Hint2 (histidine triad nucleotide binding protein 2) - Rat Genome Database

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Gene: Hint2 (histidine triad nucleotide binding protein 2) Rattus norvegicus
Analyze
Symbol: Hint2
Name: histidine triad nucleotide binding protein 2
RGD ID: 1308910
Description: Predicted to enable adenosine 5'-monophosphoramidase activity. Predicted to be involved in apoptotic process. Predicted to act upstream of or within lipid catabolic process. Predicted to be active in mitochondrial matrix. Orthologous to human HINT2 (histidine triad nucleotide binding protein 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenosine 5'-monophosphoramidase HINT2; histidine triad nucleotide-binding protein 2, mitochondrial; LOC313491
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,700,383 - 62,702,638 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl562,700,384 - 62,702,915 (-)EnsemblGRCr8
mRatBN7.2557,904,613 - 57,906,868 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,904,614 - 57,907,097 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx559,884,698 - 59,886,953 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,703,512 - 61,705,767 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,674,738 - 61,676,993 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,150,344 - 59,152,599 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,150,345 - 59,152,599 (-)Ensemblrn6Rnor6.0
Rnor_5.0563,675,136 - 63,677,391 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4560,130,993 - 60,133,248 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera556,485,081 - 56,487,336 (-)NCBICelera
RGSC_v3.1560,131,171 - 60,133,804 (-)NCBI
Cytogenetic Map5q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
mitochondrial matrix  (IEA,ISO)
mitochondrion  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:14651853   PMID:18614015   PMID:26767982  


Genomics

Comparative Map Data
Hint2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,700,383 - 62,702,638 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl562,700,384 - 62,702,915 (-)EnsemblGRCr8
mRatBN7.2557,904,613 - 57,906,868 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,904,614 - 57,907,097 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx559,884,698 - 59,886,953 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,703,512 - 61,705,767 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,674,738 - 61,676,993 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,150,344 - 59,152,599 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,150,345 - 59,152,599 (-)Ensemblrn6Rnor6.0
Rnor_5.0563,675,136 - 63,677,391 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4560,130,993 - 60,133,248 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera556,485,081 - 56,487,336 (-)NCBICelera
RGSC_v3.1560,131,171 - 60,133,804 (-)NCBI
Cytogenetic Map5q22NCBI
HINT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,812,960 - 35,815,479 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl935,812,960 - 35,815,354 (-)Ensemblhg38GRCh38
GRCh37935,812,957 - 35,815,039 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,802,957 - 35,805,042 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34935,802,956 - 35,805,042NCBI
Celera935,746,489 - 35,748,574 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,768,969 - 35,771,054 (-)NCBIHuRef
CHM1_1935,813,345 - 35,815,430 (-)NCBICHM1_1
T2T-CHM13v2.0935,833,627 - 35,836,146 (-)NCBIT2T-CHM13v2.0
Hint2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,654,227 - 43,656,445 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,654,227 - 43,656,466 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38443,654,227 - 43,656,445 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,654,227 - 43,656,466 (-)Ensemblmm10GRCm38
MGSCv37443,667,099 - 43,669,317 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36443,675,327 - 43,677,551 (-)NCBIMGSCv36mm8
Celera443,688,832 - 43,691,050 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.05NCBI
Hint2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955472500,845 - 503,067 (+)Ensembl
ChiLan1.0NW_004955472500,845 - 503,067 (+)NCBIChiLan1.0ChiLan1.0
HINT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,773,684 - 88,775,887 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,779,754 - 88,781,825 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,663,433 - 35,666,479 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,465,806 - 36,468,325 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,465,806 - 36,468,325 (-)EnsemblpanPan2panpan1.1
HINT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,342,564 - 52,344,994 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,342,567 - 52,344,947 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1150,910,135 - 50,912,566 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01153,407,581 - 53,410,013 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,407,584 - 53,409,966 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,952,089 - 51,954,522 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,936,313 - 51,938,949 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,637,771 - 52,640,202 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
HINT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11236,532,316 - 236,535,263 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,257,330 - 264,259,797 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HINT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,790,455 - 44,792,571 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,790,416 - 44,792,625 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603841,894,686 - 41,897,216 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hint2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248684,969,085 - 4,971,336 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248684,969,076 - 4,971,336 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hint2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v112,845,392 - 2,847,810 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hint2
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:87
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000021387
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021387   ⟹   ENSRNOP00000021387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl562,700,384 - 62,702,915 (-)Ensembl
mRatBN7.2 Ensembl557,904,614 - 57,907,097 (-)Ensembl
Rnor_6.0 Ensembl559,150,345 - 59,152,599 (-)Ensembl
RefSeq Acc Id: NM_001107955   ⟹   NP_001101425
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,700,383 - 62,702,638 (-)NCBI
mRatBN7.2557,904,613 - 57,906,868 (-)NCBI
Rnor_6.0559,150,344 - 59,152,599 (-)NCBI
Rnor_5.0563,675,136 - 63,677,391 (-)NCBI
RGSC_v3.4560,130,993 - 60,133,248 (-)RGD
Celera556,485,081 - 56,487,336 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101425 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98763 (Get FASTA)   NCBI Sequence Viewer  
  EDL98764 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021387
  ENSRNOP00000021387.5
RefSeq Acc Id: NP_001101425   ⟸   NM_001107955
- UniProtKB: A6IJ43 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021387   ⟸   ENSRNOT00000021387
Protein Domains
HIT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AB01-F1-model_v2 AlphaFold D4AB01 1-163 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693681
Promoter ID:EPDNEW_R4206
Type:multiple initiation site
Name:Hint2_1
Description:histidine triad nucleotide binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0559,152,614 - 59,152,674EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308910 AgrOrtholog
BioCyc Gene G2FUF-41497 BioCyc
Ensembl Genes ENSRNOG00000015866 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021387 ENTREZGENE
  ENSRNOT00000021387.7 UniProtKB/TrEMBL
Gene3D-CATH 3.30.428.10 UniProtKB/TrEMBL
InterPro His_triad-like_motif UniProtKB/TrEMBL
  Histidine_triad_CS UniProtKB/TrEMBL
  Histidine_triad_HIT UniProtKB/TrEMBL
  HIT-like_sf UniProtKB/TrEMBL
KEGG Report rno:313491 UniProtKB/TrEMBL
NCBI Gene 313491 ENTREZGENE
PANTHER PTHR23089 UniProtKB/TrEMBL
Pfam HIT UniProtKB/TrEMBL
PhenoGen Hint2 PhenoGen
PRINTS HISTRIAD UniProtKB/TrEMBL
PROSITE HIT_1 UniProtKB/TrEMBL
  HIT_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015866 RatGTEx
Superfamily-SCOP His_triad-like_motif UniProtKB/TrEMBL
UniProt A6IJ43 ENTREZGENE, UniProtKB/TrEMBL
  D4AB01_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Hint2  histidine triad nucleotide binding protein 2   Hint2_predicted  histidine triad nucleotide binding protein 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Hint2_predicted  histidine triad nucleotide binding protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED