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Gene: Lhx8 (LIM homeobox 8) Rattus norvegicus

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Symbol:

Lhx8

Name:

LIM homeobox 8

RGD ID:

1308749

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in response to ethanol. Predicted to be located in female germ cell nucleus. Predicted to be active in nucleus. Orthologous to human LHX8 (LIM homeobox 8); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Lhx7; LIM homeobox protein 8; LIM/homeobox protein Lhx8; LOC365963; MGC109530

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LHX8 (LIM homeobox 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Lhx8 (LIM homeobox protein 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lhx8 (LIM homeobox 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LHX8 (LIM homeobox 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LHX8 (LIM homeobox 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lhx8 (LIM homeobox 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LHX8 (LIM homeobox 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LHX8 (LIM homeobox 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lhx8 (LIM homeobox 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Lhx8 (LIM homeobox 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Lhx8 (LIM homeobox protein 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	LHX8 (LIM homeobox 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	lhx8a (LIM homeobox 8a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	lhx8a (LIM homeobox 8a)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Awh	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	lim-4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PXL1	Alliance	DIOPT (OrthoFinder\|OrthoInspector)
Xenopus tropicalis (tropical clawed frog):	lhx8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	lhx8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	245,904,712 - 245,929,376 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	245,904,712 - 245,929,376 (-)	Ensembl				GRCr8
mRatBN7.2	2	243,244,958 - 243,269,624 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	243,244,961 - 243,269,416 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	251,069,403 - 251,090,965 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	248,963,243 - 248,984,805 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	243,862,639 - 243,884,232 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	260,572,205 - 260,598,744 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	260,574,190 - 260,596,777 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	279,235,991 - 279,260,188 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	252,216,608 - 252,239,112 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	235,171,406 - 235,193,860 (-)	NCBI		Celera
RGSC_v3.1	2	252,231,217 - 252,253,719 (-)	NCBI
Cytogenetic Map	2	q45	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Binge Drinking (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

amosite asbestos (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

belinostat (ISO)

benzo[a]pyrene (EXP,ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dimethylarsinic acid (EXP)

dorsomorphin (ISO)

endosulfan (EXP)

entinostat (ISO)

ethanol (ISO)

folic acid (ISO)

furan (EXP)

indole-3-methanol (EXP)

L-methionine (ISO)

leflunomide (ISO)

mercury dibromide (ISO)

methoxychlor (EXP)

N-acetyl-L-cysteine (EXP)

N-nitrosodiethylamine (EXP)

okadaic acid (ISO)

orphenadrine (EXP)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

pentanal (ISO)

perfluorohexanesulfonic acid (ISO)

phenobarbital (EXP)

propanal (ISO)

SB 431542 (ISO)

serpentine asbestos (ISO)

sunitinib (ISO)

testosterone (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

triclosan (ISO)

trimellitic anhydride (ISO)

valproic acid (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA-templated transcription (IEA)

female gonad development (ISO)

forebrain neuron development (IBA,IEA,ISO)

forebrain neuron differentiation (ISO)

learning or memory (ISO)

neuron differentiation (IBA)

odontogenesis of dentin-containing tooth (ISO)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IBA)

response to ethanol (IEP)

Cellular Component

female germ cell nucleus (ISO)

nucleus (IBA,IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA)

metal ion binding (IEA)

protein binding (ISO)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IBA)

sequence-specific double-stranded DNA binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	HMGB1 neuroimmune signaling and REST-G9a gene repression contribute to ethanol-induced reversible suppression of the cholinergic neuron phenotype.	Crews FT, etal., Mol Psychiatry. 2023 Dec;28(12):5159-5172. doi: 10.1038/s41380-023-02160-6. Epub 2023 Jul 4.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11801365	PMID:12477932	PMID:12703558	PMID:15217369	PMID:15978004	PMID:16690745	PMID:18753606	PMID:23150137	PMID:23385486	PMID:24265310	PMID:25475040

Genomics

Comparative Map Data

Lhx8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	245,904,712 - 245,929,376 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	245,904,712 - 245,929,376 (-)	Ensembl				GRCr8
mRatBN7.2	2	243,244,958 - 243,269,624 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	243,244,961 - 243,269,416 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	251,069,403 - 251,090,965 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	248,963,243 - 248,984,805 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	243,862,639 - 243,884,232 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	260,572,205 - 260,598,744 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	260,574,190 - 260,596,777 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	279,235,991 - 279,260,188 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	252,216,608 - 252,239,112 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	235,171,406 - 235,193,860 (-)	NCBI		Celera
RGSC_v3.1	2	252,231,217 - 252,253,719 (-)	NCBI
Cytogenetic Map	2	q45	NCBI

LHX8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	75,128,434 - 75,199,454 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	75,128,434 - 75,161,533 (+)	Ensembl			hg38	GRCh38
GRCh37	1	75,594,119 - 75,627,218 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	75,366,707 - 75,399,806 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	73,839,451 - 73,872,551 (+)	NCBI		Celera
Cytogenetic Map	1	p31.1	NCBI
HuRef	1	73,728,993 - 73,762,092 (+)	NCBI		HuRef
CHM1_1	1	75,709,516 - 75,742,604 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	74,970,280 - 75,041,301 (+)	NCBI		T2T-CHM13v2.0

Lhx8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	154,011,925 - 154,036,190 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	154,011,931 - 154,036,296 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	154,306,288 - 154,330,560 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	154,306,294 - 154,330,659 (-)	Ensembl			mm10	GRCm38
MGSCv37	3	153,969,257 - 153,993,524 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	154,242,163 - 154,265,944 (-)	NCBI		MGSCv36	mm8
Celera	3	160,766,458 - 160,790,689 (-)	NCBI		Celera
Cytogenetic Map	3	H4	NCBI
cM Map	3	79.12	NCBI

Lhx8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	17,644,871 - 17,668,781 (-)	Ensembl
ChiLan1.0	NW_004955423	17,644,691 - 17,668,969 (-)	NCBI	ChiLan1.0	ChiLan1.0

LHX8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	151,724,416 - 151,752,072 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	150,884,884 - 150,912,497 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	74,356,372 - 74,383,984 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	76,324,804 - 76,357,879 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	76,324,804 - 76,357,879 (+)	Ensembl			panPan2	panpan1.1

LHX8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	71,329,711 - 71,355,851 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	71,329,820 - 71,352,945 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	73,992,529 - 74,018,201 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	71,921,509 - 71,947,201 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	71,920,999 - 71,947,701 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	71,416,782 - 71,442,453 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	71,362,129 - 71,387,952 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	71,856,878 - 71,882,562 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lhx8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	86,811,952 - 86,842,076 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936571	2,326,920 - 2,351,779 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936571	2,326,851 - 2,352,428 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LHX8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	138,074,855 - 138,099,810 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	138,074,673 - 138,102,025 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	128,034,492 - 128,061,739 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LHX8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	58,016,078 - 58,043,651 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	58,017,298 - 58,041,479 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666033	59,429,912 - 59,454,728 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lhx8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	21,638,856 - 21,662,776 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624742	21,638,213 - 21,662,979 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Lhx8
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	7,124,969 - 7,146,779 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Lhx8
218 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	98
Count of miRNA genes:	76
Interacting mature miRNAs:	91
Transcripts:	ENSRNOT00000009370
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	210956252	251712708	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	214404877	251712708	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	220274283	249795005	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	203664411	248664411	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	204795005	249795005	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	214404877	251712708	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	214404877	251712708	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	218051934	251712708	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	214404877	251712708	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	220274283	249795005	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	196140964	251540988	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	214404877	251712708	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	205135267	250135267	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
3	3	17	82	48	48	27	12	27	5	73	38	2	72	2	52	21

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001415091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF220000	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC090011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009370 ⟹ ENSRNOP00000009370

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	245,904,712 - 245,929,376 (-)	Ensembl
mRatBN7.2 Ensembl	2	243,244,961 - 243,269,416 (-)	Ensembl
Rnor_6.0 Ensembl	2	260,574,190 - 260,596,777 (-)	Ensembl

RefSeq Acc Id:

NM_001012219 ⟹ NP_001012219

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	245,904,712 - 245,927,478 (-)	NCBI
mRatBN7.2	2	243,244,958 - 243,267,726 (-)	NCBI
Rnor_6.0	2	260,574,187 - 260,596,777 (-)	NCBI
Rnor_5.0	2	279,235,991 - 279,260,188 (-)	NCBI
RGSC_v3.4	2	252,216,608 - 252,239,112 (-)	RGD
Celera	2	235,171,406 - 235,193,860 (-)	RGD

Sequence:

show sequence

GCGTGCTCGCCCCGGGCTCCTGACCCGCGTCTTCCTGCCTTCCCGCTCTCGCGGCGCAGTGCCC
CGGGCTCATGTCGGAGGAGTGCGGGCGGCCTGCAGCCCTGGCGGCCGGGAGGACCCGCAAAGGC
GCTGGGGAAGAAGGACTGGTGAATCCCGAGGGAGCCGGGGACGAGGACTCCTGCTCCTCCTCGG
CCCCGCTTTCCCCGTCGTCCTCGCCCCAGTCCATGGCCTCGGGCTCCGTGTGCCCACCAGGCAA
GTGTGTGTGCAGCAGCTGCGGCCTGGAGATTGTGGACAAATACCTCCTCAAGGTGAATGACTTA
TGCTGGCATGTCCGCTGTCTCTCCTGCAGTGTCTGCAGAACGTCCCTGGGAAGGCACACAAGCT
GTTACATTAAGGATAAAGACATTTTCTGTAAACTCGATTACTTCAGACGGTATGGGACACGCTG
CTCCCGCTGTGGAAGGCACATCCATTCTACTGACTGGGTCCGCAGGGCCAAGGGCAACGTGTAT
CACTTGGCTTGCTTTGCCTGCTTTTCTTGCAAGAGGCAACTGTCCACGGGAGAGGAGTTTGCCT
TGGTAGAGGAGAAGGTCCTCTGTAGAGTGCACTTTGACTGCATGCTGGACAATCTGAAGAGAGA
AGTGGAGAACGGTAATGGGATTAGTGTGGAAGGAGCCCTTCTCACAGAACAAGACGTCAATCAT
CCAAAGCCAGCCAAAAGAGCTCGGACCAGCTTCACAGCCGATCAGCTCCAGGTTATGCAAGCAC
AGTTTGCTCAGGACAACAACCCAGACGCACAGACCCTCCAGAAACTGGCAGAAAGGACAGGCTT
AAGCCGGCGAGTCATACAGGTGTGGTTTCAGAACTGCAGGGCTCGTCATAAGAAACATGTCAGT
CCCAACCACTCCTCCTCTGCCCCGGTCACAGCAGTCCCCTCATCCAGGCTGTCTCCACCCATGT
TGGAAGAAATGGCTTATTCCGCCTACGTGCCCCAGGACGGGACGATGCTGACGGCGCTGCATTC
ATACATGGACGCTCACCAACAACTCCTGGACTCCAGCCCTTGCTACCCCATACAATGACCCAAC
TGCCAATAAGTCATACTTAATTCCTTCTTTCAGGGATAGAAATGATTGAGGATATAAACCTGTC
ATTTATTATGTATAAAATACCATTGAAAAGATATTAATGTTAATTTTTTATTTAACACTCAAAG
GCATTTCGAACATCCTTTCGCCGTCCACGTATGTACCTAGAGTTGGCCTGCAAGACACTTTTAT
TAATTCTTCATTTTGGTTTTTTTTTTTTTTGGGTAAAACTTATGTTTACAAGAAGAAAACAAGT
CAAAACAATTTTTTTTGTATTGTCTGGAAATAGTTGGCTCCAGTGTGTGTCTATTAACTTATTT
GTCATCAAAAGAGCACTTTGCCTAAAAGGCAGGACTGATAGTGTGCAAAAACGTTTACAATCCT
TTGTGAAACCGTAGTTTATCATTAGTTTGTACCTGTAAGTTATTGTTATAAATATTATCTGTAT
TTTTTGTCATATACAACTTTATACCTTGAAGCTTGTATCTGTGAATTTGCAACTGAAATTTATT
TTGCCAGTGTTTTCTGGACGAGCTTGAGTGCACGTCCGTTGTAGCATGCCGCACACACCCACGG
CGGTGTCTGCACTTGGGGAGTTCTAGCTGTAAATAACACTCTAGTTTACGAAGCCTACCATCCT
AAGTTCATTAAACATTTCGCATCCTTGTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_001415091 ⟹ NP_001402020

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	245,904,712 - 245,929,376 (-)	NCBI
mRatBN7.2	2	243,244,958 - 243,269,624 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001012219	(Get FASTA)	NCBI Sequence Viewer
	NP_001402020	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF29536	(Get FASTA)	NCBI Sequence Viewer
	AAH90011	(Get FASTA)	NCBI Sequence Viewer
	EDL82535	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009370
	ENSRNOP00000009370.6

RefSeq Acc Id:	NP_001012219 ⟸ NM_001012219
- Peptide Label:	isoform 2
- UniProtKB:	A0A8J8Y3T8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSEECGRPAALAAGRTRKGAGEEGLVNPEGAGDEDSCSSSAPLSPSSSPQSMASGSVCPPGKCV CSSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSR CGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHFDCMLDNLKREVE NGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSR RVIQVWFQNCRARHKKHVSPNHSSSAPVTAVPSSRLSPPMLEEMAYSAYVPQDGTMLTALHSYM DAHQQLLDSSPCYPIQ hide sequence

Ensembl Acc Id:

ENSRNOP00000009370 ⟸ ENSRNOT00000009370

RefSeq Acc Id:	NP_001402020 ⟸ NM_001415091
- Peptide Label:	isoform 1
- UniProtKB:	Q5FVG3 (UniProtKB/TrEMBL), A6HWP9 (UniProtKB/TrEMBL), G3V6V6 (UniProtKB/TrEMBL)

Protein Domains

Homeobox LIM zinc-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V6V6-F1-model_v2	AlphaFold	G3V6V6	1-336	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308749	AgrOrtholog
BioCyc Gene	G2FUF-50763	BioCyc
Ensembl Genes	ENSRNOG00000028348	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009370	ENTREZGENE
	ENSRNOT00000009370.7	UniProtKB/TrEMBL
Gene3D-CATH	Cysteine Rich Protein	UniProtKB/TrEMBL
	Homeodomain-like	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7324565	IMAGE-MGC_LOAD
InterPro	Homeobox	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/TrEMBL
	Homeodomain-like	UniProtKB/TrEMBL
	LIM_Homeobox_TF	UniProtKB/TrEMBL
	Znf_LIM	UniProtKB/TrEMBL
KEGG Report	rno:365963	UniProtKB/TrEMBL
MGC_CLONE	MGC:109530	IMAGE-MGC_LOAD
NCBI Gene	365963	ENTREZGENE
PANTHER	LIM/HOMEOBOX PROTEIN LHX	UniProtKB/TrEMBL
	LIM/HOMEOBOX PROTEIN LHX8	UniProtKB/TrEMBL
Pfam	Homeobox	UniProtKB/TrEMBL
	LIM	UniProtKB/TrEMBL
PhenoGen	Lhx8	PhenoGen
PROSITE	HOMEOBOX_1	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
	LIM_DOMAIN_1	UniProtKB/TrEMBL
	LIM_DOMAIN_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000028348	RatGTEx
SMART	HOX	UniProtKB/TrEMBL
	LIM	UniProtKB/TrEMBL
Superfamily-SCOP	Glucocorticoid receptor-like (DNA-binding domain)	UniProtKB/TrEMBL
	Homeodomain_like	UniProtKB/TrEMBL
UniProt	A0A8J8Y3T8	ENTREZGENE, UniProtKB/TrEMBL
	A6HWP9	ENTREZGENE, UniProtKB/TrEMBL
	G3V6V6	ENTREZGENE, UniProtKB/TrEMBL
	Q5FVG3	ENTREZGENE
UniProt Secondary	Q5FVG3	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-26	Lhx8	LIM homeobox 8	Lhx8	LIM homeobox protein 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-05-12	Lhx8	LIM homeobox protein 8	Lhx8	LIM homeobox protein 8	Data merged from RGD:621268	737654	APPROVED
2008-05-12	Lhx8	LIM homeobox protein 8	Lhx8_predicted	LIM homeobox protein 8 (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-20	Lhx8	LIM homeobox protein 8			Symbol and Name status set to approved	1299863	APPROVED
2005-01-12	Lhx8_predicted	LIM homeobox protein 8 (predicted)			Symbol and Name status set to approved	70820	APPROVED
2002-08-07	Lhx8	LIM homeobox protein 8			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in cholinergic neurons of the basal forebrain	724413

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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