniProtKB/TrEMBL),   D3ZBT4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103319   ⟸   ENSRNOT00000142529
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZBT4-F1-model_v2 AlphaFold D3ZBT4 1-675 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694014
Promoter ID:EPDNEW_R4538
Type:multiple initiation site
Name:LOC100909856_1
Description:metal regulatory transcription factor 1-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05142,797,389 - 142,797,449EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308956 AgrOrtholog
BioCyc Gene G2FUF-39951 BioCyc
Ensembl Genes ENSRNOG00000025724 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000050240 Ensembl
Ensembl Transcript ENSRNOT00000031928 ENTREZGENE
  ENSRNOT00000031928.6 UniProtKB/TrEMBL
  ENSRNOT00000142529.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Zinc_finger_trans_reg UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:362591 UniProtKB/TrEMBL
NCBI Gene 362591 ENTREZGENE
PANTHER METAL RESPONSE ELEMENT-BINDING TRANSCRIPTION FACTOR-1, ISOFORM C UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Mtf1 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025724 RatGTEx
  ENSRNOG00000050240 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0ABK0LQ90_RAT UniProtKB/TrEMBL
  A6IS54 ENTREZGENE, UniProtKB/TrEMBL
  D3ZBT4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Mtf1  metal-regulatory transcription factor 1  LOC100909856  metal regulatory transcription factor 1-like  Data merged from RGD:6501193 737654 PROVISIONAL
2012-07-05 LOC100909856  metal regulatory transcription factor 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-08-29 Mtf1  metal-regulatory transcription factor 1  Mtf1  metal response element binding transcription factor 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mtf1  metal response element binding transcription factor 1   Mtf1_predicted  metal response element binding transcription factor 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mtf1_predicted  metal response element binding transcription factor 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED