Large1 (LARGE xylosyl- and glucuronyltransferase 1) - Rat Genome Database

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Gene: Large1 (LARGE xylosyl- and glucuronyltransferase 1) Rattus norvegicus
Analyze
Symbol: Large1
Name: LARGE xylosyl- and glucuronyltransferase 1
RGD ID: 1308895
Description: Predicted to enable glucuronosyltransferase activity; manganese ion binding activity; and xylosyltransferase activity. Predicted to be involved in muscle cell cellular homeostasis; protein O-linked glycosylation via mannose; and skeletal muscle organ development. Predicted to act upstream of or within several processes, including nervous system development; retina development in camera-type eye; and striated muscle cell differentiation. Predicted to be located in Golgi membrane. Predicted to be part of protein-containing complex. Predicted to be active in Golgi apparatus; neuromuscular junction; and plasma membrane. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A6 and muscular dystrophy-dystroglycanopathy type B6. Orthologous to human LARGE1 (LARGE xylosyl- and glucuronyltransferase 1); INTERACTS WITH (+)-schisandrin B; 3,3',4,4',5-pentachlorobiphenyl; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glycosyltransferase-like protein LARGE1; Large; like-glycosyltransferase; LOC361368; xylosyl- and glucuronyltransferase LARGE1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: LargeTn(sb-T2/Bart3)2.336Mcwi
Genetic Models: F344-LargeTn(sb-T2/Bart3)2.336Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81911,609,004 - 12,057,174 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1911,609,004 - 12,054,707 (-)EnsemblGRCr8
mRatBN7.21911,603,129 - 12,048,930 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1911,603,129 - 12,048,930 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1911,566,884 - 12,016,406 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01912,332,087 - 12,781,613 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01911,619,081 - 12,068,592 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01912,481,563 - 12,945,320 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1912,481,540 - 12,942,963 (-)Ensemblrn6Rnor6.0
Rnor_5.01923,595,328 - 24,054,765 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41912,043,818 - 12,497,663 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1911,480,096 - 11,923,685 (-)NCBICelera
RGSC_v3.11912,049,826 - 12,369,988 (-)NCBI
Cytogenetic Map19p12-p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aristolochic acid A  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
chloroprene  (EXP)
cisplatin  (EXP,ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
furan  (EXP)
glyphosate  (EXP)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylphenidate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
rimonabant  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine receptor signaling pathway  (ISO)
astrocyte differentiation  (ISO)
basement membrane organization  (ISO)
behavioral fear response  (ISO)
biological_process  (ND)
blood vessel development  (ISO)
bone development  (ISO)
brain development  (ISO)
cardiac muscle cell development  (ISO)
cardiac muscle tissue development  (ISO)
chemical synaptic transmission  (ISO)
connective tissue development  (ISO)
cytoskeleton organization  (ISO)
dentate gyrus development  (ISO)
determination of adult lifespan  (ISO)
gene expression  (ISO)
glycoprotein biosynthetic process  (ISO)
glycoprotein metabolic process  (ISO)
heart development  (ISO)
intracellular protein localization  (ISO)
intracellular protein transport  (ISO)
limb development  (ISO)
localization of cell  (ISO)
long-term synaptic potentiation  (ISO)
macrophage differentiation  (ISO)
memory  (ISO)
multicellular organism growth  (ISO)
muscle cell cellular homeostasis  (IEA,ISO)
muscle organ development  (ISO)
myelination  (ISO)
myotube differentiation  (ISO)
nerve development  (ISO)
neuromuscular junction development  (ISO)
neuromuscular process  (ISO)
neuromuscular process controlling posture  (ISO)
neuromuscular synaptic transmission  (ISO)
neuron migration  (ISO)
plasma membrane organization  (ISO)
post-embryonic hindlimb morphogenesis  (ISO)
post-translational protein modification  (ISO)
potassium ion transmembrane transport  (ISO)
principal sensory nucleus of trigeminal nerve development  (ISO)
protein deglycosylation  (ISO)
protein localization to membrane  (ISO)
protein localization to plasma membrane  (ISO)
protein O-linked glycosylation  (ISO)
protein O-linked glycosylation via mannose  (IBA,IEA,ISO)
protein phosphorylation  (ISO)
protein targeting to membrane  (ISO)
protein-containing complex assembly  (ISO)
reactive gliosis  (ISO)
regulation of kinase activity  (ISO)
regulation of synaptic plasticity  (ISO)
response to light stimulus  (ISO)
response to mechanical stimulus  (ISO)
retina development in camera-type eye  (ISO)
retina layer formation  (ISO)
retina vasculature development in camera-type eye  (ISO)
sensory perception of sound  (ISO)
skeletal muscle fiber development  (ISO)
skeletal muscle fiber differentiation  (ISO)
skeletal muscle organ development  (IEA,ISO)
skeletal muscle tissue regeneration  (IEA,ISO)
striated muscle cell development  (ISO)
striated muscle contraction  (ISO)
synapse organization  (ISO)
synaptic assembly at neuromuscular junction  (ISO)
transmembrane transport  (ISO)
walking behavior  (ISO)
water transport  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Mutant glycosyltransferase and altered glycosylation of alpha-dystroglycan in the myodystrophy mouse. Grewal PK, etal., Nat Genet 2001 Jun;28(2):151-4.
4. Skeletal, cardiac and tongue muscle pathology, defective retinal transmission, and neuronal migration defects in the Large(myd) mouse defines a natural model for glycosylation-deficient muscle - eye - brain disorders. Holzfeind PJ, etal., Hum Mol Genet 2002 Oct 1;11(21):2673-87.
5. Mutations in the human LARGE gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Longman C, etal., Hum Mol Genet 2003 Nov 1;12(21):2853-61. Epub 2003 Sep 9.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:22223806   PMID:23125099   PMID:23135544   PMID:24132234   PMID:25138275   PMID:25279697   PMID:25279699  


Genomics

Comparative Map Data
Large1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81911,609,004 - 12,057,174 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1911,609,004 - 12,054,707 (-)EnsemblGRCr8
mRatBN7.21911,603,129 - 12,048,930 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1911,603,129 - 12,048,930 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1911,566,884 - 12,016,406 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01912,332,087 - 12,781,613 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01911,619,081 - 12,068,592 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01912,481,563 - 12,945,320 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1912,481,540 - 12,942,963 (-)Ensemblrn6Rnor6.0
Rnor_5.01923,595,328 - 24,054,765 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41912,043,818 - 12,497,663 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1911,480,096 - 11,923,685 (-)NCBICelera
RGSC_v3.11912,049,826 - 12,369,988 (-)NCBI
Cytogenetic Map19p12-p11NCBI
LARGE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382233,066,663 - 33,922,824 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2233,162,226 - 33,922,885 (-)Ensemblhg38GRCh38
GRCh372233,668,495 - 34,318,812 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362231,999,063 - 32,646,410 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342231,993,616 - 32,640,964NCBI
Celera2217,471,158 - 18,118,297 (-)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2216,626,665 - 17,273,268 (-)NCBIHuRef
CHM1_12233,628,484 - 34,276,127 (-)NCBICHM1_1
T2T-CHM13v2.02233,627,091 - 34,380,164 (-)NCBIT2T-CHM13v2.0
Large1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39873,541,227 - 74,080,164 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl873,541,227 - 74,080,168 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38872,814,598 - 73,353,721 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,814,599 - 73,353,540 (-)Ensemblmm10GRCm38
MGSCv37875,338,498 - 75,876,455 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36875,710,671 - 76,248,628 (-)NCBIMGSCv36mm8
Celera877,131,292 - 77,664,765 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map835.08NCBI
Large1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540541,931,058 - 42,139,608 (-)Ensembl
ChiLan1.0NW_00495540541,891,430 - 42,225,066 (-)NCBIChiLan1.0ChiLan1.0
LARGE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22343,009,740 - 43,861,899 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12245,708,047 - 46,559,753 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02214,077,463 - 14,929,250 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12232,137,280 - 32,778,639 (-)NCBIPanPan1.1PanPan1.1panPan2
LARGE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11029,875,381 - 30,396,934 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1029,919,521 - 30,395,787 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1029,820,809 - 30,340,676 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01030,671,995 - 31,198,842 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1030,669,187 - 31,236,024 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11030,391,521 - 30,940,790 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01030,706,807 - 31,228,831 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01030,887,220 - 31,413,494 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Large1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494513,148,086 - 13,647,077 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364926,289,517 - 6,659,465 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364926,160,979 - 6,657,491 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LARGE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.25110,211,538 - 110,349,654 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LARGE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11916,080,482 - 16,704,968 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1916,080,430 - 16,549,495 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045109,305,163 - 109,923,917 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Large1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247501,286,336 - 1,527,159 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247501,190,712 - 1,524,051 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Large1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v117111,163 - 354,500 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Large1
3693 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:276
Count of miRNA genes:173
Interacting mature miRNAs:222
Transcripts:ENSRNOT00000064105
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131969901Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127361636Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124694445Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
D19Rat82  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81911,847,917 - 11,848,050 (+)Marker Load Pipeline
mRatBN7.21911,842,122 - 11,842,255 (+)MAPPERmRatBN7.2
Rnor_6.01912,722,385 - 12,722,517NCBIRnor6.0
Rnor_5.01923,835,236 - 23,835,368UniSTSRnor5.0
RGSC_v3.41912,290,642 - 12,290,775RGDRGSC3.4
RGSC_v3.41912,290,643 - 12,290,775UniSTSRGSC3.4
Celera1911,717,349 - 11,717,481UniSTS
RGSC_v3.11912,295,438 - 12,295,873RGD
SHRSP x BN Map196.7498UniSTS
SHRSP x BN Map196.7498RGD
Cytogenetic Map19p12-p11UniSTS
D19Got2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21911,917,082 - 11,917,253 (+)MAPPERmRatBN7.2
Rnor_6.01912,797,344 - 12,797,514NCBIRnor6.0
Rnor_5.01923,910,195 - 23,910,365UniSTSRnor5.0
RGSC_v3.41912,365,601 - 12,365,772RGDRGSC3.4
RGSC_v3.41912,365,602 - 12,365,772UniSTSRGSC3.4
Celera1911,792,301 - 11,792,482UniSTS
RGSC_v3.11912,370,428 - 12,370,598RGD
RH 3.4 Map19118.6UniSTS
RH 3.4 Map19118.6RGD
RH 2.0 Map19118.6RGD
Cytogenetic Map19p12-p11UniSTS
BF387307  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21912,011,915 - 12,012,080 (+)MAPPERmRatBN7.2
Rnor_6.01912,906,167 - 12,906,331NCBIRnor6.0
Rnor_5.01924,017,868 - 24,018,032UniSTSRnor5.0
RGSC_v3.41912,459,680 - 12,459,844UniSTSRGSC3.4
Celera1911,886,683 - 11,886,847UniSTS
Cytogenetic Map19p12-p11UniSTS
BF400276  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21912,012,070 - 12,012,232 (+)MAPPERmRatBN7.2
Rnor_6.01912,906,322 - 12,906,483NCBIRnor6.0
Rnor_5.01924,018,023 - 24,018,184UniSTSRnor5.0
RGSC_v3.41912,459,835 - 12,459,996UniSTSRGSC3.4
Celera1911,886,838 - 11,886,999UniSTS
RH 3.4 Map19127.3UniSTS
Cytogenetic Map19p12-p11UniSTS
BF399122  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21912,012,238 - 12,012,408 (+)MAPPERmRatBN7.2
Rnor_6.01912,906,490 - 12,906,659NCBIRnor6.0
Rnor_5.01924,018,191 - 24,018,360UniSTSRnor5.0
RGSC_v3.41912,460,003 - 12,460,172UniSTSRGSC3.4
Celera1911,887,006 - 11,887,175UniSTS
RH 3.4 Map19112.7UniSTS
Cytogenetic Map19p12-p11UniSTS
RH137652  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21911,641,202 - 11,641,352 (+)MAPPERmRatBN7.2
Rnor_6.01912,519,641 - 12,519,790NCBIRnor6.0
Rnor_5.01923,633,406 - 23,633,555UniSTSRnor5.0
RGSC_v3.41912,081,813 - 12,081,962UniSTSRGSC3.4
Celera1911,518,175 - 11,518,324UniSTS
Cytogenetic Map19p12-p11UniSTS
RH137727  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21911,999,754 - 11,999,913 (+)MAPPERmRatBN7.2
Rnor_6.01912,894,006 - 12,894,164NCBIRnor6.0
Rnor_5.01924,005,707 - 24,005,865UniSTSRnor5.0
RGSC_v3.41912,447,519 - 12,447,677UniSTSRGSC3.4
Celera1911,874,718 - 11,874,876UniSTS
RH 3.4 Map19130.28UniSTS
Cytogenetic Map19p12-p11UniSTS
BM388355  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81911,953,888 - 11,954,109 (+)Marker Load Pipeline
mRatBN7.21911,948,103 - 11,948,324 (+)MAPPERmRatBN7.2
Rnor_6.01912,842,478 - 12,842,698NCBIRnor6.0
Rnor_6.01912,827,817 - 12,828,037NCBIRnor6.0
Rnor_5.01923,940,845 - 23,941,065UniSTSRnor5.0
Rnor_5.01923,954,068 - 23,954,288UniSTSRnor5.0
RGSC_v3.41912,396,463 - 12,396,683UniSTSRGSC3.4
Celera1911,823,146 - 11,823,366UniSTS
RH 3.4 Map19114.8UniSTS
Cytogenetic Map19p12-p11UniSTS


Genetic Models
This gene Large1 is modified in the following models/strains:
F344-LargeTn(sb-T2/Bart3)2.336Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 13 69 181 91 90 59 100 59 6 385 205 14 166 97 99 31 23 23

Sequence


Ensembl Acc Id: ENSRNOT00000064105   ⟹   ENSRNOP00000059410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1911,609,004 - 12,054,707 (-)Ensembl
mRatBN7.2 Ensembl1911,603,129 - 12,048,930 (-)Ensembl
Rnor_6.0 Ensembl1912,481,563 - 12,942,943 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090886   ⟹   ENSRNOP00000073641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1911,609,004 - 12,054,707 (-)Ensembl
mRatBN7.2 Ensembl1911,603,129 - 12,048,710 (-)Ensembl
Rnor_6.0 Ensembl1912,481,540 - 12,942,963 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000138112   ⟹   ENSRNOP00000103054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1911,631,936 - 12,054,707 (-)Ensembl
RefSeq Acc Id: NM_001108439   ⟹   NP_001101909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,609,004 - 12,054,707 (-)NCBI
mRatBN7.21911,603,129 - 12,048,930 (-)NCBI
Rnor_6.01912,481,563 - 12,942,943 (-)NCBI
Rnor_5.01923,595,328 - 24,054,765 (-)NCBI
RGSC_v3.41912,043,818 - 12,497,663 (-)RGD
Celera1911,480,096 - 11,923,685 (-)RGD
Sequence:
RefSeq Acc Id: XM_063278105   ⟹   XP_063134175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,609,004 - 12,055,363 (-)NCBI
RefSeq Acc Id: XM_063278106   ⟹   XP_063134176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,609,004 - 12,013,648 (-)NCBI
RefSeq Acc Id: XM_063278107   ⟹   XP_063134177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,609,004 - 11,944,466 (-)NCBI
RefSeq Acc Id: XM_063278108   ⟹   XP_063134178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,609,004 - 12,055,363 (-)NCBI
RefSeq Acc Id: XM_063278109   ⟹   XP_063134179
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,609,004 - 12,057,174 (-)NCBI
RefSeq Acc Id: NP_001101909   ⟸   NM_001108439
- Sequence:
Ensembl Acc Id: ENSRNOP00000073641   ⟸   ENSRNOT00000090886
Ensembl Acc Id: ENSRNOP00000059410   ⟸   ENSRNOT00000064105
RefSeq Acc Id: XP_063134179   ⟸   XM_063278109
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063134175   ⟸   XM_063278105
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063134178   ⟸   XM_063278108
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063134176   ⟸   XM_063278106
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K618 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134177   ⟸   XM_063278107
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K618 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103054   ⟸   ENSRNOT00000138112

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K618-F1-model_v2 AlphaFold A0A0G2K618 1-756 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308895 AgrOrtholog
BioCyc Gene G2FUF-6456 BioCyc
Ensembl Genes ENSRNOG00000013742 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064105.3 UniProtKB/TrEMBL
  ENSRNOT00000090886 ENTREZGENE
  ENSRNOT00000090886.3 UniProtKB/TrEMBL
  ENSRNOT00000138112.1 UniProtKB/TrEMBL
Gene3D-CATH Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A UniProtKB/TrEMBL
InterPro Glyco_trans_8 UniProtKB/TrEMBL
  Nucleotide-diphossugar_trans UniProtKB/TrEMBL
  Xyl/GlcA_transferase UniProtKB/TrEMBL
KEGG Report rno:361368 UniProtKB/TrEMBL
NCBI Gene 361368 ENTREZGENE
PANTHER GLYCOSYLTRANSFERASE-RELATED UniProtKB/TrEMBL
  LARGE XYLOSYL- AND GLUCURONYLTRANSFERASE 1 UniProtKB/TrEMBL
Pfam Glyco_transf_49 UniProtKB/TrEMBL
  Glyco_transf_8 UniProtKB/TrEMBL
PhenoGen Large1 PhenoGen
RatGTEx ENSRNOG00000013742 RatGTEx
Superfamily-SCOP SSF53448 UniProtKB/TrEMBL
UniProt A0A0G2K618 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LEH3_RAT UniProtKB/TrEMBL
  A6JY89_RAT UniProtKB/TrEMBL
  D4A390_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Large  like-glycosyltransferase   Large_predicted  like-glycosyltransferase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Large_predicted  like-glycosyltransferase (predicted)      Symbol and Name status set to approved 70820 APPROVED