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Gene: Ephx4 (epoxide hydrolase 4) Rattus norvegicus

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Symbol:

Ephx4

Name:

epoxide hydrolase 4

RGD ID:

1308891

Description:

Predicted to enable hydrolase activity. Predicted to be located in membrane. Orthologous to human EPHX4 (epoxide hydrolase 4); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; cadmium dichloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Abhd7; abhydrolase domain containing 7; LOC289440

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EPHX4 (epoxide hydrolase 4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ephx4 (epoxide hydrolase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ephx4 (epoxide hydrolase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EPHX4 (epoxide hydrolase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EPHX4 (epoxide hydrolase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ephx4 (epoxide hydrolase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EPHX4 (epoxide hydrolase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ephx4 (epoxide hydrolase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	COQ8A (coenzyme Q8A)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	EPHX4 (epoxide hydrolase 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ephx4 (epoxide hydrolase 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ephx4 (epoxide hydrolase 4)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ceeh-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ephx4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	2,488,282 - 2,517,558 (-)	NCBI		GRCr8
mRatBN7.2	14	2,343,376 - 2,372,680 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	2,340,248 - 2,373,022 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	2,224,957 - 2,254,649 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	3,526,765 - 3,556,443 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	2,220,530 - 2,250,028 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	3,360,680 - 3,389,996 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	3,360,712 - 3,389,943 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	3,364,185 - 3,393,641 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	2,902,381 - 2,932,820 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	2,902,517 - 2,943,238 (-)	NCBI
Celera	14	2,360,897 - 2,390,947 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ephx4	Rat	Diamond-Blackfan anemia		ISO	EPHX4 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Diamond-Blackfan anemia	ClinVar	PMID:28492532
Ephx4	Rat	severe congenital neutropenia 2		ISO	EPHX4 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Neutropenia more ...	ClinVar	PMID:28492532

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ephx4	Rat	6-propyl-2-thiouracil	decreases expression	EXP		6480464	Propylthiouracil results in decreased expression of EPHX4 mRNA	CTD	PMID:24780913
Ephx4	Rat	acrylamide	increases expression	EXP		6480464	Acrylamide results in increased expression of EPHX4 mRNA	CTD	PMID:28959563
Ephx4	Rat	aldehydo-D-glucose	decreases expression	ISO	Ephx4 (Mus musculus)	6480464	Glucose results in decreased expression of EPHX4 mRNA	CTD	PMID:31525975
Ephx4	Rat	benzo[a]pyrene	decreases expression	ISO	Ephx4 (Mus musculus)	6480464	Benzo(a)pyrene results in decreased expression of EPHX4 mRNA	CTD	PMID:22228805
Ephx4	Rat	benzo[a]pyrene	decreases methylation	ISO	EPHX4 (Homo sapiens)	6480464	Benzo(a)pyrene results in decreased methylation of EPHX4 promoter	CTD	PMID:27901495
Ephx4	Rat	bisphenol A	increases methylation	ISO	Ephx4 (Mus musculus)	6480464	bisphenol A results in increased methylation of EPHX4 promoter	CTD	PMID:27312807
Ephx4	Rat	cadmium dichloride	increases methylation	EXP		6480464	Cadmium Chloride results in increased methylation of EPHX4 promoter	CTD	PMID:22457795
Ephx4	Rat	carbon nanotube	decreases expression	ISO	Ephx4 (Mus musculus)	6480464	Nanotubes more ...	CTD	PMID:25554681
Ephx4	Rat	chromium(6+)	multiple interactions	ISO	EPHX4 (Homo sapiens)	6480464	[zinc chromate results in increased abundance of chromium hexavalent ion] which results in increased expression of EPHX4 mRNA	CTD	PMID:38479592
Ephx4	Rat	D-glucose	decreases expression	ISO	Ephx4 (Mus musculus)	6480464	Glucose results in decreased expression of EPHX4 mRNA	CTD	PMID:31525975
Ephx4	Rat	Dibutyl phosphate	affects expression	ISO	EPHX4 (Homo sapiens)	6480464	di-n-butylphosphoric acid affects the expression of EPHX4 mRNA	CTD	PMID:37042841
Ephx4	Rat	fenvalerate	increases expression	EXP		6480464	fenvalerate results in increased expression of EPHX4 mRNA	CTD	PMID:30307764
Ephx4	Rat	fluoxetine	decreases expression	EXP		6480464	Fluoxetine results in decreased expression of EPHX4 mRNA	CTD	PMID:17033635
Ephx4	Rat	fonofos	increases methylation	ISO	EPHX4 (Homo sapiens)	6480464	Fonofos results in increased methylation of EPHX4 promoter	CTD	PMID:22847954
Ephx4	Rat	glucose	decreases expression	ISO	Ephx4 (Mus musculus)	6480464	Glucose results in decreased expression of EPHX4 mRNA	CTD	PMID:31525975
Ephx4	Rat	ketamine	increases expression	EXP		6480464	Ketamine results in increased expression of EPHX4 mRNA	CTD	PMID:20080153
Ephx4	Rat	lipopolysaccharide	multiple interactions	ISO	EPHX4 (Homo sapiens)	6480464	[S-(1 more ...	CTD	PMID:35811015
Ephx4	Rat	methylparaben	decreases expression	ISO	EPHX4 (Homo sapiens)	6480464	methylparaben results in decreased expression of EPHX4 mRNA	CTD	PMID:31745603
Ephx4	Rat	parathion	increases methylation	ISO	EPHX4 (Homo sapiens)	6480464	Parathion results in increased methylation of EPHX4 promoter	CTD	PMID:22847954
Ephx4	Rat	pravastatin	increases expression	EXP		6480464	Pravastatin results in increased expression of EPHX4 mRNA	CTD	PMID:27225895
Ephx4	Rat	pravastatin	affects expression	ISO	Ephx4 (Mus musculus)	6480464	Pravastatin affects the expression of EPHX4 mRNA	CTD	PMID:27225895
Ephx4	Rat	S-(1,2-dichlorovinyl)-L-cysteine	multiple interactions	ISO	EPHX4 (Homo sapiens)	6480464	[S-(1 more ...	CTD	PMID:35811015
Ephx4	Rat	Soman	decreases expression	EXP		6480464	Soman results in decreased expression of EPHX4 mRNA	CTD	PMID:19281266
Ephx4	Rat	sunitinib	decreases expression	ISO	EPHX4 (Homo sapiens)	6480464	Sunitinib results in decreased expression of EPHX4 mRNA	CTD	PMID:31533062
Ephx4	Rat	terbufos	increases methylation	ISO	EPHX4 (Homo sapiens)	6480464	terbufos results in increased methylation of EPHX4 promoter	CTD	PMID:22847954
Ephx4	Rat	thapsigargin	increases expression	ISO	EPHX4 (Homo sapiens)	6480464	Thapsigargin results in increased expression of EPHX4 mRNA	CTD	PMID:29453283
Ephx4	Rat	thiram	decreases expression	ISO	EPHX4 (Homo sapiens)	6480464	Thiram results in decreased expression of EPHX4 mRNA	CTD	PMID:38568856
Ephx4	Rat	titanium dioxide	decreases expression	EXP		6480464	titanium dioxide results in decreased expression of EPHX4 mRNA	CTD	PMID:30012374
Ephx4	Rat	trichloroethene	decreases expression	EXP		6480464	Trichloroethylene results in decreased expression of EPHX4 mRNA	CTD	PMID:33387578
Ephx4	Rat	triptonide	increases expression	ISO	Ephx4 (Mus musculus)	6480464	triptonide results in increased expression of EPHX4 mRNA	CTD	PMID:33045310
Ephx4	Rat	valproic acid	affects expression	ISO	EPHX4 (Homo sapiens)	6480464	Valproic Acid affects the expression of EPHX4 mRNA	CTD	PMID:25979313
Ephx4	Rat	valproic acid	increases expression	ISO	EPHX4 (Homo sapiens)	6480464	Valproic Acid results in increased expression of EPHX4 mRNA	CTD	PMID:23179753 and PMID:27188386
Ephx4	Rat	zaragozic acid A	decreases expression	ISO	Ephx4 (Mus musculus)	6480464	squalestatin 1 results in decreased expression of EPHX4 mRNA	CTD	PMID:27225895
Ephx4	Rat	zaragozic acid A	decreases expression	EXP		6480464	squalestatin 1 results in decreased expression of EPHX4 mRNA	CTD	PMID:27225895

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ephx4	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ephx4	Rat	catalytic activity	enables	IEA	InterPro:IPR000639	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Ephx4	Rat	epoxide hydrolase activity	enables	IEA	ARBA:ARBA00043274	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Ephx4	Rat	hydrolase activity	enables	IEA	UniProtKB-KW:KW-0378	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Ephx4	Rat	hydrolase activity	enables	IBA	MGI:99500 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Ephx4	Rat	protein binding	enables	ISO	EPHX4 (Homo sapiens)	1624291	UniProtKB:Q9NUH8 and PMID:32296183	RGD	PMID:32296183

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Ephx4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	2,488,282 - 2,517,558 (-)	NCBI		GRCr8
mRatBN7.2	14	2,343,376 - 2,372,680 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	2,340,248 - 2,373,022 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	2,224,957 - 2,254,649 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	3,526,765 - 3,556,443 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	2,220,530 - 2,250,028 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	3,360,680 - 3,389,996 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	3,360,712 - 3,389,943 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	3,364,185 - 3,393,641 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	2,902,381 - 2,932,820 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	2,902,517 - 2,943,238 (-)	NCBI
Celera	14	2,360,897 - 2,390,947 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

EPHX4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	92,029,985 - 92,063,538 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	92,029,985 - 92,063,538 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	92,495,542 - 92,529,095 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	92,268,146 - 92,301,681 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	92,207,578 - 92,241,114	NCBI
Celera	1	90,741,979 - 90,775,554 (+)	NCBI		Celera
Cytogenetic Map	1	p22.1	NCBI
HuRef	1	90,615,750 - 90,649,341 (+)	NCBI		HuRef
CHM1_1	1	92,610,387 - 92,643,948 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	91,874,824 - 91,908,391 (+)	NCBI		T2T-CHM13v2.0

Ephx4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	107,551,379 - 107,577,901 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	107,550,602 - 107,577,901 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	107,403,513 - 107,430,035 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	107,402,736 - 107,430,035 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	107,832,532 - 107,859,054 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	107,643,853 - 107,670,193 (+)	NCBI		MGSCv36	mm8
Celera	5	104,516,877 - 104,543,312 (+)	NCBI		Celera
Cytogenetic Map	5	E5- F	NCBI
cM Map	5	52.23	NCBI

Ephx4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	2,386,888 - 2,425,036 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	2,389,745 - 2,425,036 (-)	NCBI	ChiLan1.0	ChiLan1.0

EPHX4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	134,962,862 - 134,999,348 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	134,114,506 - 134,150,925 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	94,686,577 - 94,722,985 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	93,430,641 - 93,467,072 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	93,430,647 - 93,467,072 (+)	Ensembl	panpan1.1		panPan2

EPHX4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	56,863,779 - 56,900,312 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	59,569,682 - 59,608,451 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	57,246,279 - 57,284,786 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	57,246,283 - 57,285,192 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	56,923,342 - 56,962,064 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	56,899,728 - 56,938,237 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	57,362,441 - 57,400,969 (-)	NCBI		UU_Cfam_GSD_1.0

Ephx4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	101,916,019 - 101,957,457 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936537	6,990,512 - 7,031,760 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936537	6,990,854 - 7,031,788 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EPHX4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	124,960,189 - 124,992,749 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	124,961,246 - 124,992,789 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Ephx4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	5,695,912 - 5,722,597 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624742	5,695,776 - 5,722,645 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Ephx4
272 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	101
Count of miRNA genes:	82
Interacting mature miRNAs:	88
Transcripts:	ENSRNOT00000037101
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
71115	Niddm15	Non-insulin dependent diabetes mellitus QTL 15	4.8		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1217606	11030812	Rat
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1217606	16960180	Rat

BE120124

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	2,366,797 - 2,367,006 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	3,384,126 - 3,384,334	NCBI	Rnor6.0
Rnor_5.0	14	3,387,771 - 3,387,979	UniSTS	Rnor5.0
RGSC_v3.4	14	2,927,004 - 2,927,212	UniSTS	RGSC3.4
Celera	14	2,385,130 - 2,385,338	UniSTS
RH 3.4 Map	14	41.9	UniSTS
Cytogenetic Map	14	p22	UniSTS

BF415499

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	2,357,572 - 2,357,717 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	3,374,901 - 3,375,045	NCBI	Rnor6.0
Rnor_5.0	14	3,378,546 - 3,378,690	UniSTS	Rnor5.0
RGSC_v3.4	14	2,917,779 - 2,917,923	UniSTS	RGSC3.4
Celera	14	2,375,878 - 2,376,022	UniSTS
RH 3.4 Map	14	42.4	UniSTS
Cytogenetic Map	14	p22	UniSTS

D5Mit239

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	2,360,217 - 2,360,934 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	3,377,546 - 3,378,262	NCBI	Rnor6.0
Rnor_5.0	14	3,381,191 - 3,381,907	UniSTS	Rnor5.0
RGSC_v3.4	14	2,920,424 - 2,921,140	UniSTS	RGSC3.4
Celera	14	2,378,523 - 2,379,266	UniSTS
Cytogenetic Map	14	p22	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
7	8	31	106	62	66	35	8	35	6	145	52	91	44	56	31


RefSeq Transcripts	NM_001105994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250541	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769927	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091658	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091659	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC106605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213206	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000037101 ⟹ ENSRNOP00000034573

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	2,343,384 - 2,373,022 (-)	Ensembl
Rnor_6.0 Ensembl	14	3,360,712 - 3,389,943 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100966 ⟹ ENSRNOP00000083130

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	2,340,248 - 2,373,022 (-)	Ensembl

RefSeq Acc Id:

NM_001105994 ⟹ NP_001099464

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	2,488,290 - 2,517,521 (-)	NCBI
mRatBN7.2	14	2,343,384 - 2,372,615 (-)	NCBI
Rnor_6.0	14	3,360,712 - 3,389,943 (-)	NCBI
Rnor_5.0	14	3,364,185 - 3,393,641 (-)	NCBI
RGSC_v3.4	14	2,902,381 - 2,932,820 (-)	RGD
Celera	14	2,360,897 - 2,390,947 (-)	RGD

Sequence:

show sequence

TGCGCGCCCTGCTCTACTGGTCCCTGGTGTACGGCTACTGCGGGCTGTGCGCCTCCGTCCACCTGCTCAAACTTTTGTGGAGCATCGGTAGGGCGCCGGCGCAGACCTTCCGCCGGGCGGCTCGGGCC
AACCCTCCCGCTTGCCTGAACGACCCCTCCTTGGGGACCCACTGCTACGTGCGCATCAAGGACTCGGGGTTAAGATTTCACTATGTTGCTGCTGGAGAGAGGGGCAAACCCCTCATGCTGCTGCTTCA
TGGATTTCCAGAATTCTGGTATTCTTGGCGTCACCAACTGAGAGAATTTAAAAGTGAATACAGAGTCGTTGCACTGGATTTGAGGGGTTACGGAGAGTCCGATGCACCTATTCATCAAGAGAGTTACA
AGCTGGACTGTCTAATTGCAGACATAAAGGATGTTTTGGACTCCTTGGGGTATAACAAATGTGTCCTGATTGGCCATGACTGGGGAGGCATGATTGCCTGGTTGATTGCTGTCTGCTACCCTGAGATG
ATAATGAAGCTGATTGTTATTAACTTCCCACATCCAAGTGTGTTTACAGAGTATATACTGCGGCACCCTGCCCAGCTGTTCAGATCCAGCTTTTATTACTTCTTCCAAATTCCACGGCTCCCAGAACT
TATGTTCTCAATCAATGATTTCAAGGCTTTGAAACACCTGTTTACCAGTCAGAGCACTGGCATCGGAAGAAAAGGACGTCAGCTGACAACAGAAGATCTAGAAGCTTATGTTTATGTTTTCTCTCAGC
CCGGAGCACTAAGTGGTCCAATTAACCATTATCGAAACATTTTCAGCTGCCTGCCTCTCAAGCATCACATGGTGACAACACCGACGCTGCTTCTGTGGGGAGAGGAAGATGCGTTTATGGAGGTGGAG
ATGGCCGAGGTCACAAAGATTTATGTTAAAAACTACTTCAGACTCACCATTCTGTCAGAAGGTAGCCACTGGCTTCAGCAAGACCAGCCTGACATAGTGAACGGGCTGATATGGGCATTCCTGAGGGA
AGAGACAAGGAGAGACTGACTTTATCTCCTACAGGGAGTCTTTCACGGAGTCTCTGAAACCTCTTAAAAACTCGTTCATCAACTTATGTTTTATTAGGAAAAAATGCCCATTTTAATATGCTTGATTG
TAAATAAATATAGTGACTCCTGGTACTG

hide sequence

RefSeq Acc Id:

XM_008769927 ⟹ XP_008768149

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	2,488,282 - 2,515,220 (-)	NCBI
mRatBN7.2	14	2,343,376 - 2,370,294 (-)	NCBI
Rnor_6.0	14	3,360,680 - 3,388,650 (-)	NCBI

Sequence:

show sequence

GCCAACGGACTTATAATTTAGTGTAATTCATACTAATTATCGACCTGGCATATACCCAGTGCGG
TAAAATCTTTATTAAACCCAGTCTGGTGGCCATAGCATTTCATTCTCCCAAGACTCGCTACCACTAAAATAATTTTTTAAAGGTAACAGCATAGTCATATTTGTTAAGTCTGTAAGGATGAAACACAG
CTTCTGACTCTTCCTGAGATCCTCAGAATGCCTTTCTTTTCCCCAGAAGCAGAACGAAGAAGTTGACACAGTGGTGACTCTAGTCACCTAGATACTTCATTCTTCTTTTTTCCTTTTACTTCATTCTT
CTTAACATCTGTTTGTTTAGTGATGCTGGAGGTCGTCATATTGGCCGAGTCAGGCAAATGCTCTATCACTGAGTTACATCCTTAGCCCTCCCAATGACCTTCATGCCTTGGGCATCATTTAGGGGAAG
GGATGGCAGTGCTGGGGATTGAAATTAGGATCTCATGCTTGAAAGGCAAGCACCCTGCTGCTGCTCTGCAGCCTTAGCCCTTAGGCCCCATTTTCTAAACTAAGGTGATAGAGTTGAGGGAAATGACA
CGCCAGACGCTCACATCTAAAGGCTGGAAACAAAGTCCAGGCTCTGTCTTTCATAGTTCCAGGAATTTTGCTTTTCTCTTTTCCTTCCTTGACTATGCTCCCATATCCTTGGTGTCCGCAGGACTCAT
CCCTTGCTCCTGGTCCTTTCCTGGGGGTGAACTCTTGGGCACTTGTCCACTCCACTGTTAGAAACACAGATGTGACAGAGGGAACAGGCAGCAAAGGAGAGTATATATGAAACACTTGAGATCACAGA
GTGGGAAGGAGATGCCTAAAAATAAGAGAAGGGGGTGTGAATTACATAAGTGATGCCGCAGCTCTTGACGGGCAGGCAACTGAGAAAAAAAAATGTGAGGTAGACTTAGCAACATTGAAATTCAGATT
GGAATTATTTATGTATCTTGCAGGGGATGAAAGTGACACCTCACTAAGACGAAAGCTACATTGTAACATTGCTTCAGAAGCTCAAAACTATATACACAGACCTTGTAGCAGAGCAAGTAAGAGGGGTA
TTCTAAAGGGATCGCCCAAGGACTCGGGGTTAAGATTTCACTATGTTGCTGCTGGAGAGAGGGGCAAACCCCTCATGCTGCTGCTTCATGGATTTCCAGAATTCTGGTATTCTTGGCGTCACCAACTG
AGAGAATTTAAAAGTGAATACAGAGTCGTTGCACTGGATTTGAGGGGTTACGGAGAGTCCGATGCACCTATTCATCAAGAGAGTTACAAGCTGGACTGTCTAATTGCAGACATAAAGGATGTTTTGGA
CTCCTTGGGGTATAACAAATGTGTCCTGATTGGCCATGACTGGGGAGGCATGATTGCCTGGTTGATTGCTGTCTGCTACCCTGAGATGATAATGAAGCTGATTGTTATTAACTTCCCACATCCAAGTG
TGTTTACAGAGTATATACTGCGGCACCCTGCCCAGCTGTTCAGATCCAGCTTTTATTACTTCTTCCAAATTCCACGGCTCCCAGAACTTATGTTCTCAATCAATGATTTCAAGGCTTTGAAACACCTG
TTTACCAGTCAGAGCACTGGCATCGGAAGAAAAGGACGTCAGCTGACAACAGAAGATCTAGAAGCTTATGTTTATGTTTTCTCTCAGCCCGGAGCACTAAGTGGTCCAATTAACCATTATCGAAACAT
TTTCAGCTGCCTGCCTCTCAAGCATCACATGGTGACAACACCGACGCTGCTTCTGTGGGGAGAGGAAGATGCGTTTATGGAGGTGGAGATGGCCGAGGTCACAAAGATTTATGTTAAAAACTACTTCA
GACTCACCATTCTGTCAGAAGGTAGCCACTGGCTTCAGCAAGACCAGCCTGACATAGTGAACGGGCTGATATGGGCATTCCTGAGGGAAGAGACAAGGAGAGACTGACTTTATCTCCTACAGGGAGTC
TTTCACGGAGTCTCTGAAACCTCTTAAAAACTCGTTCATCAACTTATGTTTTATTAGGAAAAAATGCCCATTTTAATATGCTTGATTGTAAATAAATATAGTGACTCCTGGTACTGAAAAAAAATCTG
TGTAATTATTTTCTGTCGAA

hide sequence

RefSeq Acc Id:

XM_039091658 ⟹ XP_038947586

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	2,488,282 - 2,515,210 (-)	NCBI
mRatBN7.2	14	2,343,376 - 2,370,353 (-)	NCBI

RefSeq Acc Id:

XM_039091659 ⟹ XP_038947587

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	2,502,368 - 2,517,558 (-)	NCBI
mRatBN7.2	14	2,357,462 - 2,372,680 (-)	NCBI


Protein RefSeqs	NP_001099464	(Get FASTA)	NCBI Sequence Viewer
	XP_008768149	(Get FASTA)	NCBI Sequence Viewer
	XP_038947586	(Get FASTA)	NCBI Sequence Viewer
	XP_038947587	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL83968	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000034573.6
	ENSRNOP00000083130
	ENSRNOP00000083130.1

RefSeq Acc Id:

NP_001099464 ⟸ NM_001105994

- UniProtKB:

A6KPJ6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLLLHGFPEFWYSWRHQLREFKSEYRVVALDLRGYGESDAPIHQESYKLDCLIADIKDVLDSLGYNKCVLIGHDWGGMIAWLIAVCYPEMIMKLIVINFPHPSVFTEYILRHPAQLFRSSFYYFFQIP
RLPELMFSINDFKALKHLFTSQSTGIGRKGRQLTTEDLEAYVYVFSQPGALSGPINHYRNIFSCLPLKHHMVTTPTLLLWGEEDAFMEVEMAEVTKIYVKNYFRLTILSEGSHWLQQDQPDIVNGLIW
AFLREETRRD

hide sequence

RefSeq Acc Id:	XP_008768149 ⟸ XM_008769927
- Peptide Label:	isoform X1
- UniProtKB:	A6KPJ6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MYLAGDESDTSLRRKLHCNIASEAQNYIHRPCSRASKRGILKGSPKDSGLRFHYVAAGERGKPL MLLLHGFPEFWYSWRHQLREFKSEYRVVALDLRGYGESDAPIHQESYKLDCLIADIKDVLDSLGYNKCVLIGHDWGGMIAWLIAVCYPEMIMKLIVINFPHPSVFTEYILRHPAQLFRSSFYYFFQIP RLPELMFSINDFKALKHLFTSQSTGIGRKGRQLTTEDLEAYVYVFSQPGALSGPINHYRNIFSCLPLKHHMVTTPTLLLWGEEDAFMEVEMAEVTKIYVKNYFRLTILSEGSHWLQQDQPDIVNGLIW AFLREETRRD hide sequence

Ensembl Acc Id:

ENSRNOP00000034573 ⟸ ENSRNOT00000037101

RefSeq Acc Id:	XP_038947586 ⟸ XM_039091658
- Peptide Label:	isoform X1
- UniProtKB:	A6KPJ6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038947587 ⟸ XM_039091659
- Peptide Label:	isoform X2

Protein Domains

AB hydrolase-1

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZKP8-F1-model_v2	AlphaFold	D3ZKP8	1-266	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-16618	BioCyc
Ensembl Genes	ENSRNOG00000023389	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000037101.7	UniProtKB/TrEMBL
	ENSRNOT00000100966	ENTREZGENE
	ENSRNOT00000100966.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1820	UniProtKB/TrEMBL
InterPro	AB_hydrolase	UniProtKB/TrEMBL
	AB_hydrolase_1	UniProtKB/TrEMBL
	Epox_hydrolase-like	UniProtKB/TrEMBL
KEGG Report	rno:289440	UniProtKB/TrEMBL
NCBI Gene	289440	ENTREZGENE
PANTHER	EPOXIDE HYDROLASE	UniProtKB/TrEMBL
Pfam	Abhydrolase_1	UniProtKB/TrEMBL
PhenoGen	Ephx4	PhenoGen
PRINTS	ABHYDROLASE	UniProtKB/TrEMBL
	EPOXHYDRLASE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000023389	RatGTEx
Superfamily-SCOP	SSF53474	UniProtKB/TrEMBL
UniProt	A0A8I5ZZC4_RAT	UniProtKB/TrEMBL
	A6KPJ6	ENTREZGENE, UniProtKB/TrEMBL
	D3ZKP8_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2009-05-06	Ephx4	epoxide hydrolase 4	Abhd7	abhydrolase domain containing 7	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Abhd7	abhydrolase domain containing 7	Abhd7_predicted	abhydrolase domain containing 7 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Abhd7_predicted	abhydrolase domain containing 7 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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Imported Disease Annotations - ClinVar