Lama2 (laminin subunit alpha 2) - Rat Genome Database

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Gene: Lama2 (laminin subunit alpha 2) Rattus norvegicus
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Symbol: Lama2
Name: laminin subunit alpha 2
RGD ID: 1308889
Description: Predicted to be an extracellular matrix structural constituent. Involved in Schwann cell differentiation. Located in basement membrane and dendritic spine. Biomarker of renovascular hypertension. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to human LAMA2 (laminin subunit alpha 2); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; cell-extracellular matrix signaling pathway; dilated cardiomyopathy pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: laminin subunit alpha-2; laminin, alpha 2; LOC309368
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Lama2Tn(sb-T2/Bart3)2.2013Mcwi  
Genetic Models: F344-Lama2Tn(sb-T2/Bart3)2.2013Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8119,492,126 - 20,140,056 (+)NCBIGRCr8
mRatBN7.2117,672,675 - 18,320,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl117,672,536 - 18,320,530 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0118,491,264 - 19,143,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl118,491,384 - 19,143,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0120,002,787 - 20,647,256 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4118,203,466 - 18,885,462 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1118,324,930 - 18,885,310 (+)NCBI
Celera116,078,601 - 16,724,118 (+)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Lama2Ratcongenital merosin-deficient muscular dystrophy 1A treatmentISOLama2 (Mus musculus)13605609 RGD 
Lama2RatCOVID-19  ISOLAMA2 (Homo sapiens)9068941mRNA:decreased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Lama2Ratmuscular dystrophy susceptibilityISOLAMA2 (Homo sapiens)1600200DNA:splice-site mutation and nonsense mutationRGD 
Lama2Ratmyopia susceptibilityISOLAMA2 (Homo sapiens)13605610DNA:SNP: :rs12205363(human)RGD 
Lama2Ratrenovascular hypertension  IEP 1600206mRNA:decreased expression:heartRGD 
Lama2RatThyroid Neoplasms  IEP 1600207 RGD 
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Original Reference(s)
Lama2RatAutosomal Recessive Limb-Girdle Muscular Dystrophy Type 23  ISOLAMA2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10022829 more ...
Lama2RatCharcot-Marie-Tooth disease  ISOLAMA2 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth diseaseClinVarPMID:25648254
Lama2Ratcongenital merosin-deficient muscular dystrophy 1A  ISOLAMA2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10022829 more ...
Lama2Ratcongenital merosin-deficient muscular dystrophy 1A  ISOLAMA2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10022829 more ...
Lama2Ratcongenital merosin-deficient muscular dystrophy 1A  ISOLAMA2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10022829 more ...
Lama2Ratcongenital merosin-deficient muscular dystrophy 1A  ISOLAMA2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10022829 more ...
Lama2Ratcongenital merosin-deficient muscular dystrophy 1A  ISOLAMA2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10022829 more ...
Lama2Ratcongenital merosin-deficient muscular dystrophy 1A  ISOLAMA2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10022829 more ...
Lama2Ratcongenital merosin-deficient muscular dystrophy 1A  ISOLAMA2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10022829 more ...
Lama2Ratcongenital muscular dystrophy  ISOLAMA2 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital muscular dystrophyClinVar 
Lama2RatCongenital Muscular Dystrophy due to Partial LAMA2 Deficiency  ISOLAMA2 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital muscular dystrophy due to partial LAMA2 deficiencyClinVarPMID:10611118 more ...
Lama2Ratdilated cardiomyopathy  ISOLAMA2 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary dilated cardiomyopathyClinVarPMID:25741868 more ...
Lama2Ratgenetic disease  ISOLAMA2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:10611118 more ...
Lama2Rathypertrophic cardiomyopathy  ISOLAMA2 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypertrophic cardiomyopathyClinVarPMID:25741868 and PMID:28492532
Lama2Ratintellectual disability  ISOLAMA2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:24082139 more ...
Lama2Ratintellectual disability  ISOLAMA2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:24082139 more ...
Lama2Ratisolated elevated serum creatine phosphokinase levels  ISOLAMA2 (Homo sapiens)8554872ClinVar Annotator: match by term: HYPERCKEMIA and IDIOPATHICClinVarPMID:18700894 more ...
Lama2RatMuscle Hypotonia  ISOLAMA2 (Homo sapiens)8554872ClinVar Annotator: match by term: HypotoniaClinVarPMID:25741868
Lama2Ratmuscle tissue disease  ISOLAMA2 (Homo sapiens)8554872ClinVar Annotator: match by term: Muscle tissue disorderClinVar 
Lama2Ratmuscular dystrophy  ISOLAMA2 (Homo sapiens)8554872ClinVar Annotator: match by term: Muscular dystrophyClinVarPMID:25741868 and PMID:28492532
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Original Reference(s)
Lama2Ratcongenital merosin-deficient muscular dystrophy 1A  ISOLAMA2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Lama2Ratmuscular dystrophy  ISOLAMA2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18074402 and PMID:22906800
Lama2Ratmyopia  ISOLAMA2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23396134
Lama2Ratschizophrenia  ISOLAMA2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21822266 and PMID:23042115
Lama2Raturinary bladder cancer  ISOLAMA2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26039340
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Original Reference(s)
Lama2Ratcongenital merosin-deficient muscular dystrophy 1A  ISSLama2 (Mus musculus)13592920OMIM:607855MouseDO 

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Original Reference(s)
Lama2Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of LAMA2 mRNACTDPMID:17557909
Lama2Rat17beta-estradiol increases expressionISOLama2 (Mus musculus)6480464Estradiol results in increased expression of LAMA2 mRNACTDPMID:19484750
Lama2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOLama2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of LAMA2 mRNACTDPMID:17586704
Lama2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of LAMA2 mRNACTDPMID:34747641
Lama2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of LAMA2 mRNACTDPMID:32109520
Lama2Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expressionISOLAMA2 (Homo sapiens)64804642 more ...CTDPMID:26705709
Lama2Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOLama2 (Mus musculus)64804642 more ...CTDPMID:38648751
Lama2Rat4,4'-sulfonyldiphenol increases expressionISOLama2 (Mus musculus)6480464bisphenol S results in increased expression of LAMA2 mRNACTDPMID:30951980
Lama2Rat4,4'-sulfonyldiphenol decreases expressionISOLAMA2 (Homo sapiens)6480464bisphenol S results in decreased expression of LAMA2 mRNACTDPMID:30616060
Lama2Rat4-hydroxyphenyl retinamide decreases expressionISOLama2 (Mus musculus)6480464Fenretinide results in decreased expression of LAMA2 mRNACTDPMID:28973697
Lama2Rat9-cis-retinoic acid decreases expressionISOLAMA2 (Homo sapiens)6480464Alitretinoin results in decreased expression of LAMA2 mRNACTDPMID:15982314
Lama2Rataflatoxin B1 increases methylationISOLAMA2 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of LAMA2 intronCTDPMID:30157460
Lama2Ratall-trans-4-oxoretinoic acid decreases expressionISOLAMA2 (Homo sapiens)64804644-oxoretinoic acid results in decreased expression of LAMA2 mRNACTDPMID:15982314
Lama2Ratall-trans-retinoic acid decreases expressionISOLAMA2 (Homo sapiens)6480464Tretinoin metabolite results in decreased expression of LAMA2 mRNA and Tretinoin results in decreased expression of LAMA2 mRNACTDPMID:15982314
Lama2Ratall-trans-retinoic acid decreases expressionISOLama2 (Mus musculus)6480464Tretinoin results in decreased expression of LAMA2 mRNACTDPMID:16604517
Lama2Ratamiodarone increases expressionISOLama2 (Mus musculus)6480464Amiodarone results in increased expression of LAMA2 mRNACTDPMID:24489787
Lama2Ratamphetamine decreases expressionEXP 6480464Amphetamine results in decreased expression of LAMA2 mRNACTDPMID:30779732
Lama2Ratarsenite(3-) increases methylationISOLAMA2 (Homo sapiens)6480464arsenite results in increased methylation of LAMA2 promoterCTDPMID:23974009
Lama2Ratatrazine multiple interactionsISOLAMA2 (Homo sapiens)6480464[Atrazine co-treated with Arsenates] results in increased expression of LAMA2 mRNACTDPMID:18585445
Lama2Ratatrazine affects methylationEXP 6480464Atrazine affects the methylation of LAMA2 geneCTDPMID:28931070 and PMID:35440735

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Biological Process
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Original Reference(s)
Lama2Ratanimal organ morphogenesis involved_inIBAFB:FBgn0015774 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Lama2Rataxon guidance involved_inIBAFB:FBgn0002526 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Lama2Rataxon guidance acts_upstream_of_or_withinIEAUniProtKB:Q60675 and ensembl:ENSMUSP000000903041600115GO_REF:0000107EnsemblGO_REF:0000107
Lama2Rataxon guidance acts_upstream_of_or_withinISOLama2 (Mus musculus)1624291MGI:109613 PMID:19295126RGDPMID:19295126
Lama2Ratcell adhesion involved_inIEAUniProtKB-KW:KW-01301600115GO_REF:0000043UniProtGO_REF:0000043
Lama2Ratcell adhesion involved_inIEAInterPro:IPR0103071600115GO_REF:0000002InterProGO_REF:0000002
Lama2Ratpositive regulation of synaptic transmission, cholinergic acts_upstream_of_or_withinISOLama2 (Mus musculus)1624291MGI:1856026 PMID:8568931RGDPMID:8568931
Lama2Ratpositive regulation of synaptic transmission, cholinergic acts_upstream_of_or_withinIEAUniProtKB:Q60675 and ensembl:ENSMUSP000000903041600115GO_REF:0000107EnsemblGO_REF:0000107
Lama2Ratregulation of cell adhesion involved_inIEAInterPro:IPR0092541600115GO_REF:0000002InterProGO_REF:0000002
Lama2Ratregulation of cell migration involved_inIEAInterPro:IPR0092541600115GO_REF:0000002InterProGO_REF:0000002
Lama2Ratregulation of embryonic development involved_inIEAInterPro:IPR0092541600115GO_REF:0000002InterProGO_REF:0000002
Lama2RatSchwann cell differentiation  IEP 1600202 RGD 
Lama2Rattissue development involved_inIBAFB:FBgn0002526 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Cellular Component
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Original Reference(s)
Lama2Ratbasement membrane located_inISOLAMA2 (Homo sapiens)1624291 PMID:14557481 and PMID:2099832RGDPMID:14557481 and PMID:2099832
Lama2Ratbasement membrane  IDA 1600203 RGD 
Lama2Ratbasement membrane located_inIEAARBA:ARBA000277081600115GO_REF:0000117UniProtGO_REF:0000117
Lama2Ratbasement membrane located_inIEAUniProtKB:Q60675 and ensembl:ENSMUSP000000903041600115GO_REF:0000107EnsemblGO_REF:0000107
Lama2Ratbasement membrane located_inISOLama2 (Mus musculus)1624291 PMID:12051813 more ...RGDPMID:12051813 more ...
Lama2Ratbasement membrane located_inIEAUniProtKB-KW:KW-00841600115GO_REF:0000043UniProtGO_REF:0000043
Lama2Ratbasement membrane located_inIEAUniProtKB:P24043 and ensembl:ENSP000004003651600115GO_REF:0000107EnsemblGO_REF:0000107
Lama2Ratbasement membrane located_inIEAUniProtKB-SubCell:SL-00251600115GO_REF:0000044UniProtGO_REF:0000044
Lama2Ratbasement membrane is_active_inIBAFB:FBgn0002526 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Lama2Ratdendritic spine  IDA 1600208 RGD 
Lama2Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Lama2Ratextracellular region located_inIEAARBA:ARBA000271281600115GO_REF:0000117UniProtGO_REF:0000117
Lama2Ratneuromuscular junction is_active_inIEAUniProtKB:Q60675 and ensembl:ENSMUSP000000903041600115GO_REF:0000107EnsemblGO_REF:0000107
Lama2Ratneuromuscular junction is_active_inISOLama2 (Mus musculus)1624291 PMID:9396756RGDPMID:9396756
Lama2Ratsarcolemma located_inISOLama2 (Mus musculus)1624291 PMID:11115849 and PMID:9524190RGDPMID:11115849 and PMID:9524190
Lama2Ratsarcolemma located_inIEAUniProtKB:Q60675 and ensembl:ENSMUSP000000903041600115GO_REF:0000107EnsemblGO_REF:0000107
Lama2Ratsynaptic cleft is_active_inISOLama2 (Mus musculus)1624291 PMID:9396756RGDPMID:9396756
Lama2Ratsynaptic cleft is_active_inIEAUniProtKB:Q60675 and ensembl:ENSMUSP000000903041600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function

  
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Original Reference(s)
Lama2Ratextracellular matrix structural constituent enablesIBAMGI:99892 and PANTHER:PTN0008321381600115GO_REF:0000033GO_CentralGO_REF:0000033
Lama2Ratprotein binding enablesISOLama2 (Mus musculus)1624291UniProtKB:Q62165 and PMID:24722207RGDPMID:24722207
Lama2Ratsignaling receptor binding enablesIEAInterPro:IPR0092541600115GO_REF:0000002InterProGO_REF:0000002

Imported Annotations - KEGG (archival)

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Original Reference(s)
Lama2Ratarrhythmogenic right ventricular cardiomyopathy pathway  IEA 6907045 KEGGrno:05412
Lama2Ratcell-extracellular matrix signaling pathway  IEA 6907045 KEGGrno:04512
Lama2Ratdilated cardiomyopathy pathway  IEA 6907045 KEGGrno:05414
Lama2RatEntamoebiasis pathway  IEA 6907045 KEGGrno:05146
Lama2Rathypertrophic cardiomyopathy pathway  IEA 6907045 KEGGrno:05410
Lama2Ratmyocarditis pathway  IEA 6907045 KEGGrno:05416
Lama2Ratsmall cell lung carcinoma pathway  IEA 6907045 KEGGrno:05222
Lama2Rattoxoplasmosis pathway  IEA 6907045 KEGGrno:05145

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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy. Helbling-Leclerc A, etal., Nat Genet. 1995 Oct;11(2):216-8.
4. Correction of a splicing defect in a mouse model of congenital muscular dystrophy type 1A using a homology-directed-repair-independent mechanism. Kemaladewi DU, etal., Nat Med. 2017 Aug;23(8):984-989. doi: 10.1038/nm.4367. Epub 2017 Jul 17.
5. Expression of laminin-2 by normal and neoplastic rat C cells during the development of medullary thyroid carcinoma. Lekmine F, etal., Virchows Arch. 1999 Apr;434(4):325-32.
6. Expression of dystroglycan complex in satellite cells of dorsal root ganglia. Masaki T, etal., Acta Neuropathol (Berl). 2001 Feb;101(2):174-8.
7. Expression of dystroglycan and the laminin-alpha 2 chain in the rat peripheral nerve during development. Masaki T, etal., Exp Neurol. 2002 Mar;174(1):109-17.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Expression of laminin alpha2 chain during normal and pathological growth of myocardium in rat and human. Oliviero P, etal., Cardiovasc Res. 2000 May;46(2):346-55.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Laminin-alpha2 chain-like antigens in CNS dendritic spines. Tian M, etal., Brain Res. 1997 Aug 1;764(1-2):28-38.
17. When do myopia genes have their effect? Comparison of genetic risks between children and adults. Tideman JW, etal., Genet Epidemiol. 2016 Dec;40(8):756-766. doi: 10.1002/gepi.21999. Epub 2016 Sep 9.
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PMID:2099832   PMID:8568931   PMID:9264260   PMID:9396756   PMID:9524190   PMID:11115849   PMID:12051813   PMID:14557481   PMID:15895400   PMID:18757743   PMID:19295126   PMID:19739104  
PMID:22654118   PMID:23376485   PMID:24006456   PMID:27068509   PMID:27559042   PMID:27815338  



Lama2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8119,492,126 - 20,140,056 (+)NCBIGRCr8
mRatBN7.2117,672,675 - 18,320,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl117,672,536 - 18,320,530 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0118,491,264 - 19,143,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl118,491,384 - 19,143,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0120,002,787 - 20,647,256 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4118,203,466 - 18,885,462 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1118,324,930 - 18,885,310 (+)NCBI
Celera116,078,601 - 16,724,118 (+)NCBICelera
Cytogenetic Map1p12NCBI
LAMA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386128,883,138 - 129,516,566 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6128,883,138 - 129,516,566 (+)EnsemblGRCh38hg38GRCh38
GRCh376129,204,283 - 129,837,711 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366129,245,979 - 129,879,404 (+)NCBINCBI36Build 36hg18NCBI36
Build 346129,246,034 - 129,879,401NCBI
Celera6129,950,556 - 130,583,793 (+)NCBICelera
Cytogenetic Map6q22.33NCBI
HuRef6126,785,527 - 127,418,362 (+)NCBIHuRef
CHM1_16129,468,357 - 130,101,369 (+)NCBICHM1_1
T2T-CHM13v2.06130,076,331 - 130,710,229 (+)NCBIT2T-CHM13v2.0
Lama2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391026,857,281 - 27,493,021 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1026,856,032 - 27,495,754 (-)EnsemblGRCm39 Ensembl
GRCm381026,981,285 - 27,617,191 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1026,980,036 - 27,619,758 (-)EnsemblGRCm38mm10GRCm38
MGSCv371026,701,091 - 27,336,748 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361026,670,819 - 27,306,267 (-)NCBIMGSCv36mm8
Celera1027,907,208 - 28,541,586 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1014.23NCBI
Lama2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554369,830,030 - 10,399,891 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554369,829,777 - 10,400,101 (+)NCBIChiLan1.0ChiLan1.0
LAMA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25148,876,669 - 149,513,805 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16146,784,037 - 147,421,936 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06126,672,013 - 127,307,870 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16130,781,676 - 131,415,549 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6130,781,781 - 131,415,337 (+)Ensemblpanpan1.1panPan2
LAMA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1167,645,461 - 68,096,506 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl167,611,122 - 68,095,914 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha168,254,521 - 68,844,637 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0167,721,690 - 68,305,337 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl167,721,701 - 68,304,715 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1167,644,723 - 68,228,165 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0167,427,961 - 68,011,313 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0168,070,825 - 68,654,877 (+)NCBIUU_Cfam_GSD_1.0
Lama2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946117,593,991 - 118,159,491 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936639259,889 - 825,065 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936639259,662 - 825,170 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAMA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl133,866,850 - 34,359,698 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1133,765,412 - 34,359,741 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2137,284,919 - 37,545,503 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LAMA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11344,074,128 - 44,688,187 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1344,073,525 - 44,531,889 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604016,239,880 - 16,874,460 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lama2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247533,336,227 - 3,793,940 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247533,194,678 - 3,794,145 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Lama2
1434 total Variants

Predicted Target Of
Summary Value
Count of predictions:115
Count of miRNA genes:92
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000014917
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 30 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat

1 to 10 of 30 rows
D1Got23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2118,212,061 - 18,212,241 (+)MAPPERmRatBN7.2
Rnor_6.0119,034,627 - 19,034,806NCBIRnor6.0
Rnor_5.0120,539,064 - 20,539,243UniSTSRnor5.0
RGSC_v3.4118,776,338 - 18,776,518RGDRGSC3.4
RGSC_v3.4118,776,339 - 18,776,518UniSTSRGSC3.4
RGSC_v3.1118,776,401 - 18,776,580RGD
Celera116,616,775 - 16,616,954UniSTS
RH 3.4 Map1179.2UniSTS
RH 3.4 Map1179.2RGD
RH 2.0 Map1105.5RGD
Cytogenetic Map1p12UniSTS
RH129016  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2118,320,436 - 18,320,616 (+)MAPPERmRatBN7.2
Rnor_6.0119,143,282 - 19,143,461NCBIRnor6.0
Rnor_5.0120,647,052 - 20,647,231UniSTSRnor5.0
RGSC_v3.4118,885,258 - 18,885,437UniSTSRGSC3.4
Celera116,723,914 - 16,724,093UniSTS
RH 3.4 Map1178.2UniSTS
Cytogenetic Map1p12UniSTS
RH138034  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2117,910,359 - 17,910,570 (+)MAPPERmRatBN7.2
Rnor_6.0118,730,287 - 18,730,497NCBIRnor6.0
Rnor_5.0120,238,082 - 20,238,292UniSTSRnor5.0
RGSC_v3.4118,442,358 - 18,442,568UniSTSRGSC3.4
Celera116,316,149 - 16,316,359UniSTS
RH 3.4 Map1178.3UniSTS
Cytogenetic Map1p12UniSTS
EST-CFZ97756  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2117,718,112 - 17,718,464 (+)MAPPERmRatBN7.2
Rnor_6.0118,535,680 - 18,536,031NCBIRnor6.0
Rnor_5.0120,047,158 - 20,047,509UniSTSRnor5.0
RGSC_v3.4118,249,000 - 18,249,351UniSTSRGSC3.4
Celera116,124,057 - 16,124,408UniSTS
Cytogenetic Map1p12UniSTS
AU049510  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8119,690,444 - 19,690,731 (+)Marker Load Pipeline
mRatBN7.2117,870,999 - 17,871,286 (+)MAPPERmRatBN7.2
Rnor_6.0118,690,967 - 18,691,253NCBIRnor6.0
Rnor_5.0120,199,031 - 20,199,317UniSTSRnor5.0
RGSC_v3.4118,402,537 - 18,402,823UniSTSRGSC3.4
Celera116,276,775 - 16,277,061UniSTS
Cytogenetic Map1p12UniSTS


This gene Lama2 is modified in the following models/strains:




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000014917   ⟹   ENSRNOP00000014917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl117,672,536 - 18,320,530 (+)Ensembl
Rnor_6.0 Ensembl118,491,384 - 19,143,269 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079138   ⟹   ENSRNOP00000070049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl117,672,714 - 18,320,530 (+)Ensembl
Rnor_6.0 Ensembl118,491,384 - 19,143,269 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102071   ⟹   ENSRNOP00000078909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl117,672,536 - 18,320,530 (+)Ensembl
RefSeq Acc Id: NM_001427039   ⟹   NP_001413968
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8119,492,146 - 20,140,056 (+)NCBI
RefSeq Acc Id: XM_063264627   ⟹   XP_063120697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8119,492,126 - 20,140,056 (+)NCBI
RefSeq Acc Id: XM_063264628   ⟹   XP_063120698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8119,492,126 - 20,140,056 (+)NCBI
RefSeq Acc Id: XM_063264629   ⟹   XP_063120699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8119,492,126 - 20,140,056 (+)NCBI
RefSeq Acc Id: XM_063264630   ⟹   XP_063120700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8119,492,126 - 20,140,056 (+)NCBI
RefSeq Acc Id: XM_063264632   ⟹   XP_063120702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8119,492,126 - 20,140,056 (+)NCBI
RefSeq Acc Id: XM_063264637   ⟹   XP_063120707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8119,492,126 - 20,140,056 (+)NCBI
RefSeq Acc Id: XM_063264642   ⟹   XP_063120712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8119,492,126 - 20,140,056 (+)NCBI
1 to 5 of 11 rows
1 to 5 of 11 rows
Ensembl Acc Id: ENSRNOP00000070049   ⟸   ENSRNOT00000079138
Ensembl Acc Id: ENSRNOP00000014917   ⟸   ENSRNOT00000014917
Ensembl Acc Id: ENSRNOP00000078909   ⟸   ENSRNOT00000102071
RefSeq Acc Id: XP_063120697   ⟸   XM_063264627
- Peptide Label: isoform X1
- UniProtKB: F1M614 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120698   ⟸   XM_063264628
- Peptide Label: isoform X2
- UniProtKB: F1M614 (UniProtKB/TrEMBL)

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 52 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-62164 BioCyc
Ensembl Genes ENSRNOG00000011134 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014917 ENTREZGENE
  ENSRNOT00000014917.8 UniProtKB/TrEMBL
  ENSRNOT00000079138 ENTREZGENE
  ENSRNOT00000079138.2 UniProtKB/TrEMBL
  ENSRNOT00000102071.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
  Methyl-accepting chemotaxis protein UniProtKB/TrEMBL
  Tie2 ligand-binding domain superfamily UniProtKB/TrEMBL
InterPro ConA-like_subgrp UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF_laminin UniProtKB/TrEMBL
  Growth_fac_rcpt_N_dom UniProtKB/TrEMBL
  Laminin/Netrin_ECM UniProtKB/TrEMBL
  Laminin_B_type_IV UniProtKB/TrEMBL
  Laminin_G UniProtKB/TrEMBL
  Laminin_I UniProtKB/TrEMBL
  Laminin_II UniProtKB/TrEMBL
  Laminin_N UniProtKB/TrEMBL
NCBI Gene 309368 ENTREZGENE
PANTHER LAMININ SUBUNIT ALPHA-2 UniProtKB/TrEMBL
  NETRIN/LAMININ-RELATED UniProtKB/TrEMBL
Pfam Laminin_B UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/TrEMBL
  Laminin_G_1 UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/TrEMBL
  Laminin_I UniProtKB/TrEMBL
  Laminin_II UniProtKB/TrEMBL
  Laminin_N UniProtKB/TrEMBL
PhenoGen Lama2 PhenoGen
PRINTS EGFLAMININ UniProtKB/TrEMBL
PROSITE EGF_LAM_1 UniProtKB/TrEMBL
  EGF_LAM_2 UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/TrEMBL
  LAMININ_IVA UniProtKB/TrEMBL
  LAMININ_NTER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011134 RatGTEx
1 to 40 of 52 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Lama2  laminin, alpha 2   Lama2_predicted  laminin, alpha 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Lama2_predicted  laminin, alpha 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED