Faap20 (FA core complex associated protein 20) - Rat Genome Database

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Pathways
Gene: Faap20 (FA core complex associated protein 20) Rattus norvegicus
Analyze
Symbol: Faap20
Name: FA core complex associated protein 20
RGD ID: 1308923
Description: Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and ubiquitin-modified protein reader activity. Predicted to be involved in interstrand cross-link repair and translesion synthesis. Predicted to be located in chromatin. Predicted to be part of Fanconi anaemia nuclear complex. Orthologous to human FAAP20 (FA core complex associated protein 20); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FANCA-associated protein of 20 kDa; Fanconi anemia core complex associated protein 20; Fanconi anemia core complex-associated protein 20; Fanconi anemia-associated protein of 20 kDa; hypothetical protein LOC362678; LOC362678; RGD1308923; uncharacterized protein LOC362678
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,083,328 - 171,097,599 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5171,087,847 - 171,097,599 (+)EnsemblGRCr8
mRatBN7.25165,808,370 - 165,815,291 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,808,657 - 165,815,333 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5168,514,441 - 168,521,112 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,335,858 - 170,342,525 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05170,298,388 - 170,305,051 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05172,648,171 - 172,655,576 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,648,950 - 172,655,576 (+)Ensemblrn6Rnor6.0
Rnor_5.05176,107,051 - 176,114,290 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45172,049,605 - 172,057,673 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5164,012,575 - 164,019,087 (+)NCBICelera
RGSC_v3.15172,060,298 - 172,068,168 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromatin  (ISO)
chromosome  (IEA,ISO,ISS)
Fanconi anaemia nuclear complex  (IBA,ISO,ISS)
nuclear body  (ISO)
nucleoplasm  (ISO)
nucleus  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22266823   PMID:22343915   PMID:22396592   PMID:22705371  


Genomics

Comparative Map Data
Faap20
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,083,328 - 171,097,599 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5171,087,847 - 171,097,599 (+)EnsemblGRCr8
mRatBN7.25165,808,370 - 165,815,291 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,808,657 - 165,815,333 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5168,514,441 - 168,521,112 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,335,858 - 170,342,525 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05170,298,388 - 170,305,051 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05172,648,171 - 172,655,576 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,648,950 - 172,655,576 (+)Ensemblrn6Rnor6.0
Rnor_5.05176,107,051 - 176,114,290 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45172,049,605 - 172,057,673 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5164,012,575 - 164,019,087 (+)NCBICelera
RGSC_v3.15172,060,298 - 172,068,168 (+)NCBI
Cytogenetic Map5q36NCBI
FAAP20
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812,184,477 - 2,212,720 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12,184,461 - 2,212,720 (-)Ensemblhg38GRCh38
GRCh3712,115,916 - 2,144,159 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612,110,847 - 2,116,074 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1453,322 - 477,308 (+)NCBICelera
Cytogenetic Map1p36.33NCBI
HuRef11,391,725 - 1,419,526 (-)NCBIHuRef
CHM1_112,100,821 - 2,131,279 (-)NCBICHM1_1
T2T-CHM13v2.011,619,452 - 1,648,129 (-)NCBIT2T-CHM13v2.0
Faap20
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,333,168 - 155,341,144 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,334,259 - 155,341,144 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384155,246,904 - 155,256,687 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4155,249,802 - 155,256,687 (+)Ensemblmm10GRCm38
MGSCv374154,624,075 - 154,630,796 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364154,093,796 - 154,100,483 (+)NCBIMGSCv36mm8
Celera4157,523,985 - 157,530,697 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map486.17NCBI
Faap20
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554868,938,352 - 8,944,631 (+)Ensembl
ChiLan1.0NW_0049554868,938,352 - 8,944,631 (+)NCBIChiLan1.0ChiLan1.0
FAAP20
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21226,057,166 - 226,080,895 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11224,727,133 - 224,742,708 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01900,616 - 922,845 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112,050,834 - 2,060,251 (-)NCBIPanPan1.1PanPan1.1panPan2
FAAP20
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1557,114,784 - 57,122,854 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha557,191,775 - 57,197,502 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0557,318,030 - 57,323,781 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl557,317,845 - 57,323,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1557,308,755 - 57,314,485 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0557,201,273 - 57,206,987 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,591,183 - 57,596,926 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Faap20
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505828,165,913 - 28,169,854 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367371,296,152 - 1,300,038 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAAP20
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl664,160,768 - 64,165,101 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1664,160,760 - 64,169,663 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103225774
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120129,357,043 - 129,373,409 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20129,357,089 - 129,362,518 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605433,708,813 - 33,720,611 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Faap20
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248187,747,602 - 7,756,968 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Faap20
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v115,464,817 - 5,474,859 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:56
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000055361
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5160111176171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat

Markers in Region
RH133763  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,815,112 - 165,815,262 (+)MAPPERmRatBN7.2
Rnor_6.05172,655,398 - 172,655,547NCBIRnor6.0
Rnor_5.05176,114,112 - 176,114,261UniSTSRnor5.0
Celera5164,018,909 - 164,019,058UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000055361   ⟹   ENSRNOP00000052229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5171,087,847 - 171,097,599 (+)Ensembl
mRatBN7.2 Ensembl5165,808,657 - 165,815,291 (+)Ensembl
Rnor_6.0 Ensembl5172,648,950 - 172,655,576 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102719   ⟹   ENSRNOP00000078144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5171,091,161 - 171,097,599 (+)Ensembl
mRatBN7.2 Ensembl5165,808,941 - 165,815,285 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108872   ⟹   ENSRNOP00000088935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5171,090,683 - 171,097,599 (+)Ensembl
mRatBN7.2 Ensembl5165,809,065 - 165,815,333 (+)Ensembl
RefSeq Acc Id: NM_001108698   ⟹   NP_001102168
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,090,965 - 171,097,599 (+)NCBI
mRatBN7.25165,808,657 - 165,815,291 (+)NCBI
Rnor_6.05172,648,950 - 172,655,576 (+)NCBI
Rnor_5.05176,107,051 - 176,114,290 (+)NCBI
RGSC_v3.45172,049,605 - 172,057,673 (+)RGD
Celera5164,012,575 - 164,019,087 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239585   ⟹   XP_006239647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,083,328 - 171,097,593 (+)NCBI
mRatBN7.25165,808,370 - 165,815,288 (+)NCBI
Rnor_6.05172,648,171 - 172,655,573 (+)NCBI
Rnor_5.05176,107,051 - 176,114,290 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001102168 (Get FASTA)   NCBI Sequence Viewer  
  XP_006239647 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D4AAA5 (Get FASTA)   NCBI Sequence Viewer  
  EDL81292 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052229.2
  ENSRNOP00000088935
RefSeq Acc Id: NP_001102168   ⟸   NM_001108698
- UniProtKB: D4AAA5 (UniProtKB/Swiss-Prot),   A0A8I6GGQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239647   ⟸   XM_006239585
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000052229   ⟸   ENSRNOT00000055361
Ensembl Acc Id: ENSRNOP00000088935   ⟸   ENSRNOT00000108872
Ensembl Acc Id: ENSRNOP00000078144   ⟸   ENSRNOT00000102719
Protein Domains
UBZ2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AAA5-F1-model_v2 AlphaFold D4AAA5 1-184 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308923 AgrOrtholog
BioCyc Gene G2FUF-38931 BioCyc
Ensembl Genes ENSRNOG00000036876 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000055361.4 UniProtKB/Swiss-Prot
  ENSRNOT00000108872 ENTREZGENE
InterPro FA_core_complex_assoc UniProtKB/Swiss-Prot
  FANCA_interact UniProtKB/Swiss-Prot
  UBZ_FAAP20 UniProtKB/Swiss-Prot
KEGG Report rno:362678 UniProtKB/Swiss-Prot
NCBI Gene 362678 ENTREZGENE
PANTHER FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 20 UniProtKB/Swiss-Prot
  FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 20 UniProtKB/Swiss-Prot
Pfam FANCA_interact UniProtKB/Swiss-Prot
  UBZ_FAAP20 UniProtKB/Swiss-Prot
PhenoGen Faap20 PhenoGen
PROSITE ZF_UBZ2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000036876 RatGTEx
UniProt A0A8I5Y753_RAT UniProtKB/TrEMBL
  A0A8I6GGQ9 ENTREZGENE, UniProtKB/TrEMBL
  D4AAA5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-25 Faap20  FA core complex associated protein 20  Faap20  Fanconi anemia core complex associated protein 20  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-06-08 Faap20  Fanconi anemia core complex associated protein 20  RGD1308923  LOC362678  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1308923  LOC362678   RGD1308923_predicted  LOC362678 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1308923_predicted  LOC362678 (predicted)  LOC362678_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC362678_predicted  LOC362678 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL