Mcoln2 (mucolipin TRP cation channel 2)

Gene: Mcoln2 (mucolipin TRP cation channel 2) Rattus norvegicus

Analyze

Symbol:

Mcoln2

Name:

mucolipin TRP cation channel 2

RGD ID:

1308884

Description:

Predicted to enable NAADP-sensitive calcium-release channel activity and identical protein binding activity. Predicted to be involved in calcium-mediated signaling and monoatomic cation transmembrane transport. Predicted to act upstream of or within myeloid leukocyte migration and positive regulation of chemokine production. Predicted to be located in recycling endosome. Predicted to be active in membrane. Orthologous to human MCOLN2 (mucolipin TRP cation channel 2); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC292168; MGC124828; mucolipin 2; mucolipin-2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MCOLN2 (mucolipin TRP cation channel 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Mcoln2 (mucolipin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mcoln2 (mucolipin TRP cation channel 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MCOLN2 (mucolipin TRP cation channel 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MCOLN2 (mucolipin TRP cation channel 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mcoln2 (mucolipin TRP cation channel 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MCOLN2 (mucolipin TRP cation channel 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MCOLN2 (mucolipin TRP cation channel 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mcoln2 (mucolipin TRP cation channel 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MCOLN2 (mucolipin TRP cation channel 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Mus musculus (house mouse):	Mcoln2 (mucolipin 2)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mcoln2 (mucolipin 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	cup-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG42638	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Trpml	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mcoln2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	237,714,100 - 237,762,979 (+)	NCBI		GRCr8
mRatBN7.2	2	235,053,816 - 235,102,703 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	235,053,816 - 235,102,702 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	242,843,483 - 242,892,393 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	240,734,735 - 240,783,786 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	235,601,104 - 235,650,008 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	252,018,594 - 252,068,209 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	252,018,597 - 252,068,271 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	270,540,814 - 270,589,451 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	244,323,411 - 244,385,583 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	244,326,614 - 244,371,707 (+)	NCBI
Celera	2	227,034,241 - 227,082,591 (+)	NCBI		Celera
Cytogenetic Map	2	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

4,4'-diaminodiphenylmethane (EXP)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP)

bromobenzene (EXP)

buta-1,3-diene (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

chlordecone (ISO)

choline (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clodronic acid (ISO)

dexamethasone (EXP)

dieldrin (ISO)

dioxygen (ISO)

endosulfan (EXP)

folic acid (ISO)

FR900359 (ISO)

genistein (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

methapyrilene (ISO)

methcathinone (ISO)

methyl methanesulfonate (ISO)

nickel sulfate (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

protein kinase inhibitor (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

succimer (ISO)

sulforaphane (ISO)

temozolomide (ISO)

testosterone (EXP)

tetrachloromethane (EXP)

titanium dioxide (ISO)

valproic acid (ISO)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium-mediated signaling (IEA)

macrophage migration (ISO)

monoatomic cation transmembrane transport (IEA)

neutrophil migration (ISO)

positive regulation of chemokine (C-C motif) ligand 5 production (ISO)

positive regulation of chemokine (C-X-C motif) ligand 2 production (ISO)

positive regulation of chemokine production (ISO)

positive regulation of macrophage inflammatory protein 1 alpha production (ISO)

positive regulation of monocyte chemotactic protein-1 production (ISO)

regulation of chemokine (C-X-C motif) ligand 2 production (ISO)

Cellular Component

endosome membrane (IEA)

lysosomal membrane (IBA)

membrane (IBA)

plasma membrane (IBA)

recycling endosome (ISO)

Molecular Function

identical protein binding (ISO)

NAADP-sensitive calcium-release channel activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:26432893

Genomics

Comparative Map Data

Mcoln2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	237,714,100 - 237,762,979 (+)	NCBI		GRCr8
mRatBN7.2	2	235,053,816 - 235,102,703 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	235,053,816 - 235,102,702 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	242,843,483 - 242,892,393 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	240,734,735 - 240,783,786 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	235,601,104 - 235,650,008 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	252,018,594 - 252,068,209 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	252,018,597 - 252,068,271 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	270,540,814 - 270,589,451 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	244,323,411 - 244,385,583 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	244,326,614 - 244,371,707 (+)	NCBI
Celera	2	227,034,241 - 227,082,591 (+)	NCBI		Celera
Cytogenetic Map	2	q44	NCBI

MCOLN2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	84,925,583 - 84,997,113 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	84,925,583 - 84,997,113 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	85,391,266 - 85,462,796 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	85,163,854 - 85,235,384 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	85,103,287 - 85,174,817	NCBI
Celera	1	83,635,160 - 83,706,701 (-)	NCBI		Celera
Cytogenetic Map	1	p22.3	NCBI
HuRef	1	83,501,272 - 83,572,477 (-)	NCBI		HuRef
CHM1_1	1	85,506,121 - 85,577,633 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	84,766,210 - 84,837,786 (-)	NCBI		T2T-CHM13v2.0

Mcoln2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	145,855,552 - 145,901,269 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	145,855,588 - 145,901,268 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	146,149,796 - 146,195,514 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	146,149,833 - 146,195,513 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	145,812,797 - 145,858,476 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	146,087,229 - 146,132,898 (+)	NCBI		MGSCv36	mm8
Celera	3	152,597,587 - 152,645,127 (+)	NCBI		Celera
Cytogenetic Map	3	H2	NCBI
cM Map	3	71.03	NCBI

Mcoln2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	8,978,226 - 9,037,174 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	8,977,210 - 9,037,110 (+)	NCBI	ChiLan1.0	ChiLan1.0

MCOLN2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	141,938,347 - 142,018,835 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	141,093,585 - 141,171,845 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	117,473,542 - 117,552,814 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	86,333,534 - 86,409,043 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	86,333,534 - 86,409,043 (-)	Ensembl	panpan1.1		panPan2

MCOLN2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	62,956,797 - 63,008,527 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	62,956,804 - 63,200,612 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	65,604,897 - 65,656,536 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	63,494,889 - 63,546,421 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	63,494,883 - 63,546,415 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	63,021,712 - 63,076,135 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	62,992,176 - 63,043,489 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	63,500,378 - 63,551,982 (+)	NCBI		UU_Cfam_GSD_1.0

Mcoln2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	95,561,224 - 95,614,704 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936608	690,253 - 744,001 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936608	690,253 - 744,803 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MCOLN2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	128,776,430 - 128,836,951 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	128,772,904 - 128,836,958 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	119,212,679 - 119,272,344 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MCOLN2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	48,355,014 - 48,435,888 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	48,376,004 - 48,426,171 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	69,343,923 - 69,413,062 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mcoln2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	12,527,608 - 12,591,518 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624742	12,527,562 - 12,591,797 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mcoln2
439 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	87
Count of miRNA genes:	68
Interacting mature miRNAs:	78
Transcripts:	ENSRNOT00000020452
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	193452645	245889826	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	200990457	245990457	Rat
2298479	Eau5	Experimental allergic uveoretinitis QTL 5		0.0021	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	2	202446871	237938339	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	211744537	249053267	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	211744537	249053267	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	211744537	249053267	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	211744537	249053267	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	211744537	249053267	Rat
2317885	Alcrsp28	Alcohol response QTL 28	2.1	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	212828222	249053267	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	214226044	247136170	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	215377404	237938339	Rat
1331767	Hrtrt12	Heart rate QTL 12	3.373		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	218414747	240841241	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
9587428	Epfw6	Epididymal fat weight QTL 6	7.47	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	2	223389739	249053267	Rat
7411555	Bw132	Body weight QTL 132		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	2	223389739	249053267	Rat
631563	Hcuc3	Hepatic copper content QTL 3	3.87		liver copper amount (VT:0003065)	liver copper weight to liver dry weight ratio (CMO:0001512)	2	229059610	249053267	Rat

Markers in Region

RH134845

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	235,102,484 - 235,102,675 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	252,067,991 - 252,068,181	NCBI	Rnor6.0
Rnor_5.0	2	270,589,233 - 270,589,423	UniSTS	Rnor5.0
RGSC_v3.4	2	244,385,365 - 244,385,555	UniSTS	RGSC3.4
Celera	2	227,082,373 - 227,082,563	UniSTS
Cytogenetic Map	2	q44	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2		2	2	10	2				6		3
Low	1	11	36	28	9	28			4	17	15	8
Below cutoff		6	17	11		11	7	8	46	12	25		7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001039005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101881	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC099787	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000020452 ⟹ ENSRNOP00000020452

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	235,053,816 - 235,102,702 (+)	Ensembl
Rnor_6.0 Ensembl	2	252,018,597 - 252,068,271 (+)	Ensembl

RefSeq Acc Id:

NM_001039005 ⟹ NP_001034094

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	237,714,100 - 237,762,979 (+)	NCBI
mRatBN7.2	2	235,053,816 - 235,102,703 (+)	NCBI
Rnor_6.0	2	252,018,594 - 252,068,209 (+)	NCBI
Rnor_5.0	2	270,540,814 - 270,589,451 (+)	NCBI
RGSC_v3.4	2	244,323,411 - 244,385,583 (+)	RGD
Celera	2	227,034,241 - 227,082,591 (+)	RGD

Sequence:

show sequence

GGATCCGGGTGTCCGAACAGTGGTGACTGAGGGAATCTAGGGTCGCGCCATGCCCGAAGGCGAA
GAGACGCTGGACCTGCCAGCGTGGAACCGCGCCCCGGACCCAGCTTGGGGTCCCCAGCACAGAG
CTGCAGTGGCGTCTCTTGATTCTGAGGTGAAGGAAGAGTGTCTGAGGGAAGACCTGAAGTTCTA
CTTCATGAGTCCCTGTGAGAAATACCGAGCCAGACGCCAGATCCCATGGAAACTGGCCTTGCAG
ATTTTGAAGATAGTCATGGTAACCACACAGCTTGTTCGGTTTGGCTTAGGTAACCAGTTGGTGG
TGGCTTTCAAAGAAGATAACACTGTTGCTTTTAAGCACTTGTTTTTGAAAGGATTTTCTGGAGT
TGATGAAGATGACTACAGCTGCAGCATATACACTCAGGAGGACGCCTACGAGAGCATCTTTTTT
GCTATAAAGCAGTATCGCCATCTAAAGAACATTTCCCTGGCCACCCTTGGTTATGGAAAAAGTG
AAGACAATAGAACTGGCTTGAGATTCTGTAAGCAGCACTACAAGAGCGGGGCCATGTTTTCTTC
TAACGAGACCCTGAACATTGACAGTGACATTGAGACAGACTGCACTCACCTGGACCTCCAGGTG
CTCACCAAGGACCCCGAGGACTGGGCACAGGCATCGTTCTTCAGGCTGGATTTTCATCGGCTCG
TACAAGTGGATATCTCTTTTGCCCTCAAAGGAATTGACCTACAGGCAGTTCACTCCCGAGAGGT
ACCAGACTGTTACCTCTTTCAGAATACGATTACCTTCGACAACACGGCCCACAGTGGAAAAATC
AAAATCTACTTTAACAGCGAGGCCAACATAGAAGAATGTAAACACATGAACTTATCTGGGTCTC
TTCAGAGAAGCACCCGCTACGTCCTGGTGTTTGATGTGTTTGTCATTGCGATCTGCCTGGCATC
CCTTATCCTGTGCACAAGATCCATTGTTCTTGCTCTGAGGCTGAGGAAGAGATTTCTAAACTTC
TTCCTGGAGAAGTACAAACAACACGTGTGTGATGCTGACCGGTGGGAGTTCATCAATGGATGGT
ACGTCCTGGTCACTATCAGCGACCTCATGACAATAATTGGATCCATATTGAAGATGGAAATCAA
AGCCAAGAACCTCACAAACTATGACCTGTGCAGCATCCTGCTCGGGACGTCGACGCTCCTTGTC
TGGGTTGGAGTCATCCGATATCTGGGTTACTTTCAGACGTACAATGCGCTCATTTTAACCATGC
AGGCCTCCCTGCCCAAAGTGCTCCGGTTCAGCGCTTGCGCCGGTTTGATCTACCTGGGCTACAC
GTTCTGCGGTTGGATTGTCTTAGGGCCGTACCACGAGAAGTTTGAAAACCTGAACATCGTTGCC
GAATGCCTGTTTTCTCTGGTCAACGGTGATGACATGTTTGCCACATTTGCTCAGATCCAGCAGA
AGAGCCTCCTGGTGTGGCTGTTCAGCCGTCTCTACTTGTACTCCTTCATCAGCCTCTTCATCTA
CATGGTCCTCAGTCTTTTCATCGCGCTCATCACCGATTCGTACCACACCATTAAGAAATACCAG
CAGAATGGGTTTCCTGAAACGGATCTGCAGAAATTCCTGAAGGAGAGTGGTAGCAAAGAAGGGT
ACCAGAAGGAGCCATCAGCCTTGCTGCCCTGTTTCTGCTGTCTGAGGAGGAGAGGAAGTGATGA
CCACTTGGTTCTCGTTGATTAAAACCCTTGGCTAATGCCCATCAAGTCCACACCTCTTCATGCT
GTGGTTGTACGGAGAGGCCCAGAGGCAGCAGCAGTTCATTCAAAGATTGTCCTACTAAGTTGTG
GATCCAGAAGGAGGGGTGTCCGTGAGCTCTTGACGGGAACTGACATACCAAAGTTACTTTTGAT
AAACACAGAGTGTGAAGAGTAGGCCTCTCCTGGGAGTTAATGTGAGGGCAATGTGACAATGAAA
TTCAGCAGGAGTCTGGTCATTTGTGCCATCATAATGTTGAAAGGTTAAAAAAAAGTATTCCCTT
TTCCAAGTTGTGTAAGCAATATTTAAACCCTGGTCAAGGTGTATGTTTATTTCCAGGAAAAGAT
TCATTTCAAAATGTGATCCTTGGATTTAAAGACATTCATTAATTCATGGTCCACATAGAAATAA
ATTTGGCTTCAATACCAAATTAAGACTTGAAACTGGAGAACTGATAAACCATGTAAGGCTCACA
CTCAAAACACTAGCAGGCAGATATCTAGAACTCAGATCATGGCTGGTTGTACTGTGAGCTTGCT
TCTTTAGCAGGCATGACATGCAGTGTCCGTTAGCACAGAGAGAGCGCCTGGCTGCCCCCTCAGG
CAAGCTTCCCCGCCCTGTGCACGTGATGAGTGAGTGGCCCTAAACTTGGCGTGGCCACCTATTT
CATGAGTCAGCTCCACTGTGGTGGGGCTTTGCCCTTGTCATGGAAGGAAATGTGGATTTTTCCT
TAAATAAATTTATTTTCGTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039101881 ⟹ XP_038957809

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	237,723,352 - 237,762,979 (+)	NCBI
mRatBN7.2	2	235,063,066 - 235,102,703 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001034094	(Get FASTA)	NCBI Sequence Viewer
	XP_038957809	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH99787	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000020452
	ENSRNOP00000020452.5

RefSeq Acc Id:

NP_001034094 ⟸ NM_001039005

- UniProtKB:

Q499S1 (UniProtKB/TrEMBL), A6HWD2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPEGEETLDLPAWNRAPDPAWGPQHRAAVASLDSEVKEECLREDLKFYFMSPCEKYRARRQIPW
KLALQILKIVMVTTQLVRFGLGNQLVVAFKEDNTVAFKHLFLKGFSGVDEDDYSCSIYTQEDAY
ESIFFAIKQYRHLKNISLATLGYGKSEDNRTGLRFCKQHYKSGAMFSSNETLNIDSDIETDCTH
LDLQVLTKDPEDWAQASFFRLDFHRLVQVDISFALKGIDLQAVHSREVPDCYLFQNTITFDNTA
HSGKIKIYFNSEANIEECKHMNLSGSLQRSTRYVLVFDVFVIAICLASLILCTRSIVLALRLRK
RFLNFFLEKYKQHVCDADRWEFINGWYVLVTISDLMTIIGSILKMEIKAKNLTNYDLCSILLGT
STLLVWVGVIRYLGYFQTYNALILTMQASLPKVLRFSACAGLIYLGYTFCGWIVLGPYHEKFEN
LNIVAECLFSLVNGDDMFATFAQIQQKSLLVWLFSRLYLYSFISLFIYMVLSLFIALITDSYHT
IKKYQQNGFPETDLQKFLKESGSKEGYQKEPSALLPCFCCLRRRGSDDHLVLVD

hide sequence

RefSeq Acc Id:

ENSRNOP00000020452 ⟸ ENSRNOT00000020452

RefSeq Acc Id:	XP_038957809 ⟸ XM_039101881
- Peptide Label:	isoform X1
- UniProtKB:	A6HWD2 (UniProtKB/TrEMBL)

Protein Domains

Mucolipin extracytosolic Polycystin cation channel PKD1/PKD2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q499S1-F1-model_v2	AlphaFold	Q499S1	1-566	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691812

Promoter ID:

EPDNEW_R2337

Type:

single initiation site

Name:

Mcoln2_1

Description:

mucolipin 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	252,018,578 - 252,018,638	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308884	AgrOrtholog
BioCyc Gene	G2FUF-50906	BioCyc
Ensembl Genes	ENSRNOG00000015089	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000020452	ENTREZGENE
	ENSRNOT00000020452.7	UniProtKB/TrEMBL
Gene3D-CATH	1.10.287.70	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7934506	IMAGE-MGC_LOAD
InterPro	MCLN_ECD	UniProtKB/TrEMBL
	Mucolipin	UniProtKB/TrEMBL
	PKD1_2_channel	UniProtKB/TrEMBL
KEGG Report	rno:292168	UniProtKB/TrEMBL
MGC_CLONE	MGC:124828	IMAGE-MGC_LOAD
NCBI Gene	292168	ENTREZGENE
PANTHER	MUCOLIPIN-2	UniProtKB/TrEMBL
	PTHR12127	UniProtKB/TrEMBL
Pfam	MCLN_ECD	UniProtKB/TrEMBL
	PKD_channel	UniProtKB/TrEMBL
PhenoGen	Mcoln2	PhenoGen
RatGTEx	ENSRNOG00000015089	RatGTEx
UniProt	A6HWD2	ENTREZGENE, UniProtKB/TrEMBL
	Q499S1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-11-12	Mcoln2	mucolipin TRP cation channel 2	Mcoln2	mucolipin 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Mcoln2	mucolipin 2	Mcoln2_predicted	mucolipin 2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Mcoln2_predicted	mucolipin 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar