Csrnp2 (cysteine and serine rich nuclear protein 2) - Rat Genome Database

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Gene: Csrnp2 (cysteine and serine rich nuclear protein 2) Rattus norvegicus
Analyze
Symbol: Csrnp2
Name: cysteine and serine rich nuclear protein 2
RGD ID: 1308916
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; phosphatase binding activity; and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human CSRNP2 (cysteine and serine rich nuclear protein 2); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Csnrp2; cysteine-serine-rich nuclear protein 2; cysteine/serine-rich nuclear protein 2; LOC315308; RGD1308916; similar to TGF-beta induced apoptosis protein 12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,473,027 - 133,488,868 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7133,473,027 - 133,488,868 (-)EnsemblGRCr8
mRatBN7.27131,594,232 - 131,610,075 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,594,232 - 131,610,075 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7133,396,399 - 133,412,237 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07135,621,976 - 135,637,814 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07135,535,630 - 135,551,448 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,116,335 - 142,132,173 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,116,335 - 142,132,173 (-)Ensemblrn6Rnor6.0
Rnor_5.07139,923,806 - 139,939,644 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47139,182,243 - 139,198,084 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7128,071,529 - 128,087,360 (-)NCBICelera
RGSC_v3.17139,261,070 - 139,268,389 (-)NCBI
Cytogenetic Map7q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17726538   PMID:19389623  


Genomics

Comparative Map Data
Csrnp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,473,027 - 133,488,868 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7133,473,027 - 133,488,868 (-)EnsemblGRCr8
mRatBN7.27131,594,232 - 131,610,075 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,594,232 - 131,610,075 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7133,396,399 - 133,412,237 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07135,621,976 - 135,637,814 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07135,535,630 - 135,551,448 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,116,335 - 142,132,173 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,116,335 - 142,132,173 (-)Ensemblrn6Rnor6.0
Rnor_5.07139,923,806 - 139,939,644 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47139,182,243 - 139,198,084 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7128,071,529 - 128,087,360 (-)NCBICelera
RGSC_v3.17139,261,070 - 139,268,389 (-)NCBI
Cytogenetic Map7q36NCBI
CSRNP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381251,061,205 - 51,083,596 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1251,061,205 - 51,083,664 (-)Ensemblhg38GRCh38
GRCh371251,454,988 - 51,477,379 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361249,741,257 - 49,763,600 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341249,741,256 - 49,763,600NCBI
Celera1250,256,977 - 50,278,325 (-)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1248,487,275 - 48,509,793 (-)NCBIHuRef
CHM1_11251,421,266 - 51,443,654 (-)NCBICHM1_1
T2T-CHM13v2.01251,024,095 - 51,046,514 (-)NCBIT2T-CHM13v2.0
Csrnp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915100,377,451 - 100,393,120 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15100,377,451 - 100,393,369 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3815100,479,570 - 100,495,239 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15100,479,570 - 100,495,488 (-)Ensemblmm10GRCm38
MGSCv3715100,310,001 - 100,325,670 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615100,307,604 - 100,323,273 (-)NCBIMGSCv36mm8
Celera15102,631,828 - 102,647,498 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.32NCBI
Csrnp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555471,586,517 - 1,595,567 (-)Ensembl
ChiLan1.0NW_0049555471,584,061 - 1,601,556 (-)NCBIChiLan1.0ChiLan1.0
CSRNP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21043,102,384 - 43,124,771 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11243,099,054 - 43,121,533 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01237,669,834 - 37,692,198 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11238,572,622 - 38,596,949 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1238,579,787 - 38,594,411 (+)EnsemblpanPan2panpan1.1
CSRNP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,744,896 - 3,759,971 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,750,509 - 3,759,442 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2742,496,695 - 42,511,358 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0273,792,281 - 3,806,963 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,793,549 - 3,808,849 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,764,415 - 3,773,710 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0273,746,414 - 3,761,072 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02742,893,439 - 42,907,726 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Csrnp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494564,454,800 - 64,470,320 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365128,693,940 - 8,710,030 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365128,693,940 - 8,710,030 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSRNP2
(Sus scrofa - pig)		 No map positions available.
CSRNP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11147,270,936 - 47,293,243 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1147,270,846 - 47,293,151 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037198,806,613 - 198,829,761 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csrnp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248161,149,623 - 1,159,407 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248161,144,923 - 1,161,885 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Csrnp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11262,598,168 - 262,611,453 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Csrnp2
61 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1014
Count of miRNA genes:330
Interacting mature miRNAs:448
Transcripts:ENSRNOT00000026613
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
AW530447  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,597,532 - 131,597,712 (+)MAPPERmRatBN7.2
Rnor_6.07142,119,636 - 142,119,815NCBIRnor6.0
Rnor_5.07139,927,107 - 139,927,286UniSTSRnor5.0
RGSC_v3.47139,185,544 - 139,185,723UniSTSRGSC3.4
Celera7128,074,830 - 128,075,009UniSTS
RH 3.4 Map71075.2UniSTS
Cytogenetic Map7q36UniSTS
AA849418  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,602,759 - 131,602,889 (+)MAPPERmRatBN7.2
Rnor_6.07142,124,859 - 142,124,988NCBIRnor6.0
Rnor_5.07139,932,330 - 139,932,459UniSTSRnor5.0
RGSC_v3.47139,190,770 - 139,190,899UniSTSRGSC3.4
Celera7128,080,056 - 128,080,185UniSTS
RH 3.4 Map71053.2UniSTS
Cytogenetic Map7q36UniSTS
AW534990  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,594,351 - 131,594,458 (+)MAPPERmRatBN7.2
Rnor_6.07142,116,455 - 142,116,561NCBIRnor6.0
Rnor_5.07139,923,926 - 139,924,032UniSTSRnor5.0
RGSC_v3.47139,182,363 - 139,182,469UniSTSRGSC3.4
Celera7128,071,649 - 128,071,755UniSTS
RH 3.4 Map71075.8UniSTS
Cytogenetic Map7q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 88 59 6 352 188 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000026613   ⟹   ENSRNOP00000026613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7133,473,027 - 133,488,868 (-)Ensembl
mRatBN7.2 Ensembl7131,594,232 - 131,610,075 (-)Ensembl
Rnor_6.0 Ensembl7142,116,335 - 142,132,173 (-)Ensembl
RefSeq Acc Id: NM_001108113   ⟹   NP_001101583
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,473,027 - 133,488,868 (-)NCBI
mRatBN7.27131,594,232 - 131,610,075 (-)NCBI
Rnor_6.07142,116,335 - 142,132,173 (-)NCBI
Rnor_5.07139,923,806 - 139,939,644 (-)NCBI
RGSC_v3.47139,182,243 - 139,198,084 (-)RGD
Celera7128,071,529 - 128,087,360 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079340   ⟹   XP_038935268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,473,028 - 133,488,712 (-)NCBI
mRatBN7.27131,594,233 - 131,609,867 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101583 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935268 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL86941 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026613
  ENSRNOP00000026613.4
RefSeq Acc Id: NP_001101583   ⟸   NM_001108113
- UniProtKB: D4A1W4 (UniProtKB/TrEMBL),   A6KCK1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026613   ⟸   ENSRNOT00000026613
RefSeq Acc Id: XP_038935268   ⟸   XM_039079340
- Peptide Label: isoform X1
- UniProtKB: D4A1W4 (UniProtKB/TrEMBL),   A6KCK1 (UniProtKB/TrEMBL)
Protein Domains
Cysteine/serine-rich nuclear protein N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A1W4-F1-model_v2 AlphaFold D4A1W4 1-535 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695659
Promoter ID:EPDNEW_R6182
Type:single initiation site
Name:Csrnp2_1
Description:cysteine and serine rich nuclear protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07142,131,937 - 142,131,997EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308916 AgrOrtholog
BioCyc Gene G2FUF-32019 BioCyc
Ensembl Genes ENSRNOG00000019653 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026613 ENTREZGENE
  ENSRNOT00000026613.6 UniProtKB/TrEMBL
InterPro CSRNP_N UniProtKB/TrEMBL
  Cys/Ser-rich_nuc_prot UniProtKB/TrEMBL
KEGG Report rno:315308 UniProtKB/TrEMBL
NCBI Gene 315308 ENTREZGENE
PANTHER Cys/Ser-rich_nuc_prot UniProtKB/TrEMBL
  CYSTEINE/SERINE-RICH NUCLEAR PROTEIN 2 UniProtKB/TrEMBL
Pfam CSRNP_N UniProtKB/TrEMBL
PhenoGen Csrnp2 PhenoGen
PRINTS CYSSERRICHNP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019653 RatGTEx
UniProt A6KCK1 ENTREZGENE, UniProtKB/TrEMBL
  D4A1W4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Csrnp2  cysteine and serine rich nuclear protein 2  Csrnp2  cysteine-serine-rich nuclear protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-27 Csrnp2  cysteine-serine-rich nuclear protein 2  Csnrp2  cysteine-serine-rich nuclear protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Csnrp2  cysteine-serine-rich nuclear protein 2  RGD1308916_predicted  similar to TGF-beta induced apoptosis protein 12 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1308916_predicted  similar to TGF-beta induced apoptosis protein 12 (predicted)  LOC315308_predicted  similar to TGF-beta induced apoptosis protein 12 (predicted)  Symbol and Name status set to approved 1331353 APPROVED
2005-01-20 RGD1308916_predicted  similar to TGF-beta induced apoptosis protein 12 (predicted)  LOC315308_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC315308_predicted  similar to TGF-beta induced apoptosis protein 12 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL