Srd5a3 (steroid 5 alpha-reductase 3) - Rat Genome Database

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Gene: Srd5a3 (steroid 5 alpha-reductase 3) Rattus norvegicus
Analyze
Symbol: Srd5a3
Name: steroid 5 alpha-reductase 3
RGD ID: 1308828
Description: Predicted to enable 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity; polyprenal reductase activity; and polyprenol reductase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process; dolichyl monophosphate biosynthetic process; and polyprenol catabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Kahrizi syndrome and congenital disorder of glycosylation Iq. Orthologous to human SRD5A3 (steroid 5 alpha-reductase 3); PARTICIPATES IN steroid hormone biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-oxo-5-alpha-steroid 4-dehydrogenase 3; LOC305291; polyprenal reductase; polyprenol reductase; probable polyprenol reductase; RGD1308828; S5AR 3; similar to SRD5A2L; SR type 3; steroid 5-alpha-reductase 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81432,400,603 - 32,414,987 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1432,400,603 - 32,415,117 (-)EnsemblGRCr8
mRatBN7.21432,046,408 - 32,060,796 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1432,046,408 - 32,060,747 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1432,412,742 - 32,427,151 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01433,720,639 - 33,735,052 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01432,205,755 - 32,220,164 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01434,554,769 - 34,570,423 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1434,556,220 - 34,570,356 (-)Ensemblrn6Rnor6.0
Rnor_5.01434,387,218 - 34,402,885 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41434,318,370 - 34,333,413 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1431,347,467 - 31,361,593 (-)NCBICelera
RGSC_v3.11434,318,370 - 34,333,413 (-)NCBI
Cytogenetic Map14p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
choline  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ifosfamide  (ISO)
L-methionine  (ISO)
metformin  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nitrates  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
propiconazole  (EXP)
quercitrin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:17986282   PMID:20637498  


Genomics

Comparative Map Data
Srd5a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81432,400,603 - 32,414,987 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1432,400,603 - 32,415,117 (-)EnsemblGRCr8
mRatBN7.21432,046,408 - 32,060,796 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1432,046,408 - 32,060,747 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1432,412,742 - 32,427,151 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01433,720,639 - 33,735,052 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01432,205,755 - 32,220,164 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01434,554,769 - 34,570,423 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1434,556,220 - 34,570,356 (-)Ensemblrn6Rnor6.0
Rnor_5.01434,387,218 - 34,402,885 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41434,318,370 - 34,333,413 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1431,347,467 - 31,361,593 (-)NCBICelera
RGSC_v3.11434,318,370 - 34,333,413 (-)NCBI
Cytogenetic Map14p11NCBI
SRD5A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38455,346,242 - 55,373,100 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl455,346,213 - 55,373,100 (+)Ensemblhg38GRCh38
GRCh37456,212,409 - 56,239,267 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36455,907,166 - 55,932,235 (+)NCBIBuild 36Build 36hg18NCBI36
Celera453,714,242 - 53,739,692 (+)NCBICelera
Cytogenetic Map4q12NCBI
HuRef452,161,384 - 52,188,230 (+)NCBIHuRef
CHM1_1456,247,542 - 56,274,429 (+)NCBICHM1_1
T2T-CHM13v2.0458,834,370 - 58,861,238 (+)NCBIT2T-CHM13v2.0
Srd5a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39576,285,296 - 76,303,350 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl576,288,118 - 76,303,351 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38576,140,273 - 76,155,503 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl576,140,271 - 76,155,504 (+)Ensemblmm10GRCm38
MGSCv37576,569,302 - 76,584,496 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36577,215,052 - 77,230,246 (+)NCBIMGSCv36mm8
Celera573,411,924 - 73,427,131 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map540.5NCBI
Srd5a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544715,578,661 - 15,588,218 (-)NCBIChiLan1.0ChiLan1.0
SRD5A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2374,421,840 - 74,445,979 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1474,625,843 - 74,649,981 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0468,565,400 - 68,591,400 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1475,131,196 - 75,155,347 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl475,131,196 - 75,155,347 (-)EnsemblpanPan2panpan1.1
SRD5A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11347,627,854 - 47,643,116 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1347,627,913 - 47,642,566 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1347,585,282 - 47,601,064 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01348,238,814 - 48,254,620 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1348,238,759 - 48,253,443 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11347,914,061 - 47,929,821 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01347,442,811 - 47,458,595 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01348,391,087 - 48,406,872 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Srd5a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528528,553,298 - 28,570,808 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648217,727,310 - 17,745,225 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648217,727,418 - 17,744,780 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100525350
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1842,024,352 - 42,049,209 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2844,131,945 - 44,156,754 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SRD5A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1713,193,601 - 13,218,115 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl713,190,412 - 13,217,768 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606613,948,826 - 13,972,878 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srd5a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476114,089,900 - 14,104,408 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476114,087,772 - 14,104,348 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Srd5a3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11132,887,195 - 32,900,856 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Srd5a3
99 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:368
Count of miRNA genes:194
Interacting mature miRNAs:219
Transcripts:ENSRNOT00000003021, ENSRNOT00000059763
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143123808072970315Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143112133339507682Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142252151767521517Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat

Markers in Region
RH133327  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21432,046,547 - 32,046,732 (+)MAPPERmRatBN7.2
Rnor_6.01434,556,181 - 34,556,365NCBIRnor6.0
Rnor_5.01434,388,630 - 34,388,814UniSTSRnor5.0
RGSC_v3.41434,318,332 - 34,318,516UniSTSRGSC3.4
Celera1431,347,429 - 31,347,613UniSTS
RH 3.4 Map14381.68UniSTS
Cytogenetic Map14p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003021   ⟹   ENSRNOP00000003021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1432,400,603 - 32,415,117 (-)Ensembl
mRatBN7.2 Ensembl1432,046,408 - 32,060,747 (-)Ensembl
Rnor_6.0 Ensembl1434,556,717 - 34,570,356 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000059763   ⟹   ENSRNOP00000056514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1432,400,782 - 32,414,994 (-)Ensembl
mRatBN7.2 Ensembl1432,046,587 - 32,060,735 (-)Ensembl
Rnor_6.0 Ensembl1434,556,220 - 34,561,696 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090595   ⟹   ENSRNOP00000069749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1434,556,776 - 34,570,356 (-)Ensembl
RefSeq Acc Id: NM_001013990   ⟹   NP_001014012
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81432,400,781 - 32,414,930 (-)NCBI
mRatBN7.21432,046,586 - 32,060,735 (-)NCBI
Rnor_6.01434,556,219 - 34,570,368 (-)NCBI
Rnor_5.01434,387,218 - 34,402,885 (-)NCBI
RGSC_v3.41434,318,370 - 34,333,413 (-)RGD
Celera1431,347,467 - 31,361,593 (-)RGD
Sequence:
RefSeq Acc Id: NM_001401433   ⟹   NP_001388362
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81432,400,603 - 32,414,973 (-)NCBI
mRatBN7.21432,046,408 - 32,060,778 (-)NCBI
RefSeq Acc Id: XM_039091887   ⟹   XP_038947815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81432,400,603 - 32,414,987 (-)NCBI
mRatBN7.21432,046,415 - 32,060,793 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001014012 (Get FASTA)   NCBI Sequence Viewer  
  NP_001388362 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947815 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86584 (Get FASTA)   NCBI Sequence Viewer  
  EDL89913 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003021
  ENSRNOP00000056514
GenBank Protein Q5RJM1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001014012   ⟸   NM_001013990
- Peptide Label: isoform 1
- UniProtKB: A0A140TAI0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056514   ⟸   ENSRNOT00000059763
Ensembl Acc Id: ENSRNOP00000069749   ⟸   ENSRNOT00000090595
Ensembl Acc Id: ENSRNOP00000003021   ⟸   ENSRNOT00000003021
RefSeq Acc Id: XP_038947815   ⟸   XM_039091887
- Peptide Label: isoform X1
- UniProtKB: Q5RJM1 (UniProtKB/Swiss-Prot),   D4A5U7 (UniProtKB/Swiss-Prot),   D3ZUS5 (UniProtKB/Swiss-Prot),   A0A0G2JSH3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388362   ⟸   NM_001401433
- Peptide Label: isoform 2
- UniProtKB: Q5RJM1 (UniProtKB/Swiss-Prot),   D4A5U7 (UniProtKB/Swiss-Prot),   D3ZUS5 (UniProtKB/Swiss-Prot),   A0A0G2JSH3 (UniProtKB/TrEMBL)
Protein Domains
3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5RJM1-F1-model_v2 AlphaFold Q5RJM1 1-330 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699277
Promoter ID:EPDNEW_R9802
Type:multiple initiation site
Name:Srd5a3_1
Description:steroid 5 alpha-reductase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01434,570,374 - 34,570,434EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308828 AgrOrtholog
BioCyc Gene G2FUF-15934 BioCyc
BioCyc Pathway PWY-6129 [dolichol and dolichyl phosphate biosynthesis] BioCyc
BioCyc Pathway Image PWY-6129 BioCyc
Ensembl Genes ENSRNOG00000002216 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000003021 ENTREZGENE
  ENSRNOT00000059763 ENTREZGENE
IMAGE_CLONE IMAGE:7307843 IMAGE-MGC_LOAD
InterPro 3-oxo-5_a-steroid_4-DH_C UniProtKB/Swiss-Prot
  Dfg10/SRD5A3 UniProtKB/Swiss-Prot
KEGG Report rno:305291 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105689 IMAGE-MGC_LOAD
NCBI Gene 305291 ENTREZGENE
PANTHER POLYPRENOL REDUCTASE UniProtKB/Swiss-Prot
  PTHR14624 UniProtKB/Swiss-Prot
Pfam Steroid_dh UniProtKB/Swiss-Prot
PhenoGen Srd5a3 PhenoGen
PROSITE S5A_REDUCTASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002216 RatGTEx
UniProt A0A0G2JSH3 ENTREZGENE, UniProtKB/TrEMBL
  A0A140TAI0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZUS5 ENTREZGENE
  D4A5U7 ENTREZGENE
  PORED_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary D3ZUS5 UniProtKB/Swiss-Prot
  D4A5U7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-26 Srd5a3  steroid 5 alpha-reductase 3  RGD1308828  similar to SRD5A2L  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1308828  similar to SRD5A2L  RGD1308828_predicted  similar to SRD5A2L (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1308828_predicted  similar to SRD5A2L (predicted)  LOC305291_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC305291_predicted  similar to SRD5A2L (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL