Loxl1 (lysyl oxidase-like 1) - Rat Genome Database

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Gene: Loxl1 (lysyl oxidase-like 1) Rattus norvegicus
Analyze
Symbol: Loxl1
Name: lysyl oxidase-like 1
RGD ID: 1308752
Description: Predicted to enable protein-lysine 6-oxidase activity. Involved in aorta development and response to lipopolysaccharide. Located in acrosomal vesicle and basement membrane. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; exfoliation syndrome; and primary open angle glaucoma. Orthologous to human LOXL1 (lysyl oxidase like 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103689962; LOC315714; lysyl oxidase homolog 1; lysyl oxidase homolog 1-like; MGC105563
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8867,587,636 - 67,612,224 (-)NCBIGRCr8
mRatBN7.2858,691,763 - 58,716,365 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,692,593 - 58,716,356 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx864,222,523 - 64,247,347 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0862,500,076 - 62,524,898 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0860,364,649 - 60,389,471 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0863,067,757 - 63,092,124 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl863,067,300 - 63,092,009 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,843,790 - 62,868,157 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4862,083,052 - 62,106,827 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1862,102,104 - 62,125,881 (-)NCBI
Celera858,155,183 - 58,178,908 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbendazim  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP,ISO)
choline  (ISO)
clotrimazole  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cumene  (ISO)
Cuprizon  (EXP)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
diiodine  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
fenpyroximate  (ISO)
fentanyl  (EXP)
fenvalerate  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
methimazole  (EXP)
microcystin-LR  (EXP)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
oxaliplatin  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
picoxystrobin  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pyrimidifen  (ISO)
rotenone  (EXP,ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tebufenpyrad  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
Trapidil  (EXP)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Differential expression of lysyl oxidases LOXL1 and LOX during growth and aging suggests specific roles in elastin and collagen fiber remodeling in rat aorta. Behmoaras J, etal., Rejuvenation Res. 2008 Oct;11(5):883-9. doi: 10.1089/rej.2008.0760.
2. Molecular alterations underlying the enhanced disruption of spermatogenesis by 2,5-hexanedione and carbendazim co-exposure. Campion SN, etal., Reprod Toxicol. 2012 Jun;33(3):382-9. doi: 10.1016/j.reprotox.2012.01.014. Epub 2012 Feb 8.
3. Maternal exposure to endotoxin delays alveolarization during postnatal rat lung development. Cao L, etal., Am J Physiol Lung Cell Mol Physiol. 2009 May;296(5):L726-37. doi: 10.1152/ajplung.90405.2008. Epub 2009 Feb 13.
4. The LOXL1 gene variations are not associated with primary open-angle and primary angle-closure glaucomas. Chakrabarti S, etal., Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2343-7. doi: 10.1167/iovs.07-1557. Epub 2008 Jan 25.
5. Atomic force microscopy-based antibody recognition imaging of proteins in the pathological deposits in pseudoexfoliation syndrome. Creasey R, etal., Ultramicroscopy. 2011 Jul;111(8):1055-61. doi: 10.1016/j.ultramic.2011.03.008. Epub 2011 Mar 21.
6. LOXL1 promoter haplotypes are associated with exfoliation syndrome in a U.S. Caucasian population. Fan BJ, etal., Invest Ophthalmol Vis Sci. 2011 Apr 12;52(5):2372-8. doi: 10.1167/iovs.10-6268. Print 2011 Apr.
7. Polymorphisms in ARMS2 (LOC387715) and LOXL1 genes in the Japanese with age-related macular degeneration. Fuse N, etal., Am J Ophthalmol. 2011 Mar;151(3):550-6.e1. doi: 10.1016/j.ajo.2010.08.048. Epub 2011 Jan 13.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Evaluation of LOXL1 polymorphisms in primary open-angle glaucoma in southern and northern Chinese. Gong WF, etal., Mol Vis. 2008;14:2381-9. Epub 2008 Dec 19.
11. Association of LOXL1 gene polymorphisms with exfoliation syndrome/glaucoma and primary open angle glaucoma in a Turkish population. Kasim B, etal., Mol Vis. 2013;19:114-20. Epub 2013 Jan 28.
12. Association of LOXL1 polymorphisms with pseudoexfoliation in the Chinese. Lee KY, etal., Mol Vis. 2009 Jun 4;15:1120-6.
13. The role of lysyl oxidase-like 1 DNA copy number variants in exfoliation glaucoma. Liu Y, etal., Mol Vis. 2012;18:2976-81. Epub 2012 Dec 14.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Role of Lysyl oxidase-like 1 gene polymorphisms in Pakistani patients with pseudoexfoliative glaucoma. Micheal S, etal., Mol Vis. 2012;18:1040-4. Epub 2012 Apr 25.
16. Comparison of gene expression profiling in pressure and volume overload-induced myocardial hypertrophies in rats. Miyazaki H, etal., Hypertens Res. 2006 Dec;29(12):1029-45.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. TT polymorphism in rs2165241 and rs1048661 region in lysyl oxidase like-1 gene may have a role in stress urinary incontinence physiopathology. Ozbek E, etal., J Obstet Gynaecol Res. 2013 Jan;39(1):237-42. doi: 10.1111/j.1447-0756.2012.01942.x. Epub 2012 Jul 6.
19. An investigation into LOXL1 variants in black South African individuals with exfoliation syndrome. Rautenbach RM, etal., Arch Ophthalmol. 2011 Feb;129(2):206-10. doi: 10.1001/archophthalmol.2010.349.
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Comprehensive gene review and curation RGD comprehensive gene curation
23. The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers. Thomassin L, etal., J Biol Chem. 2005 Dec 30;280(52):42848-55. Epub 2005 Oct 26.
24. Lyst mutation in mice recapitulates iris defects of human exfoliation syndrome. Trantow CM, etal., Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1205-14. doi: 10.1167/iovs.08-2791. Epub 2008 Nov 21.
25. Lysyl oxidase-like 1 gene polymorphisms in German patients with normal tension glaucoma, pigmentary glaucoma and exfoliation glaucoma. Wolf C, etal., J Glaucoma. 2010 Feb;19(2):136-41. doi: 10.1097/IJG.0b013e31819f9330.
26. Increased choroidal neovascularization following laser induction in mice lacking lysyl oxidase-like 1. Yu HG, etal., Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2599-605. doi: 10.1167/iovs.07-1508. Epub 2008 Feb 22.
Additional References at PubMed
PMID:10022501   PMID:12477932   PMID:15482472   PMID:20551380   PMID:24006456   PMID:26804196   PMID:27068509   PMID:33563876   PMID:38331016  


Genomics

Comparative Map Data
Loxl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8867,587,636 - 67,612,224 (-)NCBIGRCr8
mRatBN7.2858,691,763 - 58,716,365 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,692,593 - 58,716,356 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx864,222,523 - 64,247,347 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0862,500,076 - 62,524,898 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0860,364,649 - 60,389,471 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0863,067,757 - 63,092,124 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl863,067,300 - 63,092,009 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,843,790 - 62,868,157 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4862,083,052 - 62,106,827 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1862,102,104 - 62,125,881 (-)NCBI
Celera858,155,183 - 58,178,908 (-)NCBICelera
Cytogenetic Map8q24NCBI
LOXL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381573,926,462 - 73,952,136 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1573,925,989 - 73,952,137 (+)EnsemblGRCh38hg38GRCh38
GRCh371574,218,803 - 74,244,477 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,005,842 - 72,031,531 (+)NCBINCBI36Build 36hg18NCBI36
Build 341572,005,872 - 72,031,529NCBI
Celera1551,098,617 - 51,121,842 (+)NCBICelera
Cytogenetic Map15q24.1NCBI
HuRef1551,050,475 - 51,076,334 (+)NCBIHuRef
CHM1_11574,336,766 - 74,362,440 (+)NCBICHM1_1
T2T-CHM13v2.01571,743,808 - 71,769,482 (+)NCBIT2T-CHM13v2.0
Loxl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39958,195,006 - 58,220,495 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl958,195,021 - 58,220,469 (-)EnsemblGRCm39 Ensembl
GRCm38958,287,723 - 58,313,212 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl958,287,738 - 58,313,186 (-)EnsemblGRCm38mm10GRCm38
MGSCv37958,135,530 - 58,161,019 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36958,086,738 - 58,111,322 (-)NCBIMGSCv36mm8
Celera955,521,427 - 55,546,968 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.65NCBI
Loxl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554503,715,421 - 3,735,219 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554503,715,109 - 3,734,641 (-)NCBIChiLan1.0ChiLan1.0
LOXL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21663,148,803 - 63,174,918 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11567,313,664 - 67,339,431 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01552,835,675 - 52,861,324 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11571,592,037 - 71,616,540 (+)NCBIpanpan1.1PanPan1.1panPan2
LOXL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13037,191,201 - 37,204,163 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3037,183,128 - 37,204,058 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3037,115,569 - 37,136,800 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03037,387,023 - 37,408,267 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3037,388,729 - 37,410,953 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13037,338,990 - 37,360,204 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03037,365,837 - 37,385,844 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03037,622,173 - 37,642,217 (+)NCBIUU_Cfam_GSD_1.0
Loxl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640115,227,470 - 115,251,814 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647133,075,461 - 33,099,910 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647133,075,542 - 33,099,877 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOXL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl759,481,412 - 59,505,149 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1759,481,410 - 59,505,161 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2764,103,016 - 64,126,771 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOXL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1269,539,383 - 9,565,082 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl269,538,758 - 9,564,751 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048132,049,338 - 132,075,535 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Loxl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624781520,143 - 537,727 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624781518,703 - 537,657 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:46
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000034300
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat

Markers in Region
RH139156  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,713,951 - 58,714,091 (+)MAPPERmRatBN7.2
Rnor_6.0863,089,720 - 63,089,859NCBIRnor6.0
Rnor_5.0862,865,753 - 62,865,892UniSTSRnor5.0
RGSC_v3.4862,104,423 - 62,104,562UniSTSRGSC3.4
Celera858,176,517 - 58,176,656UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000034300   ⟹   ENSRNOP00000032184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl858,692,593 - 58,716,356 (-)Ensembl
Rnor_6.0 Ensembl863,067,300 - 63,092,009 (-)Ensembl
RefSeq Acc Id: NM_001012125   ⟹   NP_001012125
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8867,587,636 - 67,612,224 (-)NCBI
mRatBN7.2858,691,763 - 58,716,365 (-)NCBI
Rnor_6.0863,067,757 - 63,092,124 (-)NCBI
Rnor_5.0862,843,790 - 62,868,157 (-)NCBI
RGSC_v3.4862,083,052 - 62,106,827 (-)RGD
Celera858,155,183 - 58,178,908 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001012125 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89224 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032184.5
RefSeq Acc Id: NP_001012125   ⟸   NM_001012125
- Peptide Label: precursor
- UniProtKB: Q5FWS5 (UniProtKB/TrEMBL),   E9PTE3 (UniProtKB/TrEMBL),   A6J500 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000032184   ⟸   ENSRNOT00000034300

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5FWS5-F1-model_v2 AlphaFold Q5FWS5 1-608 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696029
Promoter ID:EPDNEW_R6554
Type:initiation region
Name:Loxl1_1
Description:lysyl oxidase-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0863,091,903 - 63,091,963EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308752 AgrOrtholog
BioCyc Gene G2FUF-30272 BioCyc
Ensembl Genes ENSRNOG00000008680 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034300.7 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7309311 IMAGE-MGC_LOAD
InterPro LOX-like_protein UniProtKB/TrEMBL
  Lysyl_oxidase UniProtKB/TrEMBL
  Lysyl_oxidase_CS UniProtKB/TrEMBL
KEGG Report rno:315714 UniProtKB/TrEMBL
MGC_CLONE MGC:105563 IMAGE-MGC_LOAD
NCBI Gene 315714 ENTREZGENE
PANTHER LYSYL OXIDASE HOMOLOG 1 UniProtKB/TrEMBL
  LYSYL OXIDASE-LIKE-RELATED UniProtKB/TrEMBL
Pfam Lysyl_oxidase UniProtKB/TrEMBL
PhenoGen Loxl1 PhenoGen
PRINTS LYSYLOXIDASE UniProtKB/TrEMBL
PROSITE LYSYL_OXIDASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008680 RatGTEx
UniProt A6J500 ENTREZGENE, UniProtKB/TrEMBL
  E9PTE3 ENTREZGENE
  Q5FWS5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary E9PTE3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Loxl1  lysyl oxidase-like 1  LOC103689962  lysyl oxidase homolog 1-like  Data merged from RGD:9355195 737654 PROVISIONAL
2014-08-25 LOC103689962  lysyl oxidase homolog 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Loxl1  lysyl oxidase-like 1  Loxl1_predicted  lysyl oxidase-like 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Loxl1_predicted  lysyl oxidase-like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED